1,658 research outputs found
The American Elsewhere: Adventure And Manliness In The Age Of Expansion
No full textInterview with Jimmy L. Bryan Jr., author of The American Elsewhere: Adventure and Manliness in the Age of Expansion Interviewed by Tom Barber Civil War Book Review (CWBR): Today the Civil War Book Review is pleased to speak with Jimmy L. Bryan Jr., Associate Professor of History at Lamar ...
Just Mercy by Bryan Stevenson: W&L Law Faculty Panel
No full textOn March 27, 2019, the W&L Law Library hosted a panel discussion of Just Mercy, the bestselling true story of a lawyer exonerating the wrongly convicted and representing society’s most vulnerable through the perils of our justice system.
The event continued an annual tradition of faculty panel discussions on popular works of fiction and non-fiction with a connection to the law, featuring perspectives from W&L Law professors David Bruck, Nora Demleitner, Brandon Hasbrouck, and Jon Shapiro. Professor J.D. King moderated the discussion, and librarian Andrew Christensen provided introductory remarks.
Author Bryan Stevenson will speak at the W&L Law commencement ceremony on May 10, 2019.
Please note that, at the speaker\u27s request, Prof. Hasbrouck\u27s audio has been suppressed in this video (46:30 through 58:43)
Risk Assessment in Economic Feasibility Analysis: The Case of Ethanol Production in Texas
No full textThe objective of this study is to demonstrate the benefits of quantifying the economic viability of a proposed agribusiness under risk relative to a feasibility study which ignores risk. To achieve this objective, the economic viability of a 50 MMGPY ethanol facility in Texas is analyzed over a 10-year period in two ways: with no risk and with historical risk for prices and costs.Risk and Uncertainty,
Health Hazard Evaluation Report: HETA-91-0341-2380: Bryan Custom Plastics; Bryan, Ohio
No full textIn response to a request from the Allied Industrial Workers Union, an investigation was begun into possible hazardous working conditions at Bryan Custom Plastics (SIC-3089), Bryan, Ohio. The company manufactured plastic television cabinets and interior automotive door panels by an extrusion molding process. Workers in the spray finishing department apply a finish coating of lacquer-based paint. There were 32 spray finishers and mixing room employees. Workers complained about headaches and upper respiratory symptoms. Full shift, personal breathing zone and area sampling revealed no excess levels of exposure to total paint mist, toluene (108883), xylene (1330207), ethyl-benzene (100414), methyl- methacrylate (80626), methyl-ethyl-ketone (78933), methyl-isobutyl- ketone (108101), or n-butanol (71363). Carbon-monoxide (630080) concentrations ranged up to 34 and 90 parts per million in the spray finishing areas and quality control areas, respectively. The author concludes that health hazards from exposure to airborne particulates and organic solvents were not found at the time of the survey. There was a potential for overexposures to carbon-monoxide. The author recommends that carbon-monoxide levels be reduced, and work practices improved
Outsourcing and Skill Imports: Foreign High-Skilled Workers on H-1B and L-1 Visas in the United States
No full textThis working paper looks in detail at the H-1B and L-1 visa programs for temporary employment in the United States. Based on official data from the US Citizenship and Immigration Services and the US Department of State, H-1B and L-1 visa issuance rapidly increased in the late 1990s, followed by a marked slowdown after 2001. This points to the highly cyclical nature of both visa programs. Indian nationals and immigrants working in computer-related occupations dominate the H1-B and L-1 population in the United States, but these two groups are also found to be the most cyclical segment, with very large declines in inflows after 2001. The total population of H-1B visaholders in 2003 is estimated to range between 387,000 and 746,000, of which 160,000 to 306,000 were Indian nationals. As all data on H-1B/L-1 visaholders are gross numbers and gross jobs data for comparable categories are absent, the extent of the impact of these visa programs on the US labor market cannot be gauged precisely. A broad range of US industries and educational institutions are found to be employing H-1B recipients, with the IT industry being the dominant sector. Evidence of aggressive wage-cost cutting, including paying H-1B recipients only the legally mandated 95 percent of the prevailing US wage, is found among some H-1B employers, although no systematic abuse of the system is present.Outsourcing, offshoring, high-skilled labor, immigration, H1B/L-1 visas
Chemical neuroanatomy of 5-HT receptor subtypes in the mammalian brain
No full textCapítulo en: Bryan L. Roth (ed.). The Serotonin Receptors : From Molecular Pharmacology to Human Therapeutics. Totowa; NJ: Humana Press, 2006, p.319-364. ISBN 978-1-59745-080-5. ISBN 978-1-58829-568-2. ISBN 978-1-61737-647-4. DOI 10.1007/978-1-59745-080-5Peer Reviewe
At limits of life: multidisciplinary insights reveal environmental constraints on biotic diversity in continental Antarctica
