538,094 research outputs found
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No full textEl presente artículo tiene el propósito de la puesta en valor de los pioneros aportes sobre Galectinas desde la Universidad Nacional de Córdoba, conmemorando no sólo la celebración de los 60 años del Departamento de Química Biológica “Ranwell Caputto”, CIQUIBIC – CONICET, Facultad de Ciencias Químicas, Córdoba - Argentina (1963 - 2023); sino también al cumplirse 30 años de las primeras publicaciones (1994 - 2024) sobre una Lectina S-Lac en la Retina de Pollo (1, 2, 3, 4)
Traumatic identity and aura in David Lodge's "Author, author"
No full textEste artículo analiza la novela Author, Author (2004) de David Lodge como ejemplo de bioficción neo-victoriana centrada en una celebridad, en este caso concreto, Henry James. El género forma parte del renacimiento Victoriano actual que afecta a los estudios culturales en su conjunto. Mi argumento central es que la novela de Lodge constituye una respuesta a las ansiedades culturales actuales, en particular a las que se refieren a la crisis identitaria y autoría literaria, así como a la pérdida del aura artística de Walter Benjamin, sublimándolas a través de los traumas de finales del siglo XIX. La elección de James, como demuestra el artículo, no es casual. Es el último representante de un mundo perdido en el que el aura aún tenía un espacio; el ser humano en crisis y traumatizado porque no encaja en un status quo nuevo.This paper delves into David Lodge’s Author, Author (2004) as an example of neo-Victorian celebrity biofiction, more concretely on Henry James. The genre belongs to the wave of Victorian revival in current literature which also affects cultural studies in general. My main contention is that Lodge’s novel responds to current cultural anxieties, particularly the crisis of identity and authorship and the end of Walter Benjamin’s concept of aura, by sublimating them into late-nineteenth-century traumata. The choice of James is, the article argues, not casual. He represents the redeeming figure of a lost auratic world; the human in crisis, traumatized because he does not fit in the new status quo
Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62
No full textES-62 is an immunomodulatory phosphorylcholine (PC)-containing glycoprotein secreted by the rodent filarial nematode Acanthocheilonema viteae. Previously, the use of knockout mice has revealed the effects of ES-62 on macrophages and dendritic cells to be dependent on TLR4. However, it is possible that ES-62 may interact with additional proteins on the surfaces of target cells and hence that cells may vary with respect to receptor usage. In this study, we identified by molecular weight, proteins that interact with ES-62 and found differences amongst the immune system cells studied. Thus, whereas lymphocytes appear to have two major interacting proteins of 135 and 82 kDa, U937 monocytes only contain an ES-62-binding protein of the latter molecular weight. Binding to the proteins on B cells and U937 cells wasblocked by PC, suggesting a critical role for this ES-62 moiety in facilitating interaction. Finally, ES-62 binding is followed by internalization in both macrophages and B cells but only in the former was absence of TLR4 found to block internalization. These findings are consistent with differences in receptor usage by ES-62 amongst different cell-types
Detection of Pulmonary Tuberculosis among Patients with Cough Attending Outpatient Departments in Dar Es Salaam, Tanzania: Does Duration of Cough Matter?
