166 research outputs found
New apigel local use at treatment of oral mucous membrane radiation reactions in patients after head and neck malignant neoplasms radiation therapy = Локальное применение нового апигеля для лечения лучевых реакций слизистой оболочки полости рта у больных после лучевой терапии злокачественных новообразований в области головы и шеи
No full textKravchenko L. S., Bas N. A., Coval S. N., Davidenko O. N. New apigel local use at treatment of oral mucous membrane radiation reactions in patients after head and neck malignant neoplasms radiation therapy = Локальное применение нового апигеля для лечения лучевых реакций слизистой оболочки полости рта у больных после лучевой терапии злокачественных новообразований в области головы и шеи. Journal of Education, Health and Sport. 2016;6(2):211-222. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.46484
http://ojs.ukw.edu.pl/index.php/johs/article/view/3401
https://pbn.nauka.gov.pl/works/716557
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2016;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 05.01.2016. Revised 12.02.2016. Accepted: 21.02.2016.
УДК 616.52-006.04:616.31
ЛОКАЛЬНОЕ ПРИМЕНЕНИЕ НОВОГО АПИГЕЛЯ ДЛЯ ЛЕЧЕНИЯ ЛУЧЕВЫХ РЕАКЦИЙ СЛИЗИСТОЙ ОБОЛОЧКИ ПОЛОСТИ РТА
У БОЛЬНЫХ ПОСЛЕ ЛУЧЕВОЙ ТЕРАПИИ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЙ В ОБЛАСТИ ГОЛОВЫ И ШЕИ
Л. С. Кравченко, Н. А. Бас, С. Н. Коваль, О. Н. Давиденко
Одесский национальный медицинский университет, Одесса
Резюме
Использование лучевой терапии для лечения злокачественных новообразований в области головы и шеи наряду с увеличением числа клинических выздоровлений приводит к росту частоты осложнений в ротовой полости. Цель работы оценка эффективности местного применения нового геля «Апиор» в комплексном лечении лучевых осложнений в полости рта у больных с новообразованиями в области головы и шеи после проведенной лучевой терапии. Аппликации геля «Апиор» в комплексном лечении лучевых реакции слизистой оболочки полости рта (СОПР) у пациентов с новообразованиями в области головы и шеи после лучевой терапии благоприятно влияли на объективные и субъективные симптомы лучевых реакций. По сравнению с пациентами, у которых противовоспалительная терапия проводилась традиционными методами, у больных, в схему лечения которых включали местное применение апигеля, отмечено снижение частоты выявления отека и эрозий СОПР, реже наблюдались кровоточивость десен, явления очагового и сливного эпителиита, язвенно-некротические процессы. Отмечено более быстрое уменьшение степени выраженности ксеростомии, что способствовало улучшению гигиенического состояния полости рта, предотвращению вторичной микробной колонизации поврежденных слизистых поверхностей. Аппликации геля «Апиор» сокращали сроки восстановления структурно-функциональной целостности СОПР, что сокращало сроки реабилитации больных. Авторы пришли к выводу, что местное применение геля «Апиор» в комплексной терапии лучевых осложнений в полости рта у больных с новообразованиями в области головы и шеи, подвергшихся лучевому лечению, быстрее снижает выраженность симптомов ксеростомии и лучевых реакций СОПР, купирует их. Включение в схему лечения нового апигеля способствует улучшению гигиенического состояния полости рта, саливации, положительно влияя на неспецифическую резистентность ротовой жидкости и оказывая регенеративное действие, что повышает эффективность лечения и качество жизни больных.
Ключевые слова: лучевые реакции слизистой оболочки полости рта, лечение, лучевая терапия, ксеростомия, апигель.
