1,355,119 research outputs found
Genetic features of platinum-resistant ovarian cancer patients
No full textDubinina V. G., Rybin A. I., Mihailenko O. V., Kuznetsova O. V. Genetic features of platinum-resistant ovarian cancer patients. Journal of Health Sciences. 2014;4(14):50-56. ISSN 1429-9623 / 2300-665X.
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A50-56
http://ojs.ukw.edu.pl/index.php/johs/article/view/2014%3B4%2814%29%3A50-56
https://pbn.nauka.gov.pl/works/510233
DOI: 10.5281/zenodo.13271
http://dx.doi.org/10.5281/zenodo.13271
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1107. (17.12.2013).
© The Author (s) 2014;
This article is published with open access at Licensee Open Journal Systems of Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
Conflict of interest: None declared. Received: 15.11.2014. Revised 05.12.2014. Accepted: 08.12.2014.
Genetic features of platinum-resistant ovarian cancer patients
V. G. Dubinina, A. I. Rybin, O. V. Mihailenko, O. V. Kuznetsova
Odessa National Medical University
Abstract
The authors try to decide a problem of ovarian cancer resistance to platinum drugs by the way of correlation finding between platinum-resistance of tumor and presence of gene mutations in the patient. It was shown a variety of options for BRCA gene mutations in patients with ovarian cancer: BRCA 1 (185delAG) - 64,2%, BRCA 1 (5382 insC) - 55,7%, and BRCA 2 (6174delT) - 53,8%. Authors discovered a significant positive correlation between carriage of mutations in the BRCA genes 1/2 and the sensitivity of malignant ovarian tumors to chemotherapy with platinum. Mutations in these genes occurred significantly more often in patients with platinum-sensitive ovarian cancer.
Key words: ovarian cancer, treatment, resistance to platinum, mutation of genes, BRCA 1, BRCA 2.Dubinina V. G., Rybin A. I., Mihailenko O. V., Kuznetsova O. V. Genetic features of platinum-resistant ovarian cancer patients. Journal of Health Sciences. 2014;4(14):50-56. ISSN 1429-9623 / 2300-665X.
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A50-56
http://ojs.ukw.edu.pl/index.php/johs/article/view/2014%3B4%2814%29%3A50-56
https://pbn.nauka.gov.pl/works/510233
DOI: 10.5281/zenodo.13271
http://dx.doi.org/10.5281/zenodo.1327
Steatonyssus noctulus Rybin 1992
No full text<i>Steatonyssus noctulus</i> Rybin, 1992 <p> <i>Steatonyssus noctulus</i> Rybin, 1992: 157.</p> <p> <i>Steatonyssus noctulus</i>.—Rybin, 1995: 47; Rupp & Ludwig, 2000: 275; Baker & Craven, 2003: 6; Radovsky, 2010: 101.</p> <p> <b>Type locality:</b> Osh, Oshskaya province (Kirghizstan).</p> <p> <b>Type host:</b> <i>Nyctalus noctula</i>.</p> <p> <b>Material.</b> 2 FF, 21 N1 ex <i>Eptesicus serotinus</i> from Biological station “Venevitinovo”, 17 June 2019, leg. I. V. Budaeva; M ex <i>Nyctalus lasiopterus</i> from State Nature Reserve “Samarskaya Luka”, 7 July 2016, leg. D.G. Smirnov; N1 ex <i>Nyctalus leisleri</i> from SNR “Samarskaya Luka”, 8 July 2016, leg. D.G. Smirnov.</p> <p> <b>Distribution in Russian Federation:</b> Crimea (Stanyukovich, 1997), Pskov Province (Medvedev <i>et al</i>., 2000), Penza Province (Stanyukovich, 1997), Voronezh Province (present paper), Samara Province (present paper), Rostov Province (Zabashta <i>et al</i>., 2019), Dagestan Republic (Orlova <i>et al</i>., 2020a), [Russia] (Orlova <i>et al</i>., 2015d).</p> <p> <b>Distribution outside Russian Federation:</b> Europe (Stanyukovich, 1997; Rupp & Ludwig 2000). Asia (Rybin 1992; Stanyukovich, 1997).</p> <p> <b>Hosts.