16 research outputs found
Acute and Subacute Oral Toxicity Study of a Herbal Formulation Containing Asparagus racemosus, Tinospora cordifolia, and Trigonella foenum-graceum in Mice
No full textConclusion: The LD50 found to be greater than 2000 mg/kg BW with NOAEL at 1000 mg/kg BW in mice. It was found to be free from any genotoxicity. The herbal drug was found to be safe to level of category 4 and can be used further for clinical studies
Therapeutic Potential of Luffa acutangula: A Review on Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects
No full textLuffa acutangula (Cucurbitaceae), a perennial plant grows mainly in India, Southeast Asia, China, Japan, Egypt, and other parts of Africa, it is widely used in the traditional Indian medicinal system to treat various health conditions. The plant has been used in jaundice, diabetes, hemorrhoids, dysentery, headache, ringworm infection, and leprosy. More than 50 chemical compounds have been isolated from a plant which mainly comprises flavonoids, anthraquinones, proteins, fatty acids, saponin triterpene, volatile components, and other phytoconstituents. Crude extract of plant and its isolated compounds possess broad pharmacological activities such as antidiabetic, hepatoprotective, antiulcer, anticancer, immunomodulatory, antihyperlipidemic, antioxidant, antimicrobial, CNS depressant, analgesic, and anti-inflammatory. The toxicological evaluation in preclinical studies reported safety of the plant for human consumption, but comprehensive evaluation in clinical studies is required. However, further investigation is necessary for transformation of experience based treatment of plant into evidence based information. Evaluation of pharmacological activity with indicative biomarkers will help to reveal the mechanism of action of chemical constituents of plant extract. The data from preclinical studies recommends clinical evaluation of safety and efficacy of the plant. The current paper summarizes up-to-date information about a review of the traditional uses, phytochemistry, pharmacological activities, and toxicology to highlight the future prospects of the plant
Comparative study of garlic species (Allium sativum and Allium porrum) on glucose uptake in diabetic rats
No full textAbstractBackgroundHerbal medicines are recommended for management of diabetes in many parts of the world. Garlic is one such herb extensively used for antidiabetic activity, antimicrobial, antiarthritic, hypoglycaemic etc. Safety and efficacy of the herbal drugs used in the treatment of diabetes need to be evaluated.MethodsRat everted intestinal sac model was used to study garlic species Allium sativum and Allium porrum for their role in glucose transport. In this study test substances A. sativum and A. porrum at 2.5 and 5.0mg/ml and standard (insulin, 40μM/ml) were added to mucosal solution. Glucose concentrations were determined before and after a period of incubation. The preliminary phytochemical investigations were performed.ResultsRat everted intestinal sac experiment is mainly used to indicate glucose uptake. The mucosal disappearance, serosal appearance and gut wall content of A. porrum at a dose of 2.5mg/ml (65.12%, 40.81%, 22.34%), dose of 5.0mg/ml (64.56%, 43.56%, 21.0%). Similarly A. sativum at a dose of 2.5mg/ml (67.74%, 42.05%, 25.68%), dose of 5.0mg/ml (65.97%, 43.11%, 22.86%), Insulin at a dose of 40μm/ml (60.36%, 37.84%, 22.52%) respectively. Thus A. sativum and A. porrum showed significant reduction in all the 3 parameters observed. Further A. porrum showed more potent action
Supercritical fluid chromatography versus liquid chromatography for the enantiomeric separation of itraconazole
No full textComparative Effect of Atorvastatin and Trigonella foenum graecum L. Seeds in the Postmenopausal Hyperlipidemia
No full textTrigonella foenum graecum L. (Fabaceae) seeds have been extensively used in Ayurveda and Unani medicine. It has been used as a traditional medicine for a household remedy against various human ailments. The seeds have been shown to possess hypoglycemic, hypocholesterolaemic and antioxidant activity. The present study is to evaluate whether ovariectomised (OVX) Wistar rats could form an experimental model of postmenopausal hyperlipidemia and to evaluate the antihyperlipidemic potential of Atorvastatin (AT) and Ethyl acetate extract of Trigonella foenum graecum L. Seeds (ET) in OVX Wistar rats and toxicity associated with it. Ovariectomy was performed to mimic the postmenopausal hyperlipidemic condition in Wistar rats. The effects of AT and ET on body weight, weight of uterus and the levels of total cholesterol (TC), triglycerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL), very low density lipoprotein (VLDL) were also evaluated. The rats in OVX control group showed 51% weight gain when compared with vehicle control group. The serum TC, TG, LDL, VLDL of OVX control group was found to be increased significantly; serum HDL level was reduced and atrophy of uterus was observed in comparison with vehicle control group. The ET showed the significant (P<0.05, P<0.01) antihyperlipidemic potency when compared with AT & proportional antihyperlipidemic potency in comparison with Estradiol benzoate (EB). These findings confirm the bilateral OVX Wistar rats as a model of postmenopausal hypercholesterolemia. The significant antihyperlipidemic activity of ET thus lends pharmacological credence to the suggested use of the plant as a safe natural remedy in the treatment of postmenopausal hyperlipidemia
Homoeopathic drug dilutions of Thuja occidentalis attenuate complete Freund's adjuvant-induced arthritis in Wistar rats
No full textContext: Thuja occidentalis is prescribed in Homoeopathy in treating rheumatoid arthritis. We speculated the anti-arthritic mechanism of Homoeopathic dilutions of Thuja occidentalis against the complete Freund\u27s adjuvant (CFA)-induced arthritis in rats. Materials and Methods: Arthritis was induced (n = 28) by subplantar injection of 0.1 ml CFA in the right hind paw of rats. The oral dose of crude Thuja occidentalis was 30 mg/kg/b. i. d and that of Homoeopathic dilutions was 0.1 ml/b. i. d. Orally administered diclofenac at 5 mg/kg/day served as a standard. The treatments continued for 24 days. The severity of arthritis was determined weekly as rise in paw volume, mechanical allodynia and changes in body weight. On the 25th day, X-ray imaging of the arthritic paws was recorded, and the biopsy samples extracted from the paws were subjected to the estimation of pro-inflammatory cytokines and histological evaluations. Results: Thuja occidentalis Homoeopathic dilutions and its crude form protected rats against the CFA-induced arthritic lesions. The mother tincture, 6cH, 30cH and 200cH dilutions of Thuja occidentalis significantly reduced the CFA-induced rise in paw volume, reduced the mechanical allodynia and also reduced the levels of interleukin (IL) IL-1, IL-6 and tumour necrosis factor alpha in paw tissue. CFA-induced articular changes, oedema, cellular infiltrations and cartilage damage were reduced by Thuja occidentalis dilutions. The radiological images indicated that Thuja occidentalis treatment reduced the CFA-induced joint swelling, bone erosion and joint space narrowing. Conclusion: Our findings substantiate the anti-arthritic effects of Thuja occidentalis Homoeopathic dilutions against CFA-induced arthritis and indicate that Homoeopathic dilutions of Thuja occidentalis, particularly 6cH dilution, exert more potent anti-arthritic effects than its crude form
Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach
No full textEvaluation of Efficacy and Safety of Perfact Face Gel and Perfact Face Tablets in Management of Acne
No full text
