75 research outputs found
Falsely elevated serum tobraycin levels in a patient receiving nebulised tobramycin
No full textAbstractIt is common when treating patients with respiratory exacerbations of cystic fibrosis to use both nebulised and intravenous antibiotics. Aminoglycoside drug levels are often measured from finger-prick blood samples. We describe a case of a 14-year-old girl treated simultaneously with IV and nebulised tobramycin in whom drug levels, measured from finger prick blood samples, were erroneously high due to finger contamination by the nebulised drug. Special precautions or direct venepuncture is essential when assessing antibiotic levels in such patients
Struthers Burt
No full textIf the pen is mightier than the sword, Maxwell Struthers Burt was a stalwart warrior. Poet, essayist, novelist, short story writer, librettist, reviewer, author of a literary manifesto, contributor to letter-to-the-editor columns, and personal letter writer, Burt seems never to have stopped writing over a career of a half-century. His principal publisher was Charles Scribner’s Sons, which, under the editorial leadership of Maxwell Perkins, published the work of Ernest Hemingway, F. Scott Fitzgerald, Thomas Wolfe, and a variety of other respected writers. Burt’s articles, essays, poems, and stories appeared in many of the most successful magazines in America: Scribner\u27s Magazine, The Saturday Evening Post, The Red Book Magazine, Ladies’ Home Journal, and The North American Review. He wrote scores of reviews for such publications as The Saturday Review of Literature, the New York Times, and the Philadelphia Record. Untiringly, Burt sent his views to the editors of far-flung newspapers: the Jackson\u27s Hole Courier, the St. Petersburg Times, the Princeton Alumni Weekly, and the New York Herald Tribune. The “Most Unforgettable Character” he had ever met. an old-time cowboy named Cal Carrington, was the subject of Burt’s article in The Reader’s Digest. When totalitarianism threatened the writers’ freedom in 1941, Burt wrote and circulated the American Authors’ Manifesto, which was signed by one hundred writers, including E. B. White, Frank Waters, Floyd Dell, and Max Lerner. The Best Short Stories of 1915 honored Burt’s “The Water-Hole,” and his fine story “Each in His Generation” won first prize in the 0. Henry Memorial Award competition in 1920. Respected, frequently praised, and widely read in the 1920s and 1930s, Burt, the stalwart warrior, is today a forgotten soldier
Teaching fundamental British values in primary schools : project summary
No full textThis project developed out of academic research carried out by Alison Struthers into the practice of Fundamental British Values (FBV) and Human Rights Education (HRE) in English primary schools. In this research, the author explored the problems with the Government’s FBV agenda, and argued that because human rights values are rooted in universality, couching FBV in this broader framework would be likely to contribute to societal cohesion to a far greater extent than the potentially discriminatory FBV guidance. This project sought to action these findings by showing how teaching about FBV can be linked effectively to broader human rights values
The role of urate and xanthine oxidase in vascular oxidative stress:Future directions
No full textVascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high. The search for newer, novel ways of attenuating endothelial dysfunction has yielded several new and exciting possibilities, one of which is the manipulation of urate levels using xanthine oxidase inhibitors. Agents such as allopurinol have shown marked improvements in vascular endothelial function in various cohorts at risk of cardiovascular events. Most of the evidence so far comes from smaller mechanistic studies. The few large randomized controlled trials have failed to show any significant mortality benefit using these agents. This article highlights the potential avenues of further research such as dose-response, and the potential for these agents to regress left ventricular hypertrophy. The role of newer agents such as febuxostat and oxypurinol are discussed as well as potential reasons why some of the current newer agents have failed to live up to the promising early-phase data. It is crucial that these remaining questions surrounding urate, xanthine oxidase and the role of various agents that affect this important oxidative stress-generating system are answered, and therefore these promising agents should not be discarded prematurely
Hearing Mark: a Listener\u27s Guide
No full textAuthor: Elizabeth Struthers Malbon. Title: Hearing Mark. Publisher: Harrisburg, Pa: Trinity Pr Intl, 2002
Chemical Weathering of Strip-Mine Spoils
No full textAuthor Institution: Department of Agronomy, Ohio Agricultural Experiment Station, Wooster, Ohi
A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication
No full textThe RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension. Marked differences were found in the long-range interactions of SL9266 when the two widely used genotype 2a JFH-1 (HCVcc) and genotype 1b Con1b sub-genomic replicon systems were compared. In both genomes, there was evidence for interaction of the sub-terminal bulge loop of SL9266 and sequences around nucleotide 9110, though the replication phenotype of genomes bearing mutations that disrupted this interaction was fundamentally different. In contrast, a ‘kissing loop’ interaction between the terminal loop of SL9266 and sequences in the 3′-untranslated X-tail was only detectable in JFH-1-based genomes. In the latter, where both long-range interactions are present, they were independent, implying that SL9266 forms the core of an extended pseudoknot. The presence of the ‘kissing loop’ interaction inhibited the formation of SL9571 in the 3′-X-tail, an RNA structure implicated in genome replication. We propose that, SL9266 may contribute a switch function that modulates the mutually incompatible translation and replication events that must occur for replication of the positive-strand RNA genome of HCV
Development of a checklist for evaluating cohesion in writing.
No full textNo abstract available.The original print copy of this thesis may be available here: http://wizard.unbc.ca/record=b122037
Professional Resilience; a time for a paradigm shift in teacher education?
No full textTeacher resilience and wellbeing are current buzzwords. This chapter explores the landscape in which this focus has arising, looking at the tensions and challenges for teachers and teacher educators. Considering current teacher shortage and recruitment issues in the UK. The author argues that we should be aspiring to a situation where teachers are encouraged to take ownership of their professional position and wellbeing to “thrive in” rather than simply “survive” the profession. Drawing on research from initial teachers education providers across UK, a picture emerges to suggest that teachers educators and mentors are seeking ways to support and sustain early career teachers who are trapped between a state of resistance – opposing mandated practices that bring no benefit to themselves or their students – and one of resilience – acquiescing to those same practices to focus their efforts on managing the effect on workload and students. From an online survey and telephone interviews, the voices of those preparing teachers for the profession illuminate a range of possible approaches to support teachers. This presentation will ask if a paradigm shift is called for in the way resilience is framed for the profession
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