1,721,098 research outputs found
Analysing new Product Development and Co-creation in Industrial Networks: Pathways and Capabilities
Full text linkLo scopo della ricerca è quello di analizzare i processi di co-creazione dei nuovi prodotti nel settore business-to-business. Lo studio si focalizza sull’analisi delle modalità con cui gli attori co-creano nuovi prodotti e di quali capacità di co-creazione possono essere utilizzate in queste interazioni per gestire nel modo migliore i processi di sviluppo prodotto.
La letteratura in cui lo studio intende contribuire è quello connesso alle teorie di marketing sviluppate dall’IMP group, tramite l’analisi dei processi con cui le imprese riescono a co-creare nuovi prodotti all’interno del loro network di business. La letteratura utilizzata, oltre a quella derivante dagli studi di marketing industriale dell’IMP group, fa riferimento ai principali studi sullo sviluppo di nuovi prodotti, in termini di concettualizzazione e di definizione di un framework di sviluppo, e di concettualizzazione delle capacità di co-creazione che le imprese possono utilizzare per migliorare le loro interazioni durante lo sviluppo di nuovi prodotti.
Lo studio è stato condotto secondo la metodologia del caso di studio singolo e longitudinale, con l’ausilio della tecnica del ‘systematic combining’ per l’analisi dei dati raccolti.
L’impresa adottata come caso studio è Hyperlean, uno spin-off accademico, che ha sviluppato un software innovativo per design to cost e costing. Questa è stata scelta la sua potenziale unicità. Lo sviluppo del software, infatti, è avvenuto sin dall’inizio grazie alla collaborazione ed il sostegno da parte di diversi attori.
La tesi si focalizza sull’analisi dei processi, e per questo, vengono descritti in termini di evidenze empiriche una serie di percorsi intrapresi dall’impresa e di capacità di co-creazione utilizzate dall’impresa. Infine, sono stati individuati anche alcuni lati oscuri e criticità che l’impresa ha dovuto fronteggiare durante il processo di sviluppo prodotto in co-creazione.The aim of the research is to analyse new product development co-creation processes within industrial networks. The research is focused on the way actors of the business network co-create new products and on which co-creation capabilities these firm should use in order to succeed in these NPD processes.
The manuscript aims to contribute to the IMP theory in industrial marketing, that is currently lacking empirical studies which provide thorough understanding of the interaction processes among firms within the industrial network in order to co-create new products. The studies conducted by IMP researchers represent also the main literature forming the theoretical background of the study, together with the NPD conceptualization and co-creation capabilities descriptions.
The study adopts a single longitudinal case study methodology with systematic combining for depicting the findings. The case study analyses Hyperlean, which is an academic spin-off whose growth over time, in terms of product capabilities and revenues, is strongly tied to customers’ collaboration. Hyperlean has been chosen because of its potential uniqueness, that relies on the collaborations established with several big firms in order to develop the software by exploiting customers’ resources in terms of knowledge and technical information.
This dissertation contributes to the literature by exploring the processes of new product development in co-creation between the case company and several actors of the business network and by identifying several different new product development co-creation pathways and co-creation capabilities deployed by Hyperlean in order to sustain commercialization activities. These findings revealed also several dark sides and critical issues within the processes under investigation
Nonmonotonic and normative reasoning: a unified proof-theoretic framework
Full text linkRational agents are mostly located in dynamic environments, thereby handling incomplete information concerning the world and the rules that should govern their behavior. When elaborating such incomplete information, agents reach defeasible conclusions, that may be withdrawn when further information is available. Nonmonotonic logics are designed with the aim of modeling this mode of reasoning. This dissertation investigates different kinds of nonmonotonic logic through the lens of structural proof-theory.
