14,884 research outputs found
Una interpretación de a-ka-na-jo ( a3-ka-na-jo)
No full textThe author studies the word a-ka-na-jo in the PY Cn 328 tablet and taking into account some factors she proposes αγναιος as the reading of this word.The author studies the word a-ka-na-jo in the PY Cn 328 tablet and taking into account some factors she proposes αγναιος as the reading of this word
Environmental influences over the last 16 ka on compound-specific δ13C variations of leaf wax n-alkanes in the Hani peat deposit from northeast China
No full textCompound-specific carbon isotope ratios (δ13C) of leaf wax n-alkanes (C21-C33 odd carbon numbered n-alkanes) were measured in the Hani peat sequence from northeast China. These data were compared with lipid biomarker compositions to assess changes in local vegetation and paleoclimate for the last 16 ka The δ13C values of n-alkanes range between -36.6 and -30.7‰, showing that the compounds originate from C3 plants. Much larger variations (∼5.4‰) in the n-alkane δ13C values than those of atmospheric CO2 during the last 16 ka (< 0.5‰) indicate that the isotopic values were affected by environmental factors in addition to the postglacial δ13C variations in the atmospheric reservoir. The stratigraphic records of δ13C reveal decoupled fluctuations among the individual n-alkanes, particularly between 15.5 to 11.4 ka. Synchronous excursions in the δ13C offsets among individual n-alkanes (Δδ13C) and lipid biomarker paleoplant proxies (Paq, and C23/C31 and C27/C31) from 14.9 to 13.2 ka and 12.7 to 11.6 ka suggest that vegetational changes are the most likely causes for the decoupled δ13C variations. Parallel fluctuations of the δ13C values of terrestrial higher plant-derived C29 and C31 n-alkanes and the n-alkane average chain-length (ACL) from 11 to 6 ka indicate that the δ13C variations responded to net evaporation changes. Negative shifts in the n-alkane δ13C values coinciding with the ACL decreases at 10.5-9.3 ka and 8.1 ka indicate the short-term onset and fluctuations of the summer monsoon strength in eastern China during the early Holocene
NRF2 and chemoprevention: signaling, epigenetics and role in intestinal carcinogensis
No full textPrevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage. Chemoprevention becomes an increasing important concept and has led to the intense research about the mechanisms of actions of various chemopreventive compounds. They can be generally classified into blocking agents and suppressing agents. The chemopreventive compounds usually prevent or slow progression of cancer by maintaining a low oxidative stress and inflammatory environment in cells. This is brought about by the activation of Nrf2, the key protein being investigated in our lab. In this dissertation, I will be discussing the use of compounds as suppressing agents and blocking agents, how compounds activates Nrf2 signaling, how novel Nrf2 interaction partner IQGAP1 mediates Nrf2-Keap1 signaling axis, how expression level of Nrf2 could be regulated epigenetically, apart from the well-known post-translational control by Keap1-Ubiquitinase-Protesome axis and finally how loss of Nrf2 could enhance intestinal tumorigenesis in Apc(min/+) mice.Ph.D.Includes bibliographical referencesIncludes vitaby Ka Lung Cheun
Nearby fibroblasts' response to multiple acupuncture needle revolutions on fibroblast populated collagen gels
No full textAcupuncture is an ancient Chinese healing practice, and an alternative therapy for alleviating pain and chronic disorders. For over twenty years, research is trying to understand the mechanisms that lead to its therapeutic effect. Our laboratory investigates the cellular and molecular events in the connective tissue that occur by acupuncture needling. An in vitro assay was developed to evaluate some of the potential contributors to acupuncture’s effects using a cellular collagen gel as a loose connective tissue mimic. It was hypothesized besides immediate changes to cells under mechanical loading from an acupuncture needle, there were chemical factors released to nearby cells in acupuncture. This thesis investigates whether mechanically stimulating collagen gels with fibroblasts at different revolutions would release chemical factors to nearby fibroblasts where flow cytometry was used to observe cell proliferation as an indicator. Results reveal mechanically stimulating cellular collagen gels at different revolutions does not cause any changes in cell proliferation to nearby cells. However, dead stained mechanically stimulated cellular collagen gels showed cell death occurs around the acupuncture needle. It is possible there were no effects in cell proliferation because when a cellular collagen gel was needle manipulated, some chemical factors were released into the nearby cells. Then as needle manipulation increased, more chemical factors were released, but restricted by the larger amount of cell death around the needle from the increasing rotation.M.S.Includes bibliographical referencesby Ka Po Ch
