196,705 research outputs found
Description of the unknown males of three Chinese Meligethes (Coleoptera: Nitidulidae, Meligethinae)
No full textIn this paper we present the description of male genitalia and additional information on taxonomy of three recently described and poorly
known Chinese endemic members of the genus Meligethes Stephens, 1830, Meligethes (Odonthogethes) brassicogethoides Audisio, Sabatelli
& Jelínek, 2015, M. (O.) inexpectatus Liu, Huang, Cline, Sabatelli & Audisio, 2017, and M. (O.) tricuspidatus Liu, Huang, Cline
& Audisio, 2018
Description of the unknown males of three Chinese Meligethes (Coleoptera: Nitidulidae, Meligethinae)
No full textIn this paper we present the description of male genitalia and additional information on taxonomy of three recently described and poorly known Chinese endemic members of the genus Meligethes Stephens, 1830, Meligethes (Odonthogethes) brassicogethoides Audisio, Sabatelli and Jelínek, 2015, M. (O.) inexpectatus Liu, Huang, Cline, Sabatelli and Audisio, 2017, and M. (O.) tricuspidatus Liu, Huang, Cline and Audisio, 2018
Histamine beyond its effects on allergy: Potential therapeutic benefits for the treatment of Amyotrophic Lateral Sclerosis (ALS)
No full textALS currently remains a challenge despite many efforts in performing successful clinical trials and formulating therapeutic solutions. By learning from current failures and striving for success, scientists and clinicians are checking every possibility to search for missing hints and efficacious treatments. Because the disease is very complex and heterogeneous and, moreover, targeting not only motor neurons but also several different cell types including muscle, glial, and immune cells, the right answer to ALS is conceivably a multidrug strategy or the use of broad-spectrum molecules. The aim of the present work is to gather evidence about novel perspectives on ALS pathogenesis and to present recent and innovative paradigms for therapy. In particular, we describe how an old molecule possessing immunomodulatory and neuroprotective functions beyond its recognized effects on allergy, histamine, might have a renewed and far-reaching momentum in ALS. (C) 2019 The Author(s). Published by Elsevier Inc
Pure motor chronic inlammatory demyelinating polyneuropathy
No full textWe describe four patients affected by chronic inflammatory demyelinating polyneuropathy (CIDP) in a pure motor form. Selective involvement of motor fibers was suggested by the absence of sensory symptoms, normal sensation at neurological examination and normal findings on electrophysiological testing of sensory fibres and sural nerve biopsy. The onset of the disease occurred at a young age (3-29 years) and the clinical course was relapsing-remitting. Over a follow-up period of 1.5-14 years, periodical clinical and electrophysiological examinations showed that selective involvement of motor fibers remained a constant feature. Electromyography and nerve conduction studies continued to show a purely demyelinating neuropathy without signs of axonal impairment. All patients were steroid-unresponsive, whereas they considerably improved after being treated with immunoglobulins. Two patients were treated with interferon alpha and showed a good response. In conclusion, the occurrence in our four patients of pure motor involvement over a long period of time during which several relapses occurred, suggests that pure motor CIDP may represent the result of a specific immunological process rather than of a random distribution of inflammation throughout peripheral nerves
Histamine beyond its effects on allergy: Potential therapeutic benefits for the treatment of Amyotrophic Lateral Sclerosis (ALS)