Specifically, the thesis proposes a uniform proof-theoretic platform for monotonic and nonmonotonic extensions of classical propositional logic, based on combinations of sequents and antisequents (i.e., sequents for underivability) framed in suitable Gentzen-style calculi. The first case study is abductive reasoning, defined as the search for the missing premise in a deductively invalid argument. For any given abductive problem, we provide a syntactical procedure to generate an expected solution which does not coincide with the deductively minimal one, and which is a natural candidate for being the result of an inference to the best explanation. Next, we introduce the notion of hybrid hypersequent, where sequents and antisequents are composed in parallel to provide contrary updating on the derivation of the conclusion. We show that hybrid hypersequents are flexible enough to provide (weakly) analytic calculi for a number of logics for nonmonotonic and normative reasoning: default logics, a weak version of preferential logic R corresponding to base-generated belief revision, constrained I/O logics. Crucially, this proof-theoretic approach does not rely on ad hoc extensions of the underlying language to formalize extra-logical rules. Lastly, we present a modified notion of controlled sequent, where the turnstile is annotated with sets of formulas to prescribe what should or should not be entailed by the formulas in the antecedent. We introduce controlled sequent calculi for deontic reasoning grounded in default logic, showing that the introduction of suitable extra-logical rules permits to navigate paradoxical, dilemmatic or dynamic deontic scenarios in accordance with their intuitive assessment
STUDIO DEGLI EFFETTI TOSSICI INDOTTI DALL'ESPOSIZIONE CRONICA A MICOTOSSINE IN RUMINANTI, MEDIANTE METODI DI ACCERTAMENTO IN VIVO ED EX VIVO
No full textQuesta tesi descrive lo stato delle conoscenze degli effetti tossici da micotossine su animali d allevamento, ed alcuni esperimenti condotti per valutare gli effetti indotti da esposizione cronica da micotossine sui ruminanti. Uno studio è stato condotto su 15 aziende specializzate in sistemi di produzione intensiva di carni bovine, situate nel Nord Italia (province di Verona e Mantova), con l'obiettivo di individuare i rischi d esposizione a contaminazione da micotossine. Alcuni metodi di laboratorio sono stati sviluppati: un metodo per la determinazione di ocratossina A (OTA) accumulata in tessuti e organi; Un metodo per valutare gli effetti delle fumonisine sulla biosintesi delle basi sfingoidi sfingosina (So) e sfinganina (Sa); Un metodo per rilevare l addotto AFB1-albumina. La razione totale mescolata (TMR) è risultata positiva alla AF e FB. Tra i singoli alimenti, il mais e la semola glutinata di mais sono stati i principali responsabili della contaminazione del TMR. Il livello di contaminazione è positivamente correlato al contenuto di umidità di mais. Il metodo per la determinazione dell OTA nei tessuti ed organi ha mostrato un buon recupero medio. L'analisi del rapporto Sa/So nel sangue non ha mostrato alcun effetto negativo delle fumonisine sulla biosintesi lipidica. L'addotto AFB1-albumina è risultato positivo per il 18% dei campioni totali di sangue.The thesis describes the state of knowledge about toxic effects of mycotoxins on farm animals, and some experiments conducted to assess effects induced by chronic exposure to mycotoxins on ruminants. A field study for was carried out on 15 farms specialised for intensive beef production system, located in Northern Italy (provinces of Verona and Mantova), with the aim to identify risks of exposure to mycotoxins contamination. Some laboratory methods were performed: a method for the detection of ochratoxin A (OTA) concentration in tissues and organs; a method for evaluating the effects of fumonisin on biosynthesis of the two sphingoid bases sfingosine (So) and sphinganine (Sa); a method to detect the AFB1-albumin adduct. Total mixed rations (TMR) resulted positive for AF and FB contamination. Among single feedstuffs, corn and corn gluten feed were the main responsible for TMR contamination. Level of contamination was positively related to corn moisture content. The method for the determination of OTA in tissue and organ showed a good mean recovery. The analysis of ration Sa/So in blood did not show any negative effect by fumonisin on the lipidic biosynthesis. The AFB1-albumin adduct was positive on 18% of total blood samples
The role of passion in favouring the creation of new business: an empirical investigation of the sport context through the IMP lens
