583 research outputs found
Population entropies estimates of proteins
No full textThe Shannon entropy equation provides a way to estimate variability of amino acids sequences in a multiple sequence alignment of proteins. Knowledge of protein variability is useful in many areas such as vaccine design, identification of antibody binding sites, and exploration of protein 3D structural properties. In cases where the population entropies of a protein are of interest but only a small sample size can be obtained, a method based on linear regression and random subsampling can be used to estimate the population entropy. This method is useful for comparisons of entropies where the actual sequence counts differ and thus, correction for alignment size bias is needed. In the current work, an R based package named EntropyCorrect that enables estimation of population entropy is presented and an empirical study on how well this new algorithm performs on simulated dataset of various combinations of population and sample sizes is discussed. The package is available at https://github.com/lloydlow/EntropyCorrectWai Yee Lo
Student Expectations in the New Millennium
No full textHigher education has experienced vast changes as a result of global political and economic developments. Cultural and social changes in the last decade have also added to the continuing evolution of higher education. These changes inevitably lead to changing expectations of students entering higher education. An adequate understanding of student expectations is crucial in ensuring a good fit between higher educational institutions and their students. This study attempts to carry out a baseline descriptive-quantitative research on student expectations in the higher education of Hong Kong. Four scales have been developed to measure students’ attitude toward: 1. job-oriented curriculum design, 2. user-friendly course delivery method, 3. opportunities for lifelong learning, and 4. student consumerism. Students’ priority of what makes a good university, their reasons for going to university, and their self-perception of ability to cope with university life are also explored. The Student Expectations Questionnaire (developed by the author) was used to gather data from 857 first-year undergrads from nine institutions of higher education in Hong Kong. Analyses include, among others, gender, age, major of study as well as institution comparisons
Dyslexia in Hong Kong : challenges and opportunities
No full textAuthor name used in this publication: Cecilia W. P. Li-TsangAuthor name used in this publication: Pui Yee Grace Lung2011-2012 > Academic research: not refereed > Chapter in an edited book (author)Version of RecordPublishedC
Polypyrrole-coated fabric strain sensor with high sensitivity and good stability
No full textAuthor name used in this publication: Hing Yee J. TsangAuthor name used in this publication: C. W. M. YuenVersion of RecordPublishedVoR allowe
Single-Use, Metabolite Absorbing, Resonant Transducer (SMART) Culture Vessels for Label-Free, Continuous Cell Culture Progression Monitoring
No full textSecreted metabolites are an important class of bio-process analytical technology (PAT) targets that can correlate to cell conditions. However, current strategies for measuring metabolites are limited to discrete measurements, resulting in limited understanding and ability for feedback control strategies. Herein, a continuous metabolite monitoring strategy is demonstrated using a single-use metabolite absorbing resonant transducer (SMART) to correlate with cell growth. Polyacrylate is shown to absorb secreted metabolites from living cells containing hydroxyl and alkenyl groups such as terpenoids, that act as a plasticizer. Upon softening, the polyacrylate irreversibly conformed into engineered voids above a resonant sensor, changing the local permittivity which is interrogated, contact-free, with a vector network analyzer. Compared to sensing using the intrinsic permittivity of cells, the SMART approach yields a 20-fold improvement in sensitivity. Tracking growth of many cell types such as Chinese hamster ovary, HEK293, K562, HeLa, and E. coli cells as well as perturbations in cell proliferation during drug screening assays are demonstrated. The sensor is benchmarked to show continuous measurement over six days, ability to track different growth conditions, selectivity to transducing active cell growth metabolites against other components found in the media, and feasibility to scale out for high throughput campaigns.This article is published as Chan, Yee Jher, Dhananjay Dileep, Samuel M. Rothstein, Eric W. Cochran, and Nigel F. Reuel. "Single‐Use, Metabolite Absorbing, Resonant Transducer (SMART) Culture Vessels for Label‐Free, Continuous Cell Culture Progression Monitoring." Advanced Science (2024): 2401260. doi: https://doi.org/10.1002/advs.202401260
Black Women in Radio Collection and Oral History Project
No full textBlack Women In Radio (BWIR) is committed to the historical preservation of America's Black female broadcasters and their contributions to Black radio culture and digital media. BWIR conducts ongoing research to capture the perspectives of Black and minority women who might otherwise be excluded or overlooked in historic conversations curated by BWIR Founder, Felesha Love.