No full textALS currently remains a challenge despite many efforts in performing successful clinical trials and formulating therapeutic solutions. By learning from current failures and striving for success, scientists and clinicians are checking every possibility to search for missing hints and efficacious treatments. Because the disease is very complex and heterogeneous and, moreover, targeting not only motor neurons but also several different cell types including muscle, glial, and immune cells, the right answer to ALS is conceivably a multidrug strategy or the use of broad-spectrum molecules. The aim of the present work is to gather evidence about novel perspectives on ALS pathogenesis and to present recent and innovative paradigms for therapy. In particular, we describe how an old molecule possessing immunomodulatory and neuroprotective functions beyond its recognized effects on allergy, histamine, might have a renewed and far-reaching momentum in ALS
Meligethes (Odonthogethes) ferruginoides Audisio, Sabatelli & Jelinek 2015
No full text<i>Meligethes</i> (<i>Odonthogethes</i>) <i>ferruginoides</i> Audisio, Sabatelli & Jelínek, 2015 <p> <b>Examined material. China</b>, SICHUAN, LUDINg COUNTY, MOXI TOWN, MT. GONggA, HAILUOgOU, 2950–2970 m A.S.L., 29.575° 101.996667°, 22.vI.2017, LIU & AUDISIO LgT, bY SWEEpINg ON SHRUbS AT fOREST EDgES, 1 ♂, 2 ♀ (NWAU, CAR-MZUR, NMPC); SICHUAN, LUDINg COUNTY, MOXI TOWN, MT. GONggA, SWALLOW-GULLY, 2450–2570 m A.S.L., 29.689167° 102.066944°, 23.vI.2017, LIU & AUDISIO LgT, ON <i>Pyracantha fortuneana</i> (MAXImOWICZ) H. L. LI (ROSACEAE), 3 ♂, 5 ♀ (NWAU, CAR-MZUR, NMPC, ARCC).</p> <p> <b>Distribution.</b> CENTRAL AND SW CHINA (HUbEI, SICHUAN) (AUDISIO <i>et al.</i> 2015) (FIg. 6b).</p> <p> <b>Host-plants.</b> CONCLUSIvE SpECIfIC HOST DATA REmAINS SOmEWHAT pRObLEmATIC, bUT SOmE ADULT SpECImENS HAvE bEEN COLLECTED (SEE AbOvE: SWALLOW-GULLY, MOXI TOWN, SICHUAN, JUNE 2017) ON fLOWERS Of THE SHRUb <i>Pyracantha fortuneana</i> (MAXImOWICZ) H. L. LI (ROSACEAE), WHICH WAS RECENTLY RECOgNIZED AS THE LIKELY LARvAL HOST-pLANT Of <i>Meligethes</i> (<i>Odonthogethes</i>) <i>pseudochinensis</i> AUDISIO, SAbATELLI & JELÍNEK, 2015 (FIg. 6 IN LIU <i>et al.</i> 2017). ADDITIONAL COLLECTINg EvENTS ARE NEEDED THAT fOCUS ON ObTAININg LARvAL mATERIAL.</p>Published as part of <i>Liu, Meike, Huang, Min, Cline, Andrew Richard & Audisio, Paolo, 2018, New and poorly known Meligethes Stephens from China, with bionomical data on some species (Coleoptera: Nitidulidae: Meligethinae), pp. 546-566 in Zootaxa 4392 (3)</i> on page 561, DOI: 10.11646/zootaxa.4392.3.6, <a href="http://zenodo.org/record/1196235">http://zenodo.org/record/1196235</a>
Revision of the pollen beetle genus Meligethes (Coleoptera: Nitidulidae)
No full textA taxonomic revision of members of the genus Meligethes Stephens, 1830 is carried out. Taxonomic and distributional notes are provided on fiftythree Meligethes species, mostly known from the Eastern Palearctic and marginally from the Western Palearctic and the Orien-tal Regions. Among these, twentythree new species of Meligethes are diagnosed, figured and described: M. argentithoraxsp. n. (Central China: Shaanxi, Shanxi), M. aurantirugosussp. n. (Nepal), M. aureolineatussp. n. (Central China: Sichuan), M. aurifersp. n. (Central China: Shaanxi, Shanxi), M.brassicogethoidessp. n. (SW China: Yunnan), M. clinei sp. n. (SW China: Yunnan), M. elytralis sp. n. (Cen-tral China: Sichuan), M. ferruginoidessp. n. (Central China: Sichuan), M. cinereoargenteus sp. n. (Central China: Sichuan), M. henan sp. n. (Central China: