196,267 research outputs found
Prognostic value of the PIK3CA, AKT, PTEN mutations in oral squamous cell carcinoma: literature review
No full textOver 260,000 (2013) new oral squamous cell carcinoma (OSCC) cases are reported annually
worldwide. Despite development in OSCC management, the outcome is still unsatisfactory.
Identification of new molecular markers may be of use in prevention, prognosis and choice of an
adequate therapy.
The intracellular molecular signaling pathway of phosphatidyl-inositol-3-kinase is involved in the
process of cell growth, differentiation, migration and survival. Main components of this pathway:
PIK3CA (phosphatidylinositol-4,5-bisphosphate-3-kinase catalytic subunit α), PTEN (phosphatase
and tensin homolog deleted on chromosome 10) and AKT (serine-threonine kinase) are potential
objects of research when introducing new therapeutic agents.
The aim of this paper is to evaluate the PIK3CA, PTEN and AKT genes mutations as prognostic
factors in OSCC and to describe their role in aggressive disease progression. This is crucial for oral
cancer biology understanding and for indicating which direction new clinical treatments should
take
Znf-281 as the potential diagnostic marker of oral squamous cell carcinoma
No full textZNF-281 is a zinc finger factor which can lead to cancer progression and metastasis. Its up-regulation reported in many cancers was correlated with metastasis and worsened patients’ prognosis. This is the first study describing ZNF-281 in the context of OSCC. Oral tissue samples drawn from 66 OSCC patients and 36 control patients were collected to determine protein (using immunochemistry and the semi-quantitative H-score method) and mRNA expression levels (using the RT-qPCR reaction). Our aim was to assess the ZNF-281 expression level in OSCC and the control group. Moreover, we determined the impact of ZNF-281 on survival parameters and the association of diversified clinical parameters with ZNF-281 expression. Clinical factors such as grade, AJCC stage and radiotherapy have an impact on the ZNF-281 H-score level, whereas AJCC stage and grade have an influence on ZNF-281 mRNA expression. Our survival analysis indicated that the impact on overall survival is not statistically significant, and the prognostic potential of ZNF-281 is rather limited. Our findings show that both levels of the ZNF-281 H-score and mRNA are decreased in OSCC in comparison to normal tissue. Moreover, we estimated that the H-score can differentiate normal tissue from OSCC with a sensitivity of 97% and specificity of 93.7%
Any role of pik3ca and pten biomarkers in the prognosis in oral squamous cell carcinoma?
No full textOral squamous cell carcinoma (OSCC) accounts for 95% of the lesions in the oral cavity. Despite development in OSCC management, the outcome is still unsatisfactory. Identification of new therapies in OSCC is urgently needed. One objective of such treatment may be a signaling pathway of phosphatidylinositol 3-kinase. The study group included 92 patients treated for OSCC at the University Clinical Centre in Gdańsk, Poland. Study was performed on formalin-fixed paraffin-embedded samples from primary OSCC. Phosphatidylinositol-4,5-bisphosphate 3-kinase (PIK3CA) and phosphatase and tensin homolog encoded on chromosome 10 (PTEN) protein expression was assessed by immunohistochemistry (IHC). PIK3CA gene copy number was analyzed using chromogenic and silver in situ hybridization where molecular probes are marked by chromogens and silver ions. PIK3CA IHC H-score ≥ 70 was found in 51.65% patients, and loss of PTEN protein was noticed in 31.46% cases. PIK3CA amplification was detected in 5 tumors. In the case of PTEN protein expression, there was an inverse correlation with the T stage of the primary tumor (r = −0.243) and positive correlation