Duan wei xia mu xie lei de xin xing he nei DNA fen zi xi tong biao ji zhi jian ding
No full textLeung Ka Chun.Thesis M.Phil. Chinese University of Hong Kong 2013.Includes bibliographical references (leaves 100-110).Abstracts also in Chinese.Title from PDF title page (viewed on 21, September, 2016).Leung Ka Chun
San zhong chao jian dai teng hu dui gao wen de sheng li fan ying ji zhuan lu ti yan jiu
No full textWong, Ka Wing Karen.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 143-157).Abstracts also in Chinese.Title from PDF title page (viewed on 30, November, 2016).Wong, Ka Wing Karen
The application of S-band polarimetric radar measurements to Ka-band attenuation prediction
No full textIn September 1993, the National Aeronautics and Space Administration's Advanced Communications Technology Satellite (ACTS) was deployed into a geostationary orbit near 100° W longitude. The ACTS satellite employs two Ka-band beacons, one at 20.185 GHz and another at 27.505 GHz. Impairments due to rain attenuation and tropospheric scintillations will significantly affect new technologies for this spectrum. Heavy rain at Ka-band can easily produce 30 dB of attenuation along the propagation path. Propagation experiments being conducted in seven different climatic zones involve multiyear attenuation measurements along the satellite-earth slant path. Measurements in the B2 climatic zone are made with an ACTS propagation terminal located in northeast Colorado. In order to gain more understanding about the physical processes that are responsible for Ka-band attenuation, the Colorado State University CHILL S-band polarimetric radar is used to take radar measurements along the slant path. The Colorado Front Range experiences a variety of weather conditions throughout the year ranging from upslope rain conditions to winter storms. Four such events measured along the slant path are illustrated in this paper. They include two convective cases and two "bright-band" cases. The S-band polarimetric radar data is used to initialize radar-based attenuation-prediction models, which are applied to the four precipitation events described. The comparisons of predicted attenuation to measured attenuation are quite good. It was also found during the course of the experiment that water droplets standing on the antenna surface can cause appreciable attenuation at Ka-band frequencies. That finding needs to be recognized in future model development and statistical analysis
Amritlal Nagar Ke Upannyas \u27Manas Ka Hans\u27 Ka Vaistichya
No full textThe entire life of Tulsidas of \u27Manas Ka Hans\u27 is disturbed by the ambushes of struggles and achieves the peak of faith. Goswami Tulsidas\u27s literature, his description and grand form are one with the unshakable land of \u27faith\u27, this is universally accepted. The prevailing legends, available evidence and the author\u27s own contemplation made Tulsi Das a living legend and scholar of public life. Artistic, Sushtu, Ragakrit, Udantakaran, Darun, Knowledge-Making, Past-oriented, Story-telling, Implore, Akhyata, Scholarly, Gharsthika, Emotionless, Philanthropic
Reaction of terrestrial and marine primary producers to abrupt climate changes during the Lateglacial and Holocene of the northeastern Mediterranean : a palynological approach
No full textFür die Analyse klimagesteuerter terrestrischer und mariner Ökosystemdynamik im Spätglazial und Holozän des Ägäisraums wurden terrestrische (Pollen und Sporen) und marine Palynomorphe (organischwandige Dinoflagellatenzysten) aus einem marinen Kern des Berg-Athos-Beckens hochauflösend (d.h. in einer zeitlichen Auflösung zwischen ~30 und ~200 Jahren) untersucht. Darüber hinaus wurden Pollen und Sporen eines terrestrischen Kerns aus dem Drama-Becken (nördliches Hinterland der Ägäis) analysiert. Neben der qualitativen Analyse wurden mit Hilfe der Technik der modernen Analoge quantitative Rekonstruktionen der Paläotemperaturen und -niederschläge im terrestrischen Raum vorgenommen. Für den marinen Kern wurden außerdem Sedimenthelligkeit, Sauerstoffisotopie und magnetische Suszeptibilität untersucht. Über die Entwicklung eines konsistenten Altersmodells für beide Kerne konnten Aussagen