247 research outputs found
Scalelength of 30000 SDSS disc galaxies (Fathi+, 2010)
No full textDisc scalelength (h) for 30000 galaxies from the Sloan Digitized Sky Survey (SDSS) Data Release 7, in the r-band. Also included is the Asymmetry parameter for each galaxy. Virtual Observatory methods and tools were used to define, retrieve and analyze the images for this unprecedentedly large sample classified as spiral galaxies in the LEDA catalogue. These parameters are also available for all other SDSS bands (u,g,i,z), and they can be retrieved from the Author. An extensive discussion about the errors involved in the derived parameters can be found in Fathi et al. (2010MNRAS.406.1595F) and Fathi (2010ApJ...722L.120F) (1 data file)
Scalelength of 30000 SDSS disc galaxies (Fathi+, 2010)
No full textDisc scalelength (h) for 30000 galaxies from the Sloan Digitized Sky Survey (SDSS) Data Release 7, in the r-band. Also included is the Asymmetry parameter for each galaxy. Virtual Observatory methods and tools were used to define, retrieve and analyze the images for this unprecedentedly large sample classified as spiral galaxies in the LEDA catalogue. These parameters are also available for all other SDSS bands (u,g,i,z), and they can be retrieved from the Author. An extensive discussion about the errors involved in the derived parameters can be found in Fathi et al. (2010MNRAS.406.1595F) and Fathi (2010ApJ...722L.120F) (1 data file)
Synergistic development of an engineered biodegradable theranostic probe and lymph node organ-on-a-chip to study nanoparticle-lymphatic interactions
No full textThe lymphatic system plays a vital role in controlling immune response. Despite this, cancer often reshapes the lymphatic microenvironment and metastasizes into lymph nodes. Theranostic (therapeutic + diagnostic) nanoparticles have been used in a variety of applications, including the detection and treatment of cancer metastases in lymph nodes. However, accumulation in the liver remains a major concern with any nanoparticle-based intervention. We have developed biodegradable nanoparticles made of biliverdin, an endogenous fluorophore that results from the breakdown of hemoglobin. We demonstrated the degradation of biliverdin nanoparticles (BVNPs) in the presence of biliverdin reductase, as well as the use of BVNPs in photoacoustic imaging of sentinel lymph nodes. Fundamental studies on BVNPs demonstrated shifts in their spectral properties as a response to various stimuli, including pH changes, metal chelation, and UV irradiation. BVNPs loaded with doxorubicin (Dox-BVNPs) were used for treatment of triple-negative breast cancer. BVNPs were further modified via metal chelation for use as a magnetic resonance imaging contrast agent. Finally, hybrid biliverdin-silica particles were developed for use in fluorescence imaging in the near-infrared I and II windows. At the same time, microfluidic models were created to recapitulate the lymph node tissue microenvironment. We first developed a lymphatic vessel on-a-chip that achieved long-term culture of primary human lymphatic endothelial cells (HLECs) under gravity-driven flow. We then developed a lymphatic system on-a-chip, comprised of multiple units that each model the lymph node subscapsular sinus, high endothelial venules, and lymph nodules. This device allows for the exploration of transport of nanoparticles, cancer cells, and immune cells to and from lymph nodes.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2022-08-01The student, Parinaz Fathi, accepted the attached license on 2020-05-27 at 09:47.The student, Parinaz Fathi, submitted this Dissertation for approval on 2020-05-27 at 10:25.This Dissertation was approved for publication on 2020-06-17 at 15:05.DSpace SAF Submission Ingestion Package generated from Vireo submission #15422 on 2020-10-02 at 15:48:56Made available in DSpace on 2020-10-07T22:48:04Z (GMT). No. of bitstreams: 3
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Oncolytic viruses: A novel treatment strategy for breast cancer
No full textBreast cancer, an unceasingly occurring neoplasm, is one of the major determinants of mortality in women. Several ineffective attempts have been pursued using with conventional therapies against breast cancer. Resistance to existing therapies and their respective debilitating adverse effects have led research toward a new era of cancer treatment using viruses. Virotherapy constitutes a developing treatment modality with multiple mechanisms of therapeutic activity in which the viruses can be directly oncolyticand can express transgenes or induce host immune response against tumor cells. Several different DNA- and RNA-containing viruses have been considered for virotherapy of breast cancer including adenovirus, herpes virus, vaccinia, reovirus, Newcastle Disease virus, measles virus and vesicular stomatitis virus.
This review aims to summarize the viro-therapeutical agents against breast malignancies.
