1,721,003 research outputs found
The role of pro-inflammatory and anti-inflammatory cytokines in the development of the prostatic gland's inflammatory process = Роль прозапальних та протизапальних цитокінів в розвитку запального процесу в передміхуровій залозі
No full textKashtelyan O. A., Savytskyi I. V. The role of pro-inflammatory and anti-inflammatory cytokines in the development of the prostatic gland’s inflammatory process = Роль прозапальних та протизапальних цитокінів в розвитку запального процесу в передміхуровій залозі. Вісник морської медицини / 2022;3(96):85-90. ISSN 2707-1324
DOI http://dx.doi.org/10.5281/zenodo.7317931
УДК 616.65-002-092.-084
DOI http://dx.doi.org/10.5281/zenodo.7317931
О. А. Каштелян, І. В. Савицький
РОЛЬ ПРОЗАПАЛЬНИХ ТА ПРОТИЗАПАЛЬНИХ ЦИТОКІНІВ В РОЗВИТКУ ЗАПАЛЬНОГО ПРОЦЕСУ В ПЕРЕДМІХУРОВІЙ ЗАЛОЗІ
Міжнародна академія екології та медицини, Київ, Україна
Каштелян О. А. ORCID: 0000-0001-9922-4554
Summary. Kashtelyan O. A., Savytskyi I. V. THE ROLE OF PRO-INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES IN THE DEVELOPMENT OF THE PROSTATIC GLAND’S INFLAMMATORY PROCESS. - International Academy of Ecology and Medicine, Kyiv, Ukraine; e-mail: [email protected]. The role of the cytokine profile in the development of chronic prostatitis has been investigated. It was established that the level of pro-inflammatory cytokines increased sharply, and the level of anti-inflammatory cytokines decreased under the conditions of inflammation. In addition, a sharp increase in TGF-β was noted, which may indicate progressive fibrotic growth in the gland. At the organ level, there is a pronounced imbalance of plasma and prostatic cytokines (IL-8 and IL-10), which proves the important role of cytokine imbalance in the activation and persistence of chronic aseptic inflammation in the prostate gland.
Key words: chronic prostatitis, cytokines, pathogenesis, inflammation.
Резюме. Каштелян О. А., Савицький І. В. РОЛЬ ПРОЗАПАЛЬНИХ ТА ПРОТИЗАПАЛЬНИХ ЦИТОКІНІВ В РОЗВИТКУ ЗАПАЛЬНОГО ПРОЦЕСУ В ПЕРЕДМІХУРОВІЙ ЗАЛОЗІ. В статті представлені результаті щодо вивчення ролі цитокінового профілю в розвитку хронічного простатиту. Одержані результати дозволили свідчити про вірогідні однонаправлені і в цілому гомогенні результати динаміки про- та протизапальних цитокінів в системному кровотоці та в гомогенаті передміхурової залози при експериментальному хронічному простатиті у щурів. В цілому дані дають можливість із високою долею вірогідності постулювати положення про те, що хронічний простатит у щурів, незважаючи на досить ізольований запальний локальний процес, протікає як системне захворювання із переважним ураженням передміхурової залози. До значущих патогенетичних механізмів хронічного простатиту відносять патологічний оксидативний стрес, для кого характерним є порушення цитокінового балансу як на системному, так і на органному рівні, які знаходяться в тісному взаємозв’язку та великою мірою визначають клінічне протікання захворювання, зокрема ключового клінічного симптому – хронічного болю.
Ключові слова: хронічний простатит, цитокіни, патогенез, запалення
Research of changes in the level of vascular endothelial growth factor in experimental diabetic retinopathy. comparison of methods of correction
Get PDFSirman Ya. V., Savytskyi I. V. Research of changes in the level of vascular endothelial growth factor in experimental diabetic retinopathy. comparison of methods of correction. Journal of Education, Health and Sport. 2021;11(04): 247-257. eISSN 2391-8306. https://apcz.umk.pl/JEHS/article/view/40287
https://zenodo.org/record/7115445
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 26.02.2021. Revised: 31.03.2021. Accepted: 30.04.2021.
UDC:616-06:616-092.9
Research of changes in the level of vascular endothelial growth factor in experimental diabetic retinopathy. comparison of methods of correction
Ya. V. Sirman, I. V. Savytskyi
GE «Ukrainian Research Institute of Transport Medicine of the Ministry of Health of Ukraine»
Correspondence author: Savytskyi Ivan Volodymyrovich, 65039, Odesa, Fountain road 4-а/29, tel.+38050-381-21-83, [email protected]
Abstract
The aim of work to investigate the changes in the vascular endothelium growth factor in experimental animals, which were simulated diabetic retinopathy and against the background of its correction.
