1,721,003 research outputs found
Evaluation of the impact of active wake control techniques on ultimate loads for a 10 MW wind turbine
Full text linkWind farm control is one of the solutions recently proposed to increase the overall energy production of a wind power plant.A generic wind farm control is typically synthesized so as to optimize the energy production of the entire wind farm by reducing the detrimental effects due to wake-turbine interactions. As a matter of fact, the performance of a farm control is typically measured by looking at the increase in the power production, properly weighted through the wind statistics. Sometimes, fatigue loads are also considered in the control optimization problem. However, an aspect which is rather overlooked in the literature on this subject is the evaluation of the impact that a farm control law has on the individual wind turbine in terms of maximum loads and dynamic response under extreme conditions.In this work, two promising wind farm controls, based on wake redirection (WR) and dynamic induction control (DIC) strategy, are evaluated at the level of a single front-row wind turbine. To do so, a two-pronged analysis is performed. Firstly, the control techniques are evaluated in terms of the related impact on some specific key performance indicators, with special emphasis on ultimate loads and maximum blade deflection. Secondarily, an optimal blade redesign process is performed with the goal of quantifying the modification in the structure of the blade entailed by a possible increase in ultimate values due to the presence of wind farm control. Such an analysis provides for an important piece of information for assessing the impact of the farm control on the cost-of-energy model
Free-Form Design of Rotor Blades
Full text linkThis work investigates an integrated free-form approach for the design of rotor blades, where airfoil shapes are treated as unknowns. This leads to the simultaneous optimization of the chord, twist and structural design variables, together with the airfoil shapes along the blade. As airfoils are automatically tailored to the evolution of the blade, this process results in a better exploration of the solution space and relieves the user from the burden of up-front choices, leading to better final designs. The proposed approach is demonstrated by sizing a 2 MW wind turbine blade
Ultrasound-guided percutaneous ventriculopleural shunt placement: a minimally invasive technique
No full textVentriculopleural shunt is still considered a third-line option for CSF diversion, when both peritoneal and atrial cavity are contraindicated. Different approaches have been used and in modern surgery, lesser invasive techniques are predominant. The goal of this manuscript is to present a minimally invasive placement of a pleural catheter
Integration of prebend optimization in a holistic wind turbine design tool
Full text linkThis paper considers the problem of identifying the optimal combination of blade prebend, rotor cone angle and nacelle uptilt, within an integrated aero-structural design environment. Prebend is designed to reach maximum rotor area at rated conditions, while cone and uptilt are computed together with all other design variables to minimize the cost of energy. Constraints are added to the problem formulation in order to translate various design requirements. The proposed optimization approach is applied to a conceptual 10 MW offshore wind turbine, highlighting the benefits of an optimal combination of blade curvature, cone and uptilt angles
The in silico drug discovery toolbox: applications in lead discovery and optimization
No full textDiscovery and development of a new drug is a long lasting and expensive journey that takes around 15 years from starting idea to approval and marketing of new medication. Despite the R&D expenditures have been constantly increasing in the last few years, number of new drugs introduced into market has been steadily declining. This is mainly due to preclinical and clinical safety issues, which still represent about 40% of drug discontinuation. From this point of view, it is clear that if we want to increase drug-discovery success rate and reduce costs associated with development of a new drug, a comprehensive evaluation/prediction of potential safety issues should be conducted as soon as possible during early drug discovery phase. In the present review, we will analyse the early steps of drug-discovery pipeline, describing the sequence of steps from disease selection to lead optimization and focusing on the most common in silico tools used to assess attrition risks and build a mitigation plan
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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