NEW APIGEL LOCAL USE AT TREATMENT OF ORAL MUCOUS MEMBRANE RADIATION REACTIONS IN PATIENTS AFTER HEAD
AND NECK MALIGNANT NEOPLASMS RADIATION THERAPY
L. S. Kravchenko, N. A. Bas, S. N. Coval, O. N. Davidenko
Odessa National Medical University, Odessa
Summary
The use radiotherapy at treatment of malignant neoplasma in the area of the head and neck, together with increased chances for clinical recovery leads to increased rates of radiation complication in oral cavity. The aim of the work is estimation of efficiency of local use new gel “Apior” in complex treatment of radiation complications in cavity mouth in patients with neoplasms in the area of the head and neck who receive radiation therapy. The application of the gel “Apior” in the complex therapy of radiation reactions of the oral mucous membrane (OMM) in patients with neoplasms in the area of the head and neck after radiation treatment influenced favorably the objective and subjective symptoms of radiation reactions. In comparison with patients who were given local anti-inflammatory therapy by traditional methods, the patients with application of the apigel were observed to have fast healing of edema, OMM erosion, there were less often marked gingival hemorrhage, phenomena of local and confluent epitheliitis, ulcerotic-necrotic processes. There was observed reduction in the xerostomia level manifestation that promoted improvement of the hygienic condition of the oral cavity, prevention of the secondary microbic colonization of the damaged mucous surfaces. The application of the gel “Apior” reduced terms of restoration of the structural-functional integrity of OMM that promoted rehabilitation of the patients. Authors conclude that gel “Apior” local application in the complex therapy of radiation complications in cavity mouth in patients with neoplasms in the area of the head and neck who underwent radiation treatment reduces symptoms of xerostomia and radiation reactions OMM more quickly and stops them. Inclusion of the apigel in the scheme of treatment improvement of the hygienic condition of the oral cavity, of the salivary secretion, which have positive influence on nonspecific resistance in oral liquid and restored of the structural integrity of OMM, that improves quality of treatment and life of the patients.
Key words: radiation reactions the oral mucous membrane, treatment, radiation therapy, xerostomia, apigel.
Резюме
ЛОКАЛЬНЕ ЗАСТОСУВАННЯ НОВОГО АПІГЕЛЮ ДЛЯ ЛІКУВАННЯ ПРОМЕНЕВИХ РЕАКЦІЙ СЛИЗОВОЇ ОБОЛОНКИ ПОРОЖНИНИ РОТА У ХВОРИХ ПІСЛЯ ПРОМЕНЕВОЇ ТЕРАПІЇ ЗЛОЯКІСНИХ НОВОУТВОРЕНЬ В ДІЛЯНЦІ ГОЛОВИ ТА ШИЇ. Використання променевої терапії для лікування злоякісних новоутворень в ділянці голови та шиї разом зі збільшенням числа клінічних видужань призводить до зростання частоти ускладнень в ротовій порожнині. Мета роботи - оцінка ефективності місцевого застосування нового гелю «Апіор» в комплексному лікуванні променевих ускладнень в порожнині рота у хворих з новоутвореннями в ділянці голови та шиї після проведеної променевої терапії. Аплікації гелю «Апіор» в комплексному лікуванні променевих реакції слизової оболонки порожнини рота (СОПР) у пацієнтів з новоутвореннями в ділянці голови та шиї після променевої терапії сприятливо впливали на об'єктивні і суб'єктивні симптоми променевих реакцій. У порівнянні з пацієнтами, у яких протизапальна терапія проводилася традиційними методами, у хворих, в схему лікування яких включали місцеве застосування апігеля, відзначено зниження частоти виявлення набряку і ерозій СОПР, рідше спостерігалися кровоточивість ясен, явища осередкового і зливного епітеліїту, виразково-некротичні процеси. Відзначено швидкіше зменшення ступеня вираженості ксеростомії, що сприяло поліпшенню гігієнічного стану порожнини рота, запобігання вторинної мікробної колонізації пошкоджених слизових поверхонь. Аплікації гелю «Апіор» скорочували терміни відновлення структурно-функціональної цілісності СОПР, що скорочувало терміни реабілітації хворих. Автори дійшли висновку, що місцеве застосування гелю «Апіор» в комплексній терапії променевих ускладнень в порожнині рота у хворих з новоутвореннями в ділянці голови та шиї, які зазнали променевого лікування, швидше знижує вираженість симптомів ксеростомії та променевих реакцій СОПР, усуває їх. Включення в схему лікування нового апігеля сприяє поліпшенню гігієнічного стану порожнини рота, салівації, позитивно впливаючи на неспецифічну резистентність ротової рідини і надаючи регенеративну дію, що підвищує ефективність лікування і якість життя хворих.