The results of the analysis of the vascular growth factor in the 2nd group confirm the development of diabetic retinopathy, a particularly pronounced increase in the marker was detected on the 180th day of the development of the pathological process. It was established analyzing the data of group No. 3 that the correction of the pathological condition with hypoglycemic agents has partial positive effect but requires the involvement of additional means of correction in addition to the normalization of the level of glycemia. The results of the 4th group indicate that the involvement of a nitric oxide donor and aflibercept in the correction of diabetic retinopathy has positive effect on the reduction of the level of vascular growth factor, more pronounced compared to the 3rd group, but it does not reach normative values. It is observed that the correction of the simulated pathological condition by reducing hyperglycemia, administration of aflibercept and bromfenac (group No. 5) gives positive results, but less pronounced, compared to the data of the 4th group.
It was found that in rats in which diabetic retinopathy was modeled with subsequent correction of hyperglycemia, administration of aflibercept, L-carnitine and bromfenac (group No. 6) at the first stage, there is a pronounced effectiveness of the proposed method of correction in comparison with the previously considered methods, the established positive trend is being followed also at the 2nd and 3rd stages of the experiment, which indicates the effectiveness of this correction method.
The most pronounced positive effect of normalizing the level of vascular growth factor is observed when using a hypoglycemic drug in combination with the administration of aflibercept, a solution of L-arginine and citicoline (in group No. 7).
Keywords: experimental diabetic retinopathy; streptozotocin diabetes; vascular growth factor; correction; metformin; aflibercept; bromfenac; L-carnitine; L-arginine; citicoline
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dynamic of blood glucose levels in the model of experimental diabetic retinopathy and different ways to correct it
Get PDFSirman Y. V., Savytskyi I. V., Blavatska O. M. Dynamic of blood glucose levels in the model of experimental diabetic retinopathy and different ways to correct it. Journal of Education, Health and Sport. 2021;11(04): 366-373. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.07.036
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.07.036
https://zenodo.org/record/7115363
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 06.07.2021. Revised: 11.07.2021. Accepted: 29.07.2021.
UDC:616-06:616-092.9
Dynamic of blood glucose levels in the model of experimental diabetic retinopathy and different ways to correct it
Y. V. Sirman, I. V. Savytskyi, O. M. Blavatska
GE «Ukrainian Research Institute of Transport Medicine of the Ministry of Health of Ukraine»
Correspondence author: Savytskyi Ivan Volodymyrovich, 65039, Odesa, Fountain road 4-а/29, tel.+38050-381-21-83, [email protected]
Abstract
The aim of our study was to analyze the changes in the blood glucose level in experimental animals that simulated diabetic retinopathy and against the background of its correction. The obtained results show the development of experimental diabetes when streptozotocin is administered at a dose of 55 mg/kg of animal weight against the background of a high-fat diet. Correction with hypoglycemic agents in the 3rd group had a positive effect, but it was not able to completely normalize the level of glycemia, so the need arose for the use of additional agents. The use of aflibercept and a nitric oxide donor in the 4th group had a more pronounced positive effect compared to the 3rd group, but the result did not reach the control indicators. Combined administration of bromfenac and aflibercept in the 5th group showed itself to be less effective in the study of the blood glucose level at all stages in comparison with the data of the 4th group, in which the NO donor was involved in the correction. Administation of aflibercept, L-carnitine and bromfenac to the animals of the 6th group had a more pronounced positive effect in comparison with the group No. 5, but did not reach the values of the 4th group of the experiment. The most effective correction was the combination of metformin, aflibercept, L-arginine and citicoline in rats of the 7th group, which is evidenced by the normalization of the level of the studied indicators on the 30th and 60th days of the experiment, and on the 180th, the most pronounced decrease was recorded hyperglycemia.
Key words: experimental diabetic retinopathy; streptozotocin diabetes; blood glucose; correction; metformin; aflibercept; bromfenac; L-carnitine; L-arginine; citicoline
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
DYNAMICS OF BIOCHEMICAL MARKERS IN THE PATHOGENESIS OF EXPERIMENTAL BILE PERTONITIS
No full textZnamerovsky S. G., Savytskyi I. V., Dzygal O. F. DYNAMICS OF BIOCHEMICAL MARKERS IN THE PATHOGENESIS OF EXPERIMENTAL BILE PERTONITIS. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2020;3(88): 84-90. ISSN 0049-6804.
