34,037 research outputs found
NCAM1, TACR1 and NOS Genes and Temperament: A Study on Suicide Attempters and Controls
No full textSuicide, one of the leading causes of death among young adults, seems to be plausibly modulated by both genetic and personality factors. The aim of this study was to dissect the potential association between genetics and temperament in a sample of 111 suicide attempters and 289 healthy controls. We focused on 4 genes previously investigated in association with suicide on the same sample: the nitric oxide synthase 1 and 3 (NOS1 and NOS3), the neuronal cell adhesion molecule 1 (NCAM1), and the tachykinin receptor 1 (TACR1) genes. In particular, we investigated whether a set of genetic variants in these genes (NOS1 : rs2682826, rs1353939, rs693534; NOS3 : rs2070744, rs1799983, rs891512; NCAM1 : rs2301228, rs1884, rs1245113, rs1369816, rs2196456, rs584427; TACR1 : rs3771810, rs3771825, rs726506, rs1477157) were associated with temperamental traits at the Temperament and Character Inventory (TCI). No strong evidence was found for the association between TCI personality traits and the polymorphisms considered in the 4 genes, with the exception of an association between reward dependence trait and the rs2682826 SNP in NOS1 in the healthy sample. However, this result could be plausibly interpreted as a false-positive finding. In conclusion, our study did not support the thesis of a direct modulation of these genes on temperament; however, further studies on larger samples are clearly required in order to confirm our preliminary findings and to exclude any possible minor influence. Copyright (C) 2011 S. Karger AG, Base
Possible biomarkers modulating haloperidol efficacy and/or tolerability
No full textHaloperidol (HP) is widely used in the treatment of several forms of psychosis. Despite of its efficacy, HP use is a cause of concern for the elevated risk of adverse drug reactions. adverse drug reactions risk and HP efficacy greatly vary across subjects, indicating the involvement of several factors in HP mechanism of action. The use of biomarkers that could monitor or even predict HP treatment impact would be of extreme importance. We reviewed the elements that could potentially be used as peripheral biomarkers of HP effectiveness. Although a validated biomarker still does not exist, we underlined the several potential findings (e.g., about cytokines, HP metabolites and genotypic biomarkers) which could pave the way for future research on HP biomarkers
Personality and attempted suicide. Analysis of anger, aggression and impulsivity
No full textSuicide is one of the leading causes of death worldwide, mortality from suicide being approximately 2%. Attempted suicide appears to be a major risk factor for suicide completion. Anger, aggression and impulsivity are personality traits associated with suicide attempt. In this study we analysed a part of a previously reported sample in order to test anger, impulsivity and temperament/character scales as predictors of aggression and self-aggression in suicide attempters and to compare anger- and aggression-related traits between impulsive and premeditated suicide attempts as well as between violent and non-violent suicide methods. One-hundred-eleven consecutively admitted inpatients with a lifetime history of attempted suicide were assessed for anger (State-Trait Anger Expression Inventory, STAXI), aggression (Questionnaire for Measuring Factors of Aggression, FAF) and temperament/character (Temperament and Character Inventory, TCI). Higher aggression scores, as measured by FAF, were predicted by being male, meeting criteria for borderline personality disorder and having higher angry temperament scores as assessed by STAXI; low cooperativeness was also associated with aggression but not after controlling for STAXI scales. TCI dimensions associated with self-aggression were high harm avoidance, high impulsivity and low self-directedness; state anger, inwardly directed anger and inhibition of aggression were also predictors of self-aggression. In conclusion, impulsivity and harm avoidance have emerged as temperament dimensions independently associated with self-aggressive tendencies in personality. Such interactions could explain the correlation between temperament and suicidality but further research is needed. Anger and self-directedness appear to have some effects on suicide attempt. © 2009 Elsevier Ltd. All rights reserved
