1,228 research outputs found
Serum microRNAs as biomarkers of human lymphocyte activation in health and disease
No full textInduction of the adaptive immune system is evaluated mostly by assessment of serum antibody titers and T lymphocyte responses in peripheral blood, although T and B cell activation occurs in lymphoid tissues. In recent years, the release of microRNAs (miRNAs) in the extra-cellular environment has been exploited to assess cell functions at distance via measurement of serum miRNAs. Activated lymphocytes release a large amount of nano-sized vesicles (exosomes), containing miRNA, however there are insufficient data to determine whether this phenomenon is reflected in modulation of serum miRNAs. Interestingly, miRNA signatures of CD4+ T cell-derived exosomes are substantially different from intracellular miRNA signatures of the same cells. We have recently identified serum circulating miR-150 as a sensor of general lymphocyte activation and we strongly believe that miRNAs differentially released by specific CD4+ effector T cell subsets (Th1, Th2, Th17, and Treg) may serve as serum biomarkers of their elicitation in lymphoid tissues but also in damaged tissues, potentially providing clinically relevant information about the nature of immune responses in health and disease. © 2014 de Candia, Torri, Pagani and Abrignani
[Certamen Poético dedicado a D. Domingo de Orueta, Obispo de Almería] [Manuscrito]
No full textTexto en castellano y en latín; Letra del S. XVIIITít. tomado de Alonso-CortésFoliación de la época; folios 54 bis, 67 bis y 68 bis, con foliación moderna; apost. y recl.; caja de escritura 16,5 x 9,5 cm; 24 lín. por p.3. Primum certamen. Calliope. Heroicum Poema. (fol. 11) a) JUAN DE CANDIA. Melioris Promethei Ardentissimum zelum, ignem que caelestem, quo hominum molem ad huc rudem informavit Epos canit, ad illud Ovidii primo Metamorphoseos. Finxit in effigiem moderantum cuncta Deorum. ... (fols. 12-13) b) FRANCISCO DELGADO. [Composición en octavas] Primicias de su vena le dedica Calyope al Prometheo mas zeloso. ... (fols. 13-15) c) ANTONIO VERGARA. Aliud Epos. ... (fols. 15 v.-16 v.) d) JUAN FRANCISCO. Octavas al assumpto Heroico. ... (fols. 16 v.-18) e) MARTIN DE ALBARRACIN. Aliud de eodem. ... (fols. 18-19 v.) Poema Heroico en verso Real al mismo assumpto. ... (fols. 19 v.-22) f) PEDRO DE CANDIA. Aliud Poema Latinum. Ad illud ignem veni mittere interram et finxit in effigie [etc.]. ... (fols. 22-23) g) MARTIN DE BENAVIDES. Selva al mismo asunto. ... (fols. 23-27 v.) --4. Secundum certamen. Melpomene. Elegiacum Poema. (fol. 28) a) FRANCISCO DELGADO. Desideria, quibus informe genus hominum suum expetebat Prometheum, vota ex suo adventu, suo que ex zelo elegiaco plectro concinit vates. ... (fols. 29-30) b) LUIS MAQUEDA. Aliud ad idem. ... (fols. 30-31) c) MANUEL SANCHEZ. Al mismo assunto. Cancion. ... (fol. 31-33 v.) d) PEDRO DE CANDIA. Elegia alia ad ide[m]. ... (fols. 33 v.-34 v.) --6. Quartum certamen. Clio. Poema Lyricum. (fol. 43) a) PEDRO DE CONTRERAS. Gratulatur Prometheo pro electione ignis ad homines caelesti vita efformandos. Lyricum. [Oda] ... (fols. 44-45 v.) b) JUAN DE CANDIA. Alia Ode ad idem. ... (fol. 46-46 v.) c) PEDRO DE CONTRERAS. Lirica al mismo asunto. ... (fol. 46 v.