7,057 research outputs found
Towards molecular systems biology of gene transcription and regulation
No full textTen years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural biology, biochemistry, functional genomics, and computational methods. In this article, the efforts of our laboratory to move from an integrated structural biology of gene transcription towards molecular systems biology of gene regulation are reviewed
Computing the Cramer-Rao bound of Markov random field parameters: Application to the Ising and the Potts models
No full textThis letter considers the problem of computing the Cramer–Rao bound for the parameters of a Markov random field. Computation of the exact bound is not feasible for most fields of interest because their likelihoods are intractable and have intractable derivatives. We show here how it is possible to formulate the computation of the bound as a statistical inference problem that can be solve approximately, but with arbitrarily high accuracy, by using a Monte Carlo method. The proposed methodology is successfully applied on the Ising and the Potts models
S. Rotae Romanae decisiones recentissimae, nunquam antea in lucem editae
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No full textTo quantify gene regulation, a function is required that relates transcription factor binding to DNA (input) to the rate of mRNA synthesis from a target gene (output). Such a 'gene regulation function' (GRF) generally cannot be measured because the experimental titration of inputs and simultaneous readout of outputs is difficult. Here we show that GRFs may instead be inferred from natural changes in cellular gene expression, as exemplified for the cell cycle in the yeast S. cerevisiae. We develop this inference approach based on a time series of mRNA synthesis rates from a synchronized population of cells observed over three cell cycles. We first estimate the functional form of how input transcription factors determine mRNA output and then derive GRFs for target genes in the clb2 gene cluster that are expressed during G2/M phase. Systematic analysis of additional GRFs suggests a network architecture that rationalizes transcriptional cell cycle oscillations. We find that a transcription factor network alone can produce oscillations in mRNA expression, but that additional input from cyclin oscillations is required to arrive at the native behaviour of the cell cycle oscillator
La Greffe de l'Hévéa (Suite).
No full textCramer P. J. S. La Greffe de l'Hévéa (Suite).. In: Revue de botanique appliquée et d'agriculture coloniale, 10ᵉ année, bulletin n°102, février 1930. pp. 99-107
La Greffe de l'Hévéa.
No full textCramer P. J. S. La Greffe de l'Hévéa.. In: Revue de botanique appliquée et d'agriculture coloniale, 10ᵉ année, bulletin n°101, janvier 1930. pp. 3-10
Le greffage de l'Hevea en Indochine.
No full textCramer P. J. S. Le greffage de l'Hevea en Indochine.. In: Revue de botanique appliquée et d'agriculture coloniale, 13ᵉ année, bulletin n°138, février 1933. pp. 97-104
La production du Caoutchouc aux Indes Néerlandaises (suite et fin)
No full textCramer P. J. S. La production du Caoutchouc aux Indes Néerlandaises (suite et fin). In: Revue de botanique appliquée et d'agriculture coloniale, 21ᵉ année, bulletin n°239-240, Juillet-août 1941. pp. 425-457
La restriction de la production du caoutchouc et les producteurs hollandais (Suite et fin).
No full textCramer P. J. S. La restriction de la production du caoutchouc et les producteurs hollandais (Suite et fin).. In: Revue de botanique appliquée et d'agriculture coloniale, 11ᵉ année, bulletin n°124, décembre 1931. pp. 972-977
La culture de la Patate à Java
No full textCramer P. J. S. La culture de la Patate à Java. In: Revue de botanique appliquée et d'agriculture coloniale, 3ᵉ année, bulletin n°20, 30 avril 1923. pp. 233-241
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