77 research outputs found
The method of instructing children rationally in the arts of writing and reading. By J. Neef.
No full text338 p
Manfred Max Neef y la revolución ambientalista para América Latina, 1932-2019 (in memoriam)
No full textWith the article, it is offered a tribute to the work of Manfred Max Neef, Chilean intellectual,
politician, ecologist and economist, Alternative Nobel Prize winner in Economics, a pioneer in ecological
criticism of both productivism and extractivism in Latin America. The methodology used in this work
is based on the review of the main books published by the author, such as Barefoot Economy (1982),
Development on a Human Scale (1986), The Lost Dimension (2007), and The Unmasked Economy
(2014). It is held as an assumption that Max Neef’s work fits into a Latin American theoretical body,
which breaks intellectually with macroeconomic models, be they developmentalist or neoliberal in
nature. The originality of his contribution is in the defense of the ecological foundations for human
development at a local scale.Con el artículo, se ofrece un homenaje a la obra de Manfred Max Neef, intelectual, político, eco-
logista y economista chileno, Premio Nobel Alternativo en Economía, pionero en la crítica ecológica,
tanto en el productivismo como en el extractivismo en América Latina. La metodología empleada
en este trabajo se funda en la revisión de los principales libros publicados por el autor, tales como
Economía descalza (1982), Desarrollo a escala humana (1986), La dimensión perdida (2007) y La
economía desenmascarada (2014). Se sostiene como supuesto que la obra de Max Neef se encuadra
en un cuerpo teórico latinoamericano, que rompe intelectualmente con los modelos macroeconómi-
cos, sean de corte desarrollista o de tipo neoliberal. La originalidad de su aporte se encuentra en la
defensa de los fundamentos ecológicos para el desarrollo humano a una escala local
Author response: The synaptic ribbon is critical for sound encoding at high rates and with temporal precision
No full textWe studied the role of the synaptic ribbon for sound encoding at the synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in mice lacking RIBEYE (RBEKO/KO). Electron and immunofluorescence microscopy revealed a lack of synaptic ribbons and an assembly of several small active zones (AZs) at each synaptic contact. Spontaneous and sound-evoked firing rates of SGNs and their compound action potential were reduced, indicating impaired transmission at ribbonless IHC-SGN synapses. The temporal precision of sound encoding was impaired and the recovery of SGN-firing from adaptation indicated slowed synaptic vesicle (SV) replenishment. Activation of Ca2+-channels was shifted to more depolarized potentials and exocytosis was reduced for weak depolarizations. Presynaptic Ca2+-signals showed a broader spread, compatible with the altered Ca2+-channel clustering observed by super-resolution immunofluorescence microscopy. We postulate that RIBEYE disruption is partially compensated by multi-AZ organization. The remaining synaptic deficit indicates ribbon function in SV-replenishment and Ca2+-channel regulation
Author response: Gender bias in scholarly peer review
No full textPeer review is the cornerstone of scholarly publishing and it is essential that peer reviewers are appointed on the basis of their expertise alone. However, it is difficult to check for any bias in the peer-review process because the identity of peer reviewers generally remains confidential. Here, using public information about the identities of 9000 editors and 43000 reviewers from the Frontiers series of journals, we show that women are underrepresented in the peer-review process, that editors of both genders operate with substantial same-gender preference (homophily), and that the mechanisms of this homophily are gender-dependent. We also show that homophily will persist even if numerical parity between genders is reached, highlighting the need for increased efforts to combat subtler forms of gender bias in scholarly publishing
Modelling Capillary Effects in Heterogeneous Porous Media
No full textElectrical Engineering, Mathematics and Computer Scienc
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis
No full textWe have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of polo-like kinase 1 (Plk1). MKlp2 is a target for Plk1, and phosphorylated MKlp2 binds to the polo box domain of Plk1. Plk1 also binds directly to microtubules and targets to the central spindle via its polo box domain, and this interaction controls the activity of Plk1 toward MKlp2. An antibody to the neck region of MKlp2 that prevents phosphorylation of MKlp2 by Plk1 causes a cytokinesis defect when introduced into cells. We propose that phosphorylation of MKlp2 by Plk1 is necessary for the spatial restriction of Plk1 to the central spindle during anaphase and telophase, and the complex of these two proteins is required for cytokinesis
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
No full textMitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of the Aurora B kinase. Previously, we have demonstrated that MKlp2 recruits Polo-like kinase 1 (Plk1) to the central spindle in anaphase. We now find that in MKlp2 but not MKlp1-depleted cells the Aurora B-INCENP complex remains at the centromeres and fails to relocate to the central spindle. MKlp2 exerts dual control over Aurora B localization, because it is a binding partner for Aurora B, and furthermore for the phosphatase Cdc14A. Cdc14A can dephosphorylate INCENP and may contribute to its relocation to the central spindle in anaphase. We propose that MKlp2 is involved in the localization of Plk1, Aurora B, and Cdc14A to the central spindle during anaphase, and that the integration of signaling by these proteins is necessary for proper cytokinesis
Social indicators for real-life economics
No full textDiscusses three approaches to measuring social welfare which might overcome the problems and limitations inherent in the use of GNP statistics. The first is a modified and improved GNP; the second is a quality of life (QOL) measurement arrived at either by condensing statistics into one scale or by using subjective indicators such as how happy people say they are; and the third approach uses social reports which summarise aspects of welfare but does not attempt to give a single statistic. The author argues that the first and the third lines of analysis are of most value and suggest a four-component indicator framework. This comprises: environmental and resource accounts; an adjusted National Product; a household production account; and a social indicator framework. -M.Amos</p
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