186,913 research outputs found
Endocrine studies in a pubertal male pseudohermaphrodite with 17-ketoreductase deficiency.
No full textAuthor-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Ten years of biosimilar recombinant human growth hormone in Europe
No full textPaul Saenger Division of Pediatric Endocrinology, Department of Pediatrics, Winthrop University Hospital, Mineola, NY, USA Abstract: Recombinant human growth hormone (rhGH) has been in clinical use for more than 30 years. With the expiration of patent exclusivity for the first wave of rhGH products and other biopharmaceuticals, the opportunity emerged for the development of biosimilar medicines. A biosimilar is defined by the European Medicines Agency (EMA) as a biological medicine that is similar to another biological medicine that has already been authorized for use. The EMA led the way (well ahead of the Food and Drug Administration in the US) in developing the biosimilar concept, and the type of science-based regulatory framework required to ensure high-quality, safe, and effective biosimilar medicines; the provisions for approval of biosimilars have been in place in Europe since 2005. Under these provisions, Omnitrope® was approved by the EMA in 2006 as the world’s first biosimilar medicine; 2016 therefore marks the 10th anniversary of its approval in Europe. A substantial data set, based on clinical development studies and 10 years of postapproval use, has now accumulated for biosimilar rhGH; this data set shows that the product is an effective treatment option for children who require rhGH treatment, and has a safety profile that is consistent with the rhGH class. The decade since the EMA approved biosimilar rhGH has seen the successful approval and clinical use of 20 biosimilar medicines, confirming the integrity of the scientific basis for the biosimilar concept, as well as the quality of regulatory decision-making. Keywords: recombinant human growth hormone, Omnitrope®, biosimila
Linking entropy at rest with the underlying structural connectivity in the healthy and lesioned brain
No full textThe brain is a network that mediates information processing through a wide range of states. The extent of state diversity is a reflection of the entropy of the network. Here we measured the entropy of brain regions (nodes) in empirical and modeled functional networks reconstructed from resting state fMRI to address the connection of entropy at rest with the underlying structure measured through diffusion spectrum imaging. Using 18 empirical and 18 modeled stroke networks, we also investigated the effect that focal lesions have on node entropy and information diffusion. Overall, positive correlations between node entropy and structure were observed, especially between node entropy and node strength in both empirical and modeled data. Although lesions were restricted to one hemisphere in all stroke patients, entropy reduction was not only present in nodes from the damaged hemisphere, but also in nodes from the contralesioned hemisphere, an effect replicated in modeled stroke networks. Globally, information diffusion was also affected in empirical and modeled strokes compared with healthy controls. This is the first study showing that artificial lesions affect local and global network aspects in very similar ways compared with empirical strokes, shedding new light into the functional nature of stroke.In this work, G.D. was supported by the ERC Advanced Grant DYSTRUCTURE (n. 295129), by the Spanish Research Project PSI2016-75688-P (AEI/FEDER) and by the European Union’s Horizon 2020 research and innovation program under grant agreement n. 720270 (HBP SGA1). M.A. was supported by the ERC Advanced Grant DYSTRUCTURE (n. 295129). A.P.-A. was supported by a Juan de la Cierva fellowship (IJCI-2014–066) from the Spanish Ministry of Economy and Competitiveness. V.M.S. was supported by the Research Personnel Training program (PSI2013-42091-P) funded by the Spanish Ministry of Economy and Competitiveness
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Untersuchungen zur Strahlsimulation am MTU-Saenger-Heckmodell im TWG 1995.
No full textAls Ergaenzung zu den reinen Ueberschallmessungen der DLR Koeln (TMK und H2K) am MTU-Saenger-Heckmodell zur Untersuchung der zweidimensionalen Treibstrahl-/Aussenstroemungsinterferenz wurden im TWG der DLR Goettingen Messungen im Transschall durchgefuehrt. Es wurden Druckverteilungen im Dueseninneren, der Duesenrampe und der Modell-/Klappenunterseite gemessen und in den beiden Formen p(x)/p0d und cp(x) (p0d = Gesamtdruck im Triebwerkskanal) dargestellt. Diese Druckverteilungen wurden fuer einzelne Konturbereiche getrennt zu Kraft- und Momentenbeiwerten integriert und in geeigneter Weise zusammengefasst und praesentiert. Bei den drei Machzahlen Mach 0.9, 1.2 und 1.63 wurden jeweils zwei Duesendruckverhaeltnisse Eta = p0d/p unendlich und die drei Anstellwinkel Alpha = 0 Grad, 2 Grad und 4 Grad betrachtet. Bei M = 1.63 wurde zusaetzlich Alpha = 6 Grad eingestellt. Zur Interpretation des Stroemungsfeldes wurden Schlierenaufnahmen der Heckumstroemung gemacht
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Edward P. Wimberly, ITC, July 2011
No full textThis video is a conversation with Dr. Edward P. Wimberly. Dr. Wimberly talks about his book, "No Shame in Wesley's Gospel: A Twenty-First Century Pastoral Gospel". Brad Ost, AUC Woodruff Library, is the interviewer
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