359 research outputs found

    Economic factors affecting obesity: an application in Italy

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    The World Health Organization has stated that obesity is spreading around the world like a “global epidemic”. In 2004 the percentage of obese people in the Italian population was 9%, but the trend s increasing in recent years. Focusing on this country, the purpose of the paper is to analyze the socio-economic variables affecting obesity by means of a survey conducted in a consumer sample. Our analysis is based on a survey conducted in Italy, and the sample was composed of 999 consumers. We used a binary logit model and the dependent variable is body mass index (BMI), expressed in a dichotomic way (seriously overweight and obese, value 1, and normal weight, value 0). The results show that the condition of the seriously overweight and obese increases with age, especially in people over 65 of age. Also gender is correlated with the pathology: being seriously overweight and obese is far more likely for men than for women. An inverse relation was shown between obesity and education, and between obesity and the level of food knowledge. The results highlight that disadvantaged social categories are more susceptible to the problem of overweight and obesity. A policy implication of the analysis, to limit the spread of obesity, could lie in programs aimed at improving health and food awareness and focused on these minority groups.economics of obesity, BMI and consumer, logit model, Food Consumption/Nutrition/Food Safety, Health Economics and Policy,

    Author response

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    Detecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens before infection may be advantageous. The bacterial endotoxins lipopolysaccharides (LPS) are important immune system infection cues (Abbas et al., 2014), but it remains unknown whether animals possess sensory mechanisms to detect them prior to infection. Here we show that Drosophila melanogaster display strong aversive responses to LPS and that gustatory neurons expressing Gr66a bitter receptors mediate avoidance of LPS in feeding and egg laying assays. We found the expression of the chemosensory cation channel dTRPA1 in these cells to be necessary and sufficient for LPS avoidance. Furthermore, LPS stimulates Drosophila neurons in a TRPA1-dependent manner and activates exogenous dTRPA1 channels in human cells. Our findings demonstrate that flies detect bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved molecular mechanism.sponsorship: Vlaams Instituut voor Biotechnologie Alessia Soldano Luis Franco Guangda Liu Natalia Mora Emre Yaksi Bassem A Hassanr Fonds Wetenschappelijk Onderzoek G.0702.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0077.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0680.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0681.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0503.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0654.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0761.10N Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0596.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0565.07 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven GOA/14/011 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar European Commission IUAP P7/13 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekensr KU Leuven OT/12/091 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven PF-TRPLe Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talavera (Vlaams Instituut voor Biotechnologie, Fonds Wetenschappelijk Onderzoek|G.0702.12, Fonds Wetenschappelijk Onderzoek|G.0077.15, Fonds Wetenschappelijk Onderzoek|G.0680.10, Fonds Wetenschappelijk Onderzoek|G.0681.10, Fonds Wetenschappelijk Onderzoek|G.0503.12, Fonds Wetenschappelijk Onderzoek|G.0654.15, Fonds Wetenschappelijk Onderzoek|G.0761.10N, Fonds Wetenschappelijk Onderzoek|G.0596.12, KU Leuven|GOA/14/011, KU Leuven|OT/12/091, European Commission|IUAP P7/13, KU Leuven PF-TRPLe)status: Publishe

    Influence of compost on the mobility of arsenic in soil and its uptake by bean plants (Phaseolus vulgaris L.) irrigated with arsenite-contaminated water.

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    The influence of compost on the growth of bean plants irrigated with As-contaminated waters and its influence on the mobility of As in the soils and the uptake of As (as NaAsIIIO2) by plant components was studied at various compost application rates (3·104 and 6·104kgha-1) and at three As concentrations (1, 2 and 3mgkg-1). The biomass and As and P concentrations of the roots, shoots and beans were determined at harvest time, as well as the chlorophyll content of the leaves and nonspecific and specifically bound As in the soil.The bean plants exposed to As showed typical phytotoxicity symptoms; no plants however died over the study. The biomass of the bean plants increased with the increasing amounts of compost added to the soil, attributed to the phytonutritive capacity of compost. Biomass decreased with increasing As concentrations, however, the reduction in the biomass was significantly lower with the addition of compost, indicating that the As phytotoxicity was alleviated by the compost. For the same As concentration, the As content of the roots, shoots and beans decreased with increasing compost added compared to the Control. This is due to partial immobilization of the As by the organic functional groups on the compost, either directly or through cation bridging. Most of the As adsorbed by the bean plants accumulated in the roots, while a scant allocation of As occurred in the beans. Hence, the addition of compost to soils could be used as an effective means to limit As accumulation in crops from As-contaminated waters

