189,574 research outputs found
A distributed amplifier system for bilayer lipid membrane (BLM) arrays with noise and individual offset cancellation
No full textLipid bilayer membrane (BLM) arrays are required for high throughput analysis, for example drug screening or advanced DNA sequencing. Complex microfluidic devices are being developed but these are restricted in terms of array size and structure or have integrated electronic sensing with limited noise performance. We present a compact and scalable multichannel electrophysiology platform based on a hybrid approach that combines integrated state-of-the-art microelectronics with low-cost disposable fluidics providing a platform for high-quality parallel single ion channel recording. Specifically, we have developed a new integrated circuit amplifier based on a novel noise cancellation scheme that eliminates flicker noise derived from devices under test and amplifiers. The system is demonstrated through the simultaneous recording of ion channel activity from eight bilayer membranes. The platform is scalable and could be extended to much larger array sizes, limited only by electronic data decimation and communication capabilities
Scolytoplatypus lopchuensis Maiti & Saha
No full text11. Scolytoplatypus lopchuensis Maiti & Saha * Scolytoplatypus lopchuensis Maiti & Saha, 2009: 90. Thai distribution: N: Chiang Mai. New to Thailand. New record: Chiang Mai, Doi Inthanon NP, Checkpoint 2, 18° 31.55' N, 98° 29.94' E, 1700 m, MT, 8–15.v.2007 (Y. Areeluck) (1). Other distribution: India (W. Bengal). (2) Taxonomy: In their description of the male, Maiti and Saha (2009) fail to mention the prosternum, which is a valuable taxonomic character in Scolytoplatypus (Beaver & Gebhardt 2006). It is broadly flattened posteriorly, but tapers anteriorly to a sharp point which is more strongly sclerotised. The tapering part bears long, backwardly pointing hairs, and at the tip on each side, a small tuft of short, forwardly pointing hairs. Maiti and Saha (2009) do not mention also the extremely long tufts of hairs on the anterior coxae. These are longer than in any other species of Scolytoplatypus known to us, the longest hairs extending two-thirds of the body length. Biology: Maiti and Saha (2009) list three host species in three different families (Lauraceae, Rutaceae, Symplocaceae). Given the localities listed by Maiti & Saha (2009), and above, probably a montane species. Illustrations: D (Maiti & Saha 2009).Published as part of Beaver, R. A., Sittichaya, W. & Liu, L-Y., 2014, A Synopsis of the Scolytine Ambrosia Beetles of Thailand (Coleoptera: Curculionidae: Scolytinae), pp. 1-82 in Zootaxa 3875 (1) on pages 17-18, DOI: 10.11646/zootaxa.3875.1.1, http://zenodo.org/record/513058
Aplikasi R?sa (Rumah Say?r) unt?k ?saha Katering Kelas Menengah
No full textPT R?sa Persada mer?pakan per?sahaan start?p bergerak di bdang distrb?si bahan makanan kh?s?s bagi pelak? ?saha katering kelas menengah, dengan k?mtmen bahwa perusahaan mampu menyedakan bahan bak? makanan yang berk?altas, segar, tepat wakt? dan dengan harga yang kompettif dbandingkan c?mpett?r lainnya melalui platfom digtal Rumah Sayur (RUSA). Hal ini menjawab masalah upaya yang lebih ?nt?k mendapatkan bahan makanan karena terkat l?kasi yang ja?h dari tempat ?sahanya, ketersediaan bahan makanan, distrbusi bahan makanan dari pasar, tenaga pembelian bahan makanan, ketersediaan wakt?, serta biaya transp?rtasi yang db?t?hkan. Met?de yang dig?nakan adalah met?de k?altatif yang dkuanttatifkan. Proses peneltian kualtatif melbatkan serangkaian langkah yang sistematis untuk mengumpulkan, menganalisis, dan menginterpretasi data kualtatif yang bertujuan untuk memahami dan menjelaskan fenomena dalam konteks alamiahnya. Kesmpulan penelti adalah bahwa terdapat beberapa hal berkatan dengan pr?ses sampai dengan hasil dari peneltian yang telah dilak?kan, yat? mtigasi permasalahan sampai dengan solusi terhadap masalah yang dperoleh dari survey sehingga platform pr?t?tpe yang menghasilkan seb?ah Aplikasi sederhana yang dapat membant? wiraswasta yang bergerak di sekt?r ?saha kuliner atau katering kelas menengah dalam rangka mengel?la rantai pas?kan bahan makanan dengan bantuan teknologi informasi
Internet-of-Forensic (IoF): A blockchain based digital forensics framework for IoT applications
