1,721,000 research outputs found
Applicazioni di ragioneria -Elementi di computisteria, rilevazioni contabili e rappresentazione in bilancio
No full textMANDATORY OBLIGATIONS AND VOLUNTARY DISCLOSURE OF ITALY’S LISTED COMPANIES
No full textDirective no. 2003/51/EC of the European Parliament has established that the information should not be restricted to the financial aspects of the company's business. It is expected that, where appropriate, this should lead to an analysis of environmental and social aspects necessary for an understanding of the company's development, performance or position; hence, the level of disclosure depends on the legal framework. Lately, after the “modernization” of European accounting directives (2003/51/EC), the Italian Government has adopted Legislative Decree no. 32, 2nd February 2007, which requires to include in the Management Report, where appropriate, non-financial information relating to environmental and employee matters.
The purpose of this paper is to examine if Legislative Decree no. 32, 2nd February 2007, in addition to firm’s characteristic factors (size, location, learning capacity, economic performance, board composition, etc.,), influence the voluntary disclosure practices of listed companies in Italy.
A sample of 30 listed firms was examined using content analysis to determine the volume and the quality of disclosures. In a second step we tested the influences on disclosure of legal framework, industry and firms size.
Results show that the legal framework have an effect all on the quality and quantity of voluntary item disclosed. Our results also provide evidence that factor directly associated with the amount of environmental, social and risk information disclosed is the level of compliance with mandatory disclosure
YADAMP: Yet Another Database of Antimicrobial Peptides
No full textThis work presents an antimicrobial peptide database (YADAMP) based on an extensive literature search. This database is focused primarily on bacteria, with detailed information for 2133 peptides active against bacteria. YADAMP was born to facilitate access to critical information on antimicrobial peptides (AMPs). The main difference between YADAMP and other web databases of AMP is the explicit presence of antimicrobial activity against the most common bacterial strains. YADAMP allows complex queries, easily accessible through a web interface. Peptide information can be retrieved based on peptide name, number of amino acids, net charge, hydrophobic percentage, sequence motif, structure and activity against bacteria. YADAMP is suitable for reviewing information on AMP, and for structure–function analyses of peptides. The database can be accessed via a web‐based browser at the URL: http://www.yadamp.unisa.it
Fragment based molecular dynamics for drug design
No full textMolecular docking is a computationally efficient method used to predict the conformations adopted by the ligand within a target-binding site. A positive aspect of conventional docking is the possibility of easily distributing the calculation on dedicated grid or cluster. The receptor is usually kept rigid, therefore the changes in the binding pocket geometry induced by the ligand is overlooked. Here we present a new docking approach (DynDock) that exploits molecular dynamics to preserve the flexibility of the receptor. To maintain high computational efficiency, DynDock has been developed to be distributed on a grid. The main advantages of this method are the full flexible molecular docking achieved during the simulation and the reduced number of compounds collected
for automated quantum chemistry calculations
No full textThe accuracy of quantum mechanics (QM) simulations depends heavily on the quality of initial input files. Despite the popularity of QM simulation packages, achieving precise results still heavily relies on the user's proficiency in preparing the QM simulation systems. In this work, we present an easy-to-use tool called GUIDE, a YASARA plugin to assist researchers in quantum chemistry workflow automation using ORCA and MOPAC simulation packages. GUIDE lets users compute complex QM calculation workflows via an automated graphical window system. It allows for a more integrated and streamlined research process, as researchers can easily access all the necessary tools within one software without switching between multiple programs. This tool can save time and increase efficiency in computational chemistry methods. GUIDE is written in Python and is freely available for download at . The plugin is released under a GPL-3.0 license and is supported on Windows and Linux
Advances in Bionanomaterials II: Selected Papers from the 3rd International Conference on Bio and Nanomaterials, BIONAM 2019, September 29 – October 3, 2019
No full textThis book presents multidisciplinary research focusing on the analysis, synthesis, and design of bio and nanomaterials. Merging biophysics, biochemistry, and bioengineering perspectives, it discusses the basic properties of materials and their interaction with biological systems; the development of new medical devices, such as implantable systems; and new algorithms and methods for modeling the mechanical, physical, and biological properties of biomaterials.
The book gathers the proceedings of the 3rd International Conference on Bio and Nanomaterials, held on September 29–October 3, 2019, on an MSC cruise ship navigating the Mediterranean Sea. It particularly highlights Horizon 2020 projects, covering topics such as novel synthetic strategies for nanomaterials, the implementation of bio- and smart materials for pharmacological and medical purposes, as well as environmental applications. Intended for a broad audience of academics and professionals, it offers a comprehensive and timely snapshot of the field of biomaterials. In addition to a set of innovative theories together with the necessary practical tools for their implementation, it also addresses the current challenges in the field, fostering new discussions and possible future collaborations between diverse groups
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Artificial Chemical Neural Network for Drug Discovery Applications
No full textThe drug design aims to generate chemical species that meet specific criteria, in-cluding efficacy against a pharmacological target, good safety profile, appropriate chemical and biological properties, sufficient novelty to ensure intellectual proper-ty rights for commercial success, etc. Using new algorithms to design and evalu-ate molecules in silicon de novo drug design is increasingly seen as an effective means of reducing the size of the chemical space to something more manageable for identifying chemogenomic research tool compounds and for use as starting points for hit-to-lead optimization
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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