102,976 research outputs found

    Micryletta subaraji Sankar, I. T. Law, I. S. Law, Shivaram, Abraham & Chan 2022

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    Micryletta subaraji Sankar, I.T. Law, I.S. Law, Shivaram, Abraham & Chan, 2022 — Native; Endemic. Microhyla subaraji Sankar, I.T. Law, I.S. Law, Shivaram, Abraham & Chan, 2022: 461. Holotype: ZRC1.13370, by original designation. Type locality: “ Kranji Marshes, Singapore (1°25.1150’N, 103°43.2641’E, 8 m a.s.l)”. Subaraj’s Paddy Frog (Figure 6E) Singapore records. Micryletta inornata — I.S. Law, Thomas & I.T. Law, 2019: 5 (Old Upper Thomson Road). Micryletta — Suwannapoom et al., 2020: 587. Micryletta cf. inornata —Sankar et al., 2022: 457–462 (Kranji Marshes). Micryletta subaraji Sankar, I.T. Law, I.S. Law, Shivaram, Abraham & Chan 2022: 461–462, 464–466 (Kranji Marshes). Remarks. Micryletta subaraji represents Singapore’s latest herpetofauna addition and only endemic herpetofauna. This newly-described species was described from nine specimens collected at Kranji Marshes in 2021 (Sankar et al. 2022). Micryletta subaraji was first discovered in Singapore on 22 September 2018 when a single individual was found in leaf litter in a roadside drain along OUTR (Law et al. 2019). This individual was identified as M. inornata, a species that formerly occupied a very wide distribution from India east to southern China and south to Sumatra (Poyarkov et al. 2018; Alhadi et al. 2019), but has since then been shown to be a species complex that is being split into several new species (Miller et al. 2021) with M. inornata sensu stricto being restricted to Sumatra (Alhadi et al. 2019). Subsequently, a population was found at Kranji Marshes and specimens were collected to verify the species identification, which is now this new species. Kranji Marshes is characterised as a highly disturbed marshy, scrubland that has undergone extensive reclamation works, whereas adjacent to where the first specimen was recorded on OUTR is mature secondary forest. Given this difference in habitat, and that the OUTR specimen appears morphologically different from M. subaraji, Sankar et al. (2022) suppose it may represent a different species. Occurrence. Only known from a few individuals from OUTR and Kranji Marshes. Rare. Singapore conservation status. Critically Endangered. Conservation priority. Highest. IUCN conservation status. Not Evaluated. LKCNHM & NHMUK Museum specimens. Kranji Marshes: ZRC1.13370 (08-Jan-2021) [holotype], ZRC 1.13323 (19-Sep-2020), ZRC 1.13369 (08-Jan-2021), ZRC 1.13389 (08-Jan-2021), ZRC 1.13466 (20- Oct-2021), ZRC 1.13467 (20-Oct-2021), ZRC 1.13468 (20-Oct-2021), ZRC 1.13469 (20-Oct-2021), ZRC 1.13470 (20-Oct-2021). Additional Singapore museum specimens. No specimens. Singapore localities. Kranji Marshes—Old Upper Thomson Road. Family Ranidae Batsch, 1796 (5 species) Ranina Batsch, 1796: 179 (type genus Rana Linnaeus, 1758). Genus Chalcorana Dubois, 1992 (1 species) Rana (Chalcorana) Dubois, 1992: 326, 328 (type species: Hyla chalconota Schlegel, 1837, by original designation; gender feminine).Published as part of Figueroa, Alex, Low, Martyn E. Y. & Lim, Kelvin K. P., 2023, Singapore's herpetofauna: updated and annotated checklist, history, conservation, and distribution, pp. 1-378 in Zootaxa 5287 (1) on page 50, DOI: 10.11646/zootaxa.5287.1.1, http://zenodo.org/record/796031

    Letter, [Author unclear] to Paulina T. Merritt

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    Handwritten letter to Paulina Merritt from an unknown author, October 1, 1876.

    Handwritten biographical information on Paulina T. McClung Merritt

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    A handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.

    Synthesis and Bioassay of Azolyl Benzothiazine Carboxamides

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    Cyclic sulfonamides (sultams) gained importance due to their potential pharmaceutical activity. Amongst these, 1,2-benzothiazine-1,1-dioxide and their derivatives represent the most familiar class of non-steroidal anti-inflammatory drugs (NSAIDs) available in the market. In fact, Meloxicam and Piroxicam, the members of oxicam family are used as an analgesic and anti-inflammatory drugs. Azoles are potential chemical entities with a wide range of pharmacological activities such as anticancer, antibacterial, antifungal, antiviral and antiparasitic. In continuation of our efforts to develop potential multifunctional heterocycles, we have synthesized novel azolylbenzothiazine carboxamides and studied their cytotoxic and antioxidant activities. The results of these aspects will be discussed. © 2020 Author(s).The authors Venkatapuram Padmavathi and Panga Siva Sankar are grateful to CSIR (Council of Scientific and Industrial Research), New Delhi for financial assistance under the major research project

    Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.

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    IFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Pelevin’s Trinity in the novel “t”: author – protagonist – reader

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    The article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology

    Measuring industry-science links through inventor-author relations: A profiling method

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    In this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
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