No full textAccording to WHO estimates, tuberculosis case detection rate in Tanzania is less than 50% and this poses a major challenge to control tuberculosis in the country. Currently, one of the defining criteria for suspecting tuberculosis is cough for two weeks or more. We wanted to find out whether the prevalence of tuberculosis was different in patients who reported cough for two weeks or more, compared to patients with cough for less than two weeks. We conducted a cross sectional study in six health facilities in Dar es Salaam, between September and October 2007. All patients aged five years and above with cough were screened for pulmonary tuberculosis (PTB) by smear microscopy. Patients were divided into two groups, those who coughed for less than two weeks (<2 wks) and those who coughed for two weeks or more (> or = 2 wks). A total of 65,530 patients attended outpatients department (OPD). Out of these, 2274 (3.5%) patients reported cough. Among patients who reported cough, 2214 (97.4%) remembered their cough duration. One thousand nine hundred and seventy three patients (89.1%) coughed for >/= 2 wks as compared to 241 (10.9%) patients who coughed for <2 wks. Of those who coughed for two weeks or more, 250 (12.7%) had smear positive PTB, and of those who had coughed for less than two weeks, 21 (8.7%) had smear positive PTB. There was no statistically significant difference in prevalence of smear positive tuberculosis among the two groups (Pearson Chi-Square 3.2; p = 0.074). Detection of smear positive PTB among patients who coughed for less than two weeks was as high as for those who coughed for two weeks or more
Identifying author-inventors from Spain: methods and a first insight into results
No full textThe aim of this paper is to describe a matching and disambiguation methodology for the identification of author-inventors located in the same country. It aims to maximize precision and recall rates by taking into account national name writing customs in the name matching stage and by including a recursive validation step in the person disambiguation stage. An application to the identification of Spanish author-inventors is described in detail, where all SCOPUS 2003-2008 publications of Spanish authors are matched to all 1978-2009 EPO applications with Spanish inventors. Using this data, we identify 4,194 Spanish author-inventors. A first look at their patenting and publication patterns reveal that Spanish author-inventors make quite a significant contribution to the overall country’s scientific and technological production in the time periods considered: 27% of all EPO patent applications invented in Spain and 15% of all SCOPUS scientific articles authored in Spain, with important differences across fields and excluding journals in non-technologically relevant fields.Peer reviewe
Microbial larvicide application by a large-scale, community-based program reduces malaria infection prevalence in urban Dar es Salaam, Tanzania.
No full textBACKGROUND\ud
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Malaria control in Africa is most tractable in urban settlements yet most research has focused on rural settings. Elimination of malaria transmission from urban areas may require larval control strategies that complement adult mosquito control using insecticide-treated nets or houses, particularly where vectors feed outdoors.\ud
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METHODS AND FINDINGS\ud
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Microbial larvicide (Bacillus thuringiensis var. israelensis (Bti)) was applied weekly through programmatic, non-randomized community-based, but vertically managed, delivery systems in urban Dar es Salaam, Tanzania. Continuous, randomized cluster sampling of malaria infection prevalence and non-random programmatic surveillance of entomological inoculation rate (EIR) respectively constituted the primary and secondary outcomes surveyed within a population of approximately 612,000 residents in 15 fully urban wards covering 55 km(2). Bti application for one year in 3 of those wards (17 km(2) with 128,000 residents) reduced crude annual transmission estimates (Relative EIR [95% Confidence Interval] = 0.683 [0.491-0.952], P = 0.024) but program effectiveness peaked between July and September (Relative EIR [CI] = 0.354 [0.193 to 0.650], P = 0.001) when 45% (9/20) of directly observed transmission events occurred. Larviciding reduced malaria infection risk among children < or =5 years of age (OR [CI] = 0.284 [0.101 to 0.801], P = 0.017) and provided protection at least as good as personal use of an insecticide treated net (OR [CI] = 0.764 [0.614-0.951], P = 0.016).\ud
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CONCLUSIONS\ud
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In this context, larviciding reduced malaria prevalence and complemented existing protection provided by insecticide-treated nets. Larviciding may represent a useful option for integrated vector management in Africa, particularly in its rapidly growing urban centres
¿Qué es el plagio?