No full textData source: Supporting information, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044578#s5Multitrophic communities that maintain the functionality of the extreme Antarctic terrestrial ecosystems, while the simplest of any natural community, are still challenging our knowledge about the limits to life on earth. In this study, we describe and interpret the linkage between the diversity of different trophic level communities to the geological morphology and soil geochemistry in the remote Transantarctic Mountains (Darwin Mountains, 80uS). We examined the distribution and diversity of biota (bacteria, cyanobacteria, lichens, algae, invertebrates) with respect to elevation, age of glacial drift sheets, and soil physicochemistry. Results showed an abiotic spatial gradient with respect to the diversity of the organisms across different trophic levels. More complex communities, in terms of trophic level diversity, were related to the weakly developed younger drifts (Hatherton and Britannia) with higher soil C/N ratio and lower total soluble salts content (thus lower conductivity). Our results indicate that an increase of ion concentration from younger to older drift regions drives a succession of complex to more simple communities, in terms of number of trophic levels and diversity within each group of organisms analysed. This study revealed that integrating diversity across multi-trophic levels of biotic communities with abiotic spatial heterogeneity and geological history is fundamental to understand environmental constraints influencing biological distribution in Antarctic soil ecosystems.Catarina Magalhães, Mark I. Stevens, S. Craig Cary, Becky A. Ball, Bryan C. Storey, Diana H. Wall, Roman Tűrk and Ulrike Ruprech
Pharmacosynthetics: Reimagining the pharmacogenetic approach
No full textPharmacology, in its broadest interpretation, is defined as the study of the interaction between physiological entities and drugs. In modern neuropsychopharmacology, this interaction is viewed as the drug itself on one side and signal transducer (receptor), the signal transduction cascade (effector proteins, second messengers), the cellular response (transcriptional regulation, activity modulation), the organ response (brain circuitry modulation), and, finally, the whole organism response (behavior) on the other. In other words, pharmacology has structured itself around the idea that the exogenous molecule (the drug) encodes a “signal” leading to everything on the other side including, in extreme renditions, a physiological response. The inference is that engaging a particular signal transduction pathway in a defined cell type leads inexorably to a prototypic physiological response. Thus, for instance, serotonergic activation of 5-HT2A receptors in rat aortic smooth muscle cells leads to an increase in intracellular Ca++ (via IP3 release) and smooth muscle contraction (Roth et al., 1986). Here, we suggest that the invention of synthetic ligand – GPCR pairs (aka DREADDs, RASSLS, ‘pharmacogenetics’) permits the study of pharmacology using a shifted equation: more of the signal transduction elements moved to the left and, subsequently, under experimental control. For the purposes of disambiguation and to clarify this new interpretation as a creation of pharmacological manipulation, we present the term pharmacosynthetics to describe what has heretofore been called pharmacogenetics or chemicogenetics. This review discusses this new interpretation and reviews recent applications of the technology and considerations of the approach
Dopaminergic and Behavioral Deficits Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1
No full textThe manifestations of Parkinson's disease are caused by reduced dopaminergic innervation of the striatum. Loss-of-function mutations in the DJ-1 gene cause early-onset familial parkinsonism. To investigate a possible role for DJ-1 in the dopaminergic system, we generated a mouse model bearing a germline disruption of DJ-1. Although DJ-1(-/-) mice had normal numbers of dopaminergic neurons in the substantia nigra, evoked dopamine overflow in the striatum was markedly reduced, primarily as a result of increased reuptake. Nigral neurons lacking DJ-1 were less sensitive to the inhibitory effects of D2 autoreceptor stimulation. Corticostriatal long-term potentiation was normal in medium spiny neurons of DJ-1(-/-) mice, but long-term depression (LTD) was absent. The LTD deficit was reversed by treatment with D2 but not D1 receptor agonists. Furthermore, DJ-1(-/-) mice displayed hypoactivity in the open field. Collectively, our findings suggest an essential role for DJ-1 in dopaminergic physiology and D2 receptor-mediated functions
Correction : Accurate, fast, data efficient and interpretable glaucoma diagnosis with automated spatial analysis of the whole cup to disc profile (PLoS ONE (2019) 14:1 (e0209409) DOI: 10.1371/journal.pone.0209409)
No full textThe second author, Bryan M. Williams, should also be listed as a corresponding author. Dr. Williams’ email address is: [email protected]
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