201 research outputs found
Executive summary (Eagar (Ariz.). Police Department)
No full textabstract: A report of the organization and activities of the Eagar Police Department
Eagar Inc v. James Leroy Eagar : Reply Brief
No full textREPLY BRIEF OF APPELLANT JAMES LEROY EAGAR ON APPEAL FROM THE SECOND JUDICIAL DISTRICT COURT OF DAVIS COUNTY, STATE OF UTAH HONORABLE RODNEY S. PAG
On two new species of the genus Darwinula (Crustacea, Ostracoda) from New Zealand
No full textWe report on two new Recent species of the genus Darwinula (D. aotearoa spec. nov. and D. kohanga spec. nov.) from New Zealand. Both soft part and valve morphology are described and figured. The taxonomic position of the two species within the Recent darwinulid fauna is discussed
Retinal S-antigen Th1 cell epitope mapping in patients with Behcet's disease
No full textBackground - Retinal S-antigen (S-Ag) is a most characterized autoantigen of autoimmune uveitis. The recognized immunodominant epitope of human S-Ag in patients with uveitis has not been identified. In this study, we selected certain patients with active uveitis to map the Th1 cell epitope spectrum of human S-Ag in Behcet's disease(BD). Methods - Blood samples were taken from eight active BD patients who showed an immune response to 40 mixed overlapping peptides spanning the entire sequence of human S-Ag. Peripheral blood mononuclear cells were isolated and stimulated with single S-Ag peptide at 5 mu g/ml or 20 mu g/ml. Single-cell immune responses were measured by IFN-gamma ELIspot assay. Results - BD patients heterogeneously responded to the S-Ag peptides at two concentrations. In general, the responses to 5 mu g/ml peptides were slightly stronger than those to 20 mu g/ml peptides, while the maximum SFC frequency to single peptide at the two concentrations was similar. Several peptides including P31, P35 and P40 induced a prominent response, with the frequency of S-Ag specific cells being about 0.007%. Significant reactivity pattern shift was noted in patients with different disease courses. Conclusions - Certain active BD patients have S-Ag specific Th1 cells with a low frequency. The S-Ag epitope specificity between patients is highly heterogeneous, and varies with the uveitis cours
Chronicle (Paterson, NJ) Vol. 30, No. 43, Oct. 26, 1958
No full textLocal information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements. This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952)
Mold, flow, and economic considerations in high temperature precision casting
No full textThesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2013.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (p. 46-47).Casting high temperature alloys that solidify through a noticeable two phase region, specifically platinum-ruthenium alloys, is a particularly challenging task due to their high melting temperature and this necessitates careful design of the mold material and mold geometry to produce defect free castings. Here fluid flow, heat flow, and chemical interactions were investigated with simulations and casting experiments. Three mold recipes were developed; an improved magnesium-phosphate binder silica sand based system, a magnesium-aluminum phosphate binder alumina sand based system, and a colloidal zirconia sol binder zirconia sand based system. The fluid and heat flow analysis has shown, and has been verified by experiment, that using a mold material with a low heat diffusivity, (the product of thermal conductivity, heat capacity, and density) will improve casting quality by delaying solidification and reducing interdentritic porosity. A simple economic framework was developed to compare the price of different ceramics with the results showing that silica is a more economic mold material at an estimated 75% yield over a zirconia or alumina mold with a 100% yield. This framework neglected how secondary processing and efficiency gains affect cost. The likely implementation of this research will be a zirconia face coat supported in the flask by magnesium phosphate bonded silica. This will provide the required heat diffusivity and mechanical support at the lowest cost to minimize interdentric porosity.by Matthew S. Humbert.S.M
Fire Safety of Grounded Corrugating Stainless Steel Tubing in a Structure Energized by Lightning
No full textCorrugated stainless steel tubing (CSST) has been used for more than 20 years as a replacement for conventional black iron gas piping. CSST has a thinner tubing wall and is susceptible to damage from lightning activity when discharges enter a structure, potentially resulting in perforation of the CSST wall and fire ignition. Grounding has been promoted by CSST manufacturers as a solution to this problem. We use modeling and simulation of voltage potentials and arc currents to evaluate the effects of grounding on the voltage potential across CSST, which can result in arc initiation, and charge through the arc, which can result in melting and perforation of the CSST wall. Our results show multiple scenarios where a 10 kA 10 × 350 s current waveform with 1 Ω grounding of the CSST still results in voltages greater than the arc initiation threshold of 25 kV and charge through the arc greater than 1.2 C, the perforation threshold we measured. For the case where lightning enters the structure through an outdoor light fixture or chimney, the presence of a grounding wire increases the charge through the arc from 0.13 C to 2.22 C. These results indicate that good grounding of CSST will not necessarily prevent arc initiation nor perforation of the CSST wall by lightning. Good grounding may in fact exacerbate the problem of lightning damage to CSST depending on where lightning enters the building and the electrical parameters of the path to ground
Analyses of electrode heat transfer in gas metal arc weld ing. Welding journal 70(1 ):20-s to 31-s.