über eine regionale, klimagesteuerte Differenzierung zwischen der Vegetationsentwicklung im Küstenbereich und der Vegetationsentwicklung in intramontanen Ökosystemen getroffen werden. Während des Pleniglazials (~21 ka bis ~14,7 ka BP) herrschten im nördlichen Ägäisraum kühle und vor allem trockene Bedingungen vor. Offen liegende Schelfflächen wurden von einer Pinus-dominierten Vegetation besiedelt, bis der Schelf während des anschließenden Meiendorf-Bølling-Allerød-Interstadialkomplexes (~14,7 ka bis ~12,7 ka BP) durch den Schmelzwasserpuls MWP-1A überflutet wurde. Während des Meiendorf-Bølling-Allerød-Interstadialkomplexes herrschten im nördlichen Ägäisraum etwas humidere Bedingungen als während des Pleniglazials. In der anschließenden Jüngeren Dryas (~12,7 ka bis ~11,7 ka BP) war das Klima hingegen mindestens ebenso arid und die Oberflächenwassertemperaturen in der Nordägäis fast ebenso gering wie während des Pleniglazials. Das lokale Klima im Drama Becken war von ~21 ka BP bis zum Ende der Jüngeren Dryas generell trockener als die allgemeinen Klimabedingungen im nördlichen Ägäisraum. Die Vegetationsentwicklung im nördlichen Ägäisraum wurde während des Spätquartärs vor allem durch die zur Verfügung stehende Feuchtigkeit gesteuert. Auch nach der Jüngeren Dryas war die Humidität im Ägäisraum zu gering, um eine Wiederbewaldung zu ermöglichen, wie sie in Mitteleuropa und dem westlichen Mittelmeergebiet bereits ab ~11,6 ka BP stattfand. Ein Vegetationsrückschlag um ~11,0 ka BP korreliert mit der aus Mitteleuropa bekannten präborealen Oszillation bzw. dem 11,2-ka-Klimaereignis. Die holozäne Wiederbewaldung setzte im östlichen Ägäisraum erst ab 10,2 ka BP ein; sie wurde durch einen sukzessiven Anstieg der Winterniederschläge von ~225 auf über ~300 mm/Jahr ermöglicht. Sowohl dieser Anstieg der Winterniederschläge als auch ihr Rückgang nach 7,0 ka BP sind eng mit der Ablagerung des Sapropels S1 (zwischen ~9,6 ka und ~7,0 ka BP) verknüpft. Die relativ humiden und milden Winterbedingungen während der Ablagerung des S1 wurden von durch Vegetationsrückschläge dokumentierten, kurzfristigen Klimaereignissen bei ~9,3 ka, ~8,7 ka, ~8,2 ka und ~7,6 ka BP unterbrochen. Diese kurzfristigen Klimaereignisse gehen mit Unterbrechungen bzw. Abschwächungen der S1-Bildung einher. Besonders ausgeprägt ist der regionale Ausdruck des 8,2-ka-Ereignisses, welches für die am stärksten ausgeprägte und auch aus anderen Bereichen des östlichen Mittelmeers überlieferte Unterbrechung des S1 zwischen ~8,4 ka und ~8,0 ka verantwortlich zeichnet. Während der Bildung des S1 wurde die Klimaentwicklung im Ägäisraum generell weniger vom Klimasystem der hohen Breiten beeinflusst als vielmehr vom Monsunsystem der niederen Breiten. Allerdings war die Intensität des Sibirischen Hochs während des frühen Holozäns und nach dem S1-Intervall ein wichtiger Faktor für das Winterklima. Auch während des Holozäns wurden Klimaschwankungen im Drama-Becken deutlicher von der lokalen Vegetation reflektiert als von der Vegetation des nördlichen Ägäisraums im Allgemeinen. So wirkte sich z.B. das 8,2-ka-Ereignis sehr stark auf die Vegetationsentwicklung im Drama Becken aus; es verursachte einen Rückgang der Sommer- und Wintertemperaturen um mehr als 3° C. Dieser starke Temperatureinbruch ist auf lokale mesoklimatische Effekte zurückzuführen. Die Vegetation in den Randbereichen der Ägäis erfuhr weitere Rückschläge bei ~6,5 ka, ~5,6 ka und ~4,3 ka BP. Die Einbrüche bei ~5,6 ka und ~4,3 ka BP sind mit rapiden Klimaänderungen in großen Teilen der Nordhemisphäre korrelierbar, die ebenso wie die Jüngere Dryas und das 8,2-ka-Klimaereignis Einfluss auf Hochkulturen in Nordostafrika und im Mittleren Osten hatten. Die aus dem Holozän überlieferten Klimadaten machen deutlich, dass dieser Zeitraum von einer weitaus stärkeren Klimavariabilität geprägt wurde als noch bis vor kurzem angenommen.To unravel the climate-driven dynamics of terrestrial and marine ecosystems in the Aegean region during the Lateglacial and Holocene, terrestrial (pollen and spores) and marine (organic-walled dinoflagellate cysts) palynomorphs from a marine core from the Mount Athos Basin (Northern Aegean Sea) were analyzed in a temporal resolution of ~200 to ~30 years. These analyses were complemented by sediment lightness, oxygen isotope and magnetic susceptibility measurements. Furthermore, pollen and spores from a terrestrial core from the Drama Basin (northern borderlands of the Aegean Sea) were examined. Quantitative temperature and precipitation reconstructions were carried out using the modern analogues technique. Based on the