122,946 research outputs found
Dattena M., Rocca S., Manunta L., Pilichi S., Mara L., Sanna D., Manunta A., Sanna Passino E., Cappai P
No full textDa un sapere a un altro. James Peacock architetto, inventore e scienziato sociale nell'Inghilterra del secolo dei Lumi
No full textJames Peacock fu un’espressione poliedrica di un’epoca caratterizzata
da un persistente eclettismo dei saperi e delle competenze. Questo
articolo ricostruisce la sua opera come architetto, inventore e scienziato
sociale. La visione ordinata di un mondo governabile attraverso
i numeri, la curiosità per l’“avverabile” e per il “possibile”, l’utilitarismo
orientato alla giustizia sociale e il desiderio di partecipare ai
grandi dibattiti del tempo, gli conferiscono spessore, e soprattutto ci
aiutano a comprendere il lavorìo sotterraneo di quell’«Illuminismo
pratico, gentile e soffuso» che condusse la società britannica ad affermare
una presenza forte non soltanto nel Vecchio Continente
Sant'Imbenia
No full textNel decennale della ripresa delle indagini sul sito di S.Imbenia il contributo cerca di analizzare gli aspetti commerciali e politici della piazza del mercato. I contributi di Luca Sanna sul rilievo 3D e sulla fotogrammetria, di Beatrice De Rosa sulla tecnologia della ceramica ed Elisabetta Garau sulle anfore da trasporto offrono un ampio panorama dei ritrovamenti e degli studi compiuti in questi anni.After ten years of research at S. Imbenia (Alghero-Sardinia) this paper looks at the site as a productive commercial and political site. The contribution of L. Sanna on 3D and photogrammetry, of Beatrice De Rosa on pottery technology ann Elisabetta Garau on transport amphorae give a wide picture of the findings and of the studies carried out in these years
A. Goëtze, Hittite Sanna-’one’ : Lang XI, 1935
No full textD. L. A. Goëtze, Hittite Sanna-’one’ : Lang XI, 1935. In: Revue hittite et asianique, 3e année, fascicule 22-23, 1936. p. 204
Infrared spectrun and theoretical study of the dinitrogen pentoxide molecule (N2O5) in solid argon L. Bencivenni, N. Sanna, L. Schriver-Mazzuoli, A. Schriver,
No full textSynthesis and antiproliferative activity of 3-aryl-2-(1H-benzotriazol-1-yl)acrylonitriles. Part III
No full textA new series of 30 3-aryl-2-(1H-benzotriazol-1-yl)acrylonitriles were synthesized and tested for biological activity as part of our research in the antimicrobial and antitumor fields. In particular, title compounds were evaluated in vitro against representative strains of Gram-positive and Gram-negative bacteria (S. aureus, Salmonella spp), mycobacteria (M. fortuitum, M. smegmatis ATCC 19420 and M. tuberculosis ATCC 27294), yeast and mould (C. albicans ATCC 10231 and A. fumigatus). Furthermore, their antiretroviral activity against HIV-1 was determined in MT-4 cells together with cytotoxicity. In these assays title compounds and 47 additional derivatives described previously (P. Sanna, A. Carta, M.E. Rahbar Nikookar, Eur. J. Med. Chem. 35 (2000) 535-543; P. Sanna, A. Carta, L. Gherardini, M.E. Rahbar Nikookar, Farmaco 57 (2002) 79-87) were tested for their capability to prevent MT-4 cell growth. All compounds resulted devoid of antibacterial, antifungal and anti-HIV-1 activity. In anti-mycobacterial assays several compounds resulted active (MIC(50)=6.0-70 microM) against M. tuberculosis. However, since they showed cytotoxicity against MT-4 cells at lower concentrations (CC(50)=0.05-25 microM), their anti-mycobacterial activity was not selective. For this reason, the most cytotoxic compounds were also evaluated for antiproliferative activity against a panel of human cell lines derived from both hematological and solid tumors. Compound 34 resulted the most potent compound against the above human tumor-derived cell lines
Hypericum hircinum L. come nuovo duplice inibitore delle funzioni di DNA polimerasi e di ribonucleasi H associate alla trascrittasi inversa (RT) di HIV-1 efficace anche su mutanti resistenti ad analoghi non-nucleosidici della RT