with a 5-year survival (r = 0.235). The number of copies of the PIK3CA gene was associated with the tumor grading (r = 0.208). The present study shows that loss of PTEN protein and the grading (p = 0.040), distant metastases (p = 0.033), smoking (p = 0.016), and alcohol abuse (p = 0.042) were prognostic factors for the survival of patients with OSCC. In contrast, the presence of amplification and OSCC on the floor of the mouth resulted in a nearly six-fold increase in the risk of shortening survival (p = 0.037). Our finding suggests a potential prognostic significance of PTEN loss and PIK3CA amplification in OSCC. Future studies are needed to confirm our results
The scope of the controls carried out by the Supreme Court to adjudicate on complaint against an appellate court judgment
No full textThe amendments to the Code of Criminal Procedure that came into force after 15 April 2016, created an extraordinary new appeal measure – complaint against an appellate court judgment. It is described in Chapter 55a of the Code. The complaint against an appellate court judgment can be filed to the Supreme Court if the appellate court reversing the judgment of the court of first instance refers the case for re-examination. According to Article 539a § 1 of the Code, the complaint may be filed due to a violation of Article 437 or due to any one of the infringements listed in Article 439 § 1. The article analyses the legal construction of the regulation, the condition of its application and the scope of the controls carried out by the Supreme Court to adjudicate on complaint against the appellate court judgment. The author draws particular attention to the kind of negligence of the court of appeal which should be taken into account by the Supreme Court. Besides, the article shows discrepancies arising between decisions of the Supreme Court on the points of law which justified the setting aside of the judgment and the referral [email protected] Sakowicz – profesor nadzwyczajny w Katedrze Postępowania Karnego Uniwersytetu w Białymstoku.Andrzej Sakowicz – Associate Professor in the Department of Criminal Procedure at the University of Bialystok.Uniwersytet w BiałymstokuBierć A., Proceduralne aspekty tworzenia dobrego prawa, (w:) A. Bierć (red.), Legislacja w praktyce, Warszawa 2002.Czarnecki P., Skarga na wyrok sądu odwoławczego. (Non)sens nowego rozdziału 55a kodeksu postępowania karnego?, Czasopismo Prawa Karnego i Nauk Penalnych 2016, nr 2.Finga M., Glosa do postanowienia Sądu Najwyższego z dnia 10 lutego 2017 r., IV KS 6/16, Gdańskie Studia Prawnicze – Przegląd Orzecznictwa 2017, nr 1.Finga M., Orzekanie reformatoryjne w instancji odwoławczej w polskim procesie karnym, Warszawa 2016.Gil D., Skarga na wyrok sądu odwoławczego jako nowy nadzwyczajny środek zaskarżenia w procesie karnym, Ius et Administratio 2016, nr 3.Kociubiński W., Własne ustalenia faktyczne sądu odwoławczego i ich wpływ na treść rozstrzygnięcia w postępowaniu odwoławczym, PS 2003, nr 7-8.Kustra E., Polityczne problemy tworzenia prawa, Toruń 1994.Lach A., Skarga na wyrok sądu odwoławczego, (w:) A. Lach (red.), Postępowanie karne po nowelizacji z dnia 11 marca 2016 roku, Warszawa 2017.Rogoziński P., Zakres postępowania dowodowego na rozprawie apelacyjnej a stwierdzenie konieczności przeprowadzenia na nowo w całości przewodu sądowego przez sąd pierwszej instancji (art. 437 § 2 kpk.), (w:) S. Steinborn (red.), Postępowanie odwoławcze w procesie karnym – u progu nowych wyzwań, Warszawa 2016.Sakowicz A., Kilka uwag o współzależnościach karnego materialnego i prawa karnego procesowego w związku z nowelą z dnia 11 marca 2016 r., (w:) A. Lach (red.), Postępowanie karne po nowelizacji z dnia 11 marca 2016 roku, Warszawa 2017.Sakowicz A. (red.), Kodeks postępowania karnego. Komentarz, Warszawa 2018.Steinborn S. , Skarga na wyrok kasatoryjny sądu odwoławczego na tle systemu środków zaskarżenia w polskim procesie karnym, (w:) T. Grzegorczyk, Olszewski Radosław (red.), Verba volant, scripta manent. Proces karny, prawo karne skarbowe i prawo wykroczeń po zmianach z lat 2015-2016. Księga pamiątkowa poświęcona Profesor Monice Zbrojewskiej, Warszawa 2017.