4,248 research outputs found
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease
No full textChronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators. A better understanding of the pathobiology of COPD is critical for the development of novel therapies. In the present review, we have discussed the roles of oxidative/aldehyde stress, inflammation/immunity, and chromatin remodeling in the pathogenesis of COPD. An imbalance of oxidants/antioxidants caused by cigarette smoke and other pollutants/biomass fuels plays an important role in the pathogenesis of COPD by regulating redox-sensitive transcription factors (e.g., NF-κB), autophagy and unfolded protein response leading to chronic lung inflammatory response. Cigarette smoke also activates canonical/alternative NF-κB pathways and their upstream kinases leading to sustained inflammatory response in lungs. Recently, epigenetic regulation has been shown to be critical for the development of COPD because the expression/activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in airways of COPD patients. Hence, the significant advances made in understanding the pathophysiology of COPD as described herein will identify novel therapeutic targets for intervention in COPD
Roles of simulation model on production of high performance nanocarbon polymer biocomposites
No full textA nanocarbon polymer biocomposite is a material that consists of a polymer matrix that is reinforced with nanocarbon particles. Nanocarbon particles can include materials such as carbon nanotubes, graphene, and
carbon black. The polymer matrix provides the bulk of the material’s mechanical and structural properties, while the nanocarbon particles provide additional strength, stiffness, and conductivity. The combination of the polymer and nanocarbon particles can result in a biocomposite material with unique properties that make it suitable for a wide range of applications, including biomedical, electronic, and environmental fields
Environmental toxicity, redox signaling and lung inflammation:the role of glutathione
No full textGlutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is tightly regulated and has been implicated in redox signaling and also in protection against environmental oxidant-mediated injury. Changes in the ratio of the reduced and disulfide form (GSH/GSSG) can affect signaling pathways that participate in a broad array of physiological responses from cell proliferation, autophagy and apoptosis to gene expression that involve H(2)O(2) as a second messenger. Oxidative stress due to oxidant/antioxidant imbalance and also due to environmental oxidants is an important component during inflammation and respiratory diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and asthma. It is known to activate multiple stress kinase pathways and redox-sensitive transcription factors such as Nrf2, NF-kappaB and AP-1, which differentially regulate the genes for pro-inflammatory cytokines as well as the protective antioxidant genes. Understanding the regulatory mechanisms for the induction of antioxidants, such as GSH, versus pro-inflammatory mediators at sites of oxidant-directed injuries may allow for the development of novel therapies which will allow pharmacological manipulation of GSH synthesis during inflammation and oxidative injury. This article features the current knowledge about the role of GSH in redox signaling, GSH biosynthesis and particularly the regulation of transcription factor Nrf2 by GSH and downstream signaling during oxidative stress and inflammation in various pulmonary diseases. We also discussed the current therapeutic clinical trials using GSH and other thiol compounds, such as N-acetyl-l-cysteine, fudosteine, carbocysteine, erdosteine in environment-induced airways disease
Rahman Dahlan's appointment as Minister in PM's Dept hailed
No full textKUALA LUMPUR: Communications and Multimedia Minister Datuk Seri Dr Salleh Said Keruak said yesterday Sabah stands to gain from the appointment of Datuk Seri Abdul Rahman Dahlan as Minister in the Prime Minister's Department in the Cabinet reshuffle on Monday
Kad Hari Raya
No full textKad ucapan hari raya yang diutuskan kepada Profesor Diraja Ungku Abdul Aziz daripada Dr. Abdul Rahman Mohd Sai
Impact on biocomposites using various types of nanocarbon and polymer
No full textThe development of environmentally friendly and sustainable materials is improving rapidly in various types of industries worldwide. This includes the development of biocomposites which is defined as a material that is composed of either two or more different types of materials where one of the materials is naturally derived and these materials are combined to produce a new material with enhanced performance compared to its individual constituent materials (Abenojar et al., 2021). The usage of
