1,721,126 research outputs found
Cutaneous Fibropapilloma in a Red Deer (Cervus elaphus) Associated with Cervus elaphus Papillomavirus in Portugal
No full textA pedunculated cauliflower-like mass was detected on the left posterior limb of a subadult male red deer (Cervus elaphus) after a hunt in Portugal. Histologically the lesion was classified as cutaneous fibropapilloma. The identification of Cervus elaphus papillomavirus (CePV-1 variant) was based on sequencing of the L1 gene. The L2 sequence revealed a nine-nucleotide deletion, as already reported in the Italian and Hungarian CePV-1, further supporting the theory that this is a distinctive genomic characteristic of this viral variant, as this feature has been found in distinct cases from geographically distant countries. In addition, a coinfection with bovine papillomavirus was evidenced by amplification and sequencing of the E5 gene, confirming the ability of Delta papillomaviruses to cross-infect different animal species and providing more evidence that wildlife may act as reservoir for papillomaviruses affecting domestic species. Papillomavirus infection in red deer has been sporadically described in different European countries; in this work, we describe the identification of a CePV-1 variant infection associated with a red deer fibropapilloma in Portugal
SPRAYABLE PHARMACEUTICAL COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING SUCRALFATE GEL
No full textThe present invention relates to pharmaceutical compositions for topical use comprising sucralfate gel, PVA and optionally a vegetable product comprising tocotrienols and tocopherols. In particular, these compositions have proved to be suitable for being sprayed, thus finding advantageous application in the treatment of skin lesions, even very deep lesions, such as second-degree burns
Zoonoses—Diseases Naturally Transmitted From Animals to Humans
No full textDiseases that are naturally transmitted from animals to humans
are called zoonoses or zoonotic diseases. More than 70% of all
human infectious diseases came from animals, including Ebola,
human immunodeficiency virus (HIV/AIDS), avian influenza and
Monkeypox. The COVID-19 pandemic is also a novel zoonosis,
caused by a coronavirus that probably came from bats. Zoonoses
can happen any time humans come into contact with animals or
animal products. Children, people with weakened immune systems
or chronic health conditions, and pregnant women are at higher
risk of contracting zoonoses. Zoonoses are widespread—not only in
forests and wild environments but also in urban areas. This article
includes background information on zoonoses and how they move
into humans. It also provides helpful tips to avoid infection with these
diseases. Finally, it discusses the importance of preventing disease in
animals, so that animal diseases are not transmitted to humans
Bovine papillomavirus type 7 in Italy: complete genomes and sequence variants
No full textTwo novel bovine papillomavirus type 7 (BPV-7) variants have been identified in teat cutaneous papillomas affecting dairy cows in northern Italy. The entire genome sequences of two BPV-7 Italian variants showed major sequence differences in the long control region (LCR) and in the L2 gene compared to the Japanese reference strain. In order to define the stability of these genetic variants, the L2 and LCR sequences of seven further BPV-7 positive isolates were characterized. An insertion of six amino acids in the L2 structural protein has been detected in all samples while different genetic variants have been identified for the LCR. These findings provide new insights on intra-type variability of BPVs and represent a starting point for future studies aimed at establishing the biological role of the different BPV genomic regions and investigating the pathogenic potential of papillomavirus variants
Molecular identification of neglected zoonotic pathogens on biopsies of Leishmania-like skin lesions
No full textEditorial: Taking a Fresh Look at Old Zoonoses, What Have We Been Missing in One Health Research and Education?
Full text linkNo abstract available.https://www.frontiersin.org/journals/public-healthdm2022Veterinary Tropical Disease
Identification and characterization of Fringilla coelebs Papillomavirus 1 (FcPV1) in free-living and captive birds in Italy
No full textA papillomavirus (PV) was identified by negative-staining electron microscopy in skin lesions of two bird species (Fringillidae) in Italy. Genetic analyses revealed an FcPV1 with a low genetic variability in the E6, E7, E1, E2, and L1 genes and the long control region when compared to the FcPV1 reference strain
Effects of Tail Docking in sheep on histological features of the muscles of the pelvic diaphragm
No full textTail docking in sheep husbandry is often performed due to tradition rather than necessity. This practice causes mild to moderate acute pain and the magnitude of the pain associated with tail removal seems to be related to length of tail removed. Ultra-short docking increases the risk of rectal and vaginal prolapse at lambing relative to sheep with longer tails and predisposes to neuroma and nerve degeneration.
The aim of the present study was to evaluate the histological features of the muscles and the related nerves of the pelvic diaphragm in adult sheep subjected in the past to caudectomy as well as in intact lambs.
After euthanasia, small samples of external anal sphincter, levator ani, coccygeal muscles and branches of deep perineal nerve were obtained, processed according to the usual histological techniques and stained with hematoxylin-eosin and Masson's trichrome.
The results showed changes in shape and size of the muscle fibers of the adult sheep. In fact, enlarged or “moth-eaten” fibers were observed amidst normal sized fibers in each of the three muscles of the pelvic diaphragm; furthermore, some internal nuclei were observed. On the contrary, the lambs’ muscles appeared normal.
Conversely, the nerve fibers were found to be normal both in sheep and lambs.
The muscle abnormalities observed in tail-docked sheep suggest that caudectomy, in the long term, may predispose to prolapses.
Improved understanding of the long-term consequences of tail docking, especially the possibility of chronic pain, is needed
PAPILLOMAVIRUS IN HEALTHY SKIN AND MUCOSA OF WILD RUMINANTS IN THE ITALIAN ALPS
No full textWe investigated healthy skin and mucosal specimens of wild ruminants in the Italian Alps. We identified bovine papillomavirus (BPV)-2 DNA in the healthy skin of wild ruminants and documented coinfection of BPV-1 and Cervus elaphus papillomavirus (CePV)-1 in a healthy red deer (Cervus elaphus). We also demonstrated cross-infections of BPVs of the genus Xipapillomavirus, both as single virus infection and also in association with Deltapapillomavirus types 1 and 2, confirming that host tropism of papillomaviruses is not as species-specific as previously thought. Our results suggest that subclinical infections could be linked to the presence of domestic ruminants sharing the same habitat with wild species and that the wildlife may act as a reservoir for papillomaviruses affecting domestic species
Multiple gene typing and phylogeny of avipoxvirus associated with cutaneous lesions in a stone curlew
No full textAvipoxvirus (APV) infections have been observed in a wide variety of wild, captive and domestic avian hosts, recently including a range of island endemic and endangered species. However, not enough is known about genome diversity and phylogenetic relationships of APVs, as well as their host-range specificity. A wild stone curlew (Burhinus oedicnemus) was recovered in Sardinia (Italy), showing large wart-like lesions and nodules on both legs and toes, which resulted positive to poxvirus by PCR. Histopathological examination of the lesions showed ballooning degeneration and large intracytoplasmic inclusion bodies consistent with APV infection. A multiple gene sequencing approach was applied to highlight the phylogenetic relationships of this virus with a panel of selected APVs at the clade and subclade levels. This novel isolate was characterized by sequencing partial 4b core protein, P35 (locus fpv140) and DNA polymerase genes and phylogenetic analyses assigned it to clade A, (Fowlpox virus, FWPV), subclade A2. Conservation implications of avian pox presence in Sardinian stone curlews and possibly in other island bird species are discussed
- …