Henan), M. luteoornatus sp. n. (SW China: Yunnan), M. marmotasp. n. (Nepal), M. nivalissp. n. (SW and central China: Xizang and Chongqing), M. martessp. n. (Central China: Shaanxi, Shanxi, Sichuan), M. nigroaeneus sp. n. (SW China: Yunnan),M. occultus sp. n. (SW China: Yunnan), M. pseudochinensis sp. n. (Central China: Hubei), M. pseudopectoralis sp. n. (SW China: Yun-nan), M. schuelkei sp. n. (Central China: Sichuan, Shaanxi), M. simulator sp. n. (Central-N China: Shanxi), M. stenotarsus sp. n. (SW China: Yunnan, Xizang), M. tryznai sp. n. (SW China: Yunnan), and M. volkovichi sp. n. (SW China: Yunnan).Revaluations at specific rank from synonymy are introduced for Meligetheslutra Solsky 1860, and for M. melleus Grouvelle, 1908. Three new synonymies are established: MeligethesbrevipilusKirejtshuk, 1980 = M.auripilis Reitter, 1889 (syn. n.), Meligethes zakharenkoi Kirejtshuk, 2005 = M.shirakii Sadanari Hisamatsu, 1956 (syn. n.), and Meligethes shirozui Sadanari Hisamatsu, 1965 = M.wagneri Rebmann, 1956 (syn. n.). Complete redescriptions are given for MeligethesbinotatusGrouvelle, 1894, M. castanescens Grouvelle, 1903, M. ferrugineus Reitter, 1873, and M. melleus Grouvelle, 1908. The male of Meligethes lloydi Easton, 1968, is described and figured for the first time. The female genitalia of Meligethes auricomus Rebmann, 1956, M. cinereus Jelínek, 1978, and M. griseus Jelínek, 1978 are described and figured for the first time. Available information on insect-host-plant relationships and ecology are summarized for each species; probably all are as-sociated as larvae with flowers of Rosaceae, chiefly of members of the closely related genera Rosa L., Rubus L., Prunus L., and Cratae-gus Tourn. ex L. All treated species are grouped in two here revaluated subgenera (Meligethes s.str. and Odonthogethes Reitter, 1871), and tentatively grouped also in species-groups and (when necessary) species-complexes, based on their morphology
Allele-specific silencing as therapy for familial amyotrophic lateral sclerosis caused by the p.G376D TARDBP mutation
No full textAmyotrophic lateral sclerosis is a neurodegenerative disease characterized by the degeneration of motor neurons. There is no treatment for this disease that affects the ability to move, eat, speak and finally breathe, causing death. In an Italian family, a heterozygous pathogenic missense variant has been previously discovered in Exon 6 of the gene TARDBP encoding the TAR DNA-binding protein 43 protein. Here, we developed a potential therapeutic tool based on allele-specific small interfering RNAs for familial amyotrophic lateral sclerosis with the heterozygous missense mutation c.1127G > A. We designed a small interfering RNA that was able to diminish specifically the expression of the exogenous Green Fluorescent Protein (TAR DNA-binding protein 43(G376D) mutant protein) in HEK-293T cells but not that of the Green Fluorescent Protein (TAR DNA-binding protein 43 wild-type). Similarly, this small interfering RNA silenced the mutated allele in fibroblasts derived from patients with amyotrophic lateral sclerosis but did not silence the wild-type gene in control fibroblasts. In addition, we established that silencing the mutated allele was able to strongly reduce the pathological cellular phenotypes induced by TAR DNA-binding protein 43(G376D) expression, such as the presence of cytoplasmic aggregates. Thus, we have identified a small interfering RNA that could be used to silence specifically the mutated allele to try a targeted therapy for patients carrying the p.G376D TAR DNA-binding protein 43 mutation
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