</b> <i>Nyctalus noctula</i> (Stanyukovich, 1997; Medvedev <i>et al</i>., 2000; Zabashta <i>et al</i>., 2019), <i>Ny</i>. <i>lasiopterus</i> (present paper), <i>Ny</i>. <i>leisleri</i> (present paper), <i>Miniopterus schreibersi</i> (Stanyukovich, 1997); <i>Eptesicus serotinus</i> (present paper).</p>Published as part of <i>Orlova, M. V., Klimov, P. B., Orlov, O. L., Smirnov, D. G., Zhigalin, A. V., Budaeva, I. V., Emelyanova, A. A. & Anisimov, N. V., 2021, A checklist of bat-associated macronyssid mites (Acari: Gamasina: Macronyssidae) of Russia, with new host and geographical records, pp. 537-564 in Zootaxa 4974 (3)</i> on page 551, DOI: 10.11646/zootaxa.4974.3.4, <a href="http://zenodo.org/record/4778060">http://zenodo.org/record/4778060</a>
Роль гомеостатистических механизмов в формировании результативности платинолечения больных с раком яичника = Role homeostatistic mechanisms in the formation of performance platinum treatment of patients with ovarian cancer
No full textRybin A. I. Роль гомеостатистических механизмов в формировании результативности платинолечения больных с раком яичника = Role homeostatistic mechanisms in the formation of performance platinum treatment of patients with ovarian cancer. Journal of Education, Health and Sport. 2016;6(6):405-414. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.55835
http://ojs.ukw.edu.pl/index.php/johs/article/view/3593
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2016;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 05.05.2016. Revised 25.05.2016. Accepted: 16.06.2016.
РОЛЬ ГОМЕОСТАТИСТИЧЕСКИХ МЕХАНИЗМОВ В ФОРМИРОВАНИИ РЕЗУЛЬТАТИВНОСТИ ПЛАТИНОЛЕЧЕНИЯ БОЛЬНЫХ С РАКОМ ЯИЧНИКА
А. И. Рыбин
Одесский национальный медицинский университет
Реферат
Автор, на основании анализа результатов исследования гомеостатистических механизмов (детоксикационная функция печени, цикл оксида азота; обмен серусодержащих аминокислот) у 121 больной раком яичника и разной чувствительностью к препаратам платины, приходит к заключению, что реализация генетически определенной чувствительности рака яичника к препаратам платины связана с этими механизмами. Автор полагает, что активность цикла оксида азота влияет на уровень эндогенной интоксикации и устойчивость организма к внешним воздействиям. Уровень содержания SS-SH групп и их связь с белковыми или липопротеидными комплексами, очевидно, определяет уровень сульфид-платиновых комплексов, а состояние детоксикационной системы, возможно, определяет жизни таких комплексов и эффективность лечения, соответственно.
Ключевые слова: рак яичника, гомеостатические механизмы; SS-SH группы, оксид азота.
ROLE hOMEOSTATISTIC MECHANISMS IN THE FORMATION OF PERFORMANCE PLATINUM TREATMENT OF PATIENTS WITH OVARIAN CANCER
A. I. Rybin
Odessa National Medical University
Abstract
The author, based on the analysis results of the study gomeostatisticheskih mechanisms (liver detoxification function, nitric oxide cycle, exchange of sulfur-containing amino acids) in 121 patients with ovarian cancer and different sensitivities to drugs of platinum, comes to the conclusion that the implementation of a genetically determined sensitivity of ovarian cancer to the drugs of platinum associated with these mechanisms. The author believes that the activity of nitric oxide cycle affect the level of endogenous intoxication and the body's resistance to external influences. The level of SS-SH groups content and their relation to protein or lipoprotein complexes, obviously determines the level of sulphide-platinum complexes, and the state of detoxification system may determine the lifetime of such systems and the effectiveness of treatment, respectively.
