419 research outputs found
Ruinen Griechenlands nach Stuart, Revett, Chandler, Pars, Leroy und andern
No full textRUINEN GRIECHENLANDS NACH STUART, REVETT, CHANDLER, PARS, LEROY UND ANDERN
Die Ruinen Griechenlands nach Stuart, Revett, Chandler, Pars, Leroy, und andern (-)
Ruinen Griechenlands nach Stuart, Revett, Chandler, Pars, Leroy und andern (I. Heft) ( - )
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Titelseite ([1])
Erklärung der Kupfer. Explication des estampes. ([2])
Kupfertafeln Blatt VIII-XI, XXII-XXIV (VIII)
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Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge
No full textEpidemiological studies suggest skeletal growth is programmed during intrauterine and early postnatal life. We hypothesise that bone development may be altered by maternal diet and have investigated this using a microswine model of maternal protein restriction (MPR). Mothers were fed a control diet (14% protein) or isocaloric low (1%) protein diet during late pregnancy and for 2 weeks postnatally. Offspring were weaned at 4 weeks of age to ad lib or calorie-restricted food intake groups. Femur and vertebra were analysed by micro computed tomography in offspring 3-5 months of age. Caloric restriction from 4 weeks of age, designed to prevent catch-up growth, showed no significant effects on bone structure in the offspring from either maternal dietary group. A maternal low protein diet altered trabecular number in the proximal femur and vertebra in juvenile offspring. Cortical bone was unaffected. These results further support the need to understand the key role of the nutritional environment in early development on programming of skeletal development and consequences in later life
A contribuição de David Kupfer para a análise da política de inovação brasileira nos anos 2000
No full textThe main features of the Brazilian industrialization process and its consequences, with the external debt crisis in the 1990s and the changes brought by economic liberalization in the same decade, were themes intensely debated by David Kupfer throughout his fruitful academic career. More recently, when the deindustrialization process of the Brazilian economy advanced, Kupfer introduced the term “Brazilian industrial disease” to refer to the chronic crisis that impacted Brazilian industry over the last 40 years. In this discussion, one of the recurrent themes was the insufficiency of the science, technology, and innovation (S,T&I) policy implemented in the country in the 2000s to leverage the industrial development. This is the object of this article, when discussing the most recent results brought by the Innovation Survey (Pintec) in the light of Kupfer’s contributions. The decline of the S,T&I policy is made explicit in the latest edition of Pintec, in 2017, confirming aspects anticipated by the author in several works.As principais características do processo de industrialização brasileiro e seus desdobramentos, com a crise da dívida externa nos anos 1990 e as mudanças trazidas pela liberalização econômica nessa mesma década, foram temas intensamente debatidos por David Kupfer ao longo de sua profícua carreira acadêmica. Mais recentemente, quando avança o processo de desindustrialização da economia brasileira, Kupfer introduziu o termo “doença industrial brasileira” para se referir à crise crônica que se abateu sobre a indústria nos últimos quarenta anos. Nessa discussão, um dos temas recorrentes foi o da insuficiência da política de ciência, tecnologia e inovação (C,T&I) implementada no país nos anos 2000 para alavancar o desenvolvimento industrial. Esse é o objeto deste artigo, ao discutir os resultados mais recentes trazidos pela Pesquisa de Inovação (Pintec) à luz das contribuições de Kupfer. O declínio da política de C,T&I se explicita na última edição da Pintec, em 2017, confirmando aspectos antecipados pelo autor em diversos trabalhos
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No full textA partir da investigação dos determinantes históricos e sociais que transformaram a escola em um dispositivo regulador da inclusão da criança no domínio do saber médico psiquiátrico, busca-se discutir o lugar e a função que a medicalização na infância tem ocupado no laço social, fundamentalmente, para as instituições que se ocupam da criança na atualidade. Para tanto, retoma de que maneira se produziu a constituição de um saber e de discursos psicológicos e psiquiátricos sobre a criança, investigando de que maneira esses discursos produzem obstáculos ao processo educativo e civilizatório, numa lógica em que o mal-estar, quando não reconhecido, retorna ao discurso sob a forma de patologia. Ocasião em que a criança é transformada em objeto de amor eterno ou de pesquisa científica, impedindo a morte da representação narcísica primária do infans no laço social que, organizado a partir do discurso da ciência e do capitalismo, sustenta a promessa do encontro entre o ideal e o sujeito numa lógica em que a medicalização sustenta a possibilidade de realização dessa promessa, mesmo às custas da morte do sujeitoFrom the investigation of historic and social determinants which have transformed the school into a regulator of the inclusion of the child in the medical psychiatrical knowledge domain, this work seeks to discuss the place and role that medicalization during the childhood has occupied in the social bond, fundamentally, for the institutions that deal with children nowadays. To do this, it revisits the ways that led to the production of a knowledge constitution as well as the psychological and psychiatrical discourses about the child, investigating how these discourses produce obstacles in the educational and civilization process, in a logic in which malaise, when not recognized, returns to the discourse as a pathology. In this occasion, the child is transformed into an object of eternal love or scientific research, preventing the death of the primary narcissistic representation of the infans in the social bond which, when organized by the discourse of science and capitalism, sustains the promise of the encounter between the ideal and the subject in a logic in which medicalization sustains the possibility of the realization of this promise, even at the expense of the subjects deat
Clinical trials in hospitalized heart failure patients: targeting interventions to optimal phenotypic subpopulations