The BWIR Collection will highlight the careers of 30 radio luminaries including Founder and Chairperson of Urban One Cathy Hughes, Media Icon Dyana Williams, and syndicated radio personalities Angela Yee, DeDe McGuire, and Jasmine Sanders and more. Hundreds of hours of audio, video, interviews, photos, and mementos were donated to offer a look at both the struggles and triumphs of Black women in radio and media
Narrative art and act in the fourth gospel: aspects of the Johannine point of view
No full textThis thesis assumes that the narrative form of the Fourth Gospel is important for understanding the Gospel's meaning. Narrative is a communicative transaction whereby meaning is transmitted from author to reader via the way the story is told. Meaning is also established by overt speech-acts, and the 'act' performed in the overall structuring of the story. It arises within a context of rule-governed speech behaviour which determines parameters and implications that inform understanding. The Gospel's narrative form meets with readers' conventional expectations about how it relates to ostensive historical reality. Factors internal and external help determine genre. Part one examines aspects of the Gospel's narrative art. The way in which the narrative situation varies over the course of the narrative is outlined. The implied author manipulates the narration to create a close association in the reader’s mind between the narrator and the beloved disciple. In John 3 the voice of the narrator merges with those of Jesus and John. These strategies have implications for the Gospel's theological meaning and the relationship of the implied author to the story world. Speech-act theory elucidates the narrative act by which the implied author conveys the Gospel's message and seeks to induce belief in the reader. Part two considers the Gospel's relationship to historical reference. Factors which influence a decision as to whether or not the Gospel is to be taken as fictional are examined, for example, whether aspects of the narration suggest fictional discourse and whether the speech-acts operate within a 'pretended' world. Descriptive categories for the Gospel as natural narrative and 'display text' are proposed, as is a flexible model of genre, which modulates the poles of 'fiction' and 'history'. An analysis of the Temple Cleansing pericope provides illustration of the Gospel’s status as an historically-based, theological display text
A Transfer Report on the Development of a Framework to Evaluate Search Interfaces for their Support of Different User Types and Search Tactics
No full textAs the understanding of search systems, user needs and seeking strategies is developing, the design of search user interfaces is evolving to support more complicated and exploratory forms of search. With the design of new search features that enable these richer modes of exploration, comes the need to better understand the support they provide. In this report a new evaluation framework is presented that analyses search features for how they a) contribute to an overall interface, b) allow users to carry out different search tactics, and c) support different types of users and their needs. The novel contributions of the framework improve on some of the limitations of typical user studies, and allow search systems to be systematically analysed in much more detail and in much less time. The presented evaluation framework is then validated in three ways. First the validity of the models used as the building blocks of the framework are investigated through related work. Second the method of integrating these building-block models is validated and strengthened by consensus of expert opinion. Third, the overall approach is validated by comparing its analyses to the results of previously carried out user studies. The validation process has shown both the value of the framework and identified areas of future work that should be addressed for the framework to be completed. This report concludes with the set of contributions that the framework makes, and why the remaining work will be challenging, but critical to the final design
The TESS Grand Unified Hot Jupiter Survey
No full textHot Jupiters – gas giant planets that orbit their stars once every few days – were a surprising discovery at the dawn of the exoplanet era. The existence of these massive planets so close to their host stars contradicted previous theories of planet formation, and their origins remain unclear. Even though hundreds of hot Jupiters have now been found, the sample was drawn from a diverse collection of ground-based surveys with heterogeneous selection biases, making it difficult to draw statistical inferences about this population.This dissertation presents the TESS Grand Unified Hot Jupiter Survey – our effort to leverage NASA’s Transiting Exoplanet Survey Satellite (TESS) to expand the statistical sample of hot Jupiters by an order of magnitude. By uniformly searching the sky for transiting exoplanets, TESS allows us to unify the past three decades of ground-based planet searches with new discoveries, thereby assembling a homogeneous catalog of 400 transiting hot Jupiters orbiting FGK stars brighter than G ≤ 12.5. Chapter 2 contains our initial forecasts and feasibility study for this survey, where we found that ≈ 50% of hot Jupiters around such a sample of stars remained to be discovered. Chapters 3 through 5 describe the discovery of 60 new giant planets from our survey, based on follow-up photometric, imaging, and spectroscopic data. These observations are key to confirming the planet candidates from TESS and eliminating false positives. We highlight the first statistical findings to emerge from our survey in Chapter 6, where we show that the orbital period distribution of hot Jupiters does not depend the metallicity of their host stars.