DOI http://dx.doi.org/10.5281/zenodo.4156227
http://www.herald.com.ua
УДК 616 - 092.9 : 616 - 0.35
DOI http://dx.doi.org/10.5281/zenodo.4156227
DYNAMICS OF BIOCHEMICAL MARKERS IN THE PATHOGENESIS OF
EXPERIMENTAL BILE PERTONITIS
S. G. Znamerovsky, I. V. Savytskyi, O. F. Dzygal
Odessa National Medical University, Odessa, Ukraine
Summary
Biliary peritonitis (BP), which is a severe disease of the abdominal cavity in severity, prognosis and mortality rate depends on endogenous intoxication Systemic Inflammatory Reaction Syndrome (SIRS) is considered in surgical practice as a non-specific response to injury. The study was performed on 180 Wistar rats weighing 180-200 g. The animals were divided into 4 groups. As a result of the conducted researches it is proved that the level of leukocytes is an important diagnostic test in the pathogenesis of experimental peritonitis. When studying the dynamics of leukocyte levels on the first and third days of the experiment, its increase is noted against the background of experimental biliary peritonitis. The results of the 4th group indicate a decrease in this indicator against the background of the proposed method of remediation and are closer to the values of the norm in comparison with the 3rd group. On the 7th day of the experiment, data on the normalization of this marker in the 4th group were obtained.
Key words: biliary peritonitis, model, sanitation of abdominal cavity, leukocytes, correctio
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Research of changes in the level of endothelin-1 in experimental diabetic retinopathy. comparison of methods of correction
Get PDFSirman Y. V., Preis N. I., Savytskyi I. V. Research of changes in the level of endothelin-1 in experimental diabetic retinopathy. comparison of methods of correction. Journal of Education, Health and Sport. 2021;11(10):411-422. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.10.038
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.10.038
https://zenodo.org/record/6449122
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 30.09.2021. Revised: 12.10.2021. Accepted: 29.10.2021.
UDC:616-06:616-092.9
RESEARCH OF CHANGES IN THE LEVEL of ENDOTHELIN-1 IN EXPERIMENTAL DIABETIC RETINOPATHY. COMPARISON OF METHODS OF CORRECTION
Y. V. Sirman, N. I. Preis, I. V. Savytskyi
SE "Ukrainian Research Institute of Transport Medicine of the Ministry of Health of Ukraine"
Abstract
Diabetic retinopathy (DR) according to the WHO is the main cause of decreased vision and blindness due to diabetes.
The aim of the study: to compare the effectiveness of correction of vasoconstriction in experimental diabetic retinopathy under the influence of different methods of correction.
Our results indicate a violation of the functional state of blood vessels on the 30th day of experimental diabetic retinopathy with subsequent progression of pathological changes on the 60th and 180th day of the study, as evidenced by a significant increase in endothelin-1 in the 2nd group (p <0.001), most pronounced in the 3rd stage.In the analysis of data of group №3 it was found that the correction of pathological conditions with hypoglycemic agents has a positive effect, but does not allow to significantly correct pathologically increased levels of endothelin-1, which indicates the need for additional correction tools other than hyperglycemia.The results of group 4 indicate that the involvement of a donor of nitric oxide and aflibercept in the correction of diabetic retinopathy corrects the level of the studied marker, the most pronounced effect is observed on the 180th day of the experiment, but normative values can not be achieved. It was found that in the 5th group, in which the correction of the simulated pathological condition was performed by reducing hyperglycemia, the introduction of aflibercept and bromfenac gives positive results, but less pronounced than in the 4th group, where L-arginine solution was added to the complex correction. .It was found that rats of group 6, which simulated diabetic retinopathy with subsequent correction of hyperglycemia, administration of aflibercept, L-carnitine and bromfenac have a pronounced effectiveness of the proposed method of correction compared to previous methods, the level of vasoconstriction stage and continues to recover in the following stages of the experiment, but does not reach the normative values. The obtained data suggest that the method of correction selected in group 7, which includes reduction of hyperglycemia, administration of aflibercept, solution of L-arginine and citicoline is most effective for normalizing vascular tone and structural and functional state of the endothelium.
Key words: experimental diabetic retinopathy; endothelial dysfunction; endothelin-1; vasoconstriction; correction
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