Key Scientific Concepts of Review: In this review paper, we proposed a new strategy to virus’s
combinatorial treatments using several kinds of transgenes and drugs. These recombinant viruses have provided evidence of treatment efficacy against human breast cance
Médiation et protection de l’enfance [Le travail social à l’épreuve de la conflictualité parentale]
No full textThis contribution aims to examine the conditions for using mediation in the scope of child protection during follow-up by social workers in families. Providing child-rearing support for children in situations of parental conflict through traditional approaches of social work has proven to be unsatisfactory for the professionals concerned. Looking on the one hand at the points of agreement between the field of mediation and that of traditional social work (in-home child-rearing support), the author identifies the main problems for users and difficulties regarding professionals’ involvement.Cette contribution vise à examiner les conditions d’application de la médiation dans le cadre de la protection de l’enfance lors des suivis réalisés par les travailleurs sociaux au sein des familles. La prise en charge éducative des enfants en situation de conflit parental par les approches traditionnelles du travail social se révèle insatisfaisante pour les professionnels concernés. Tout en étudiant les points de concordance entre le champ de la médiation et celui du travail social traditionnel (action éducative en milieu ouvert), l’auteur repère les principales problématiques des usagers et les difficultés d’intervention des professionnels.Ben Mrad Fathi. Médiation et protection de l’enfance [Le travail social à l’épreuve de la conflictualité parentale]. In: Politiques sociales et familiales, n°107, 2012. pp. 65-75
Study frequency of hypertension and obesity and their relationship with lifestyle factors (nutritional habits, physical activity, cigarette consumption) in Ardabil city physicians, 2012-13
No full textBackground and Objective: Few studies have been done on lifestyle of Iranian physicians. As physicians have important role in health promotion, the main goal of the study was to assess the lifestyle of this influential group. Materials and Methods: A cross-sectional descriptive study was conducted on lifestyle of all registered physicians of Ardabil hospitals, Iran, 2012–13. In this research, 225 physicians were selected, by using simple random sampling. Demographic and lifestyle data were obtained by self-report using standard questionnaires, physical activity by official Iranian short-version of the international physical activity questionnaire, and dietary intake by food frequency questionnaire. Weight and height was performed according to standard protocols by using standardized and zero calibrated instruments. Data were analyzed by inferential statistics using Statistical Package for the Social Sciences.16 software. Results: Findings showed that 8% of participants were hypertensive, 21.3% smoker, 40%–47% inactive, 51.1% overweight, and 18.2% obese. There was a significant relationship between blood pressure and self-reported lifestyle habits (P < 0.05). And 70.7% of males and 74.1% of females had regular 10-min walking each day and moderate activity of males was significantly higher than females (P < 0.05). Food frequency weekly consumption of overweight and obese physicians were significantly higher than normal weight physicians (P < 0.05). Conclusion: Few doctors follow a healthy lifestyle; this may have a negative effect on society attitude about health
Personalized absorbable gastrointestinal stents for intestinal fistulae and perforations
No full textGastrointestinal (GI) tract perforations and obstructions are relatively frequent surgical emergencies, are potentially life-threatening, and can occur from several different sources. In general, treatment requires urgent surgical repair or resection and at times can lead to further complications. Currently available stents are non-absorbable, are manufactured in a narrow size range, and/or are limited to usage in locations that are accessible for endoscopic removal post-healing. The use of 3D-printed bioresorbable polymeric stents will provide patients with a stent that can prevent leakage, is tailored specifically to their geometry, will degrade with time to eliminate the need for further surgeries for stent removal post-healing, and will be usable in locations that are not endoscopically accessible. This project focused on the characterization of polycaprolactone-polydioxanone (PCL-PDO) composites for use in a bioresorbable gastrointestinal stent. Dynamic Mechanical Analysis (DMA) tests were conducted to separately analyze the effects of composition, the filament formation process, and physiological temperature on the PCL-PDO material properties. The proposed stent design was then modelled using computer-aided design, and Finite Element Analysis (FEA) was used to simulate the effects of physiologically relevant forces on stent integrity. The presence of hydrolysable ester bonds was confirmed using FTIR spectroscopy, and composite morphology was examined with scanning electron microscopy. In vitro studies were used to evaluate the biocompatibility of the polymer composite, finding that the PCL:PDO filament had no negative impact on cell viability over a period of 48 hours, and in fact was conducive to cell proliferation over a period of 3 days. PCL-PDO stents were then 3D-printed and placed in vivo in a pig model, and histological evaluation was used to determine the safety of these stents. Further analyses were conducted through stent placement in ex vivo pig intestines.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01The student, Parinaz Fathi, accepted the attached license on 2017-12-08 at 10:42.The student, Parinaz Fathi, submitted this Thesis for approval on 2017-12-08 at 10:49.This Thesis was approved for publication on 2017-12-12 at 09:02.DSpace SAF Submission Ingestion Package generated from Vireo submission #11917 on 2018-03-13 at 10:37:57Made available in DSpace on 2018-03-13T17:35:52Z (GMT). No. of bitstreams: 3
