1,721,021 research outputs found
Professor Ruth Duncan: a pioneer in the field of polymer therapeutics
Full text linkThis special issue of the Journal of Drug Targeting marks the past, and the continuing contribution of Ruth Duncan to the field of drug delivery, more specifically the branch termed ‘Polymer Therapeutics’. The three of us have witnessed, for more than 20 years, Ruth’s never-ending enthusiasm and persistence in many different interdisciplinary arenas under this banner, and the immense scientific contribution to the field of drug delivery this vision (and tenacity) has generated. It has been a pleasure for us to edit this special issue, which pays tribute to her outstanding achievements within the context of the Journal of Drug Targeting’s Lifetime Achievement Award for 2017
Dendrimer biocompatibility and toxicity
No full textThe field of biomedical dendrimers is still in its infancy, but the explosion of interest in dendrimers and dendronised polymers as inherently active therapeutic agents, as vectors for targeted delivery of drugs, peptides and oligonucleotides, and as permeability enhancers able to promote oral and transdermal drug delivery makes it timely to review current knowledge regarding the toxicology of these dendrimer chemistries (currently under development for biomedical applications). Clinical
experience with polymeric excipients, plasma expanders, and most recently the development of more "classical polymer"-derived therapeutics can be used to guide development of "safe" dendritic polymers. Moreover, in future it will only ever be possible to designate a dendrimer as "safe" when related to a specific application. The so far limited clinical experience using dendrimers make it impossible to designate any particular chemistry intrinsically "safe" or "toxic". Although there is widespread concern as to the safety of nano-sized particles, preclinical and clinical experience gained during the development of polymeric excipients, biomedical polymers and polymer therapeutics shows that judicious development of dendrimer chemistry for each specific application will ensure development of safe and important materials for biomedical and pharmaceutical use
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
In honour of Professor Ruth Duncan, recipient of the Journal of Drug Targeting’s Lifetime Achievement Award for 2017
No full textA photograph of Professor Ruth Duncan, recipient of the Journal of Drug Targeting’s Lifetime Achievement Award for 2017 (courtesy of R. Duncan).It is the time of year to honour the recipient of the Journal of Drug Targeting’s Life-time Achievement Award for 2017. The Lifetime Achievement Award is an unsolicited award given annually to honour the sustained outstanding scientific achievements of a researcher working in the broad fields of drug delivery and targeting. This year’s winner as always was selected by a scientific panel comprising members of the Editorial board and representatives from Taylor and Francis, the publishers of Journal of Drug Targeting.
It gives me great personal pleasure to announce that Professor Ruth Duncan is the recipient of this year’s Journal of Drug Targeting’s Lifetime Achievement Award for her life-long, high profile, translational research into polymer-based drug delivery systems – a field she prefers to call ‘polymer therapeutics’. Prof Duncan was formerly a Director of the Centre for Polymer Therapeutics at the Welsh School of Pharmacy, Cardiff University, UK – where I had the pleasure of being her colleague after she played a key role in my recruitment as Professor of Drug Delivery in the same school in 2002. Ruth currently holds the honorary positions of Professor Emerita at Cardiff University, and Visiting Professorships at the University of Greenwich, UK, and Centro de Investigación Príncipe Felipe, Valencia, Spain. As a reflection of her extensive multidisciplinary skills, Ruth has previously held posts of ‘Professor of Cell Biology and Drug Delivery’ at the School of Biological Sciences, University of Keele, UK, and at the School of Pharmacy, University of London (now University College, London). She is a graduate of Liverpool University (BSc in Zoology) and Keele University (PhD awarded in 1979) where she studied cell uptake mechanisms involving pinocytosis/endocytosis and lysosomal trafficking.Scopu
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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