1,176 research outputs found
Effectiveness and safety of oxycodone/naloxone in the management of chronic pain in patients with systemic sclerosis with recurrent digital ulcers: two case reports
No full textNicola Ughi, Chiara Crotti, Francesca Ingegnoli Division of Rheumatology, Department of Clinical Sciences and Community Health, Gaetano Pini Institute, The University of Milan, Milan, Italy Abstract: Digital ulcers (DUs) are a severe and frequent clinical feature of patients with systemic sclerosis (SSc). The presence of DUs may cause severe pain and often lead to impairment of patient’s functional activities and health-related quality of life. Moreover, poor patient cooperation during the wound care procedure due to pain may be associated with a negative outcome of DU healing. Therefore, pain management has a key role in patients with SSc. These two case reports describe the effectiveness and safety of oxycodone/naloxone in patients with SSc complicated by painful chronic DUs. Such a therapy has provided pain relief and consequently an increased compliance during redressing wounds. Keywords: oxycodone, naloxone, systemic sclerosis, pain, digital ulcer, scleroderma, analgaesia, wound healing, opioids, calcinosis, UCLA-SCTC GIT 2.
Addizioni Urbane
No full textL'articolo a cura di Sergio Crotti pubblica il progetto redatto dall'autore A. Giovannelli al VI Seminario Internazionale di progettazione Architettonica e Urbana "Addizioni Urbane" diretto da S. Crotti, promosso dal Politecnico di Milano
Crotti P., Fiorini L., Ferraboli S., Baroncelli R., Sarrocco S., Vannacci G., Gobbi E. (2016) Velvet Complex and Gliotoxin Biosynthesis in Trichoderma afro-harzianum T6776.
No full textMethods for the genetic manipulation of marine bacteria
No full textGenetic manipulation of bacteria is a procedure necessary to obtain new strains that express peculiar and defined genetic determinants or to introduce genetic variants responsible for phenotypic modifications. This procedure can be applied to explore the biotechnological potential associated with environmental bacteria and to utilize the functional properties of specific genes when inserted into an appropriate host. In the past years, marine bacteria have received increasing attention because they represent a fascinating reservoir of genetic and functional diversity that can be utilized to fuel the bioeconomy sector. However, there is an urgent need for an in-depth investigation and improvement of the genetic manipulation tools applicable to marine strains because of the paucity of knowledge regarding this. This review aims to describe the genetic manipulation methods hitherto used in marine bacteria, thus highlighting the limiting factors of the different techniques available today to increase manipulation efficiency. In particular, we focus on methods of natural and artificial transformations (especially electroporation) and conjugation because they have been successfully applied to several marine strains. Finally, we emphasize that, to avoid failure, future work should be carried out to establish tailored methodologies for marine bacteria.How to cite: Zeaiter Z, Mapelli F, Crotti E, et al. Methods for the genetic manipulation of marine bacteria. Electron J Biotechnol 2018;33. https://doi.org/10.1016/j.ejbt.2018.03.003. Keywords: Conjugation, Electroporation, Genetic manipulation, Genome engineering, Marine bacteria, Metagenomic library, Natural competence, Next-generation DNA sequencing, Single-cell genome analysis, Suicide vectors, Transformatio
Stereoselective Ring Opening of Bicyclic Nitroso Diels-Alder Cycloadducts with Carbon Nucleophiles
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The Road to Designing Integrated Neuromuscular Training Programs for Children and Adolescents: A Systematic Review and Meta-Analysis
No full text: Li, M, Crotti, M, Martins, R, Tiernan, C, Lyons, M, Lander, N, Barnett, LM, and Duncan, MJ. The road to designing integrated neuromuscular training programs for children and adolescents: A systematic review and meta-analysis. J Strength Cond Res 39(8): e1043-e1060, 2025-Integrative neuromuscular training (INT) combines motor competence and strength development to boost athletic performance, but its specific components and effects on children and adolescents are not well understood. Three predetermined principles (INT exercise categories, INT progression modalities, and INT program effectiveness) were used to guide this review. Electronic databases SPORTDiscus, MEDLINE (Ovid), APA PsycINFO, Cochrane Library, Web of Science, and Embase were searched. Search terms related to study design, population, and intervention were identified, and risk of bias was appraised using the Physiotherapy Evidence Database (PEDro) Scale. Narrative synthesis indicated "strength training" (18 out of 30 studies, 60%), particularly core strength exercises (72.2%), was the most common in INT exercise categories. Twelve out of 30 studies (40%) met at least 2 types of INT progression modalities (i.e., volume-based progressions, intensity-based progressions, and complexity-oriented progressions). Meta-analysis reported significant improvements in countermovement jump (mean difference [MD] 3.32 cm, 95% CI [2.07, 4.38]; p = 0.00), push-up (MD 3.74 repetitions, 95% CI [1.53, 5.95]; p = 0.00), and sprint (standardized MD -0.18 s, 95% CI [-0.26 to -0.09]; p = 0.00), but not in flexibility. Subgroup analysis revealed that meeting all the 3 progression modalities significantly enhanced sprint (standardized MD -0.76 s, 95% CI [1.21 to -0.31]; p = 0.03) and flexibility (MD 6.38 cm, 95% CI [5.45 to 7.31]; p = 0.00). This review provides evidence that INT programs have a positive effect on improving children and adolescents' physical fitness and is regarded as a promising protocol. This review and future research can inform a call to action for using INT as a novel approach for developing motor competence, strength, and conditioning simultaneously during childhood and adolescence
In-field assessment of bridge pier scour by means of Fiber Bragg Gratings: System and algorithms
No full textBLESS (Bed LEvel Seeking System) is a sedimeter that measures riverbed level around bridge pier in water. It is based on Fiber Bragg Gratings and the working principle is based on the measurement of the different heat dissipation behaviour in the saturated soil compared to the flowing water. It is an innovative part of a complex monitoring system installed on a road bridge over the Po river (Italy). After two years of data storage, a comparison of two different methods to detect the riverbed level can be performed. One of them showed results in satisfactory agreement with those provided by a traditional reference device, i.e., an echo sounder. Furthermore, coupling the two different proposed bed level estimation methods allows deriving significant information about the health status of the sedimeter. The device is reliable enough to operate and survive in very harsh environments and it is ready for further engineering applications
Mounier educatore: quel mistero chiamato persona
No full textThis article focuses on the philosophy of personalism and its educational applications, especially the author develops a pedagogical analysis on the Mounier’s personalist idea. According to Mounier, we must respect “the inviolable mystery of the person” because the person is the highest value
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