Alaskan Author and Historian Dan O'Neill
No full textDan O'Neill has become a living legend in Alaska. He is the author of The Firecracker Boys: H-Bombs, Inupiat Eskimos, and the Roots of the Environmental Movement; A Land Gone Lonesome: An Inland Voyage Along the Yukon River; The Last Giant of Beringia: The Mystery of the Bering Land Bridge, and recently Stubborn Gal: The True Story of an Undefeated Sled Dog Racer, a children's book published by the University of Alaska Press. Dan came to Alaska in 1975 and has done a variety of things including dog mushing, trapping, hunting, working in construction, and on the pipeline. As research associate at the UAF Oral History program, he produced radio and television documentaries for public broadcasting, and for several years he wrote a column of political opinion for the Fairbanks Daily News-Miner
S24-01 - Neuroticism: an Intermediate Phenotype for Major Depression
No full textThere is strong evidence for a heritability of major depression as shown by family, twin- and adoption studies. Several studies suggest a heritability for unipolar depression between 35 and 75% which is much lower than the heritability of bipolar disorder or schizophrenia. There is no doubt, that major depression is not caused by any single gene but it is a disease with complex genetic features. Furthermore, some subtypes, as early-onset or recurrent depression may have a higher heritability than other forms of depression. Neuroticism as an intermediate phenotype of MDD, which is a trait that reflects a tendency toward negative mood states, and has been linked to internalizing depressive conditions. For these reasons Dan Rujescu will present genome-wide and candidate gene studies, demonstrating a genetic approach for discovering potentially important pathogenic pathways for which clinically powerful (bio)markers may eventually be developed. He will discuss neuroticism as an intermediate phenotype of MDD, which is a trait that reflects a tendency toward negative mood states and has been linked to internalizing depressive conditions.</jats:p
Maoa and Maob polymorphisms and personality traits in suicide attempters and healthy controls: a preliminary study
No full textSerotonergic neurotransmission dysfunctions have been well documented in patients with suicidal behaviour. We investigated monoamine oxidase A (MAOA: rs2064070, rs6323, rs909525) and B (MAOB: rs1799836, rs2311013, rs2205655) genetic modulation of personality traits (Temperament and Character Inventory, TCI) as endophenotype for suicidal behaviour. 108 suicide attempters and 286 healthy controls of German origin were screened. Among females, allelic analyses revealed associations between MAOA rs6323 A allele and higher Harm Avoidance in suicide attempters and MAOB rs2205655 A allele and higher Cooperativeness scores in healthy controls. Among males, MAOA rs909525 A allele was associated with higher Reward Dependence in suicide attempters. Multivariate analyses controlling for age and educational level mainly confirmed results. Case-control analyses in this subsample do not differ from our previously reported one. Despite of the small sample size, a possible involvement of these genes in the modulation of personality traits closely related to suicidal behaviour cannot be excluded
PERANCANGAN APLIKASI ELECTRONIC MEDICAL RECORD (EMR) PADA INSTALASI RAWAT INAP BERBASIS WEB
No full textPelayanan medik dewasa ini membutuhkan sistem yang lebih efektif dan efisien, baik dalam
penggunaan waktu, tenaga maupun sarana. Dalam pengelolaan rekam medik, kenyataan masih
umumnya penggunaan rekam medik manual yang dinilai tak lagi andal menangani data medik
melahirkan ide konversi rekam medik manual kertas ke rekam medik elektronik karena efektivitas dan
efisiensinya.
Penelitian ini bertujuan menciptakan aplikasi rekam medik elektronik yang lebih dikenal
sebagai EMR (Electronic Medical Record) dari rekam medik kertas di Instalasi Rawat Inap Rumah
Sakit Umum Ananda Salatiga. Rekam medik elektronik dirancang dengan membuat form-form isian
catatan-catatan medik dalam proses perawatan pasien selama dirawat. Data-data medik ini kemudian
disimpan dalam basis data sistem dan dikelola secara digital. Setiap kali pengisian data medik pada
form-form tertentu, sistem akan menghasilkan kode yang membawa informasi khusus.