Świecki D. (red.), Kodeks postępowania karnego. Komentarz do zmian 2016, Warszawa 2016.Świecki D., Konstrukcja apelacji jako środka odwoławczego w procesie karnym, Warszawa 2018.Woźniewski K. , Oddalenie wniosku dowodowego przez sąd odwoławczy na podstawie art. 452 § 2 kpk., (w:) T. Grzegorczyk, R. Olszewski (red.), Verba volant, scripta manent. Proces karny, prawo karne skarbowe i prawo wykroczeń po zmianach z lat 2015-2016. Księga Pamiątkowa poświęcona Profesor Monice Zbrojewskiej, Warszawa 2017.Wróblewski K., Tęcza-Paciorek A.M., Skarga na wyrok sądu odwoławczego, Palestra 2017, nr 9.Zagrodnik J. , Instytucja skargi na wyrok sądu odwoławczego (rozdział 55a kpk.) – zarys problematyki, (w:) T. Grzegorczyk, R. Olszewski (red.), Verba volant, scripta manent. Proces karny, prawo karne skarbowe i prawo wykroczeń po zmianach z lat 2015-2016. Księga Pamiątkowa poświęcona Profesor Monice Zbrojewskiej, Warszawa 2017.Zagrodnik J. , Metodyka pracy obrońcy i pełnomocnika w sprawach karnych i karnych skarbowych, Warszawa 2016 .23115517
Istota prywatności
No full textZdigitalizowano i udostępniono w ramach projektu pn. Rozbudowa otwartych zasobów naukowych Repozytorium Uniwersytetu w Białymstoku, dofinansowanego z programu „Społeczna odpowiedzialność nauki” Ministra Edukacji i Nauki na podstawie umowy SONB/SP/512497/2021Dr Andrzej Sakowicz. Asystent w Katedrze Prawa Karnego. Stypendysta Towarzystwa im. Maxa Plancka (Instytut Maxa Plancka we Freiburgu Bryzgowijskim). Temat rozprawy doktorskiej: Prawnokarne gwarancje prywatności. Specjalizuje się w problematyce międzynarodowowych standardów ochrony praw człowieka w dziedzinie wymiaru sprawiedliwości w sprawach karnych, ze szczególnym uwzględnieniem prywatności jednostki, a także prawnokarnych regulacji wymiaru sprawiedliwości i spraw wewnętrznych w ramach Unii Europejskiej. Autor lub współautor ponad trzydziestu publikacji dotyczących wyżej wspomnianej tematyki, m.in.: Granice prawa do prywatności osób odbywających karę pozbawienia wolności. Przegląd Więziennictwa Polskiego 2004, Nr 43; Komentarz do decyzji ramowej UE w sprawie europejskiego nakazu aresztowania (w:) E. Zielińska (red.) Unia Europejska - prawo karne, tom VII, Instytut Wymiaru Sprawiedliwości, Warszawa 2004; Zagadnienia prawnokarne integracji europejskiej. Traktatowy chaos czy ład prawny (w:) System sprawiedliwości w Unii Europejskiej pod red. M. Prekowskiego, Warszawa 2003; Zasada ne bis in idem na gruncie art. 114 kodeksu karnego, Przegląd Sądowy 2003, nr 10.22924
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Assessment of Eutrophication in the Barnegat Bay-Little Egg Harbor System: Use of SAV Biotic Indicators of Estuarine Condition
No full textEutrophication poses a threat to the long-term health of the Barnegat Bay-Little Egg Harbor Estuary. Nutrient enrichment and associated organic carbon loading in this shallow, coastal lagoon have been linked to an array of cascading environmental problems such as increased micro- and macroalgal growth, harmful algal blooms (HABs), altered benthic invertebrate communities, impacted harvestable fisheries, and loss of essential habitat (e.g., seagrass and shellfish beds). This study examines the demographics of Zostera marina in the estuary over the 2008 study period to determine its status and trends. The environmental factors responsible for changes in the structure and function of the seagrass beds are also discussed
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