20 research outputs found
ROLE OF POLITICAL PARTY MOUTHPIECES IN DIGITAL POLITICAL COMMUNICATION:
No full textA party mouthpiece is a newspaper, broadcast channel, media outlet, or any medium of communication that expresses the opinion of the government, political party or any political organization. The study focused on digital content analysis of mouthpieces of two ideologically opposing mainstream Indian political parties - Indian National Congress (INC) and Bharatiya Janata Party (BJP) with respect to key political developments in 2019. The events selected for study were – Lok Sabha Election Results 2019, Amendment of Article 370, Ram Mandir Verdict by the Supreme Court of India and the passage of Citizenship Amendment Act (CAA). The e-version of the mouthpieces Congress Sandesh and Kamal Sandesh were chosen for the study with an aim to determine the nature of digital political narratives constructed around these political events. Congress Sandesh (directing to National Herald) was actively seen providing an oppositional narrative to BJP’s “majoritarian nationalism'' using rhetorical communication as it accused the BJP of being divisive. Congress is projected as a party that represents interests of religious minorities; safeguards Indian democracy and its secular values. Contrary to the INC’s political narratives in the digital space, the BJP through Kamal Sandesh identified itself as the only corruption free government since independence, a party that opposes sectarian vote bank politics, dynasty politics, advocates religious rights of the majority and promotes meritocracy. The study demonstrates how political actors use digital spaces other than social media platforms to further their political agendas and establish a community of digital audiences who consume such content to reinforce their political beliefs and identities
An exploratory study on gathering evidences and forms of evidences for successful forensic audit
No full textEvidence is one of the powerful tool required to complete any forensic accounting assignment successfully, keeping in mind this requirement author has tried to elaborate on term evidence its meaning and the different forms in this research paper. This clarity of idea will also help forensic auditor for giving decision on many forensic audits. The researcher has tried to explain in detail the evidence, importance of evidence, forms of evidence and techniques for gathering the evidences in this paper
Theatre of independent India: Indian drama written in English
No full textThe study focuses on the situation of drama written in the English language whose authors are Indians. Particular attention is paid to the development of drama in the English language in India after 1947, e.g. in the period after gaining the independence, up to the present. Having outlined the main trends, the author deals with work of two dramatists, whose pieces enjoy a considerable public reception on stages in India as well as internationally. They are Girish Karnad and Mahesh Dattani. Both of them create in the spirit of mutually different streams of modern Indian drama. In Karnad's play The Fire and the Rain and in Dattani's Tara, the author particularly observes those aspects that depose of the playwright's approach to psychological, social and mythological themes. The aim of the study is, above all, to offer a basic survey of the issue that has been recently attracting attention of Western theatre studies.The study focuses on the situation of drama written in the English language whose authors are Indians. Particular attention is paid to the development of drama in the English language in India after 1947, e.g. in the period after gaining the independence, up to the present. Having outlined the main trends, the author deals with work of two dramatists, whose pieces enjoy a considerable public reception on stages in India as well as internationally. They are Girish Karnad and Mahesh Dattani. Both of them create in the spirit of mutually different streams of modern Indian drama. In Karnad's play The Fire and the Rain and in Dattani's Tara, the author particularly observes those aspects that depose of the playwright's approach to psychological, social and mythological themes. The aim of the study is, above all, to offer a basic survey of the issue that has been recently attracting attention of Western theatre studies
Erratum:Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development (Proceedings of the National Academy of Sciences of the United States of America (2019) 116 (22754-22763) DOI: 10.1073/pnas.1908762116)
No full textCorrection for "Mutations in thyroid hormone receptor á1 cause premature neurogenesis and progenitor cell depletion in human cortical development," by Teresa G. Krieger, Carla M. Moran, Alberto Frangini, W. Edward Visser, Erik Schoenmakers, Francesco Muntoni, Chris A. Clark, David Gadian, Wui K. Chong, Adam Kuczynski, Mehul Dattani, Greta Lyons, Alexandra Efthymiadou, Faraneh Varga-Khadem, Benjamin D. Simons, Krishna Chatterjee, and Frederick J. Livesey, which was first published October 18, 2019; 10.1073/pnas.1908762116 (Proc. Natl. Acad. Sci. U.S.A. 116, 22754-22763). The authors note that "In Fig. 4D, the horizontal line that highlights the comparison between neuronal activity in the three control lines and one of the three THRA mutant lines was drawn to end above the TRá1-FS382 mutation, rather than the TRá1- FS397 mutation. The placement of the horizontal line incorrectly indicated that neuronal activity in TRá1-FS382 mutation neurons was significantly lower than that of controls, whereas activity in TRá1-FS397 neurons was not. The figure has been amended, and now the horizontal line correctly indicates that neuronal activity in TRá1-FS397 neurons was significantly lower than that of controls, whereas activity in TRá1-FS382 neurons was not. We apologize for any confusion this labeling error may have caused." The corrected Fig. 4 and its legend appear below. The authors also note that the author name Faraneh Varga- Khadem should instead appear as Faraneh Vargha-Khadem. The corrected author line appears below. The online version has been corrected.</p