No full textWith one possible exception, the last decade of clinical trials in hospitalized heart failure (HHF) patients has failed to demonstrate improvement in long-term clinical outcomes. This trend necessitates a need to evaluate optimal drug development strategies and standards of trial conduct. It has become increasingly important to recognize the heterogeneity among HHF patients and the differential characterization of novel drug candidates. Targeting these agents to specific subpopulations may afford optimal net response related to the particular mode of action of the drug. Analyses of previous trials demonstrate profound differences in the baseline characteristics of patients enrolled across global regions and participating sites. Such differences may influence risks for events and interpretation of results. Therefore, the actual execution of trials and the epidemiology of HHF populations at the investigative sites must be taken into consideration. Collaboration among participating sites including the provision of registry data tailored to the planned development program will optimize trial conduct. Observational data prior to study initiation may enable sites to feedback and engage in protocol development to allow for feasible and valid clinical trial conduct. This site-centered, epidemiology-based network environment may facilitate studies in specific patient populations and promote optimal data collection and clear interpretation of drug safety and efficacy. This review summarizes the roundtable discussion held by a multidisciplinary team of representatives from academia, National Institutes of Health, industry, regulatory agencies, payers, and contract and academic research organizations to answer the question: Who should be targeted for novel therapies in HHF
Pontisches anonymes Kupfer
No full textThe author discusses copper coinage with a leather helmet, Iess often a helmeted head or a rose, depicted on the obverse and a star and half-moon or bow on the reverse (Baldwin, RN, 1913). According to the most widely accepted view, these coins were struck by the governors of Mithradates VI in Pontos, Colchis or Bosporus. The author tries to justify a somewhat different opinion about this anonymous copper: that it was struck in Pontos under the predecessors of Mithradates VI. He cites several factors which favour this view, for example: the absence of anonymous coinage in hoards (both Pontic and Bosporan) of Mithradates's time, the abundance of city copper during the reign of this king, the absence in this latter coinage of the countermarks which are characteristic of the anonymous copper coinage, the greater weight of the anonymous coins, and the differing metallic composition of the anonymous and city issues.
By analysing the countermarks the author arrives at a new chronological classification of the anonymous Pontic coinage, nearly the reverse of the classification adopted by Baldwin. In Appendix II are published several rare coins of this type from the Hermitage collection
"Nec tecum nec sine te" : Language-Music Interplays in Musical Responses to Samuel Beckett
No full textIntermediality is rarely a one-way street: Throughout his career, Samuel Beckett employed a variety of modes of expression and media in his works, and – vice versa – it is partly owing to the strong role played by music in his works that Samuel Beckett's works figure so prominently in compositional history from 1930 to the present day. In fact, with more than 250 Beckett-based compositions of different genres and styles and from various countries responding to virtually the entire Beckettian œuvre, Beckett's poems, plays and prose have exerted an influence on composers unequalled by those of any other 20th-century author. This study shows that Beckett's double-coded language, sounds and images have served as a blueprint for crossing medial and social gaps in favor of a de-hierarchization of both the author-audience relationship and the intermedial interplay. As a result of this paradigm shift toward more participatory artistic modes and toward a postmodern "radical pluralization" (Wolfgang Welsch) of meaning and expressive vehicles, Beckett regarded music as an equal interlocutor of language and, vice versa, composers have become more receptive to entirely new modes of text-setting. "Nec tecum nec sine te," a Latin phrase by Ovid cited by Beckett to describe the double-edged relationship between Hamm and Clov from Endgame – interdependent yet noncommittal – equally applies to the text-music interplays portrayed in the present work
Alogliptin after Acute Coronary Syndrome in Patients with Type 2 Diabetes
No full textAbstract BACKGROUND: To assess potentially elevated cardiovascular risk related to new antihyperglycemic drugs in patients with type 2 diabetes, regulatory agencies require a comprehensive evaluation of the cardiovascular safety profile of new antidiabetic therapies. We assessed cardiovascular outcomes with alogliptin, a new inhibitor of dipeptidyl peptidase 4 (DPP-4), as compared with placebo in patients with type 2 diabetes who had had a recent acute coronary syndrome. METHODS: We randomly assigned patients with type 2 diabetes and either an acute myocardial infarction or unstable angina requiring hospitalization within the previous 15 to 90 days to receive alogliptin or placebo in addition to existing antihyperglycemic and cardiovascular drug therapy. The study design was a double-blind, noninferiority trial with a prespecified noninferiority margin of 1.3 for the hazard ratio for the primary end point of a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. RESULTS: A total of 5380 patients underwent randomization and were followed for up to 40 months (median, 18 months). A primary end-point event occurred in 305 patients assigned to alogliptin (11.3%) and in 316 patients assigned to placebo (11.8%) (hazard ratio, 0.96; upper boundary of the one-sided repeated confidence interval, 1.16; P<0.001 for noninferiority). Glycated hemoglobin levels were significantly lower with alogliptin than with placebo (mean difference, -0.36 percentage points; P<0.001). Incidences of hypoglycemia, cancer, pancreatitis, and initiation of dialysis were similar with alogliptin and placebo. CONCLUSIONS: Among patients with type 2 diabetes who had had a recent acute coronary syndrome, the rates of major adverse cardiovascular events were not increased with the DPP-4 inhibitor alogliptin as compared with placebo
Sprite on Mach
No full textthis paper explains why we ported Sprite to Mach. Section 3 sketches the design of the Sprite server and discusses a few of the problems that arose during design and testing. Section 4 shows how the Sprite server is smaller and more portable than native Sprite. Section 5 shows that the server is significantly slower than native Sprite, and it explains some of the known bottlenecks. Section 6 evaluates the Sprite server, and Section 7 lists possible future work. Section 8 closes with some general conclusions from the project. + Author's current address: SunSoft, Inc., 2550 Garcia Avenue, MS MTV05-40, Mountain View, CA 94043-1100
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