1,359 research outputs found
Building Breastfeeding Research Relations and Beyond: An Interview With Fiona Dykes
No full textProfessor Fiona Dykes is Professor Emerita of Maternal and Infant Health at the University of Central Lancashire in the United Kingdom (UCLAN). Fiona has a particular interest in the global, sociocultural, and political influences upon infant and young child feeding practices; her methodological expertise is in ethnography and other qualitative research methods. She founded the Maternal and Infant Nutrition and Nurture Unit (MAINN) in 2000 which she led until she retired from her full-time professorship in 2020. Fiona established the associated MAINN Conference in 2007. The MAINN conference is a 3 day, international, peer reviewed event held bi-annually in the United Kingdom and, more recently, in alternate years overseas (Sydney, Australia; Falun, Dalarna, Sweden; and Florida, United States). The conference draws together key researchers in the field of infant and young child feeding from around the world. Fiona was a founding member of the journal Maternal and Child Nutrition. She is author of Breastfeeding in Hospital: Mothers, Midwives and the Production Line (Routledge) and co-author, with Dr Tanya Cassidy, of Banking on Milk: An Ethnography of Donor Human Milk Relations (Routledge). She is also joint editor of several books including Infant and Young Child Feeding: Challenges to Implementing a Global Strategy (Wiley-Blackwell) and Ethnographic Research in Maternal and Child Health (Routledge). This interview was conducted on April 20, 2023, by Dr. Tanya Cassidy, and is based on a verbatim transcription and edited for readability
Karyotyping lymph node biopsies in non-Hodgkin's lymphoma
No full textCulture and transport methods are described that allow chromosomes to be obtained from lymph node biopsies with a high success rate, even when the biopsy is taken at a distant site from the cytogenetic laboratory. Optimal banding techniques for the identification of these chromosomes are given, along with hints on how to correct any problems encountered on initial staining. We also describe how to prepare this material for fluorescence in situ hybridization techniques, both for further delineation of complex chromosomal rearrangements and for interphase analysis in cases in which conventional cytogenetics has not been successful
Handbook of biochemistry and molecular biology / edited by Roger L. Lundblad, Fiona M. Macdonald.
No full textIncludes bibliographical references and index.Book fair 2013.xvii, 1080 p. :Edited by renowned protein scientist and bestselling author Roger L. Lundblad, with the assistance of Fiona M. Macdonald of CRC Press, this fourth edition of the Handbook of Biochemistry and Molecular Biology represents a dramatic revision -- the first in two decades -- of one of biochemistry's most referenced works. This edition gathers a wealth of information not easily obtained, including information not found on the web." "Offering a molecular perspective not available 20 years ago, it provides physical and chemical data on proteins, nucleic acids, lipids, and carbohydrates. Presented in an organized, concise, and simple-to-use format, this popular reference allows quick access to the most frequently used data. Covering a wide range of topics, from classical biochemistry to proteomics and genomics, it also details the properties of commonly used biochemicals, laboratory solvents, and reagents." "Just a small sampling of the wealth of information found inside the handbook" : "Buffers and buffer solutions" -- "Heat capacities and combustion levels" -- "--Reagents for the chemical modification of proteins" -- "Comprehensive classification system for lipids" -- "Biological characteristics of vitamins" -- "A huge variety of UV data" -- "Recommendations for nomenclature and tables in biochemical thermodynamics" -- "Guidelines for NMR measurements for determination of high and low pka values" -- "Viscosity and density tables" -- "Chemical and physical properties of various commercial plastics" -- "Generic source-based nomenclature for polymers" -- "Therapeutic enzyme
Elaine M. Alexander: 2023 Cook Prize Gold Medal Acceptance Speech
No full textAuthor Elaine M. Alexander gives an acceptance speech for Anglerfish: The Seadevil of the Deep, illustrated by Fiona Fogg (Candlewick)https://educate.bankstreet.edu/cook/1007/thumbnail.jp
How many focus markers are there in Konkomba?
No full textThis article discusses the divergent status of the two particles lé and lá in the grammar of Konkomba, a Gur language (Niger-Congo) of the Gurma subgroup. While previous studies claim that both particles are focus markers, this author argues that only the particle lá should be analyzed as a pure pragmatic device. Distributional studies suggest that the use of particle lé, on the other hand, is only required under specific focus conditions, and primarily represents a syntactic device
Identification of a novel t(7;14) translocation in multiple myeloma resulting in overexpression of EGFR
No full textIGH translocations in myeloma are a primary event and determine the prognostic outcome of a patient. These events are characterized by FISH and classical cytogenetics, but in a small proportion of samples a translocation involving the IGH locus can be detected but the partner chromosome cannot be identified. These cases are usually genetically complex and are the result of cryptic events that cannot be discerned at the resolution of FISH. Here we analyzed a sample with an unidentified translocation partner using a targeted capture and massively parallel sequencing. We identified the partner chromosome as a t(7;14) with the breakpoint upstream of EGFR. This sample over-expresses the target oncogene, EGFR. This case represents a rare and novel translocation in myeloma, from which a targeted personalized treatment, in the form of EGFR inhibitors, which are commonly used in other cancer types, could be used
"If you keep your problems in your stomach the dogs cannot steal them" : trauma, forgiveness, and con-viviality in Rwanda : an ethnographic study following the healing and rebuilding our communities (HROC) project in Gisenyi, Rwanda
No full textIncludes abstract.Includes bibliographical references (leaves 75-79).By bringing together survivors of the genocide with released prisoners to discuss trauma, healing, and trust, Healing and Rebuilding Our Communities (HROC) in Rwanda may help people to broaden their networks of support and rebuild everyday life. ... After 1994, Rwandans, particularly in Gisenyi, found that many neighbours were strangers and members of "the other side". Few Rwandans are able to meet their daily needs without accessing relationships of reciprocity, so how are such relation- ships established after genocide? In this thesis I argue that restoring relationships of reciprocity is critical to the restoration of the everyday in Rwanda. The genocide in 1994 was unarguably a traumatic experience for the population in Rwanda, and it damaged common modes of social interaction. But for those I spoke to, forgiveness was important to the process of healing..
