780 research outputs found
Dr D.B. Smuts : Onderstepoort staff
No full textScanned image of a photographic glass-plate negativeDr D.B. Smuts, Onderstepoort staff memberin the Section of Nutrition in the late 1930's. He was co-author of the article "The Nutritive Value of Animal Proteins.-
The Biological Values of Fishmeal, Whale and Fishmeal, Meatmeal, Meat and Bonemeal, Crayfishmeal, and White Fishmeal" published in the Onderstepoort Journal of Veterinary Science and Animal Industry, Volume 16, Numbers 1 and 2, January and April, 1941.Digitised by the Department of Library Services, University of Pretoria, 2019ab201
Letter, 1858 May 8, D.B. Sanchez (?) to Henry Honaker
No full textLetter regarding the sale of a bull. Last name of author unclear, possibly Sanchez or San..z
The Documentary Art of Filmmaker Michael Rubbo
No full textMichael Rubbo’s groundbreaking work has had a deep and enduring impact on documentary filmmaking worldwide, though his name has remained relatively unknown. In The Documentary Art of Michael Rubbo, author D.B. Jones traces Rubbo’s filmmaking from his days as a film student at Stanford, through his twenty years at the National Film Board of Canada, where Rubbo developed his distinct documentary style. Jones then describes Rubbo’s post-NFB venture into feature film directing, followed by Rubbo’s return to his native Australia, first as an executive with the Australian Broadcasting Corporation, and later as a director of feature-length documentaries and maker of short, personal films for YouTube. Exploring locales from Montreal to Vietnam, topics as diverse as plastic surgery and French Marxism, and from interviewing Margaret Atwood to documenting a failed attempt to interview Fidel Castro, Rubbo’s wide-ranging work establishes his innovative, personal, lyric, and spontaneous documentary style. In The Documentary Art of Michael Rubbo D.B. Jones reveals not only the depth of meaning in Rubbo’s films, but also the depth of their influence on filmmaking itself
The Documentary Art of Filmmaker Michael Rubbo
No full textMichael Rubbo’s groundbreaking work has had a deep and enduring impact on documentary filmmaking worldwide, though his name has remained relatively unknown. In The Documentary Art of Michael Rubbo, author D.B. Jones traces Rubbo’s filmmaking from his days as a film student at Stanford, through his twenty years at the National Film Board of Canada, where Rubbo developed his distinct documentary style. Jones then describes Rubbo’s post-NFB venture into feature film directing, followed by Rubbo’s return to his native Australia, first as an executive with the Australian Broadcasting Corporation, and later as a director of feature-length documentaries and maker of short, personal films for YouTube. Exploring locales from Montreal to Vietnam, topics as diverse as plastic surgery and French Marxism, and from interviewing Margaret Atwood to documenting a failed attempt to interview Fidel Castro, Rubbo’s wide-ranging work establishes his innovative, personal, lyric, and spontaneous documentary style. In The Documentary Art of Michael Rubbo D.B. Jones reveals not only the depth of meaning in Rubbo’s films, but also the depth of their influence on filmmaking itself
The Documentary Art of Filmmaker Michael Rubbo
No full textMichael Rubbo’s groundbreaking work has had a deep and enduring impact on documentary filmmaking worldwide, though his name has remained relatively unknown. In The Documentary Art of Michael Rubbo, author D.B. Jones traces Rubbo’s filmmaking from his days as a film student at Stanford, through his twenty years at the National Film Board of Canada, where Rubbo developed his distinct documentary style. Jones then describes Rubbo’s post-NFB venture into feature film directing, followed by Rubbo’s return to his native Australia, first as an executive with the Australian Broadcasting Corporation, and later as a director of feature-length documentaries and maker of short, personal films for YouTube.
Exploring locales from Montreal to Vietnam, topics as diverse as plastic surgery and French Marxism, and from interviewing Margaret Atwood to documenting a failed attempt to interview Fidel Castro, Rubbo’s wide-ranging work establishes his innovative, personal, lyric, and spontaneous documentary style. In The Documentary Art of Michael Rubbo D.B. Jones reveals not only the depth of meaning in Rubbo’s films, but also the depth of their influence on filmmaking itself.Ye
Approaches to introduce helical structure in cysteine-containing peptides with a bimane group
No full textFirst published: 09 June 2021An i-i+4 or i-i+3 bimane-containing linker was introduced into a peptide known to target Estrogen Receptor alpha (ERα) in order to stabilise an α-helical geometry. These macrocycles were studied by CD and NMR to reveal the i-i+4 constrained peptide adopts a 310-helical structure in solution, and an α-helical conformation on interaction with the ERα coactivator recruitment surface in silico. An acyclic bimane-modified peptide is also helical, when it includes a tryptophan or tyrosine residue; but is significantly less helical with a phenylalanine or alanine residue, which indicates such a bimane modification influences peptide structure in a sequence dependent manner. The fluorescence intensity of the bimane appears influenced by peptide conformation, where helical peptides displayed a fluorescence increase when TFE was added to phosphate buffer, compared to a decrease for less helical peptides. This study presents the bimane as a useful modification to influence peptide structure as an acyclic peptide modification, or as a side-chain constraint to give a macrocycle.Aimee J. Horsfall, Daniel P. McDougal, Denis B. Scanlon, John B. Bruning, Andrew D. Abel