HOW TO CALCULATE SPIN-SPIN COUPLING AND SPIN-ROTATION COUPLING STRENGTHS AND THEIR UNCERTAINTIES FROM SPECTROSCOPIC DATA: APPLICATION TO THE STATE OF DIATOMIC LITHIUM
No full textAuthor Institution: Department of Chemistry, Oxford University, Oxford, OX1 3QZ, UK; Chemical Science Division, Lawrence Berkeley National Laboratory, Berkeley, 94720-8176, USARecent high-resolution ( cm) photo-association spectroscopy (PAS) data of seven previously unexplored vibrational levels of the state of Li have allowed for the first ever experimental determination of the spin-spin and spin-rotation coupling constants in a diatomic lithium system, XX (2013)}. For triplet states of diatomic molecules such as the state of Li, the three spin-spin/spin-rotation resolved energies associated with a ro-vibrational state were expressed explicity in terms of and in 1929 by Kramer's first-order formulas, 422 (1929)} and then in 1937 by Schlapp's more refined formulas, 342 (1937)}. Given spectroscopic data, while it has never been difficult to extract and from Schlapp's formulas, it has been a challenge to reliably predict how accurate these extracted values are. This is for two reasons: (1) the lack of a rigorous method to estimate the uncertainty in , (2) the non-linearity of Schlapp's coupled equations has meant that traditionally they have had to be solved numerically by Newton iterations which makes error propagation difficult. The former challenge has been this year solved by Le Roy with a modification of Hutson's perturbation theory of, 851 (1981)}, and the latter problem has now been solved by symbolic computing software that solves Schlapp's coupled non-linear equations analytically for the first time since their introduction in 1937
Do good health and material circumstances protect older people from the increased risk of death after bereavement?
No full textThis is an open access Article. Copyright @ 2012 The AuthorsAn increased risk of death in persons who have suffered spousal bereavement has been described in many populations. The impact of modifying factors, such as chronic disease and material circumstances, is less well understood. The authors followed 171,120 couples 60 years of age or older in a United Kingdom primary care database between 2005 and 2010 for an average of 4 years. A total of 26,646 (15.5%) couples experienced bereavement, with mean follow up after bereavement of 2 years. In a model adjusted for age, sex, comorbid conditions at baseline, material deprivation based on area of residence, season, and smoking status, the hazard ratio for mortality in the first year after bereavement was 1.25 (95% confidence interval: 1.18, 1.33). Further adjustment for changes in comorbid conditions throughout follow up did not alter the hazard ratio for bereavement (hazard ratio = 1.27, 95% confidence interval: 1.19, 1.35). The association was strongest in individuals with no significant chronic comorbid conditions throughout follow up (hazard ratio = 1.50, 95% confidence interval: 1.28, 1.77) and in more affluent couples (P = 0.035). In the first year after bereavement, the association between bereavement and death is not primarily mediated through worsening or new onset of chronic disease. Good health and material circumstances do not protect individuals from increased mortality rates after bereavement.This study was funded by a grant from the Dunhill Medical Trust
ARNT2 mutation causes hypopituitarism, post-natal microcephaly, visual and renal anomalies
No full textWe describe a previously unreported syndrome characterized by secondary (post-natal) microcephaly with fronto-temporal lobe hypoplasia, multiple pituitary hormone deficiency, seizures, severe visual impairment and abnormalities of the kidneys and urinary tract in a highly consanguineous family with six affected children. Homozygosity mapping and exome sequencing revealed a novel homozygous frameshift mutation in the basic helix-loop-helix transcription factor gene ARNT2 (c.1373-1374dupTC) in affected individuals. This mutation results in absence of detectable levels of ARNT2 transcript and protein from patient fibroblasts compared with controls, consistent with nonsense-mediated decay of the mutant transcript and loss of ARNT2 function. We also show expression of ARNT2 within the central nervous system, including the hypothalamus, as well as the renal tract during human embryonic development. The progressive neurological abnormalities, congenital hypopituitarism and post-retinal visual pathway dysfunction in affected individuals demonstrates for the first time the essential role of ARNT2 in the development of the hypothalamo-pituitary axis, post-natal brain growth, and visual and renal function in humans. © 2013 The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved
Placement Podcasts - The University of Huddersfield Experience
No full textTheme: Innovative Projects
Title: Placement Podcasts
The University of Huddersfield Experience
Lisa Ward, TQEF Work Placement and Project Manager, Vice Chancellor’s Office,
University of Huddersfield, [email protected]
Jane Gaffikin, TQEF Project Officer Vice Chancellor’s Office,
University of Huddersfield, [email protected]
Synopsis
Aims and Objectives
The University of Huddersfield is one of the top five providers of sandwich education in the UK. However, like many institutions in the UK, we are aware that as student expectations change, we need to do more to encourage our students to take up the wide variety of sandwich and other work placement opportunities available.
