1,720,956 research outputs found
Synthesis,characterization and cytotoxic activity on breast cancer cellsof new half-titanocenes derivatives
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Synthesis, characterization and cytotoxicity studies of novel organo-metallic compounds
Get PDF2012 - 2013Despite the discovery of cis-platin in the treatment of cancer there has
been a considerable exploration on the antitumoral activity of other
transition metal complexes. One of the main problems about the
application of transition metal complexes for chemotherapy is their
potential toxicity. For instance, recently the attention has been focused
on titanium based complexes, which could have significant potential
effect against solid tumor. The advantage of Ti(IV) complexes is their
relative biological compatibility, which mostly leads to mild and revisable
side effects. However, the hydrolytic instability of known Ti(IV)
complexes and formation of various different species upon water addition
makes their therapeutic application problematic, and raises a strong
interest in the development of relatively stable Ti(IV) complexes with well
defined hydrolytic behavior that demonstrate appreciable cytotoxic
activity. Strong ligand binding is also of interest to avoid complete ligand
stripping by transferrin, so that the ligand may be used as a target for
structure–activity relationship investigations.
Titanocene dichloride (Cp2TiCl2) shows an average antiproliferative
activity in vitro but promising results in vivo. Considerable work has been
performed in developing therapeutic analogues of Cp2TiCl2 by varying
the central metal, the labile ligands (Cl) and the bis-cyclopentadienyl
moiety. In particular, small changes to the Cp ligand can strongly affect
the hydrolytic stability and water solubility properties of the metallocenes
and have an impact on the cytotoxic activity.
For a better exploration of the parameters affecting activity and its
mechanistic aspects, the synthesis and investigation of particularly
designed complexes based on different strongly coordinating ligands has
been our main purpose
We synthesized novel titanocene and half-titanocene derivatives, having
substituted cyclopentadienyl ligands; all the complexes have been fully
characterized by NMR, elemental analysis and MS. Additionally we
studied the rate of hydrolysis of these complexes. Starting from the
reflection that the different activities of the complexes could be related to
their different stabilities, the hydrolysis stability represents a first
possible indication on the achievable cytotoxic effects of synthesized
compounds.
The synthesized compounds have been evaluated for their cytotoxic
potential against cancer cell lines. Most of these compounds showed
significant anti-proliferative effects compared to cisplatin [edited by Author]XII n.s
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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