nanotechnology by using natural resources is able to improve the structural and functional properties of the biocomposites (Adamu et al., 2019). Hence, the production of nanocarbon polymer biocomposites are developing rapidly as it combines the superior properties of nanocarbon and
natural polymers. Nanocarbon is one of the materials that is able to enhance the mechanical and thermal strength of the polymers and it offers a range of advantages such as energy-efficient, abundant, and high thermal stability (Rizal et al., 2021). To further improve the properties of biocomposites, the usage of natural polymers is also applied which can improve biocompatibility, abundant, less toxic, and biodegradable (Amini et al., 2021)
Sejarah evolusi sunnah:Studi Pemikiran Fazlur Rahman
No full textThis study tries to analyze Fazlur Rahman?s thought on the historical evolution of the sunnah as his response to some orientalists when he was in the West and to muslem scholars who had blamed him when he was in Pakistan. In fact, the study of Prophetic Sunnah applied by orientalists came up with conclution that the`sunnah is not original from the Prophet period. It is so since muslim scholars in Indo-Pakistan contradiction and are not in line with Rahman?s views of sunnah. In critizing the orientalists?s views of Prophetic Sunnah, Rahman tried to elaborate the historical contect of sunnah. According to him, the false views of orientalists were naturally caused by their overlapping perception of sunnah as the living practice and the concept of normative. For muslim scholars, Rahman realized the numerous thoughts among them. Rahman pointed out that evolution of sunnah was historically valid and originally sourced from Muhammad. It is the source of Islamic law. Rahman also said that sunnah is a living tradition of prophet?s Muhammad and a general umbrella concept
Dietary polyphenols mediated regulation of oxidative stress and chromatin remodeling in inflammation
No full textPEMIKIRAN FAZLUR RAHMAN TENTANG PENDIDIKAN DAN RELEVANSINYA DALAM DUNIA MODERN
No full textPragmatic education thought-instrumental is a philosophic point of view that blends with the religious viewpoint of abstract speculation in outlining the education. One of renewing Islamic education is Fazlur Rahman. According to him, the goal of Islamic education are as renewal which is the initial step in the Islamization for all aspects of human life.
The study of library (library research) i.e. research sourced from material libraries using a qualitative approach. In this case, the author does exploration of a number of primary data as well as secondary data. The author does an analysis of the concept of Islamic education prespective Fazlur Rahman and relevance against the modern world.
The concept of educational thought Fazlur Rahman i.e. the Qur\u27an as a guide in resolving every problem and the answer and make the human person that are creative, have moral values in accordance with the Qur\u27an. Whereas, education as an alternative to the secular science by receiving updates and tried to enter it with Islamic concepts as for Islamic education renewal effort started from the educational objectives, educational system, learners, educators and the means of education. The relevance of educational thought on modern world Fazlur Rahman now is integration between religion and discrimination through public education, omission of religion and public education, this has been done wrong by the College namely IAIN with try to follow the thinking of education Fazlur Rahman dare change the State Islamic University (UIN)
Inspirasi Said Nursi: peranan kerohanian dalam kehidupan
No full textBuku ini merupakan tinta usaha gemblingan sepasukan pendidik dari AHAS KIRKHS, Universiti Islam Antarabangsa Malaysia dengan hasrat membantu memurnikan kefahaman masyarakat moden nusantara mengenai konsep tauhid, taslim dan pembentukan iman yang hakiki. Dalam mendepani cabaran hidup yang semakin menguji ketahanan mental mutakhir ini, buku ini mempersembahkan syarahan hasil tadabbur karya Badiuzzaman Said Nursi dalam koleksi Rasa’il al-Nur, dengan membekalkan tips bagi membentuk kerohanian yang teguh. Melalui penguasaan pelbagai disiplin ilmu oleh Said Nursi yang merangkumi ilmu akli dan naqli, beliau telah menawarkan ubat-ubat maknawi bagi pelbagai isu rohani dan spiritual di zaman moden melalui farmasi al-Quran. Usaha ini diharapkan dapat membantu memahami tujuan penciptaan manusia oleh Allah s.w.t. melalui proses tafakkur, lalu menghadirkan kelazatan dan kebahagiaan rohani dalam kehidupan seharian
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