105,604 research outputs found

    Luigi Vigna, Sant' Anselmo Filosofo

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    S. G. Luigi Vigna, Sant' Anselmo Filosofo. In: Revue néo-scolastique. 7ᵉ année, n°28, 1900. pp. 456-457

    The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

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    The ATP-dependent chromatin-remodelling enzyme Chd1 is a 168-kDa protein consisting of a double chromodomain, Snf2-related ATPase domain, and a C-terminal DNA-binding domain. Here, we show the DNA-binding domain is required for Saccharomyces cerevisiae Chd1 to bind and remodel nucleosomes. The crystal structure of this domain reveals the presence of structural homology to SANT and SLIDE domains previously identified in ISWI remodelling enzymes. The presence of these domains in ISWI and Chd1 chromatin-remodelling enzymes may provide a means of efficiently harnessing the action of the Snf2-related ATPase domain for the purpose of nucleosome spacing and provide an explanation for partial redundancy between these proteins. Site directed mutagenesis was used to identify residues important for DNA binding and generate a model describing the interaction of this domain with DNA. Through inclusion of Chd1 sequences in homology searches SLIDE domains were identified in CHD6-9 proteins. Point mutations to conserved amino acids within the human CHD7 SLIDE domain have been identified in patients with CHARGE syndrome. The EMBO Journal (2011) 30, 2596-2609. doi:10.1038/emboj.2011.166; Published online 27 May 2011</p

    Van Sant-Houghton Company ; San Pedro, Los Angeles, and Salt Lake Rail Road Company ; 10 Stall Roundhouse ; Girders ; Lynndyl, Utah [1]

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    Blueprint of Van Sant-Houghton Company ; San Pedro, Los Angeles, and Salt Lake Rail Road Company ; 10 Stall Roundhouse ; Girder G-1, G-1-R, G-1-L, G-4, G-4-R, G-4-L ; Lynndyl, Utah ; Drawing 110

    Van Sant-Houghton Company ; San Pedro, Los Angeles, and Salt Lake Rail Road Company ; 10 Stall Roundhouse ; Girders ; Lynndyl, Utah [2]

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    Blueprint of Van Sant-Houghton Company ; San Pedro, Los Angeles, and Salt Lake Rail Road Company ; 10 Stall Roundhouse ; Girder G-2, G-2-R & L, G-3, G-3-R & L ; Lynndyl, Utah ; Drawing 110

    Van Sant-Houghton Company ; San Pedro, Los Angeles, and Salt Lake Rail Road Company ; 10 Stall Roundhouse ; Girders ; Lynndyl, Utah [3]

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    Blueprint of Van Sant-Houghton Company ; San Pedro, Los Angeles, and Salt Lake Rail Road Company ; 10 Stall Roundhouse ; Girder G-6-R, G-6-L, G-5 ; Lynndyl, Utah ; Drawing 111

    Regan Zane Named Inaugural David G. and Diann L. Sant Endowed Professor | College of Engineering

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    A new professorship in Utah State University’s College of Engineering honors longtime supporters David G. and Diann L. Sant and empowers a new generation of the most qualified engineering faculty.https://digitalcommons.usu.edu/engineering_news/1274/thumbnail.jp

    Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung

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    Dieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods
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