-47 v) d) NICOLAS JIMENEZ. Soneto al mismo asunto. ... (fol. 48) e) PEDRO DE CANDIA. Alia Ode ad idem. ... (fols. 49-50) f) ANTONIO VERGARA. Alia Ode ad idem. ... (fol. 50-50 v.) --7. Quintum certamen. Urania. Poema Epigrammaticum. (fol. 51) a) MARTIN DE ALBARRACIN. Inquirenti cur noster Prometheus intus Igniger Deus à Sophocle nuncupatus, apud Ignigenas hospitium acceptet? Respondet Epigramma. ... (fol. 52) b) NICOLAS JIMENEZ. Aliud ad idem. ... (fol. 52) c) JUAN DE CANDIA. Aliud ad idem. ... (fol. 52) d) FRANCISCO DELGADO. Aliud ad idem. ... (fol. 52 v.); Aliud ad idem. ... (fol. 52 v.) e) PEDRO DE CANDIA. Aliud ad idem. ... (fol. 52 v.) g) JUAN PEREZ. Dezima[s] al mismo asunto. ... (fol. 53); Otra al mismo asumto. ... (fol. 53) h) JUAN FRANCISCO. Octavas rimas al mismo asumto. ... (fols. 53 v-54 v.) --8. Sextum certamen. Polyhymnia. Poema Symbolicum. (fol. 54 bis) a) FRANCISCO GUTIERREZ. ... Hieroglifico [-segundo Hieroglifico] con su explicacion. ... (fol. 45-45 v.) b) JUAN DE CANDIA. Tercero Hieroglifico con su explicacion. ... (fol. 45 v.) c) FERNANDO CANSINO. Empresa [-segunda empresa] con su explicacion. ... (fol. 46) d) PEDRO DE CANDIA. [Emblemas, jeroglifico y empresa] ... (fols. 46-47 v.) e) MARTIN DE ALBARRACIN. Otro Hieroglifico. ... (fol. 48) --9. Septimu[m] certamen. Thalía. Poema Glossematicum. (fol. 59) a) ANTONIO VERGARA. Glossema huius versus. ... (fol. 60) b) PEDRO DE CANDIA. Aliud euisde[m] versus [y epigrama] ... (fol. 60-60 v.) c) FRANCISCO DELGADO. Alia Epigramma. ... (fol. 60 v.) d) PEDRO DE CANDIA. Glosas Españolas de esta redondilla. ... (fols. 61-62) e) MANUEL SANCHEZ. Otra glosa en decimas a la misma redondilla. ... (fols. 62-63) f) FRANCISCO DE SANTILLAN. Otra glossa a la misma redondilla. ... (fols. 63-64) g) PEDRO DE CANDIA. Glossa primera. Al zelo y charidad con que el mejor Prometheo procura la conversion del pecador. ... (fol. 64-64 v.) h) FRANCISCO DELGADO. Soneto. ... (fol. 64 v.) i) FRANCISCO DE SANTILLAN. Glossa tercera. Del mismo verso y al mismo asunto. Soneto. ... (fol. 65) j) JUAN FRANCISCO. Glossa en octava. ... (fol. 65 v.) --10. Octavu[m] certamen. Terphsicore. Poema Anagrammaticu[m]. (fol. 66) a) MARTIN DE ALBARRACIN. Epigramma anagram[atic]um ... Anagramma O Ductor, mi venias. ... (fol. 67) b) FRANCISCO DELGADO. Anagramma. ... (fol. 67) c) PEDRO DE CANDIA. ... Anagramma. Uret nimis a Deo Luco. ... (fol. 67 v.) d) JUAN PEREZ. Anagramma. Tu mi Jesu dona corde. ... (fol. 67 v.) --11. Nonum certamen. Erato. Poema varium. (fol. 67 bis) a) MANUEL SANCHEZ. In honorem tanti Principis Acrostichis labyrint[hae]us. (fol. 68) b) PEDRO DE CANDIA. Logogriphus. ... (fol. 68); Acrostica Lyra. En alabanza del Señor D. Domingo de Orueta Obispo de Almería. (fol. 68 v.) c) ANTONIO VERGARA. Acrostichys Labirinth[ae]us. ... (fol. 68 bis) d) FRANCISCO DELGADO. Coplas en que se inquiere la causa por que nuestro Prometheo se digno ospedarse en la casa de los hijos del fuego?. ... (fol. 69-69 v.) e) JUAN FRANCISCO. Ecos en la venida del Illmo. Señor Don Domingo de Orueta ... (fol. 70) f) MANUEL SANCHEZ. Agradecidas a su venida piden instantemente [sic] dilate su partida. Decimas. ... (fols. 71-72)1. Meliori Prometheo Ignis à Deo divinitus illati in terras. Inductori ... Doctori huius seculi ... D. D. D. Dominico de Orueta in Salmanticensi olim Athenaeo Philosophiae ac Theologiae Sacrae Primº Mº Divi Bartholomaei maioris Collegii toga insignito. ... Poeticum hoc certamen pro debitis referendis gratiis. Amoris tesseram, observantia pignis gratittud[in]is monumentum. Ignigene Granatensis Juventus D. O. S. A. (fol. 1)5. Tertium certamen. Euterpe. Bucolicum Poema. a) PEDRO DE CONTRERAS. Humanitatem et Curam erga sibi subditos commendat Eccloga. Ad illud Ovidii. Tristium lib. 2º. ... (fols. 36-37 v.) b) FRANCISCO GUTIERREZ. Festivos plausus obtanti Principis adventum. Pastorilis Eccloga decantat. ... (fols. 37 v.