No full textEl plagio es tomar un fragmento de una obra artística o intelectual ajena y hacerlo pasar como propio, sin la debida acreditación del autor.Plagiarism is taking a fragment of another's artistic or intellectual work and passing it off as one's own, without due accreditation of the author
Eindrapportage
No full textThe supervision of foreign nationals that is currently in operation focuses upon tracing and removing illegal immigrants. Furthermore, it is possible to make a distinction between supervision in the Netherlands (combating unlawful residence) and the so-called mobile supervision of foreign nationals [mobiel toezicht vreemdelingen, mtv] (combating illegal immigration). The latter form of supervision will be carried out by the Royal Military Constabulary, for the purpose of which so-called MTV brigades were formed in 1994. These MTV brigades carry out targeted, random checks on the border with Germany and Belgium. The checks can be carried out on motorways, in (international) trains and on waterways. They can contribute towards combating (organised forms) of illegal immigration (the so-called repressive function) as well as towards preventing illegal immigration (the so-called preventative function). On the instructions of the Research and Documentation Centre (WODC) of the Ministry of Justice, ES&E (Eysink Smeets & Etman) carried out research during the first half of 2001 into the effectiveness of the mobile supervision of foreign nationals. On the basis of the results of this study, it must be concluded that there should be serious doubts with regard to the effective contribution made to the combating of illegal immigration by the mobile supervision of foreign nationals. This doubt relates both to the repressive function and the preventative function of the mobile supervision of foreign nationals.Het operationele vreemdelingentoezicht richt zich op het opsporen en verwijderen van illegale vreemdelingen. Daarbij kan onderscheid worden gemaakt tussen toezicht in het binnenland (bestrijding illegaal verblijf) en het zogenoemde mobiel toezicht vreemdelingen (mtv) (bestrijding illegale immigratie). Dit laatste toezicht wordt uitgevoerd door de KMar, waarvoor in 1994 zogenoemde MTV-brigades zijn geformeerd. Deze MTV-brigades voeren aan de grens met Duitsland en België gerichte, steekproefsgewijze controles uit. De controles kunnen worden uitgevoerd op autowegen, in (internationale) treinen en op vaarwegen. een bijdrage te leveren aan de bestrijding (van georganiseerde vormen) van illegale immigratie; de zogenoemde repressieve functie, en;een bijdrage te leveren aan het voorkomen van illegale immigratie; de zogenoemde preventieve functie. In opdracht van het Wetenschappelijk Onderzoek- en Documentatie Centrum (WODC) van het Ministerie van Justitie heeft ES&E (Eysink Smeets & Etman) in de eerste helft van 2001 onderzoek verricht naar de effectiviteit van het mobiel toezicht vreemdelingen. Op basis van de resultaten van dit onderzoek moet worden geconcludeerd dat aan de effectieve bijdrage aan de bestrijding van illegale immigratie door het mobiel toezicht vreemdelingen sterk moet worden getwijfeld. Deze twijfel betreft zowel de repressieve functie als de preventieve functie van het mobiel toezicht vreemdelingen
Dar es Salaam Regional and District Projections.
No full textThis report presents population projections for the period 2003 to 2025 for Dar es Salaam Region. The projections were made using a Cohort Component Method (Spectrum System), whereby three components responsible for population change, namely: mortality, fertility and migration were projected separately as well as HIV/AIDS prevalence. The projected components were then applied to 2002 midyear base population in order to come up with the desired projections from 2003 to 2025. The report gives mortality, fertility, migration and HIV/AIDS assumptions, and shows Dar es Salaam’s demographic and socio-economic future trends. The results include estimated population by sex in single years and five-year age groups as well as some demographic indicators. Population growth for the period 2003 to 2025 shows a decrease in growth rates. The projections show that population growth rate will decrease from 1.99 percent in 2003 (with a population of 2,535,594) to 0.27 percent in 2025 (with a population of 3,055,456). Sex Ratio at birth is projected to increase slightly from 102 male per 100 females in 2003 to 103 male per 100 females in 2025. Mortality estimates show that Infant Mortality Rate (IMR) is expected to decline for both sexes from 80 deaths per 1,000 live births in 2003 to 49 deaths per 1,000 live births in 2025. Under Five Mortality Rate (U5MR) for both sexes will also decline from 122 deaths per 1,000 live births in 2003 to 71 deaths per 1,000 live births in the year 2025. As expected, the mortality projected estimates further show that the life expectancy at birth for females is higher compared to that of males. Life expectancy at birth for Dar es Salaam will decline from 55 years in 2003 to 52 years in 2025 for both sexes. For male population, life expectancy at birth will almost remain at 53 years for the whole period. For female population, the life expectancy at birth will decline from 57 years in 2003 to 52 years in 2025. On fertility, TFR will decline from 2.7 children per woman in 2003 to about 2 children per woman in 2025.\u
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