1,720,984 research outputs found
New antithrobotic agents
No full textThe main clinical indications for anticoagulant agents are treatment and prophylaxis of venous and arterial thromboembolism and acute coronary syndromes. For decades, two anticoagulants, heparin and warfarin, have been the principal drugs available. Dicumaroid agents have serious limitations due to their narrow therapeutic range, needing close monitoring. The interaction with food and drugs and the numerous interindividual variations result in unstable effects on coagulation parameters. On the other side, heparins have an exclusive parenteral use and a risk of immunological adverse reactions. Heparin induced thrombocytopenia is the most serious complication. The limitations of existing oral and parenteral anticoagulant agents have prompted the search for alternative anticoagulant drugs. This paper reviews new anticoagulant agents describing their pharmacological and clinical properties. It focuses on the target of their anticoagulant action inside the coagulation pathway, and analyzes the clinical trials providing indications for new clinical anticoagulation strategies. Agents currently under study include direct thrombin inhibitors, indirect activated factor X inhibitors, and inhibitors of tissue factor and activated factor VII. The new anticoagulant agents may demonstrate improvements in effectiveness, safety convenience and cost-effectiveness compared with current anticoagulants
Controlled query evaluation in description logics through consistent query answering
Full text linkControlled Query Evaluation (CQE) is a framework for the protection of confidential data, where a policy given in terms of logic formulae indicates which information must be kept private. Functions called censors filter query answering so that no answers are returned that may lead a user to infer data protected by the policy. The preferred censors, called optimal censors, are the ones that conceal only what is necessary, thus maximizing the returned answers. Typically, given a policy over a data or knowledge base, several optimal censors exist. Our research on CQE is based on the following intuition: confidential data are those that violate the logical assertions specifying the policy, and thus censoring them in query answering is similar to processing queries in the presence of inconsistent data as studied in Consistent Query Answering (CQA). In this paper, we investigate the relationship between CQE and CQA in the context of Description Logic ontologies. We borrow the idea from CQA that query answering is a form of skeptical reasoning that takes into account all possible optimal censors. This approach leads to a revised notion of CQE, which allows us to avoid making an arbitrary choice on the censor to be selected, as done by previous research on the topic. We then study the data complexity of query answering in our CQE framework, for conjunctive queries issued over ontologies specified in the popular Description Logics DL-Lite n and ec perpendicular to . In our analysis, we consider some variants of the censor language, which is the language used by the censor to enforce the policy. Whereas the problem is in general intractable for simple censor languages, we show that for DL-Lite n ontologies it is first-order rewritable, and thus in AC 0 in data complexity, for the most expressive censor language we propose
A novel approach to controlled query evaluation in DL-Lite
Full text linkIn Controlled Query Evaluation (CQE) confidential data are protected through a declarative policy and a (optimal) censor, which guarantees that answers to queries are maximized without disclosing secrets. In this paper we consider CQE over Description Logic ontologies and study query answering over all optimal censors. We establish data complexity of the problem for ontologies specified in DL-LiteR and for variants of the censor language, which is the language used by the censor to enforce the policy. In our investigation we also analyze the relationship between CQE and the problem of Consistent Query Answering
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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