Anecdotal evidence has shown that the best ambassadors for placements are the students who have al-ready benefited from them. Therefore we have instigated an original project entitled ‘Placement Pod casts’ to film and / or audio record students talking about their placement experiences. This material will be used to encourage students to take up placement opportunities and to market the University as a centre of excellence for sandwich placements and other work placement opportunities.
Experiences Covered
The paper addresses the following themes:
• Industry experiences including service, healthcare and other sectors. The students that we are film-ing come from traditional areas of student placements, and newer areas including nursing, social work and careers guidance.
• Best practices: The traditional area of written case studies is well developed. This project looks at moving this forward.
• Enabling Technologies: How we intend to host the finished ‘pod casts’ and ‘videos’ on technolo-gies such as the web and DVD.
Issues to be addressed
We are currently in the early phases of this project. Initial filming has taken place of a group of stu-dents. The paper will discuss technical and practical issues associated with the project. My intention is to showcase a short film showing the work that we have done.
The author will then request audience participation in answering the question: ‘Why and how have stu-dent expectations changed vis-à-vis sandwich programmes, and how does technology like pod casts meet the new expectations?
Transcriptomic sex differences in early human fetal brain development
No full text\ua9 The Author(s) 2025.The influence of sex chromosomes and sex hormones on early human brain development is poorly understood. We therefore undertook transcriptomic analysis of 46,XY and 46,XX human brain cortex samples (n = 64) at four different time points between 7.5 and 17 weeks post conception (wpc), in two independent studies. This developmental period encompasses the onset of testicular testosterone secretion in the 46,XY fetus (8wpc). We show differences in sex chromosome gene expression including X-inactivation genes (XIST, TSIX) in 46,XX samples; core Y chromosome genes (n = 18) in 46,XY samples; and two Y chromosome brain specific genes, PCDH11Y and RP11-424G14.1. PCDH11Y (protocadherin11 Y-linked) regulates excitatory neurons; this gene is unique to humans and is implicated in language development. RP11-424G14.1 is a long non-coding RNA. Fewer differences in sex hormone pathway-related genes are seen. The androgen receptor (AR, NR3C4) shows cortex expression in both sexes, which decreases with age. Global cortical sex hormone effects are not seen, but more localized AR mechanisms may be important with time (e.g., hypothalamus). Taken together, our data suggest that limited but potentially important sex differences occur during early human fetal brain development. (Figure presented.
Leptin and adiponectin in children and young persons with congenital adrenal hyperplasia
No full text\ua9 The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.OBJECTIVES: Patients with congenital adrenal hyperplasia (CAH) have increased prevalence of metabolic problems. We studied adiponectin, leptin and resistin in children with CAH, in relation to BMI, treatment, hormonal and metabolic biomarkers. DESIGN AND METHODS: We analysed 101 patients with 21-hydroxylase deficiency (54 females, 13.0 \ub1 2.92 years) from 13 centres in the United Kingdom, and 83 sex- and age-matched controls. Blood parameters (leptin, adiponectin, resistin, metabolic and hormonal markers) were measured in fasted state, between 09:00 and 11:00, after the first glucocorticoid (GC) dose. RESULTS: A difference in adipokines between patients and controls was only found for leptin in males (patients > control, P = .033). In patients and controls, leptin had a positive relationship with BMI-SDS (P < .001). However, adiponectin decreased with the BMI only in patients (P < .001). Contrary to published evidence on the effect of synthetic steroids on leptin, in our cohort, leptin decreased with the increasing first daily hydrocortisone (HC) dose (Log10Leptin = 4.1- 0.08xfirstGCdose (mg/m2), P = .009) but not with the total daily dose. When correcting for BMI, a positive relationship between leptin and insulin was only found in controls (P < .001). Adiponectin decreased with steroid precursor and androgen concentrations (17-hydroxyprogesterone, androstenedione, testosterone, 11-hydroxyandrostenedione, 11-ketotestosterone) in patients. CONCLUSION: Our findings indicate a decrease in leptin with the HC dose, consistent with a detrimental effect of glucocorticoid on satiety and hunger pathways in CAH. Adiponectin was decreased in patients with increased androgens concentrations, suggesting it may be used as an indicator of metabolic risk associated with poor hormonal CAH control