No full textPurpose This study aims to explore entrepreneurship in new business ventures created by athletes, with a particular focus on the role of network relationships influenced by passion. The aim is to examine how both domain-specific and entrepreneurial passion contribute to the formation and development of interpersonal and inter-organizational relationships for new ventures initiated by athletes. Design/methodology/approach The research uses a multiple case study methodology, analysing two in-depth case studies of athletes who transitioned into entrepreneurship within their respective sports. The first case focuses on Roberto Ricci, a former windsurfer who founded a global company producing and selling surfing apparel and equipment. The second case examines Enrico Fulgenzi, a professional racing driver who created a racing team that provides racing services internationally. Findings This study underscores the pivotal role of passion in new business creation, suggesting that passion facilitates the establishment and development of both personal and inter-organizational relationships as the business evolves. Originality/value This study provides a fresh perspective on entrepreneurial passion within the sports industry. By applying the market-as-network theoretical framework, it highlights how passion drives the creation of personal and business relationships in new ventures
Hypersequent calculi for propositional default logics
Full text linkIn this paper, we investigate default reasoning from a structural proof-theoretic perspective. We introduce hybrid hypersequent calculi for propositional default logics, where extra-logical rules directly capture default rules, while parallel composition of sequents and antisequents formalizes contrary updating on the conclusions of extra-logical rules. We establish the admissibility of structural rules and the invertibility of logical rules, showing that cut-free proofs exhibit a weakened form of analyticity. Next, we prove that specific hybrid hypersequent calculi are sound and weakly complete with respect to credulous consequence based on \L{}ukaszewicz extensions. Lastly, we propose a hypersequent-based decision method for skeptical consequence which circumvents the need for early computation of all extensions
Some remarks on the Curry-Howard correspondence for classical logic
No full textIn this note we focus on simply typed λ μ-calculus, the image under Curry-Howard correspondence of the →, ⊥-fragment of minimal logic extended with classical reductio. We show that simply typed λ μ-calculus delivers a non-trivial interpretation of the distinctive form of irrelevance of conclusions of reductio w.r.t. discharged assumptions, while providing a privileged normalization procedure for the →, ⊥-fragment. We give a detailed analysis of the intensional incompleteness of the →, ⊥-fragment w.r.t. full classical logic, and then discuss the philosophical significance of the failure of Böhm’s theorem for simply typed λ μ-calculus
Symbiotic, opportunistic, and probiotic microbes: new advances in understanding their interaction with immune system
Full text linkIn this thesis we analysed the impact of Saccharomyces cerevisiae, Acinetobacter baumannii, and Lactobacillus reuteri on human immune system.
S. cerevisiae is a yeast harboring the human gastrointestinal tract, and the interaction with human blood dendritic cells (DCs) was never been investigated. We found that conventional DC (cDCs) and plasmacytoid DCs (pDCs) sense S. cerevisiae and that cDCs induce IL-6 and IL-17 production, while pDCs IFN-α and IL-10 with pro- and anti-inflammatory properties, respectively. These results could have relevant implication in health and diseases associated to microbiota dysbiosis.
A. baumannii is a nosocomial bacteria promoting pathology in immunocompromised hosts. We analysed for the first time the response of human innate immune cells to A. baumannii ATCC19606T (low virulence) and ACICU (high virulence). We found that macrophages promote killing of both bacterial strains, monocytes kill preferentially ATCC19606T, DCs and monocytes produce cytokines. Importantly, ACICU induces lower expression of two cytokines that have been associated to protection against A. baumannii: IL-10, IFN-α. Thus, we identified mechanisms potentially related to the high virulence of the multidrug-resistant strain.
L. reuteri is a probiotic with beneficial properties. We studied the effect of L. reuteri in children with autism spectrum disorder (ASD), characterized by social problems and gastrointestinal dysbiosis. Since we previously demonstrated a pro-social effect of L. reuteri supplementation, we analysed the effects of probiotic on immune system and microbiota. We observed an increase of fecal F.prausnitzii and E. rectale, with anti-inflammatory properties, and a decrease of plasmatic soluble CD40L, with pro-inflammatory properties, in probiotic-treated ASD children. These results indicate an anti-inflammatory role of probiotic L. reuteri in ASD children.
Overall, we uncovered new mechanisms involved in the regulation of host/microbe interaction, with potential implication in the response to pathogenic infections, prevention of excessive inflammation, and exploitation of beneficial effect of microbiota and probiotic
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