No full textDigital forensic in Internet-of-Thing (IoT) paradigm is critical due to its heterogeneity and lack of transparency of evidence processing. Moreover, cross-border legalization makes a hindrance in such process pertaining to the cloud forensic issues. This urges a forensic framework for IoT which provides distributed computing, decentralization, and transparency of forensic investigation of digital evidences in cross-border perspectives. To this end, we propose a framework for IoT forensics that addresses the above mentioned issues. The proposed solution called Internet-of-Forensics (IoF) considers a blockchain tailored IoT framework for digital forensics. It provides a transparent view of the investigation process that involves all the stakeholders (e.g., heterogeneous devices, and cloud service providers) in a single framework. It uses blockchain-based case chain to deal with the investigation process including chain-of-custody and evidence chain. Consensus is used for consortium to solve the problems of cross-border legalization. This is also beneficial for a transparent and ease of forensic reference. The programmable lattice-based cryptographic primitives produce reduced complexities. It shows benefits for power-aware devices and puts an add-on to the novelty of the presented idea. IoF is generic; hence, it can be used by autonomous security operation centers, cyber-forensic investigators and manually initiated evidences under chain-of-custody for man-made crimes. Security services are assured as required by the framework. IoF is experimented and compared with the other state-of-the-art frameworks. The outcomes and analysis prove the efficiency of IoF concerning complexity, time consumption, memory and CPU utilization, gas consumption, and energy analysis
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Saha-Langmuir surface ionization relation
No full textIon production rate in cesium thermionic converter related to Saha-Langmuir surface ionization equatio
SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells
No full textSAHA, an inhibitor of histone deacetylase activity, has been shown to sensitize tumor cells to apoptosis
induced by TRAIL, a member of TNF-family. In this paper we investigated the effect of SAHA/TRAIL
combination in two breast cancer cell lines, the ERa positive MCF-7 and the ERa negative MDA-MB231.
Treatment of MDA-MB231 and MCF-7 cells with SAHA in combination with TRAIL caused detachment of
cells followed by anoikis, a form of apoptosis which occurs after cell detachment, while treatment with
SAHA or TRAIL alone did not produce these effects. The effects were more evident in MDA-MB231 cells,
which were chosen for ascertaining the mechanism of SAHA/TRAIL action. Our results show that SAHA
decreased the level of c-FLIP, thus favouring the interaction of TRAIL with the specific death receptors
DR4 and DR5 and the consequent activation of caspase-8. These effects increased when the cells were
treated with SAHA/TRAIL combination. Because z-IEDT-fmk, an inhibitor of caspase-8, prevented both
the cleavage of the focal adhesion-kinase FAK and cell detachment, we suggest that activation of caspase-
8 can be responsible for both the decrement of FAK and the consequent cell detachment. In addition,
treatment with SAHA/TRAIL combination caused dissipation of DJm, activation of caspase-3 and
decrement of both phospho-EGFR and phospho-ERK1/2, a kinase which is involved in the phosphorylation
of BimEL. Therefore, co-treatment also induced decrement of phospho-BimEL and a concomitant
increase in the dephosphorylated form of BimEL, which plays an important role in the induction of
anoikis.
Our findings suggest the potential application of SAHA in combination with TRAIL in clinical trials for
breast cancer
A recursive formula for the product of element orders of finite abelian groups
No full textLet G be a finite group and let ψ(G) denote the sum of element orders of G; later this concept has been used to define R(G) which is the product of the element orders of G. Motivated by the recursive formula for ψ(G), we consider a finite abelian group G and obtain a similar formula for R(G)
EVALUATION OF HISTONE DEACETYLASE INHIBITOR EFFECTS ON THYROID CANCER
No full textAbstract
Histone deacetylases (HDACs) play a crucial role in the proper regulation of cellular functions through their connection with chromatin and transcriptional regulation. Alterations in HDAC activity have been reported in several types of cancer encouraging development of HDAC inhibitors (HDACis) for cancer treatment. The antitumor activity of HDACi has been demonstrated, in clinical trials, in both solid and non solid neoplasias at doses well tolerated by patients. However, the molecular basis for their tumor selectivity is unknown. Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies, having a poor prognosis and being refractory to conventional chemo- and radiotherapy. To the aim to find an innovative therapy for the treatment of ATCs, we studied the effects of two potent HDACis, SAHA and MS-275, on rat thyroid cell lines transformed by the v-ras-Ki oncogene which is frequently mutated in ATCs. We show that: i) HDAC 1 and HDAC 2 are overexpressed in anaplastic thyroid carcinomas compared to normal thyroid; ii) SAHA and MS-275 induce apoptosis selectively in completely transformed rat thyroid cells; iii) TNF-related apoptosis-inducing ligand (TRAIL) is the main mediator of cell death induced by SAHA; iv) SAHA stabilize TRAIL protein by affecting its proteasome-mediated degradation
Replication Data for: Why Don't Politicians Talk About Meat? The Political Psychology of Human-Animal Relations in Elections
No full textR code with 2 datasets (Study 1 and Study 2 in paper)
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