Ключові слова: променеві реакції слизової оболонки порожнини рота, лікування, променева терапія, ксеростомія, апігель
Nuevos datos sobre el paisaje vegetal de las primeras ocupaciones de Mallorca: el Coval Simó (Escorca, Mallorca)
No full textThe Coval Simó shelter provides some of the oldest evidence for settlement on the island of Mallorca and the Balearic archipelago. It also has the peculiarity of being a habitat in a mountain area, so that the human groups that settled there had to adapt their agricultural and farming system to this environment. The plant remains (wood charcoal and seeds) recovered in the occupation levels allow us to address these issues, since they are the result of the different activities developed in this cavity: fuel for domestic activities, food for livestock, etc. The results of this study show that between the III and II millennium cal BC, an agricultural system based on livestock and cereal farming was implemented, which exploited local forest formations to obtain resources, among them, firewood. The plants that were exploited show the existence of juniper forests, with the presence of maples and legumes, among other shrubs and bushes.El Coval Simó constituye una de las evidencias más antiguas de poblamiento en la isla de Mallorca y en el archipiélago balear. Tiene, además, la particularidad de ser un hábitat en zona de montaña, de modo que los grupos humanos que se asentaron allí debieron de adaptar su sistema agropecuario y de explotación del entorno a este medio. Los restos vegetales (carbones y semillas) recuperados en los niveles de ocupación del yacimiento permiten aproximarse a estas cuestiones, ya que son resultado de las distintas actividades desarrolladas en esta cavidad: combustible para las actividades domésticas, alimento para el ganado, etc. Los resultados de este estudio muestran que entre el III y II milenio cal BC se implantó un sistema agropecuario basado en la ganadería y en el cultivo de cereales, que realizaba una explotación de las formaciones forestales locales para la obtención de recursos, entre ellos, el combustible leñoso. Las formaciones vegetales explotadas remiten a la existencia de bosques de enebros o sabinas, con presencia de arces y matorrales de leguminosas, entre otros arbustos y matas
Can Standard Preferences Explain the Prices of out of the Money S&P 500 Put Options
No full textPrior to the stock market crash of 1987, Black-Scholes implied volatilities of S&P 500 index options were relatively constant across moneyness. Since the crash, however, deep out-of-the-money S&P 500 put options have become %u2018expensive%u2019 relative to the Black-Scholes benchmark. Many researchers (e.g., Liu, Pan and Wang (2005)) have argued that such prices cannot be justified in a general equilibrium setting if the representative agent has %u2018standard preferences%u2019 and the endowment is an i.i.d. process. Below, however, we use the insight of Bansal and Yaron (2004) to demonstrate that the %u2018volatility smirk%u2019 can be rationalized if the agent is endowed with Epstein-Zin preferences and if the aggregate dividend and consumption processes are driven by a persistent stochastic growth variable that can jump. We identify a realistic calibration of the model that simultaneously matches the empirical properties of dividends, the equity premium, the prices of both at-the-money and deep out-of-the-money puts, and the level of the risk-free rate. A more challenging question (that to our knowledge has not been previously investigated) is whether one can explain within a standard preference framework the stark regime change in the volatility smirk that has maintained since the 1987 market crash. To this end, we extend the model to a Bayesian setting in which the agent updates her beliefs about the average jump size in the event of a jump. Note that such beliefs only update at crash dates, and hence can explain why the volatility smirk has not diminished over the last eighteen years. We find that the model can capture the shape of the implied volatility curve both pre- and post-crash while maintaining reasonable estimates for expected returns, price-dividend ratios, and risk-free rates.
