323,202 research outputs found
Mikrochemische Untersuchungen der rothen Blutkörperchen
No full textMIKROCHEMISCHE UNTERSUCHUNGEN DER ROTHEN BLUTKÖRPERCHEN
Mikrochemische Untersuchungen der rothen Blutkörperchen (1) (-
Verzeichniss dreier Sammlungen aus dem Nachlasse von Kunstliebhabern und im rothen Collegio versteigert werden soll
No full textVERZEICHNISS DREIER SAMMLUNGEN AUS DEM NACHLASSE VON KUNSTLIEBHABERN UND IM ROTHEN COLLEGIO VERSTEIGERT WERDEN SOLL
Verzeichniss dreier Sammlungen aus dem Nachlasse von Kunstliebhabern und im rothen Collegio versteigert werden soll ([I])
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Titelseite ([I])
[Vorwort] ([III])
A. ([1])
B. (2)
C. (8)
D. (13)
E. (17)
F. (18)
G. (19)
H. (20)
I. / K. (21)
L. (22)
M. (24)
N. (29)
O. / P. (30)
R. (34)
S. (39)
T. (45)
U. / V. (46)
W. (49)
Z. (52)
Zeichnungen (52)
Kupferstiche (62)
Handzeichnungen (126)
Englische Karrikaturenkupferstiche (127)
Kupferstiche (127)
Kupferstichwerke (169)
Handzeichnungen (172)
Kupferstiche (178)
Originalhandzeichnungen (180)
Kupferstiche (181)
Unbekannte altdeutsche Meister (195)
Handzeichnungen (195)
Kupferstiche (198)
Kupferstichmappen (206
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Reinstating location improves mnemonic access but not fidelity of visual mental representations
No full textSee: Martarelli, C. S., Ovalle-Fresa, R., Popic, D., Globig, L. K., & Rothen, N. (accepted). Reinstating location improves mnemonic access but not fidelity of visual mental representations. Cortex
Silica nanoparticles and their interaction with cells : a multidisciplinary approach
No full textSilica nanoparticles are increasingly used as drug delivery systems and for biomedical imaging.
Therapeutic and diagnostic agents can be incorporated into the silica matrix to improve the stability
and solubility of hydrophobic drugs in biological systems. However, the safety of silica
nanoparticles as drug carriers remains controversial. To date, no validated and accepted nanospecific
tests exist to predict the potentially harmful impact of these materials on the human body.
The mechanism proposed for hemolysis of unmodified silica nanoparticles is based on the electrostatic
interaction between the silanol surface groups and the quaternary ammonium in the choline
head group of the phospholipids. However, a detailed understanding of this process is missing.
In this thesis, different silica nanoparticles where synthesized, characterized, and tested in two cell
lines regarding viability and oxidative stress. Hemolysis was assessed using red blood cells. Furthermore,
the hemolytic mechanism of a chosen silica nanoparticle type was investigated in depth
using a biophysical chemistry approach. We used the dye-leakage assay, isothermal titration
calorimetry, solid state nuclear magnetic resonance, and flow cytometry to elucidate this mechanism.
Our results revealed that silica nanoparticles with a porous surface and negative surface charge
had the strongest impact on viability in a concentration dependent manner. This is in contrast to
non-porous silica nanoparticles. None of the studied particles caused oxidative stress in either cell
lines. Particles with a negative surface charge induced hemolysis. The mechanism responsible for
the hemolysis for silica nanoparticles had no electrostatic component. The nuclear magnetic resonance
data revealed no interaction with the choline group. However, nuclear magnetic resonance
data suggested the presence of faster tumbling species.
Our toxicological and mechanistic studies showed potential hazards of spherical amorphous silica
nanoparticles. Physico-chemical properties mediating toxicity in living cells were identified.
We propose that our standardized silica nanoparticles may serve as a readily available reference
material for nanotoxicological investigations. Mechanistic data did not support an electrostatic
interaction as postulated in the literature, but rather a strong adsorption process that may lead
to hemolysis. Furthermore, the presence of faster tumbling species suggested the formation of
smaller lipid bilayer structures upon silica nanoparticles exposure. Flow cytometry data revealed
that their size is about 100 nm. It remains to be proven if the bilayer wraps around the hemolytic
silica nanoparticles, if an exclusive formation of smaller species without wrapping is present, or
both of the aforementioned
Reinstating location improves mnemonic access but not fidelity of visual mental representations
No full textSee: Martarelli, C. S., Ovalle-Fresa, R., Popic, D., Globig, L. K., & Rothen, N. (accepted). Reinstating location improves mnemonic access but not fidelity of visual mental representations. Cortex
Reinstating location improves mnemonic access but not fidelity of visual mental representations
No full textSee: Martarelli, C. S., Ovalle-Fresa, R., Popic, D., Globig, L. K., & Rothen, N. (accepted). Reinstating location improves mnemonic access but not fidelity of visual mental representations. Cortex
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