403 research outputs found
Diffusion weighted image and intravoxel incoherent motion magnetic resonance imaging are potential lenvatinib treatment response biomarkers for advanced hepatocellular carcinoma
No full text博士論文 要旨Abstract/本文Full 以下に掲載：Journal of Clinical Images 6(2) pp.1145-1153 2023. MedDocs Publishers. 共著者：Yu Zhang, Satoshi Kobayashi, Azusa Kitao, Yudai Shogan, Naoki Ohno, Noboru Takata, Takeshi Terashima, Kuniaki Arai, Tatsuya Yamashita, Taro Yamashita, Norihide Yoneda, Kazuto Kozaka, Toshifumi Gabat
Supplemental Material - Early Versus Delayed Surgery for Elderly Traumatic Cervical Spinal Injury: A Nationwide Multicenter Study in Japan
No full textSupplemental Material for Early Versus Delayed Surgery for Elderly Traumatic Cervical Spinal Injury: A Nationwide Multicenter Study in Japan by Naoki Segi, Hiroaki Nakashima, Sadayuki Ito, Noriaki Yokogawa, Takeshi Sasagawa, Kota Watanabe, Satoshi Nori, Toru Funayama, Fumihiko Eto, Hideaki Nakajima, Yoshinori Terashima, Ryosuke Hirota, Ko Hashimoto, Yoshito Onoda, Takeo Furuya, Atsushi Yunde, Shota Ikegami, Masashi Uehara, Hidenori Suzuki, Yasuaki Imajo, Hiroshi Uei, Hirokatsu Sawada, Kenichi Kawaguchi, Kazuo Nakanishi, Nobuyuki Suzuki, Yasushi Oshima, Tomohiko Hasegawa, Yoichi Iizuka, Hitoshi Tonomura, Hidetomi Terai, Koji Akeda, Shoji Seki, Masayuki Ishihara, Gen Inoue, Haruki Funao, Toshitaka Yoshii, Takashi Kaito, Katsuhito Kiyasu, Hiroyuki Tominaga, Kenichiro Kakutani, Daisuke Sakai, Tetsuro Ohba, Bungo Otsuki, Masashi Miyazaki, Kenta Murotani, Seiji Okada, Shiro Imagama, and Satoshi Kato in Global Spine Journal</p
Diffusion weighted image and intravoxel incoherent motion magnetic resonance imaging are potential lenvatinib treatment response biomarkers for advanced hepatocellular carcinoma
No full text金沢大学博士(医学）博士論文 要旨Abstract/本文Full 以下に掲載：Journal of Clinical Images 6(2) pp.1145-1153 2023. MedDocs Publishers. 共著者：Yu Zhang, Satoshi Kobayashi, Azusa Kitao, Yudai Shogan, Naoki Ohno, Noboru Takata, Takeshi Terashima, Kuniaki Arai, Tatsuya Yamashita, Taro Yamashita, Norihide Yoneda, Kazuto Kozaka, Toshifumi Gabatadoctoral thesi
Avermectina, un Gran Antiparasitario
No full textLa autora resalta el trabajo de Satoshi Omura y William Campbell que dio lugar al descubrimiento de la avermectina para el tratamiento de las enfermedades por nemátodos
The Combination Therapy of Gemcitabine Plus Paclitaxel Induced Complete Response in a Tongue Skin Brain Metastasis of Bladder Carcinoma : A Case Report
No full textTongue, skin and brain metastases of bladder cancer are very rare and few cases have been reported. We report a case of tongue, skin and brain metastases of bladder cancer. A 61-year-old woman was referredto our hospital with gross hematuria. Transurethral resection of the bladder (TURBT), tongue biopsy andskin biopsy were performed. Pathological findings showed urothelial carcinoma, G2, micropapillaryvariant, pT2＞ and tongue and skin metastases from urothelial carcinoma of bladder. After three cycles ofchemotherapy (gemcitabine plus paclitaxel), tongue and skin metastases disappeared. Cystoscopy revealedno tumor of bladder. Eleven months later, she was admitted to our hospital because of disturbance ofconsciousness. Magnetic resonance imaging (MRI) showed multiple brain metastases. Rechallenge ofchemotherapy (gemcitabine plus paclitaxel) restored from disturbance of consciousness and MRI showedpartial response of brain metastases. We performed six additional courses of chemotherapy. Skin, tongueand brain metastases from bladder cancer indicate poor risk. Chemotherapy (gemcitabine plus paclitaxel)could be effective against these matastases
Diffusive-thermal effect on local chemical structures in premixed hydrogen-air flames
No full textThe diffusive-thermal effect plays an important role in the intrinsic instability of premixed flames. A two-dimensional direct numerical simulation of the propagation of premixed hydrogen-air flames was performed using a detailed chemical kinetics model. The cellular behavior of a lean hydrogen-air flame was analyzed on the basis of its chemical structure. The primary consequence of the diffusive-thermal effect was found to be a change in the buildup process of reactive intermediates by the chain reaction mechanism at the preheat zone. The resultant chemical structure at the main reaction zone can be explained by the local composition change of the gas flowing into the reaction zone from the preheat zone
A role for SUMO modification in transcriptional repression and activation