Dumb Money: Mutual Fund Flows and the Cross-Section of Stock Returns
No full textWe use mutual fund flows as a measure for individual investor sentiment for different stocks, and find that high sentiment predicts low future returns at long horizons. Fund flows are dumb money %uF818 by reallocating across different mutual funds, retail investors reduce their wealth in the long run. This dumb money effect is strongly related to the value effect. High sentiment also is associated high corporate issuance, interpretable as companies increasing the supply of shares in response to investor demand.
Risk Aversion and Clientele Effects
No full textWe use traded options on growth and value indices to test for clientele differences in risk preferences. Value investors appear to have exhibited a higher average level of risk aversion than growth investors for two different time periods in the late 1990’s and early 2000’s. We construct a model of time-varying clientele preferences that allows investors with different levels of risk-aversion to switch between investment styles conditional upon the evolution of returns and risk. The model makes predictions about the autocorrelations structure of measured risk parameters and also about the autocorrelation and cross-autocorrelation of fund flows by style. Empirical tests of the model provide evidence consistent with the existence of style switchers—investors who move funds between growth and value securities. We construct trading strategies in the value and growth index options markets that effectively buy risk from one clientele and sell it to another. These strategies generated modest positive returns over the period of study.
The Home Bias and Capital Income Flows between Countries and Regions
No full textThis paper documents a marked increase in international consumption risk sharing throughout the recent globalization period. Unlike earlier studies that have found it difficult to document a consistent effect of financial globalization on international consumption comovements, we make use of the information implicit in the relative levels of consumption and output to measure long-run risk sharing among OECD countries and US federal states. We derive our empirical setup from a deliberately simplistic model in which countries can trade perpetual claims to each other?s output (Shiller securities). This model allows us to identify the channels through which improvements in international risk sharing have come about. The model predicts crosscountry and cross-regional income flows with considerable precision. Both international income flows as well as consumption risk sharing have increased since 1990, in line with the gradual removal of country portfolio home bias documented elsewhere. Still, the increase in international income flows falls short of explaining all of the consumption risk sharing we see in international data. We show that heterogeneity in countries? gross foreign asset positions is important in explaining this result. While countries with less portfolio home bias enjoy better consumption risk sharing, our findings also suggest that heterogeneity in country portfolios opens an separate channel for consumption risk sharing, possibly through asymmetric valuation effects that have been emphasized in the recent literature. --Consumption Risk Sharing,International and regional business cycles,Capital flows,Home Bias,Non-stationary panel data
Disposition Matters: Volume, Volatility and Price Impact of a Behavioral Bias
No full textIn this paper, we estimate the behavioral component of the Grinblatt and Han (2002) model and derive several testable implications about the expected relationship between the preponderance of disposition-prone investors in a market and volume, volatility and stock returns. To do this, we use a large sample of individual accounts over a six-year period in the 1990's in order to identify investors who are subject to the disposition effect. We then use their trading behavior to construct behavioral factors. We show that when the fraction of irrational' investor purchases in a stock increases, the unexplained portion of the market price of the stock decreases. We further show that statistical exposure to a disposition factor explains cross-sectional differences in daily returns, controlling for a host of other factors and characteristics. The evidence is consistent with the hypothesis that trade between disposition-prone investors and their counter-parties impacts relative prices.
Portfolio Diversification and City Agglomeration
No full textWe relate the degree of investor portfolio focus to the broader urban economic context of the household. Using a detailed panel of investors in Sweden over the period 1995 to 2000, we find that the level of investor diversification, as measured by number of stocks in the portfolio and by the average correlation among holdings, is partially explained by city industrial characteristics. We find that rural portfolios are more diversified than urban portfolios and that portfolio diversification is characterized by factors associated with urban growth. We consider a number of theories to explain investor focus, including behavioral biases, real and perceived informational advantage, local social competition and hedging of non-tradable risk. We find little evidence to support social and hedging motives to explain the lack of portfolio diversification, and some evidence in favor of perceived informational advantage in an urban setting. We attribute this evidence as support for the broader 'knowledge spillover' processes documented in the recent urban economics literature. Portfolio effects may be added to the list of factors that define and differentiate urbanism.
Does asymmetric information cause the home equity bias?