development of a consistent age model for both cores, a spatially differentiated reconstruction of the vegetation dynamics in coastal settings and in intramontane ecosystems could be achieved. During the Pleniglacial (~21 kyr to ~14.7 kyr BP), the Aegean region was under the influence of cool and dry conditions. Exposed shelf areas were colonized by a Pinus-dominated vegetation until their flooding (notably through meltwater pulse MWP-1A) in the course of the Meiendorf-Bølling-Allerød interstadial complex (~14.7 kyr to ~12.7 kyr BP). During the Meiendorf-Bølling-Allerød interstadial complex, climate conditions were more humid than during the Pleniglacial. A pronounced climatic setback is registered for terrestrial environments during the Younger Dryas (~12.7 kyr to ~11.7 kyr BP) when conditions were nearly as arid and cold as during the Pleniglacial. Surface-water temperatures in the northern Aegean Sea also decreased markedly during that time. The local climate in the Drama Basin was generally dryer than in the greater northern Aegean Region from ~21 kyr BP until the end of the Younger Dryas. Vegetation dynamics in the northern Aegean Region were more driven by the available humidity than by temperature. After the Younger Dryas, when the Holocene reforestation started in Central Europe, humidity in the Aegean region was still insufficient to support reforestation. Tree populations even declined around ~11.0 kyr BP; this vegetation setback correlates with, but is more strongly pronounced than the preboreal oscillation known from Central Europe. Holocene reforestation did not start before ~10.2 kyr BP when winter precipitation successively increased from ~225 to ~300 mm/year. This increase and also a winter precipitation decrease after ~7.0 kyr BP is closely related with the formation of Sapropel S1 in the Aegean Sea (between ~9.6 kyr und ~7.0 kyr BP). The relatively humid winter conditions during S1 formation were interrupted by short-term climate setbacks at ~9.3 kyr, ~8.7 kyr, ~8.2 kyr, and ~7.6 kyr BP, which are documented by declines in thermophilous tree pollen. These climate setbacks are coeval with a weakening or interruption of S1 formation. The regional imprint of the 8.2-kyr climatic event is particularly strongly pronounced. This event caused the strongest interruption of S1 formation from ~8.4 to ~8.0 kyr BP. During S1 formation, the climate dynamics in the Aegean Region were less strongly influenced by the climate systems of the higher latitudes, but also bear a signature of the monsoonal system of the lower latitudes. However, the intensity of the Siberian High was an important factor in controlling winter climate conditions in the northern Aegean Region during the Early Holocene and after the S1 interval. Climate dynamics were more clearly reflected by the vegetation of the Drama Basin than by the vegetation in the northern Aegean Region in general. The 8.2-kyr-climate-event e.g. had a major influence on the vegetation dynamics in the Drama Basin and caused a decline in winter and summer temperatures by more than 3° C. This can be explained by local mesoclimatic effects. The vegetation in the borderlands of the Aegean Sea experienced further setbacks around ~6.5 kyr, ~5.6 kyr and ~4.3 kyr BP. The setbacks around ~5.6 kyr and ~4.3 kyr BP can be correlated with climate setbacks known from other regions in the Mediterranean region, which had great influence on human cultures in north-eastern Africa and in the Middle East. The climate data from the Holocene show that the climate during this time interval was much more variable than previously presumed
An accountability model for Pakeha practitioners
No full textThis paper outlines a model of accountability for Pakeha practitioners developed over many years
as a practising community psychologist involved in research and development projects in Aotearoa
in the 1980s and 1990s, during an era of contract-funded health projects, and increasing
prominence of the Treaty of Waitangi2. The model could be termed 'transformative' in that it
reverses the usual flow of power by making the Pakeha practitioner accountable to relevant Maori
authority, and maximises the potential for new outcomes and new learning for all parties. A brief
case study is outlined where the model placed a local iwi governance structure and a national
psychiatric survivor organisation in positions of authority alongside the funder of a mental health
project. Helpful conditions, positive outcomes and barriers to transformative accountability
processes are briefly discussed
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