    Politiche urbane e strategie territoriali in Basilicata

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    The chapter investigates the level of integration of the Basilicata region within the overall territorial strategies emerging at the scale of Mezzogiorno, Italy and Euromediterranean context. In detail, it is analyzed the role of Basilicata’s cities in the scenario of the creation of a “meridian corridor” within the European urban network

    Development and application of a fast ultra-high performance liquid chromatography-trapped ion mobility mass spectrometry method for untargeted lipidomics

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    The alteration of lipid profile in biological specimens, such as plasma, mirrors abnormalities in their homeostasis and offers pivotal information for disease comprehension. Fast analytical methods are needed to highlight changes in plasma lipid profile and deliver rapid results. In this study we developed a fast reversed phase ultra high performance liquid chromatography-trapped ion mobility mass spectrometry (RP-UHPLC-TIMS-MS) method for untargeted lipidomics. A short, narrow-bore fully porous particle CSH column (50 mm x 2.1 mm, 1.7 mu m) was used, and by selecting appropriate flow rate, temperature and gradient conditions, the total analysis time was reduced from 20 to 4 min. TIMS was operated in parallel accumulation serial fragmentation mode (PASEF) which allowed to select multiple precursors for MS/MS and separate co-eluting lipids based on their different mobility. Lipid annotation was performed by rule-based approach, comparison with LipidBlast spectral library and manual data curation, by taking into account class-specific fragmentation pattern, accurate mass, adduct form, retention behavior in RP and comparison of their collision cross-section (CCS) values for increased confidence. 306 unique lipids from 21 subclasses were annotated from 20 mu L of plasma, while their concentration was estimated by class-specific deuterated internal standards. The analytical method was validated and finally applied to elucidate the alteration of plasma lipid profiles in a small cohort of amyotrophic lateral sclerosis (ALS) patients. Univariate and multivariate statistics evidenced significant differences with respect to control patients, particularly in the levels of ether linked lipids (PC-O, PE-O, PE-P and LPC-O), sphingolipids (Ceramides), and triacylglycerols, showing the usefulness of this fast approach in providing accurate and rapid results with respect to longer ( >= 15 min) untargeted UHPLC-HRMS methods. (c) 2022 Elsevier B.V. All rights reserved

    Sorption of Arsenite on Cu-Al, Mg-Al, Mg-Fe, and Zn-Al Layered Double Hydroxides in the Presence of Inorganic Anions Commonly Found in Aquatic Environments

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    Use of layered double hydroxides (LDHs) in the environmental field is gaining popularity due to their potential to sorb toxic anions, attributed to their large surface area, high anion exchange capacity, and good thermal stability. In this study, four different LDHs (i.e., Cu-Al-, Mg-Al-, Mg-Fe-, and Zn-Al-LDH) were synthesized to select one or more efficient sorbents, capable of removing arsenite [As(III)] from contaminated waters. In particular, we studied the following: (1) X-ray diffraction patterns and specific surface area of the synthesized LDHs; (2) sorption isotherms of As(III) at pH 7.0; and (3) sorption of As(III) on LDHs, in the presence of inorganic anions [carbonate (CO3), chloride (Cl), fluoride (F), phosphate (PO4), sulfate (SO4)] commonly present in aquatic environments. The poorly crystalline LDHs (i.e., Cu-Al-LDH and Mg-Fe-LDH) sorbed greater amounts of As(III) than the well-crystalline LDHs (i.e, Mg-Al-LDH and Zn-Al-LDH). The efficiency of the competing anions at inhibiting As(III) sorption by the LDHs was Cl ≤ F < SO4 << CO3 << PO4, regardless of initial ligand/As(III) molar ratios (R) or LDH. Although Cu-Al-LDH sorbed lower amounts of As(III) than the Mg-Fe-LDH, it showed, surprisingly, a higher affinity for As(III). This surprising behavior puts this LDH in the forefront as a potential sorbent for the treatment of arsenic-contaminated waters
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