No full textThe home equity bias is one of the many puzzles existing in international finance. This puzzle is characterized by the concentration of domestic equity in any investor's portfolio, which is in contradiction with the benchmark of full diversification in a world mutual fund. Based on Admati's (1985) and Gehrig's (1993) noisy rational expectation models, the author tries to explain the effect of asymmetric information in the home equity bias puzzle. While asymmetric information helps to explain the puzzle for the case of one domestic, and one foreign equity, this result relies on very restrictive assumptions. Using a model with one domestic asset and two foreign assets, the author illustrates that asymmetries of information are also consistent with home equity bias reversals. One proposition generalizes these results. Simulations corroborate the main theoretical predictions of the model presented by the author.Payment Systems&Infrastructure,Economic Theory&Research,Financial Intermediation,International Terrorism&Counterterrorism,Environmental Economics&Policies,International Terrorism&Counterterrorism,Economic Theory&Research,Environmental Economics&Policies,Financial Intermediation,Insurance Law
Artistic valences in the Moldavian engraving of the ’70s and ’80s of the XX century
No full textGravura moldovenească din anii ’70–’80 ai secolului al XX-lea, deși rezidă în caracterul evolutiv al graficii sovietice din precedenta perioadă postbelică, constituie un compartiment important al artei plastice contemporane. În lucrarea de față vor fi analizate, în mod preliminar, aspectele de figurare tehnică, predilecțiile tematice și procedeele artistice utilizate de către graficieni în creația lor grafică din cadrul deceniilor opt și nouă ale secolului trecut. De asemenea, ne propunem să efectuăm o analiză selectivă a stampelor executate în perioada de referință, care atestă soluționări inedite ale subiectelor artistice, în vederea relevării aspectelor distinctive de organizare compozițională a imaginii artistice și de obținere a expresiilor semnificativ-simbolice ale conținutului artistic. În anii ’70 ai secolului trecut se evidențiază stampele grafice ale artiștilor plastici, mulți dintre care au activat și în perioada precedentă: I. Bogdesco, I. Tabârţă, L. Beleaev, V. Coval, V. Cojocaru, Gh. Guzun, V. Lavrenov, E. Childescu, D. Savastin, Gh. Vrabie, A. Colîbneac, F. Hămuraru, I. Cavarnalî, V. Coreachin ș. a. Un aspect distinctiv al evoluției gravurii moldovenești de după 1980 îl constituie faptul că, în perioada respectivă, în spațiul artistic al republicii apare o pleiadă de tineri graficieni, a căror creație a marcat o nouă fază în constituirea gravurii naționale contemporane de la sfârșitul secolului al XX-lea: N. Coreachina, N. Danilenco, V. Kuzmenko, R. Cuțiuba, I. Liberman, S. Zamșa, E. Zavtur ș.a.Although residing in the evolutionary character of the Soviet graphics from the previous post-war period, the Moldavian engraving of the ’70s and ’80s of the XX century is an important compartment of the contemporary plastic art. In the present paper, the technical figurative aspects, thematic predilections and artistic procedures used by graphic artists in their graphic creation during the seventh and eighth decades of the previous century will be analyzed. We also propose to perform a selective analysis of the stamps executed during the reference period, which attests to the original solutions of the artistic subjects, in order to reveal the distinctive aspects of the compositional organization of the artistic image and to obtain the symbolic-significant expressions of the artistic content. In the seventh decade of the XX century, the graphic stamps of the plastic artists were revealed, many of whom activated in the previous period: I. Bogdesco, I. Tabarta, L. Beleaev, V. Coval, V. Cojocaru, Gh. Guzun, V. Lavrenov, E. Childescu, D. Savastin, Gh. Vrabie, A. Colibneac, F. Hamuraru, I. Cavarnali, V. Coreachin and others. A distinctive aspect of the evolution of the Moldavian engraving after 1980 is the fact that during this period in the artistic space of the Republic, there emerged a plethora of young graphic artists such as N. Coreachina, N. Danilenco, V. Kuzmenko, R. Cutiuba, I. Liberman, S. Zamșa, E. Zavtur and others, whose creation marked a new phase in the constitution of the contemporary national engraving of the end of the XX century
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