14 research outputs found
TERTIARY AMINO POLYMERS BY POLYADDITION OF 2,2'-ALKYLENEDIIMINODIETHANETHIOLS TO 1,4-BISMETHACRYOYLPIPERAZINE
No full textThe synthesis of poly(methacrylamido-thioetheramine)s by thermal polyaddition of 2,2'-alkylenediiminodiethanethiols to 1,4-bismethacryloylpiperazine is reported. These products show less pronounced hydrolytic behavior in acidic aqueous solution than the corresponding poly(acrylamido-thioetheramine)s. They were characterized by viscometric measurements, elemental analyses, Fourier transform infrared spectrophotometer, nuclear magnetic resonance and differential scanning calorimeter
Adattamenti del trasporto osmolare speculare al riassorbimento sodico nella fase pre-ipertensiva del modello sperimentale SHR
No full textAdattamenti nella regolazione di tonicità midollare renale nella fase preipertensiva del modello sperimentale SHR.
No full textOsmolar transport related to sodium hyper-reabsorption in pre-hypertensive phase of experimental arterial hypertension.
No full textIpertrofia ventricolare sinistra e sistema nitrossidergico miocardio nella fase pre-ipertensiva del modello sperimentale SHR
No full textRole of superoxide anion in prehypertensive phase of SHR: Effect of transient tempol treatment.
No full textOn a method of estimating the expenditure elasticity from concentration curves
No full textIn 1960 N.S. Iyengar developed a new method of estimating the expenditure elasticity of a specific item from two concentration curves the Lorenz curve of total expenditure (or income) and a generalized Lorenz curve which relates the proportion of consumption of the specific item to the proportion of consumers spending up to a given level of the total expenditure. On the assumptions of log normality of total expenditure distribution and of constancy of elasticity, the author derived an expression for elasticity that is valid just for two particular points of the range of the concentration curves. In this work we give a new expression for elasticity that can be calculated for any point of the range of the concentration curves. Iyengar's results follows as particular cases of it. Moreover, the two underlying hypotheses can be easily checked through this same expression. A generalization of a concentration curve recently studied by M. Zenga is also considered giving rise to an equivalent formula for elasticity Finally, a numerical illustration based on expenditure data in Italy shows the advantages of the new suggested approach compared to former results obtained by R. Guarini
CHARACTERIZATION OF MYOCARDIAL HYPERTROPHY IN PREHYPERTENSIVE SPONTANEOUSLY HYPERTENSIVE RATS: INTERACTION BETWEEN ADRENERGIC AND NITROSATIVE PATHWAYS
No full textOBJECTIVE AND METHODS:
Left ventricular hypertrophy in human and experimental hypertension is not always associated with pressure overload but seems to precede an increase in blood pressure. In this study, performed in male 5-week-old prehypertensive spontaneously hypertensive rats (SHR; n = 65) and age-matched Wistar-Kyoto rats (n = 56), the relationship between myocardial structure and activation of the adrenergic and nitric oxide systems was evaluated.
RESULTS:
Body weight, blood pressure and heart rate were similar in both groups. A higher left ventricle/body weight ratio was found in SHR, as a result of greater mononuclear (+47%) and binuclear (+43%) myocyte volumes, without changes in interstitial collagen. Both adrenergic and nitric oxide pathways were activated in SHR, as expressed by higher myocardial norepinephrine content, tyrosine hydroxylase activity, myocardial nitric oxide synthase 3 expression and protein nitration, indicating greater peroxynitrite (ONOO) generation from nitric oxide and superoxide. No difference was measured in nitric oxide synthase 1 expression, whereas nitric oxide synthase 2 was undetectable. A positive correlation between myocardial tyrosine hydroxylase activity and protein nitration was observed in SHR (r = 0.328; P < 0.01). Early treatment with a superoxide dismutase mimetic, 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl, from the third to the fifth week of age, reduced ONOO generation, protein nitration and sympathetic activation in SHR without changes in myocardial structure.
CONCLUSION:
In prehypertensive SHR, left ventricular hypertrophy is associated with adrenergic and nitrosative imbalance. Early superoxide dismutase mimetic treatment in SHR effectively reduces higher myocardial ONOO generation, sympathetic activation, and heart rate without affecting the development of myocardial hypertrophy