No full textABSTRACT. Heat and fluid flow in the electrode during gas metal arc welding are considered approximately, experimentally, analytically and numerically for ranges of electrodes and materials of practical importance. Estimation of the governing nondimensional parameters and pertinent time scales provides insight into droplet formation and detachment while demonstrating that the behavior of the solid electrode may be considered to be quasisteady. The time scale estimates show that a steady-state, spherical flow calculation for the droplet would be inappropriate and possibly misleading. Experimental observations of the formation of a tapering tip, forming as electrical current is increased in steel electrodes shielded by argon gas, are found quantitatively consistent with numerical simulations based on the hypothesis that additional thermal energy is evolved along the cylindrical side surface of the electrode due to electron condensation
Mechanism of Action of Coenzyme B₁₂ : I. Mechanism of Action of Coenzyme B₁₂. Hydrogen Transfer in the Isomerization of β-Methylaspartate to Glutamate. II. Kinetic Studies of 3-Fluoro-1,2-Propanediol, a New Substance for Dioldehydrase. III. Reaction of 5'-Deoxyinosylcobalamen with Propanediol Dehydrase. IV. Adenosine Deaminase
No full textNOTE: Text or symbols not renderable in plain ASCII are indicated by [...]. Abstract is included in .pdf document.
PART I. Use of a mixture of non- and tetradeutero-beta-methylaspartate with coenzyme B12 dependent beta-methylaspartate-glutamate mutase has shown that the hydrogen that migrates becomes one of three equivalent hydrogens during the reaction. Kinetic isotope effects suggest that cleavage of the bond in the substrate from carbon to that hydrogen which migrates is an important component of the rate determining step. The evidence also supports the existence of an intermediate which can partition with similar probabilities to beta-methylaspartate or to glutamate. Some possible mechanistic implications of these findings are discussed.
PART II. The mechanism and the kinetics of the action of diol dehydrase on 3-fluoro-1,2-propanediol, a new substrate for diol dehydrase, were examined. The results of this study lead to a reexamination of the kinetic behavior of the natural substrate, 1,2-propanediol, with diol dehydrase. The [...] values of (S)-, (RS)-, and (R)-3-fluoro-1,2-propanediol were found to be 340[...], 128[...], and 104[...] respectively, compared to 368[...], 250[...], and 191[...], for the corresponding isomers of 1,2-propanediol. A modification of the existing analytical procedure for the determination of aldehyde was necessary in order to measure the values of Km for these substrates. Km values for (S)-, (RS)-, and (R)-3-fluoro-1,2-propanediol were found to be [...], [...], and [...] respectively. For (R)-, (RS)-, and (S)-1,2-propanediol, Km values were measured at [...], [...], and [...] respectively.
These results show that the (R)- and (S)- isomers of both substrates exhibit simple competitive behavior for the active site in the racemic mixture, and that both the (R)- and (S)- isomers of the substrate pass through a similar transition state in the enzyme catalyzed conversion to aldehyde.
PART III. The reactivity of 5'-deoxyinosylcobalamin in the propanediol dehydrase reaction was examined. This coenzyme B12 analogue showed no coenzyme activity in the diol dehydrase reaction. 5'-Deoxyinosylcobalamin was found to inhibit the activity of coenzyme B12 although it bound less efficiently than the natural coenzyme by a factor of 100. Previously reported experiments regarding the release of 5'-deoxyinosine by this system were shown to be inconclusive.
PART IV. The kinetic behavior of 5'-deoxyadenosine in the adenosine deaminase reaction has been examined. The low catalytic rate and inefficient binding observed for this substrate suggest that the 5'-hydroxyl is very important to both catalysis and binding of ribosyladenines. In spite of the low catalytic rate and the poor binding, adenosine deaminase was used to effectively synthesize 5'-deoxyinosine from 5'-deoxyadenosine
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