-38 v.) c) MARTIN DE BENAVIDES. Alaban el zelo del ... Obispo de Almería Dn. Domingo de Orueta. ... (fols. 38 v.-41)> Soneto. Idem Auctor. ... (fol. 41-41 v.) e) LUIS MAQUEDA. Alia ad idem [Egloga]. ... (fols. 41 v.-42 v.) --2. FERNANDO CANSINO. [Preliminares] a) Epistola dedicatoria. ... (fol. 2-2 v.) b) Ludi Apollinaris indictio. ... (fols. 3-6) c) Panegyrica fabul[ae] expositio. ... (fols. 7-10) d) ADRIAN SALCEDO. Illustm.º D. D. Dominico de Orueta Almeriensi Episcopo Poeticum Jesuani ... Certamen Elegia dedicat. ... (fol. 10-10 v.) -
Transpiration in plants: A thermodynamic imperative
No full textIn this article we determine the importance of transpiration in plants at three different levels of organization: the plant itself, the ecosystem, and the biosphere, all in terms of entropy production due to transpiration. We propose that transpiration is a thermodynamic imperative rather than a physiological burden for the plant. Plants have not replaced their prevalent metabolism C3 with those of less loss of water, C4 or CAM. We argue that the fact that plants retain higher rates of transpiration along evolution could be explained using thermodynamic criteria.

Curvature of -manifolds
No full textThe Chinea–Gonzalez class C5⊕ C12 consists of the almost contact metric manifolds that are locally described as double-twisted product manifolds , I being an open interval, M a Kähler manifold and λ1, λ2 smooth positive functions. In this article, we investigate the behavior of the curvature of C5⊕ C12-manifolds. Particular attention to the N(k)-nullity condition is given and some local classification theorems in dimension 2 n+ 1 ≥ 5 are stated. This allows us to classify C5⊕ C12-manifolds that are generalized Sasakian space forms. In addition, we provide explicit examples of these spaces
Critical behavior near a phase transition between retrieval and non-retrieval regimes in a LIF network with spatiotemporal patterns
No full textSome reduction theorems for even-dimensional slant submanifolds of a -manifold
No full textWe esatblish conditions that allow us to reduce the codimension of a slant submanifold of an almost contact metric manifold which falls in the Chinea-Gonzales class . The Reeb vector field of the ambient space is assumwed to be orthogonal to the considered submanifolds
Contribution to the knowledge of the biology of shad (Prochilodus platensis Holmberg)of the Rio de la Plata
No full textAnálisis del crecimiento y estudio bioeconómico del sábalo (Prochilodus platensis Holmberg) en la cuenca del Plata.(PDF tiene 31 paginas.)IInstituto Nacional de Tecnología Agropecuaria (INTA), Secretaría de Estado de Agricultura y Ganadería de la NaciónProBiota: Programa para el estudio y uso sustentable de la biota australDebe citarse:
CABRERA, S. E. & C. CANDIA . 1964. Contribución al conocimiento de la biología del sábalo (Prochilodus platensis Holmberg). Revista de Investigaciones Agropecuarias, Instituto Nacional de Tecnología Agropecuaria, Buenos Aires, Serie 1 - Biología y Producción Animal, 1(4): 57-84. Series: Serie Documentos Relacionados - ProBiot
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides
No full textUsing N-[4-(hexyloxy)phenyl]piperidine-3-carboxamide (17c) as a structural lead, a number of isomers, derivatives, and ring-opened analogs were synthesized and tested for their ability to block the in vitro aggregation of human platelets induced by adenosine 5'-diphosphate (ADP). For the most active compounds, inhibition of the platelet aggregation triggered by arachidonic acid (AA) and ADP-induced intraplatelet calcium mobilization was also demonstrated. Based on quantitative structure-activity relationships (QSARs), we proved the impact of hydrophobicity on antiplatelet activity by a nonlinear (parabolic or bilinear) relationship between pIC(50) and lipophilicity, as assessed by RP-HPLC capacity factors and Clog P (i.e. calculated 1-octanol-water partition coefficients). This study highlighted the following additional SARs: quasi-isolipophilic isomers of 17c (isonipecotanilides and pipecolinanilides) and ring-opened analogs (e.g. anilide of beta-alanine) exhibited lower antiplatelet activity; methylation of the piperidine nitrogen of 17c has no effect, whereas alkylation with an n-propyl group decreases the activity by a factor of approximately 2, most likely due to a conformation-dependent decrease in lipophilicity
First Report of Lactococcus petauri in the Pumpkinseed (Lepomis gibbosus) from Candia Lake (Northwestern Italy)
No full textAuthor Contributions: Conceptualization, P.P., S.C., and M.P.; methodology, F.B., S.C., P.P., and M.P.; formal analysis, F.B., S.C., A.Z., and T.B.L.; investigation, S.C., P.P., and P.L.A.; resources, M.P.; data curation, P.P.; writing—original draft preparation, F.B., P.P., S.C., and M.P.; writing—review and editing, P.P., J.F.F.-G., and M.P.; supervision, S.C. and P.P.; project administration, M.P.; funding acquisition, M.P. All authors have read and agreed to the published version of the manuscript.Lactococcus petauri has emerged as a pathogen affecting farmed fish. In this case report, L. petauri was isolated from Lepomis gibbosus captured in Lake Candia, located in Piedmont, Northwestern Italy. Initially identified as L. garvieae using conventional methods like RAPID 32 ID STREP and MALDI-TOF, molecular analysis based on sequencing of the 16S-23S rRNA internal transcribed spacer region (ITS) confirmed it as L. petauri. The study also assessed the isolated strain’s pathogenicity by examining hemolysin and capsule cluster genes, revealing only hemolysin 2 amplicon; notably, the fish exhibited no lesions or pathological alterations. The L. petauri strain from this study displayed resistance to several antibiotics, being sensitive only to ampicillin, amoxicillin, florfenicol, and G-penicillin. This research provides new insights into host range of L. petauri and raises awareness of potential public health implications, particularly concerning zoonotic potential.
Key Contribution: L. petauri is reported for the first time in fish species in Italy; in particular, it is reported in wild pumpkinseed capture in Lake Candia located in Piedmont.Città Metropolitana di Torino (Italia)Depto. de Sanidad AnimalFac. de VeterinariaTRUEpu
Storage capacity of phase-coded patterns in sparse neural networks
No full textWe study the storage of multiple phase-coded patterns as stable dynamical attractors in recurrent neural networks with sparse connectivity. To determine the synaptic strength of existent connections and store the phase-coded patterns, we introduce a learning rule inspired to the spike-timing–dependent plasticity (STDP). We find that, after learning, the spontaneous dynamics of the network replays one of the stored dynamical patterns, depending on the network initialization. We study the network capacity as a function of topology, and find that a small-world–like topology may be optimal, as a compromise between the high wiring cost of long-range connections and the capacity increase
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