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Previous issue date: 2017-12-12Embargo set by: Seth Robbins for item 105490
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I can see that you’re suffering : The nurse’s encounter of relatives who lost a family member due to sudden death
No full textBakgrund: Sjuksköterskan är den person som är närmast patienten, och är den som oftast är med när en patient avlider. De anhöriga som lämnas kvar drabbas alltid av förlusten efter en död, och det är sjuksköterskans ansvar att sköta omvårdnaden av dessa anhöriga. I Sverige dör årligen cirka 90 000 personer, varav 11600 räknas som plötsliga dödsfall. När döden kommer plötsligt orsakar den ett enormt trauma som riskerar att inverka negativt på de efterlevandes hälsa, om de inte får rätt omhändertagande. Syfte: Syftet med studien var att identifiera och beskriva sjuksköterskans bemötande av anhöriga som förlorat en familjemedlem i plötslig död. Design: Allmän litteraturstudie med systematiskt tillvägagångssätt. Metod: Litteratur söktes i databaserna CINAHL, PubMed, PsychINFO, Scopus, Eric och Swemed+. Under sökningen användes svenska Mesh-termer, booleska söktermer, fri sökning och thesaurus-sökning. 16 artiklar kvalitetsgranskades, varav 13 artiklar gick vidare för analys. Av dessa var 12 av kvalitativ art, och en av kvantitativ. Resultat: Bemötandet av anhöriga innefattar många områden. Följande huvudkategorier identifierades: Egenvård, att skapa en relation, att ge utrymme, att delge, att vara professionell, samt att lämna situationen. Konklusion: Då en patient har avlidit är det viktigt att sjuksköterskan är kompetent att ta hand om de sörjande anhöriga. Sjuksköterskan behöver vara relationsfokuserad i sitt bemötande av dessa, för att kunna se deras behov och ge dem rätt omvårdnad. De anhöriga är i akut behov av information för att skapa sig en förståelse och acceptans för det plötsliga dödsfallet
The impact of Industry 4.0 on bottleneck analysis in production and manufacturing : Current trends and future perspectives
No full textBottleneck analysis, known as one of the essential lean manufacturing concepts, has been extensively researched in the literature. Recently, there has been a move towards using new Industry 4.0-based concepts and technologies in the development of bottleneck analysis. However, the interrelations between bottleneck analysis and Industry 4.0 have not been studied thoroughly. The present study addresses this gap and performs a systematic literature review on articles available in major scientific databases (i.e., Web of Science and Scopus) to investigate the impact of Industry 4.0 on the advancement of bottleneck analysis in production and manufacturing. Bibliometric analysis and content review were performed to extract the quantitative and qualitative data. Results revealed that only five out of 15 design principles and five out of eleven technologies of Industry 4.0 were addressed previously in developing bottleneck analysis methods. In addition to highlighting the existing gaps in the literature and proposing topics for future research, several potential development streams are proposed by studying the design principles and technologies of Industry 4.0, which have not been considered in bottleneck analysis before.CC BY 4.0Corresponding author at: Division of Intelligent Production Systems, School of Engineering Science, University of Skövde, 54128 Skövde, Sweden. E-mail addresses: [email protected], [email protected] (M. Fathi).This study was funded by the Knowledge Foundation (KKS), Sweden, through the ACCURATE 4.0 project, under grant agreement No. 20200181.ACCURATE 4.
Strategic supplier selection for renewable energy supply chain under green capabilities (fuzzy BWM-WASPAS-COPRAS approach)
No full textThe supplier selection problem (SSP) is a significant issue in renewable supply chain management (RSCM). Selecting a strategic green supplier can not only discover the sustainable development of supply chains but also optimize the consumption rate of resources and decrease the negative environmental effects, which adopts to the green development context. As a multiple criteria group decision-making (MCGDM) problem, choosing a strategic green supplier is important to renewable supply chains. However, how to choose a strategic green supplier for supply chains is a great effort. Hence, In the present work, evaluating a set of strategic suppliers is primarily based on green capabilities by using an integrated fuzzy Best Worst Method (FBWM) with the other two techniques, namely COPRAS (Complex Proportional Assessment of Alternatives) and WASPAS (Weighted Aggregated Sum-Product Assessment). Initially, nine strategic supplier selection criteria have been identified through literature review and a real-world case study of Iran's renewable energy supply chain is deliberated to exhibit the proposed framework's applicability. The applied methodology and its analysis will provide insight to decision-makers of strategic supplier selection. It may aid decision-makers and the procurement department in differentiating the significant strategic green supplier selection criteria and assess the strategic green supplier in the local and global market supply chain. Finally, the strengths and limitation of the framework are discussed by using comparative analysis with other methods.CC BY 4.0Corresponding author: Masood Fathi, Division of Intelligent Production Systems, School of Engineering Science, University of Skövde, 54128, Skövde, Sweden. E-mail addresses: [email protected] (B. Masoomi), [email protected] (I.G. Sahebi), [email protected] (M. Fathi), [email protected] (F. Yıldırım), [email protected] (S. Ghorbani).</p
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