Pada akhirnya, sistem akan menghasilkan deret kode ICD (International Statistical
Classification of Diseases and Related Health Problems) dari kode-kode yang dihasilkan pada
pengisian form-form catatan medik. Deretan kode-kode ini mampu menggambarkan perkembangan
kondisi pasien dan penanganan medik yang diberikan selama perawatan. Data-data medik yang
tersimpan dapat ditampilkan kembali dalam bentuk catatan medik digital.
Kata kunci: rekam medik, rawat inap, EMR, IC
Correspondence regarding the possiblity of a Kephart Memorial
No full textThis 1968 correspondence, between Jackson E. Price and Dan Davis, discusses the possibility of “Memorial Center” to Horace Kephart (1862-1931), noted naturalist, woodsman, journalist, and author and promoter of the Great Smoky Mountains National Park
Analisis Tata Kelola Maritim Indonesia: Implementasi Visi Pemerintah Daerah Istimewa Yogyakarta
No full textIndonesia sebagai negara maritim memiliki banyak peluang dan ancaman. Hal tersebut memerlukan adanya perhatian yang lebih besar terhadap wilayah laut. Penelitian ini membahas strategi Pemerintah Indonesia untuk meningkatkan peluang ekonomi dan mengatasi tantangan melalui Poros Maritim Dunia. Tujuan riset ini adalah menganalisa kebijakan Pemerintah Indonesia dan Pemerintah Provinsi Daerah Istimewa Yogyakarta (DIY) dalam pengembangan wilayah pesisir menggunakan teori geopolitik dan teori kekuatan laut. Penelitian ini menerapkan metode kualitatif studi kasus. Data yang digunakan berupa data primer melalui wawancara dan data sekunder yang diperoleh dari buku, artikel jurnal dan publikasi daring. Penulis menemukan bahwa sinergitas penegak hukum, diplomasi maritim sudah cukup baik, namun perlu lebih aktif melibatkan masyarakat untuk pengelolaan sumber daya hayati yang berkelanjutan dan peningkatan SDM masyarakat pesisir. Sementara Visi Gubernur DIY bernama Abad Samudera Hindia belum terlaksana dengan maksimal. Masyarakat membutuhkan tambahan pembangunan TPI baru dan pengembangan TPI menjadi PPN dan PPS untuk meningkatkan produktivitas dan kesejahteraan nelayan. Dapat disimpulkan bahwa pemerintah pusat dan daerah harus selalu memperhatikan pengelolaan laut, khususnya untuk pemanfaatan sumber daya dan pangan. Bahwa laut memiliki kekayaan alam yang berlimpah dapat digunakan meningkatkan gizi masyarakat dan pendapatan negara. Title: Indonesian Maritime Governance Analysis: Implementation of the Vision of the Yogyakarta Special Region GovernmentIndonesia, as a maritime country, has many opportunities and threats. This condition requires greater attention to the sea area. This research discusses the strategy of the Government of Indonesia to increase economic opportunities and overcome challenges through the World Maritime Fulcrum. This research aims to analyze the policies of the Government of Indonesia and the Provincial Government of DIY in developing coastal areas using geopolitical theory and the theory of sea power. This study uses a qualitative case study method. The data used are primary data through interviews and secondary data obtained from books, journal articles and online publications. The author finds that the synergism between law enforcement and maritime diplomacy is good enough. However, it is necessary to involve the community more actively in the sustainable management of biological resources and to increase the human resources of coastal communities. Meanwhile, the vision of the Governor of DIY called the Century of the Indian Ocean, has not been implemented optimally. The community needs additional construction of new TPI and development of TPI to become PPN and PPS to increase the productivity and welfare of fishermen. It can be concluded that the central and regional governments must always pay attention to marine management, especially for utilising resources and food. That the sea has abundant natural wealth can be used to improve people’s nutrition and state income
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