141,603 research outputs found
Shoichi Sakata: His life, the Sakata model and his achievements
No full textThe Sakata model was but one aspect of Shoichi Sakata's life and achievements. To better understand the context in which the model was developed, this paper outlines various aspects of his career, from family background and education, scientific work, friendship with Mituo Taketani, involvement in policymaking, and role of the Elementary Particle Theory Group. It is only then that we can truly appreciate the Sakata model and Sakata's importance to Japan
Portée éducative du conte Sakata en République Démocratique du Congo
No full textPartant de la motivation et de l’intérêt personnels face à la tradition orale et aux contes en particulier, l’Auteure s’est assignée l’objectif d’analyser le contenu du conte traditionnel Sakata en s’appuyant sur la méthode de Denise Paulme, afin de faire ressortir l’intérêt pédagogique caché dans ce genre littéraire. Pour atteindre son objectif, elle est partie des discours épistémologiques de la pédagogie narrative, afin de démontrer les capacités contenues dans la narration en général et dont I’éducateur peut s’en servir pour orienter son action éducative dans un éventail plus large des matières scolaires en référence à la théorie des intelligences multiples de Gardner Howard.
A fronte della motivazione e dell’interesse personali per la tradizione orale e i racconti in particolare, l’Autrice si propone di analizzare il contenuto del racconto tradizionale Sakata basato sul metodo di Denise Paulme, al fine di evidenziare l’interesse didattico nascosto in questo genere letterario. Per raggiungere il suo obiettivo, ella tiene conto degli approcci epistemologici della pedagogia narrativa al fine di dimostrare le possibilità contenute nella narrazione in generale, che l’educatore può utilizzare per orientare la propria azione educativa in un più ampio ventaglio di materie scolastiche, così come sostiene Howard Gardner nella Teoria delle intelligenze multiple.
Given her motivation and personal interest in oral tradition, and in stories in particular, the author uses Denise Paulme’s method to analyze traditional Sakata story content to bring to light the didactic interest hidden in this literary genre. To accomplish her task she takes into account the epistemological approaches of narrative pedagogy in order to demonstrate the possibilities contained in narrative in general that an educator can use to guide his or her educational activity within a broader range of scholastic material, as Howard Gardner argues in his Theory of Multiple Intelligences.
Al frente de la motivación y del interés personales por la tradición oral y los relatos en particular, la Autora se propone analizar el contenido del relato tradicional Sakata, basado en el método Denise Paulme, para poner en evidencia el interés didáctico que entraña este género literario. Para alcanzar su objetivo, tiene en cuenta los enfoques epistemológicos de la pedagogía narrativa con el fin de demostrar las posibilidades contenidas en la narración en general, que el educador puede utilizar para orientar la propia acción educativa en un más amplio abanico de materias escolares, como sostiene Howard Gardner en la Teoría de las inteligencias múltiples
Supplementary Data for Paper Entitled "Dynamic Behaviour of the Silica-Water-Bio Electric Double Layer in the Presence of Divalent Electrolyte"
No full textThis deposit includes supplementary data for the paper:
Lowe, B.M., Maekawa, Y., Shibuta, Y., Sakata, T., Skylaris, C.-K. and Green, N.G. (2016) Dynamic Behaviour of the Silica-Water-Bio Electrical Double Layer in the Presence of a Divalent Electrolyte. Physical Chemistry Chemical Physics, https://doi.org/10.1039/C6CP04101A
The data include:
- High-Resolution Molecular Dynamics Videos (.avi) "MD_video_trajectories.zip"
- Molecular Dynamics Trajectories (.xyz file format) "xyz_files.tar.bz2" [Now separated into 6 tar archives, all ending "_xyz_file.tar]
- Data files - Data extracted form the Trajectories, such as the charge distribution and water orientation "data.tar.bz2"
- Code used to analyse the data, and to plot the graphs in the publication - "analysis_and_images.zip"
Funded by JSPS 2015 Summer Fellowship.</span
ON/OFF Control of the Flipping Motion of Diuranyl Bis(Salophen) Macrocycle by Extremely Strong Binding with Fluoride Ion
No full textDiuranyl bis(salophen) complex 1 features a relatively slow conformational motion, induced by an intramolecular O═U═O···UO2 binding motif, which interconverts the two nonsymmetric halves of the ligand. This flipping motion, which constitutes one of the fundamental molecular motions, can be completely halted by addition of fluoride anion, which is bound to 1, reaching one of the highest affinities reported to date. This system represents a model to study flipping dynamics in light of the possibility of developing novel types of molecular machines based on it
Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model
No full textThe Otsuka Long-Evans Tokushima fatty rat is an animal model of Type 2 diabetes mellitus (DM), which is characterized by diastolic dysfunction associated with decreased sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a). The aim of this study was to examine whether gene transfer of SERCA2a can influence coronary blood flow and cardiomyocyte diameter in this model. DM rats were injected with adenovirus carrying SERCA2a (DM+SERCA) or beta-galactosidase gene (DM+betaGal). Coronary blood flow was measured in cross-circulated excised hearts 3 days after infection. Although in all groups coronary blood flow remained unchanged even if left ventricular (LV) volume or intracoronary Ca(2+) infusion was increased, the DM+SERCA group showed a sustained increase in coronary blood flow compared with the other groups. This result suggests that the sustained high coronary blood flow is a specific response in SERCA2a-overexpressed hearts. Although the LV weight-to-body weight ratio (LV/BW) and cardiomyocyte diameter were higher in the DM and DM+betaGal groups than in the non-DM group, in the DM+SERCA group, these measurements were restored to non-DM size. The percentages of collagen area in the three DM groups was significantly higher than results shown in non-DM rats, and there were no significant differences in collagen area percentage among the three DM groups. These results suggest that a lowered LV/BW by SERCA2a overexpression is due mainly to reduced size of cardiomyocytes without any changes in collagen area percentage. In conclusion, in DM failing hearts, SERCA2a gene transfer can increase coronary blood flow and reduce cardiomyocyte size without reduction in collagen production
Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins
No full textThe aim of this study was to examine whether short- and long-term gene transfer of Ca(2+) handling proteins restore left ventricular (LV) mechanoenergetics in aortic banding-induced failing hearts. Aortic-banded rats received recombinant adenoviruses carrying sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) (Banding+SERCA), parvalbumin (Banding+Parv) or beta-galactosidase (Banding+betagal), or an adeno-associated virus carrying SERCA2a (Banding+AAV.SERCA) by a catheter-based technique. LV mechanoenergetic function was measured in cross-circulated hearts. "Banding", "Banding+betagal" and "Banding+saline" groups showed lower end-systolic pressure at 0.1 ml intraballoon water (ESP(0.1)), higher end-diastolic pressure at 0.1 ml intraballoon water (EDP(0.1)) and slower LV relaxation rate, compared with "Normal" and "Sham". However, "Banding+SERCA" and "Banding+Parv" showed high ESP(0.1), low EDP(0.1) and fast LV relaxation rate. In "Banding", "Banding+betagal" and "Banding+saline", slope of relation between cardiac oxygen consumption and systolic pressure-volume area, O(2) cost of total mechanical energy, was twice higher than normal value, whereas slope in "Baning+SERCA" and "Banding+Parv" was similar to normal value. Furthermore, O(2) cost of LV contractility in the 3 control banding groups was approximately 3 times higher than normal value, whereas O(2) cost of contractility in "Banding+SERCA", "Banding+AAV.SERCA" and "Banding+Parv" was as low as normal value. Thus, high O(2) costs of total mechanical energy and of LV contractility in failing hearts indicate energy wasting both in chemomechanical energy transduction and in calcium handling. Improved calcium handling by both short- and long-term overexpression of SERCA2a and parvalbumin transforms the inefficient energy utilization into a more efficient state. Therefore enhancement of calcium handling either by resequestration into the SR or by intracellular buffering improves not only mechanical but energetic function in failing hearts
Genome‑wide analysis of the aquaporin genes in melon (Cucumis melo L.)
No full textMelon (Cucumis melo L.) is a very important crop throughout the world and has great economic importance, in part due to its nutritional properties. It prefers well-drained soil with low acidity and has a strong demand for water during fruit set. Therefore, a correct water balance—involving aquaporins—is necessary to maintain the plants in optimal condition. This manuscript describes the identification and comparative analysis of the complete set of aquaporins in melon. 31 aquaporin genes were identified, classified and analysed according to the evolutionary relationship of melon with related plant species. The individual role of each aquaporin in the transport of water, ions and small molecules was discussed. Finally, qPCR revealed that almost all melon aquaporins in roots and leaves were constitutively expressed. However, the high variations in expression among them point to different roles in water and solute transport, providing important features as that CmPIP1;1 is the predominant isoform and CmTIP1;1 is revealed as the most important osmoregulator in the tonoplast under optimal conditions. The results of this work pointing to the physiological importance of each individual aquaporin of melon opening a field of knowledge that deserves to be investigated.This study was funded by the Spanish Ministerio de Ciencia, Innovación y Universidades (RTC-2017-6119-2), was co-financed by SAKATA SEED IBERICA S.L.U. and was developed under the auspices of the Spanish Higher Council for Scientific Research (CSIC
El estado de flujo de efectivo como herramienta de gestión en la toma de decisiones financieras de la empresa agrícola Hoja Redonda S.A.C, distrito de San Isidro, Lima año 2017
No full textLa presente investigación se lleva a cabo con el propósito de mejorar la calidad de análisis e interpretación de movimientos de los fondos, así como evaluar la capacidad que tiene la entidad de generar liquidez, lo que permitirá determinar de qué manera el estado de flujo de efectivo como herramienta de gestión influye en la toma de decisiones financieras de la empresa agrícola Hoja Redonda S.A.C. año 2017. La hipótesis que se consideró en este trabajo de investigación es que la herramienta de gestión, estado de flujo de efectivo, tiene efecto en la toma de decisiones, en base a los análisis financieros, al eficiente control del manejo de recursos y a la correcta aplicación de la Norma Internacional de Contabilidad N° 7 en la empresa agrícola Hoja Redonda S.A.C. Los indicadores considerados para la variable independiente del estado de flujo de efectivo son las actividades de operación, actividades de inversión y actividades de financiamiento; para la variable dependiente se consideró lo siguiente; decisiones operativas, decisiones de inversión y decisiones de financiamiento. La metodología que se empleó para la elaboración del presente trabajo es de investigación aplicada, no experimental, descriptiva, explicativa y correlacional. La población está constituida por los trabajadores de la empresa agrícola Hoja Redonda S.A.C. del área administración, contabilidad, finanzas y logística, entre hombre y mujeres. Para obtener los resultados de la muestra se utilizó los instrumentos de recolección de datos como la encuesta y se utilizó la escala de Likert la cual nos permite evaluar el grado de conformidad del encuestado a través de las tablas de frecuencia y procesamiento de datos a través de la teoría del software SPSSSubmitted by Hidalgo Alvarez Jofre ([email protected]) on 2020-10-07T03:00:23Z
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