14 research outputs found
Author response to reviewer 1 of Ferracci et al., acp-2018-12', Valerio Ferracci, 16 Apr 2018
No full text
Atelier de recherche Writing the city [into the urban] à l'Institut d'études avancées de Paris les 3 et 4 mai 2018
No full textL'Institut d'études avancées de Paris accueille les 3 et 4 mai prochains un atelier de recherche organisé par Pushpa Arabindoo, résidente 2017-2018 de l'IEA de Paris, avec le soutien de l'UCL Urban Laboratory et de la FMSH. Cet atelier, intitulé Writing the city [into the urban], réunira autour de l'écriture de la ville et de la réflexion sur la planétarisation du phénomène urbain des écrivains (sarah Butler, Diran Adebayo) et des universitaires. L'atelier abordera en particulier, dans une pe..
A History of the Desire for Christian Unity. Ecumenism in the Churches (19th–21st Century)
No full textA History of the Desire for Christian Unity is a multi-volume reference work on the history of ecumenism. This reference work is a reconstruction of the arc of time in which the Christian churches transitioned from a position of hostility to one of dialogue, and from separation to forms of communion. Scholars across the continents and disciplines explore a history of individuals and groups, generations and assemblies, documents and programs, theologies and practices, all firmly placed within the framework of a desire for unity. This first volume traces the long-term roots and reconstructs the historical, theological, and political junctures that marked the beginning of a distinctive movement that runs throughout the nineteenth and into the heart of the twentieth century
L'Unità dei Cristiani. Storia di un Desiderio
No full textUna ricostruzione storica di insieme del tempo in cui le chiese cristiane sono passate dall'ostilità al dialogo e dalla separazione a forme di comunione. Primo di tre volumi, questo tomo ripercorre le radici di lungo periodo e ricostruisce gli snodi storici, teologici e politici che hanno segnato l'avvio di un vero e proprio movimento che percorre il secolo XIX e arriva nel cuore del Novecento
Modulation of E-Cadherin Monomer Folding by Cooperative Binding of Calcium Ions
No full text10 pagesInternational audienceClassical cadherins are transmembrane glycoproteins involved in calcium-dependent cellcell adhesion. Calcium ions are coordinated at the interface between successive modules of the cadherin ectodomain and are thought to regulate the adhesive interactions of cadherins when present at millimolar concentrations. It is widely accepted that calcium plays a critical role in cadherin-mediated cell-cell adhesion, but the nature of cadherin-calcium binding remains a matter of debate. We investigated the parameters of noncovalent cadherin-calcium binding, using the two N-terminal modules of E-cadherin (E/EC12) with a native N-terminal end and nondenaturing electrospray ionization mass spectrometry. By directly visualizing the molecular complexes, we demonstrated that E/EC12 binds three calcium ions, with an average KD of 20 ( 0.7 íM. These calcium ions bound cooperatively to E/EC12 in its monomeric state, and these properties were not modified by an N-terminal extension consisting of a single methionine residue. This binding induced specific structural changes, as shown by assessments of protease sensitivity, circular dichroism, and mass spectrometry. Furthermore, the D103A mutation (a residue involved in E-cadherin adhesive function) modified calcium binding and led to a loss of cooperativity and the absence of structural changes, despite calcium binding. As the amino acids involved in calcium binding are found within the cadherin consensus motif, our findings may be relevant to other members of the cadherin famil
Validation of ammonia diffusive and pumped samplers in a controlled atmosphere test facility using traceable Primary Standard Gas Mixtures
No full textWe report the determination of ammonia (NH3) diffusive sampling rates for six different designs of commercial
diffusive samplers (CEH ALPHA sampler, Gradko diffusion tube, Gradko DIFRAM-400, Passam ammonia sampler,and ICS Maugeri Radiello radial sampler (blue and white turbulence barriers)), together with the validation test results for a pumped sampler (CEH DELTA denuder). The devices were all exposed in the UK's National Physical Laboratory's (NPL) controlled atmosphere test facility (CATFAC). For each of the seven diffusive sampler exposure tests there were traceable concentrations of ammonia (in the range 3–25 μgm−3) generated under well-defined conditions of temperature, relative humidity and wind speed, which are applicable to a variety of ambient monitoring environments. The sampler exposure time at each concentration was 28 days,
except for the radial devices, which were exposed for 14 days. The work relied on the dilution of newly developed
stable Primary Standard Gas Mixtures (PSMs) prepared by gravimetry in passivated gas cylinders as a method of improving the metrological traceability of ammonia measurements. The exposed diffusive samplers were sent blind to the participants for analysis and the reported NH3 concentrations were then compared against the known reference concentration. From the results for each sampler type a diffusive sampling rate was calculated and compared against the rate used routinely by the participants. Some measurement results were in good agreement with the known traceable reference concentration (particularly for one diffusive sampler design (ALPHA)), while other devices exhibited over-reading and under-reading (each with a clear bias). The new diffusive sampling rates determined in the laboratory study were then applied to measurements in a field comparison campaign, and this was found to deliver an improvement in agreement between the different devices deployed