Looking forward, we present an update on the current status of the survey in Chapter 7, including new planet confirmations, a list of false positives, and a preliminary magnitude-limited catalog of hot Jupiters. Finally, in Chapter 8, we provide a glimpse at the demographic results from the full sample, including a 4-σ detection of the “period pile-up” at ≈ 3 days, and quantifying how hot Jupiter occurrence rates depend on stellar metallicity. These are the first clues toward understanding the enigmatic origins of hot Jupiters
Double-Edged Weapon – Reflections on the Scope of the Sanctions Imposed as a Punishment for Genocide in Ukraine
No full textArtykuł składa się z trzech podstawowych komponentów, w których zastosowano metodologię prawno-historyczną i prawno-porównawczą. W wielu częściach tekstu dotyczących obiegowo znanych informacji, niewymagających szczegółowej prezentacji, autor podkreśla selektywność swojej analizy. W pierwszej części, mającej charakter analizy terminologicznej, wyjaśnia treść pojęć, takich jak „zbrodnie ludobójstwa, które wymagają komentarza dotyczącego komponentów definicyjnych tych zbrodni odróżniających je od innych morderstw, gwałtów i przestępstw wojennych. Wobec decyzji Międzynarodowego Trybunału Karnego nakazującej aresztowanie prezydenta Putina za zbrodnie wojenne, wyjaśnienia wymagało stanowisko Trybunału, że termin zbrodnie wojenne jest użyty w szerokim znaczeniu, gdyż jurysdykcja Trybunału nad zbrodniami wojennymi, obejmuje również zbrodnie ludobójstwa i zbrodnie przeciwko ludzkości. Artykuł wyjaśnia również proces kształtowania się prawnego znaczenia terminu „sankcje”. Autor podkreśla w tej części, że głównym jego celem nie jest szczegółowe wyliczanie zmieniających się i uzupełnianych sankcji, ale rozważenie, w jakim stopniu sankcje już nałożone wpłynęły na kryzys rosyjskiej ekonomii i w jakim przyczyniły się do recesji „ekonomii globalnej”. W tej części dotyczącej analizy terminologicznej, artykuł wyjaśnia różnice między nurtami globalizacji i glokalizacji często utożsamianymi z ekonomią globalną. Druga część prezentuje problemy, które kraje gospodarki rynkowej starały się rozwiązać przed rozpoczęciem rosyjskiej agresji na Ukrainę. Wiele kwestii, takich jak „kryzys klimatyczny”, „pandemia” czy zjawisko „inflacji” wydaje się być obiegowo zrozumiała. Dla szerszego jednak wyjaśnienia tych zjawisk zastosowanie metodologii komperatywnej było najwłaściwsze. Część trzecia, przedstawia analizę skuteczności nałożonych na Rosję sankcji, a przede wszystkim ich kontrybucji do ekonomicznej izolacji Rosji. Część ta ma na celu również ocenę, w jakim stopniu nałożone na Rosję sankcje potęgują istniejące problemy ekonomiczne krajów Zachodu i w jakim stopniu mogą stanowić tytułową „broń obosieczną?”.The article consists of three basic components in which the author uses legal-historical and legal-comparative methodology. In many parts of the text concerning commonly known information which does not require a detailed presentation, the author emphasizes the selectivity of his comments. In the first part, which is a terminological analysis, the author explains the content of terms such as “genocide”, which require commentary on the definitional components of these crimes that distinguish them from other murders, rapes and war crimes. In view of the decision of the International Criminal Court ordering the arrest of President Putin for war crimes, clarification was required that the Court uses the term war crimes in a broad sense, and, in fact, the Court’s jurisdiction over war crimes also includes crimes of genocide and crimes against humanity. The article also explains the process of the development of the legal meaning of the term “sanctions”. The author emphasizes in this section that his main purpose is not to enumerate in detail the changing and supplemented sanctions, but to consider to what extent the sanctions already imposed have affected the crisis of the Russian economy and to what extent they have contributed to the recession of the “global economy”. In this section, the article explains the differences between the currents of globalization and the globalization which is often identified with global economics. The second part presents the problems that the countries of the market economy tried to solve before the start of the Russian aggression against Ukraine. Many issues, such as the “climate crisis”, “pandemic” or the phenomenon of “inflation”, seem to be widely understood. However, for a broader explanation of these phenomena, the author used the comparative methodology which was the most appropriate. The third part focuses on the analysis of the effectiveness of the sanctions imposed on Russia, and, above all, on their contribution to the economic isolation of Russia. 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