439 research outputs found
Unfair terms in consumer contracts: a perspective based on case law, with a special focus on the EU Court of Justice.
No full textThe paper corresponds to the speech given by the Author (entitled «Unfair terms in consumer contracts: a perspective based on case law, with a special focus on the EU Court of Justice») when participating in the conference «Aktuelle Entwicklungen im Europäischen und internationalen ZVR» (University of Sassari, 26-27 September 2023): the Author has briefly examined the concept of “unfair” contractual terms by putting the stress on a number of questions of particular interest, such as the limits surrounding the possible “replacement” of such clauses
Antibodies generated in cats by a lipopeptide reproducing the membrane-proximal external region of the feline immunodeficiency virus transmembrane enhance virus infectivity.
No full textThe immunogenicity of a lipoylated peptide (lipo-P59) reproducing the membrane-proximal external region (MPER) of the transmembrane glycoprotein of feline immunodeficiency virus (FIV) was investigated with cats. In the attempt to mimic the context in which MPER is located within intact virions, lipo-P59 was administered in association with membrane-like micelles. Analyses showed that in this milieu, lipo-P59 had a remarkable propensity to be positioned at the membrane interface, displayed a large number of ordered structures folded in turn helices, and was as active as lipo-P59 alone at inhibiting FIV infectivity in vitro. The antibodies developed differed from the ones previously obtained by immunizing cats with the nonlipoylated version of the peptide (G. Freer, S. Giannecchini, A. Tissot, M. F. Bachmann, P. Rovero, P. F. Serres, and M. Bendinelli, Virology 322:360-369,2004) in epitope specificity and in the fact that they bound FIV virions. However, they too lacked virus-neutralizing activity and actually enhanced FIN infectivity for lymphoid cell cultures. It is concluded that the use of MPER-reproducing oligopeptides is not a viable approach for vaccinating against FIV
Children's right to information in civil proceedings in Italy.
No full textThe present article refers to the sections of the Italian National Report
drafted by the author in the context of her participation in the Minor’s right to information
in eu civil actions project; such a project focused on children’s right to
information within the framework of civil proceedings in the eu. In the article, emphasis
has been put on how the child’s right to be informed in this specific context
is enshrined in the Italian legal system. Furthermore, the paper analyses the right
at issue under the perspective of case law, referring mainly to the Italian Corte di
cassazione, the European Court of Human Rights and the Court of justice of the European Union
DETECTION OF B-EPITOPES ON THE P24 GAG PROTEIN OF FELINE IMMUNODEFICIENCY VIRUS BY MONOCLONAL-ANTIBODIES
No full textSeven monoclonal antibodies were obtained after immunization of mice with purified sodium dodecyl sulfate (SDS)-disrupted feline immunodeficiency virus (FIV). Six antibodies specifically bound antigens in the cytoplasm of FIV-infected cells as determined by indirect immunofluorescence and reacted with FIV p24 gag gene product in immunoblots. One reacted positively with virus-infected cells, but failed to recognize FIV structural proteins by immunoblotting. Using competition binding studies, the anti-p24 monoclonals were shown to detect four distinct B-cell epitopes. Competition with sera of FIV-infected cats showed that such epitopes are immunogenic also in the natural host species
Hepatitis C virus - Biology, pathogenesis, epidemiology, clinical description, and diagnosis
No full textThe Relationship of Disruptive Behavior and Intent to Leave Current Nursing Position
No full textAbstract\ud
\ud
of\ud
\ud
THE RELATIONSHIP OF DISRUPTIVE BEHAVIOR AND INTENT TO \ud
LEAVE CURRENT NURSING POSITION\ud
\ud
by\ud
\ud
Megan Rose Bendinelli\ud
\ud
\ud
\ud
Statement of Problem\ud
Disruptive behavior is a complex phenomenon that encompasses many acts and is often negatively experienced and witnessed by many professionals in the workforce. Disruptive behavior remains prevalent amongst nurses and is detrimental to the individual, organizations, and the workforce.\ud
\ud
Sources of Data\ud
Data were collected from a convenience sample of RN to BSN and MSN nursing students currently enrolled at a southern California state university. Students were asked to complete an online survey of four questionnaires: the Negative Acts Questionnaire Revised, Michigan???s Organizational Assessment Questionnaire, a demographic data sheet, and a professional characteristics survey to describe the subjects.\ud