No full textThe HIV-1 reverse transcriptase (RT) is an asymmetric heterodimer enzyme that, during the viral replication, carries out RNA- and DNA-dependent DNA polymerization, strand displacement synthesis, strand transfer, and that degrades the RNA strand in RNA:DNA hybrids. The latter activity is termed Ribonuclease H (RNase H) [1]. The two catalytic sites are inter-dependent and, in fact, mutations in the polymerase domain affect the RNase H activity, and vice versa. Both RT activities are essential for viral replication, and therefore are considered excellent targets for drug development. While all RT inhibitors approved for therapy target the DNA polymerase activity, there is the pressing need of new RT inhibitors possibly targeting the RNase H function and also active on RTs resistant to the known non-nucleoside inhibitors (NNRTI). Within a project to find new natural agents inhibiting the replication of HIV-1 virus from Sardinian plants [2], the dried aerial parts of Hypericum hircinum L. (Clusiaceae) was soxhlet extracted to obtain three extracts (acetone, acetone:ethanol and ethanol). All three extracts have been assayed on the two enzymatic associated activities, the RNA-dependent DNA polymerase (RDDP) and the RNase H activities and they were shown inhibit both functions at a low micromolar range. Subsequently, the acetone:ethanol extract was fractionated and a high, medium and low polarity fractions were obtained which were active in inhibiting both RT wt activities. When tested on the K103N and Y181C RTs, the acetone:ethanol extract and all fractions, inhibited both RDDP and RNase H functions. These fractions will be further fractionated to isolate the active principles. The analysis of NMR profile of all active fractions, indicates that, together with known hypericin and hyperforin, other aromatoid and unsaturated compounds are present, that are possibly responsible of the biological activity. We are now determining the structures of these unknown compounds.
References [1] E. Tramontano Mini-Rev. Med. Chem. 2006, 6, 727; [2] C. Bicchi, P. Rubiolo, M. Ballero, C. Sanna, M. Matteodo, F. Esposito, L. Zinzula, E.Tramontano, Planta Medica, 2009, 75, 1331-1335
Sulla innervazione sensitiva dei genitali esterni femminili: risultati preliminari su nutria, coniglio e criceto
No full textPapers of Ernst Leumann (417): Jānakīharaṇa : 1. Der aus der ceylones. Sanna zu entnehmende Wortbestand
No full textJānakīharaṇa : 1. Der aus der ceylones. Sanna zu entnehmende WortbestandAlmost empty. - Only I,29 + 30 are transcribed. - Unbound leaf: "Einiges von der Handschrift L"Katalognummer: 417Medium/Umfang: pp. 1-11 + 1 unbound leafLokale Notation: Schu: 3.A.Projektmetadaten:20 : Jānakīharaṇa : 1. Der aus der ceylones. Sanna zu entnehmende Wortbestand
30b: Schu: 3.A.
40 : Kumāradāsa
77 : pp. 1-11 + 1 unbound leaf
90 : 417
93 : Almost empty. - Only I,29 + 30 are transcribed. - Unbound leaf: "Einiges von der Handschrift L
Growth of Listeria Monocytogenes in ready to eat salads at different storage temperatures and valuation of virulence genes expression
No full textBACKGROUND:
Vegetables are major components of a healthy and balanced diet. However, 25% of foodborne diseases are linked to the consumption of vegetables.
STUDY DESIGN:
The aim of this work was to assess the microbiological risks associated with consumption of ready to eat salads (RTE).
METHODS:
Microbiological challenge tests were carried out for the evaluation of the L. monocytogenes growth potential in RTE salads stored at different temperatures.
RESULTS:
The results indicate that L.monocytogenes was able to grow (δ ≥ 0.5) in all storage conditions considered at the end of shelf life. In order to evaluate the virulence role of L. monocytogenes, the temperature-dependent transcription of major virulence genes was also investigated by RT-PCR.
CONCLUSIONS:
The microbiological challenge test allowed us to confirm, as also demonstrated by other authors, that RTE salads are able to support the growth of L. monocytogenes strains (d δ≥ 0.5) stored under different temperatures
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