No full textSince the discovery of the SUMO (small ubiquitin-related modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription. Conjugation of SUMO to target proteins has generally been considered as a repressive modification. However, there are now a growing number of examples where SUMOylation has been shown to activate transcription. Here, we discuss whether there is something intrinsically repressive about SUMOylation, or if the outcome of this modification in the context of transcription will prove to be largely substrate-dependent. We highlight some of the technical challenges that will be faced by attempting to answer this question
ブドウ球菌のグルタミン酸呼吸に対する諸種阻害剤及び抗生物質の作用
No full textThe author studied the action of various inhibitors and antibiotics on the glutamaterespiration of staphylococci under the consideration of physiological structure of the cell. Staphylococcus citreus and aureus (Terashima) were used as the test organisms, and L-glutamic acid as the substrate. The results were as follows: 1) Thionine, sodium arsenite and 8-hydroxyquinoline inhibited the respiration of intact cells of staphylococci markedly, but did not inhibit that of cell-free extracts. The inhibitive action of these three sorts of inhibitors was stronger on Staph. aureus (Terashima) than on Staph. citreus. 2) In intact cells, the inhibition of respiration by potassium cyanide and sodium azide was not restored by addition of thionine. In cell-free extracts, however, the inhibition by these two sorts of inhibitors was well restored by thionine. 3) By addition of thionine, the inhibition of the respiration of cell-free extracts by octanole was not so well restored as that by cyanide or azide. 4) 2, 4-Dinitrophenol inhibited the glntamate-respiration of both of the intact cells and cell-free extracts. 5) Of all the antibiotics tested, aureomycin was the only one which noticeably inhibited the glutamate-respiration of staphylococci
Action of Various Inhibitors and Antibiotics on Glutamate-Respiration of Staphylococcus
No full textThe author studied the action of various inhibitors and antibiotics on the glutamaterespiration of staphylococci under the consideration of physiological structure of the cell. Staphylococcus citreus and aureus (Terashima) were used as the test organisms, and L-glutamic acid as the substrate. The results were as follows: 1) Thionine, sodium arsenite and 8-hydroxyquinoline inhibited the respiration of intact cells of staphylococci markedly, but did not inhibit that of cell-free extracts. The inhibitive action of these three sorts of inhibitors was stronger on Staph. aureus (Terashima) than on Staph. citreus. 2) In intact cells, the inhibition of respiration by potassium cyanide and sodium azide was not restored by addition of thionine. In cell-free extracts, however, the inhibition by these two sorts of inhibitors was well restored by thionine. 3) By addition of thionine, the inhibition of the respiration of cell-free extracts by octanole was not so well restored as that by cyanide or azide. 4) 2, 4-Dinitrophenol inhibited the glntamate-respiration of both of the intact cells and cell-free extracts. 5) Of all the antibiotics tested, aureomycin was the only one which noticeably inhibited the glutamate-respiration of staphylococci
Normothermic treatment in acute clinical encephalitis: a case report
No full textAbstract Introduction Encephalitis is a common infection of the brain, associated with a high risk of mortality and morbidity despite intensive supportive therapy. This report describes a patient with acute clinical meningoencephalitis who responded dramatically when her body temperature was decreased to normothermia (36 to 37°C) in combination with barbiturate therapy. Case presentation A 15-year-old, previously healthy girl presented with a 2-day history of headache and meningeal stiffness and pyrexia. Cranial magnetic resonance imaging showed high-intensity signals in the splenium of the corpus callosum on T2-weighted and diffusion-weighted images. On day 4 of admission, the level of consciousness decreased and ataxic respiration and apnea appeared. After that, fever (body temperature >40°C) developed with remarkable tachycardia. The body temperature was decreased with the use of a forced-air-cooling blanket and head cooling. The core temperature, measured in the bladder, was maintained at between 36 and 37°C for 5 days. During the period of normothermia, thiopental sodium was given continuously for 3 days. After normothermia, the level of consciousness increased without the development of fever, and ventilatory support was withdrawn. Conclusion Our experience suggests that normothermic treatment in combination with barbiturate therapy may be an effective option for the management of brain swelling associated with acute meningoencephalitis, particularly when accompanied by a persistent high fever.</p
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