\ud
Conclusions Reached\ud
Disruptive behavior and intent to leave one???s current place of employment were significantly correlated in this study, r (48) = 0.63, p ??? 0.001. This relationship was robust and not explained by demographic or workplace variables.NURSIN
Feline immunodeficiency virus-infected cat sera associated with the development of broad neutralization resistance in vivo drive similar reversions in vitro
No full textWe previously reported that, upon reinoculation into cats, a neutralization-sensitive, tissue culture-adapted strain of feline immunodeficiency virus constantly reverted to the broad neutralization resistance typical of primary virus isolates and identified residue 481 in the V4 region of the surface glycoprotein as a key determinant of the reversion. Here, we found that well-characterized immune sera, obtained from cats in which such reversion had occurred, selected in tissue culture in favor of virus variants that also had a neutralization-resistant phenotype and had amino acid 481 changed, thus indicating that the host's humoral immune response is capable of driving the reversion in the absence of other intervening factors. In contrast, a second group of immune sera, elicited by a virus variant that had already reverted to neutralization resistance in independent cats, induced the emergence of escape mutants lacking broad neutralization resistance and neutralized fewer virus variants. It is proposed that the viral variants used to produce the two sets of sera may have generated different antibody repertoires
AIDS VACCINATION STUDIES USING AN EX VIVO FELINE IMMUNODEFICIENCY VIRUS MODEL: REEVALUATION OF NEUTRALIZING ANTIBODY LEVELS ELICITED BY A PROTECTIVE AND A NONPROTECTIVE VACCINE AFTER REMOVAL OF ANTI-SUBSTRATE CELL ANTIBODIES
No full textFrom Bendinelli to Arban: Styles of Articulation Within Selected Trumpet Method Books
No full textThe earliest known trumpet method book to be compiled was Tutta L \u27arte della Trombetta (The Entire Art of Trumpet-Playing) in 1614 by Cesare Bendinelli. This book proved to be the pioneer for six that followed by: Girolamo Fantini (1638), Johann Ernst Altenberg (1795), Joseph-Gebhardt Kresser (1836), Raniero Cacciamani (1853), Francois Georges Auguste Dauverne (1857), and Jean Baptist Arban (1864). These books alone attest that articulation was a worthy topic of discussion during this 250-year period. The purpose of this paper is to address how articulation developed through the above seven method books as well as consider how articulation is taught and studied today. I have started with Bendinelli because no earlier method book is known. I am ending with Arban because it is both a touchstone for all those who aspire to play valved brass instruments 1 and a seminal source for methods to follow it in like manner of articulation principles. The plan for this paper is: (1) to discuss the trumpeter\u27s role and the use of trumpet; (2) to explore how articulation was addressed with examples in these above methods\u27 texts; (3) to exemplify the style of articulation that the Arban employed as the standard and why this standard is important; and (4) to discuss varied opinions of Arban\u27s style and draw potential points of comparison.
In order to more fully contextualize the concept of articulation, a brief digression must be made to pre-Bendinelli (pre 17th Century) to discuss uses of the trumpet and why articulation was important. In his book, The Trumpet, Edward Tarr writes of the evolution of the trumpet from its early history to modern day. Tarr exemplifies trumpets from nine different societies including the Egyptians circa 1415 B.C., the Israelites as recorded in the bible circa 37-100 A.D., and the Greeks in the second half of the fifth century B.C. He states, It is significant to note that the various kinds of trumpets, from prehistoric beginnings up to the Romans, had either a military or a religious function. 2 Furthermore Dauverne, author of the first trumpet method book at the Paris Conservatory, explains:
It [The trumpet] is involved in all political and religious institutions; it presides over all ceremonies and all celebrations; it declares war, gives the signal to combats, sounds the retreat of the vanquished, proclaims the triumph of the victors; in games and in feasts it applauds by its fanfares the victory of those who receive the crowns.
- …
