125,638 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Location map of examined localities in the Altai-Sayan region.
No full text<p>Abbreviations: B. R. - Biosphere Reserve; Z. – Zapovednik (National Park). Dashed line: state borders, solid line: Altai-Sayan region borders according to WWF ecoregion.</p
Influence of citric acid on calcium sulfate dihydrate crystallization in aqueous media
No full textThe crystallization of Calcium sulfate dihydrate produced by the reaction between pure Ca(OH)(2) suspension and H2SO4 solution was investigated at different pH values, temperatures and citric acid concentrations. Crystal size distributions, filtration rates and zeta potentials of gypsum were determined as a function of citric acid concentrations at pH 3.5 and 65 degrees C. The influence of citric acid on the morphology of gypsum was also investigated and discussed. The average particle size of gypsum was reached to maximum in the presence of approximately 2500 ppm citric acid concentration, where the minimum cake resistance and maximum filtration rate were obtained. In the presence of citric acid, various crystal morphologies such as tabular, plate-like, double-taper leaf-like and flower-like, etc., were obtained. The change of morphology is related to the preferential adsorption of citric acid on different crystallographic faces. (c) 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
p73 and p63 regulate the expression of fibroblast growth factor receptor 3
No full textp53, p63 and p73 make a family of transcription factors that play a vital role in development and cancer. All p53 family members have more than one promoter producing Transactivating (TA) and Dominant Negative (ΔN) isoforms and their mRNAs are subjected to extensive splicing at 3' end to produce multiple protein products. p53 is usually inactivated by point mutations during tumorigenesis, whereas the expression levels and p63 and p73 are modulated to give tumor cells a selective advantage. In this study, aiming to find novel targets of the p53 family members, we identified FGFR3 as a gene transcriptionally controlled by p63 and p73. FGFR3 has been implicated in development and tumor biology as activating mutations of this gene was described in skeletal disorders, non-invasive skin conditions and superficial bladder cancers. We found that TAp73, TAp63 and DeltaNp63 was capable of inducing FGFR3. siRNA mediated downregulation of DeltaNp63 decreased endogenous FGFR3 protein levels. Our findings of this new link between p53 family proteins and FGFR3 may help understanding the transition of superficial bladder cancers to an invasive phenotype
p73 and p63 regulate the expression of fibroblast growth factor receptor 3
No full textp53, p63 and p73 make a family of transcription factors that play a vital role in development and cancer. All p53 family members have more than one promoter producing Transactivating (TA) and Dominant Negative (DeltaN) isoforms and their mRNAs are subjected to extensive splicing at 3' end to produce multiple protein products. p53 is usually inactivated by point mutations during tumorigenesis, whereas the expression levels and p63 and p73 are modulated to give tumor cells a selective advantage. In this study, aiming to find novel targets of the p53 family members, we identified FGFR3 as a gene transcriptionally controlled by p63 and p73. FGFR3 has been implicated in development and tumor biology as activating mutations of this gene was described in skeletal disorders, non-invasive skin conditions and superficial bladder cancers. We found that TAp73, TAp63 and DeltaNp63 was capable of inducing FGFR3. siRNA mediated downregulation of DeltaNp63 decreased endogenous FGFR3 protein levels. Our findings of this new link between p53 family proteins and FGFR3 may help understanding the transition of superficial bladder cancers to an invasive phenotyp
Improved algorithm for dynamic b-Matching
No full textRecently there has been extensive work on maintaining (approximate)
maximum matchings in dynamic graphs. We consider a generalisation of
this problem known as the maximum b-matching: Every node v has a positive integral capacity bv, and the goal is to maintain an approximate) maximum cardinality subset of edges that contains at most bv edges incident on every node v. The maximum matching problem is a special case of this problem where bv = 1 for every node v.
Bhattacharya, Henzinger and Italiano [ICALP 2015] showed how to maintain a O(1) approximate maximum b-matching in a graph in O(log3 n) amortised update time. Their approximation ratio was a large (double digit) constant.
We significantly improve their result both in terms of approximation
ratio as well as update time. Specifically, we design a randomised dynamic algorithm that maintains a (2 + )-approximate maximum b-matching in expected amortised O(1= 4) update time. Thus, for every constant 2 (0; 1), we get expected amortised O(1) update time. Our algorithm generalises the framework of Baswana, Gupta, Sen [FOCS 2011] and Solomon [FOCS 2016] for maintaining a maximal matching in a dynamic graph
Large bandwidth mode order converter by differential waveguides
No full textIn this article, we propose a large bandwidth mode-order converter design by dielectric waveguides with equal lengths but different cross-sectional areas. The efficient conversion between even and odd modes is verified by inducing required phase difference between the equal length waveguides of different widths. Y-junctions are composed of both tapered mode splitter and combiner to connect mono-mode waveguide to multi-mode waveguide. The converted mode profiles at the output port show that the device operates successfully at designed wavelengths with wide bandwidth. This study provides a novel technique to implement compact mode order converters and direction selective/sensitive photonic structures. © 2015 Optical Society of America
GEOCHEMISTRY AND ORIGIN OF THE EASTERN SAYAN OPHIOLITES, TUVA-MONGOLIAN MICROCONTINENT (SOUTHERN SIBERIA)
No full textThe Eastern Sayan ophiolites (1020 Ma) of the Tuva-Mongolian microcontinent are believed to be the most ancient ophiolite of the Central Asian Orogenic Belt [Khain et al., 2002].The Eastern Sayan ophiolites (1020 Ma) of the Tuva-Mongolian microcontinent are believed to be the most ancient ophiolite of the Central Asian Orogenic Belt [Khain et al., 2002]
P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis
No full textThe p73 protein, a member of the p53 family, has both developmental and tumorigenic functions. Here we show that p73 is cleaved by caspase-3 and -8 both in vitro and in vivo during apoptosis elicited by DNA-damaging drugs and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor ligation. TAp73 and some of its cleavage products are localized to mitochondria. siRNA-mediated downregulation of p73 expression induced a small but significant change in the susceptibility of HCT116 cells to TRAIL-induced apoptosis. A transcription-deficient mutant of TAp73 enhanced TRAIL-induced apoptosis suggesting that p73 protein has transcription-independent functions during death receptor-mediated apoptosis. Additionally, recombinant p73 protein induced cytochrome c release from isolated mitochondria providing evidence that nonnuclear p73 may have additional functions in the progression of apoptosis
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