Keywords: ovarian cancer, homeostatic mechanisms; SS-SH group, the nitrogen oxide
THE ROLE OF RADIATION THERAPY IN THE TREATMENT OF PATIENTS WITH THE VULVAR CANCER = РОЛЬ ПРОМЕНЕВОЇ ТЕРАПІЇ В ЛІКУВАННІ ХВОРИХ НА РАК ВУЛЬВИ
No full textRybin A.I. THE ROLE OF RADIATION THERAPY IN THE TREATMENT OF PATIENTS WITH THE VULVAR CANCER = РОЛЬ ПРОМЕНЕВОЇ ТЕРАПІЇ В ЛІКУВАННІ ХВОРИХ НА РАК ВУЛЬВИ. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2020;4(62):13-29. ISSN 1818-9385
DOI http://dx.doi.org/10.5281/zenodo.4396140
http://aptm.org.ua
УДК 616-006(075.8)
DOI: http://dx.doi.org/10.5281/zenodo.4396140
THE ROLE OF RADIATION THERAPY IN THE TREATMENT OF
PATIENTS WITH THE VULVAR CANCER
Rybin A.I.
Odessa National Medical University, Odessa, Ukraine
Summary
Vulvar cancer is a rare malignant tumor, accounting for 3-8% of the total incidence of malignant tumors of the female reproductive system. However, in the structure of mortality, this pathology ranks fourth after cancer of the cervix, uterine body and ovaries and amounts to 18.2%. Features of the anatomical structure of the external genital organs of a woman with a developed system of blood and lymphatic vessels cause an aggressive course, a tendency to metastasis and rapid growth of a tumor of this localization. Prospects for the timely diagnosis of vulvar cancer and vaginal tumors are directly related to an increase in literacy and oncological alertness of staff in general medical institutions, in the implementation of which not only the detection of the disease in the early stages, but also work with women from risk groups to refer them to further examination and, if necessary, for treatment in a specialized institution. High mortality from these diseases is associated with the appeal of women at the late stages of the development of the oncological process, as well as with the insufficient effectiveness of the therapy, which necessitates the development of research in this area.
Key words: vulvar cancer, x-ray therapy, chemotherapy
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The quality of life of patients with ovarian cancer as an indicator of functional assessing the effectiveness of anticancer therapy
No full textKolesnik O. O., Rybin A. I. The quality of life of patients with ovarian cancer as an indicator of functional assessing the effectiveness of anticancer therapy. Journal of Education, Health and Sport. 2017;7(5):539-551. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.804238
http://ojs.ukw.edu.pl/index.php/johs/article/view/4517
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).
1223 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2017;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 05.05.2017. Revised: 23.05.2017. Accepted: 31.05.2017.
UDK 618.11-006.6-085.28.036.8
THE QUALITY OF LIFE OF PATIENTS WITH OVARIAN CANCER
AS AN INDICATOR OF FUNCTIONAL ASSESSING
THE EFFECTIVENESS OF ANTICANCER THERAPY
O. O. Kolesnik*, A. I. Rybin**
*National Cancer Institute, Kyiv
**Odessa National Medical University, Odessa
Abstract
The aim of this study was to evaluate quality of life in patients with platinumresistant ovarian cancer, depending on the pharmacoresistance and differentiated use of chemotherapy. It is shown that the output value by the subscales of the questionnaires EORTC QLQ-C30 and FACT-G in patients assigned to different clinical groups were comparable. When using a differentiated approach in the treatment of patients with ovarian cancer significantly improved performance on physical scales (PF), role (RF) and emotional functioning (EF). In addition, patients from III and IV groups had decreased intensity of nausea (NV) and general weakness (FA). With differentiated application of chemotherapeutic agents with metabolic support total score by FACT-G questionnaire was in Group III 77,8±0,9 points, and in the IV group - 77,9±0,8 points, which was significantly higher than obtained in the first and group II - 72,2±1,2 and 71,6±0,9 points. Described differences were held during all follow-up observation.
Key words: ovarian cancer, chemotherapy, platinum resistance, platinum refractoriness, quality of life
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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