The Chronology of the Ross Sea II glaciation, an Antarctic glaciation of Illinoian Age
No full textA meltwater stream in the Marshall Valley, southern Victoria Land, Antarctica has revealed a stratigraphy of glacial drift and lacustrine lake beds.
The sequence has been differentiated by U/Th dating into the Ross Sea I Glaciation (15-30,000 years B.P.), represented by a gypsum bed and the Ross Sea II(?) Glaciation (130-180,000 years B.P.), represented by three calcium carbonate and gypsum beds.
The three Ross Sea II(?) lake beds may be differentiated from one another by an increasing calcite content with age, and a systematic change in the crystal type and morphology of the carbonates.
Chemical analysis of the lake beds reveals that their components have differing sources. The freezing on of seawater and/or frozen out seawater precipitates can quantitatively provide the salts required. However U isotope studies shows that a weathered crustal component is present in the lake beds. Stable isotope analysis indicates that the meltwaters were formed at high altitudes of 1,900 m (Ross Sea I) and 2,500 m (Ross Sea II(?)), and originated as snow, precipitated approximately 5,000 km to the south.
Ice sheet incursion into the valley created a proglacial lake. Calcium carbonate and gypsum were precipitated due to increased lake saturation conditions. Stable isotope studies show that the calcium carbonate deposition was triggered biologically by phytoplankton. The morphology of the calcium carbonate and the presence of gypsum indicates that evaporitic conditions were also necessary for lake bed deposition, with the distribution of gypsum and calcium carbonate within the lake being controlled by depth of water.
Correlation of lake bed geochronology and geochemistry, together with the stratigraphy of the stream sections provides a glacial history of Marshall Valley for the last 180,000 years B.P. The last two Ross Sea glacial sequences rest upon an unconformably eroded glacial surface. The Ross Sea II(?) Glaciation commenced at 180,000 years with a glacial ice incursion into the valley, a stillstand, proglacial lake occupation and deposition of a lake bed. The ice front then advance farther up the valley, depositing large terminal loop moraines between Sections III and IV. The ice then retreated at least 2 km.
A second glacial advance commenced prior to 160,000 years, stillstanded and produced the 160,000 year lake bed, before retreating. A minor fluctuation and readvance, deposited another lake bed (160,000 years) or reworked the previous lake bed into the overlying stratigraphy, before the ice retreat.
The deposition of the 130,000 year lake bed was also a the result of a stillstand, before the retreat and cessation of the Ross Sea II(?) glaciation.
The Ross Sea I Glaciation involved the advance of a glacier front from an ice sheet occupying the McMurdo Sound and the deposition of a gypsum lake bed (15-30,000 years B.P.). With the retreat of the ice front, downwasting of ice-cored moraines in the mouth of the valley began, and currently continues.
The geochronology of the Ross Sea II(?) Glaciation correlates with eustatic sea level lowering in the Illinoian (Isotope Stage 6). Subsurface drilling indicates that the calcium carbonate deposition was a unique event but at least 8 earlier glacial incursions had occurred in the Marshall Valley.
The geochronology of the Ross Sea I Glaciation correlates with the eustatic sea level lowering in the Wisconsin (Isotope Stage 2).
The chronology and isotopic composition of the proglacial lake deposits can be matched to those in other ice-free valleys exposed to McMurdo Sound
Facilitating independence: The benefits of a post-diagnostic support project for people with dementia.
No full textProviding support in the form of information, advice and access to services or social events is promoted as beneficial for people newly diagnosed with dementia and their families. This paper reports on key findings from an evaluation of a post-diagnostic support pilot project in Scotland addressing local service gaps, namely information provision, emotional and practical support and maintaining community links. Twenty-seven participants (14 people newly diagnosed with dementia and 13 family carers) were interviewed at two time points: T1 shortly after joining the pilot project and T2 approximately six months later, to ascertain their views on existing services and the support offered by the pilot project. A comparative thematic analysis revealed that the project facilitated increased independence (associated with increased motivation and self-confidence) of people with dementia. The project illustrates what can be achieved if resources are targeted at providing individualised post-diagnostic support, particularly where there are service delivery gaps
The t(14;20) is a poor prognostic factor in myeloma but is associated with long term stable disease in MGUS
No full textA large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behaviour was compared to a group characterised by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering myeloma (1/148, <1%) with a higher incidence in MGUS (9/193, 5% p=0.005). Strong associations with del(13) (76%), nonhyperdiploidy (83%) and gain of 1q (58%) were seen but no association with an IgA M-protein or absence of bone disease was noted. All three translocations were associated with poor outcome in myeloma, but strikingly all t(14;20) MGUS/smouldering myeloma cases (n=10) had stable, low level disease. In contrast, the 10 t(14;16) and 25 t(4;14), MGUS/smoldering myeloma cases were associated with both evolving and non-evolving disease. None of the associated genetic abnormalities helped to predict for progression from MGUS or smoldering myeloma
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