July 13, 1905 Page four Puebla had a rough passage up the coast Juryterm called and list selected M.G. Baker sells his hotel in Tacoma Chemakum Tribe No. 1 installs its officers Whatcom and Zapora in collision Washington Elks stand high in the list
No full textConger, J.R.D.; Tibbals, H.L.; Attridge, Arthur; Edgill, Noah; Macomber, Julius; Baker, M.G.; Hamilton, Bert; Ray, Scanlon; Brown, J.D.; Wescott, D.B.; Trimble, D.P.; Krueger, Charles; Klocker, Oscar; Scott, James W.B.; Olson, Charles A.; Mercereau, C.W.; Manson, P.A.; Krueger, C.A.; Forsyth, R.W.; Biggs, E.T.; Denkewalter, Otto W.; Heath, J.C.; Snyder, N.S.; Franklyn, James P.; Weiderholt, George; Sorge, Otto; Torjusen, T.; Lake, William T.; Rickman, Charles E.; Bushey, G.W.; Achenbach, John; Oakley, J.H.;steamer Puebla; liner Minnesota; steamer Whatcom; steamer Zaporo
Capturing value increase in urban redevelopment : a study of how the economic value increase in urban redevelopment can be used to finance the necessary public infrastructure and other facilities
No full textContains fulltext :
83166.pdf (Publisher’s version ) (Open Access)Everyone would agree that urban development, especially when involving the building of residential areas, should be accompanied by sufficient and good public infrastructure and facilities. We all want neighborhoods with the necessary roads, green areas, social facilities, affordable housing and public spaces of high quality. At the same time, nowadays, governments are facing severe cuts in public expenditure. So who is going to pay for all that quality? In the Netherlands and in many other countries, achieving these public goals has become a problem, especially in the regeneration of deteriorated inner cities sites. This book offers insight in how the economic value increase that arises from urban development can serve to finance the quality we want, without the need for public subsidies. The findings and recommendations made in this book focus on Western Europe, mainly on successful and alternatively less successful recent experiences in Spain, England and the Netherlands. Public bodies can use the recommendations to create the necessary conditions to improve the involvement of property developers and landowners in the financing of infrastructure and facilities. Property developers and landowners can find formulas for private-public partnership that can lead to lower development costs and risks, allowing them to pay for good infrastructure and facilities while maintaining profitability. Scholars will find here the theoretical backgrounds for this relevant topic. The author has both an academic and a professional background in the practice of urban development.Radboud Universiteit Nijmegen, 22 november 2010Promotor : Needham, D.B.451 p
Inhibition of Siah ubiquitin ligase function
No full textTumor hypoxia induces the upregulation of hypoxiainducible factor 1a (Hif-1a), which in turn induces the expression of genes including VEGF to recruit new blood vessel outgrowth, enabling tumor growth andmetasta sis. Interference with the Hif-1 pathway and neoangiogenesis is an attractive antitumor target. The hydroxylation of Hif-1a by prolyl-hydroxylase (PHD) proteins during normoxia serves as a recognition motif for its proteasomal degradation. However, under hypoxic conditions, hydroxylation is inhibitedan dfurt hermore, PHD proteins are themselves polyubiquitylated and degraded by Siah ubiquitin ligases. Our data demonstrate for the first time that inhibition of the interaction between Siah and PHD proteins using a fragment derived from a Drosophila protein (phyllopod) interferes with the PHD degradation. Furthermore, cells stably expressing the phyllopod fragment display reduced upregulation of Hif-1a protein levels and Hif-1-mediated gene expression under hypoxia. In a syngeneic mouse model of breast cancer, the phyllopod fragment reduced tumor growth and neoangiogenesis and prolonged survival of the mice. In addition, levels of Hif-1a andits target Glut-1 are reduced in tumors expressing the phyllopodfragment . These data show, in a proof-of principle study, that Siah protein, the most upstream component of the hypoxia pathway yet identified, is a viable drug target for antitumor therapies.A. Möller, C.M. House, C.S.F. Wong, D.B. Scanlon, M.C.P. Liu, Z. Ronai and D.D.L. Bowtel
Second Coming
No full textHank Jones isn\u27t your typical alien abductee. There were no tractor beams, probes, or government conspiracies involved-no, Hank met his kidnappers at a bar. They weren\u27t exactly hard to miss-Elvis, a seven-foot tall Elvis clone, and Lawrence, a grounded European gent, were the only UCLA supporters in a bar full of Hoosiers. Still, Hank has nothing better to do. It\u27s spring break, there\u27s a pile of freshman essays on his desk, and his thesis is going nowhere. Worse, his ex is sleeping with his dissertation director. He needs a friend, and these aliens will do. Besides, Elvis and Lawrence could really use a hand-they haven\u27t visited Earth since the 1950s, and now they\u27re lost in Indiana, not realizing that things have changed. They need to get to Washington: if they don\u27t warn the president about a coming nuclear arms race, the planet will be destroyed. But the American public don\u27t seem too worried. Aliens? And one of them looks like Elvis? Facebook and Twitter are aflame. Oprah and The Tonight Show hang on the phone. The apocalypse will have to wait. Second Coming is the hilarious new novel by D.B. Borton , author of the Cat Caliban and Gilda Liberty series. Taking aim at consumerism, the cult of celebrity, and the self-destructiveness of humanity, it nonetheless finds joy in the pleasures of basketball, dogs, and rock \u27n\u27 roll.https://digitalcommons.owu.edu/eng_books/1015/thumbnail.jp
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