1,721,080 research outputs found
Trattamento delle lesioni cartilaginee della caviglia con l’impianto di condrociti autologhi su membrana collagenica
No full textImpianto di menisco collagenico (CMI): risultati preliminari ed analisi morfologica ed ultrastrutturale dell'impianto
No full textValutazione ecografica del tendine di Achille e dell'entesi rotulea nei giocatori di calcio e basket: potrebbe essere utile per prevedere lo sviluppo di lesioni muscolari e tendinee?
No full textBACKGROUND: Achilles and patellar entheseal abnormalities are frequently seen in athletes and healthy subjects at ultrasound (US) evaluation. However, to our knowledge, no studies have been performed to assess the possible asso-ciation between the presence of subclinical entheseal abnormalities and the possibility to develop muscular injuries in professional athletes. The aim of this study was: to compare US entheseal abnormalities in a group of athletes with age and sex-matched healthy controls and to assess the 12 months risk for the development of symptomatic muscular and tendon injuries at lower limb. METHODS: Consecutive soccer and basket players attending our clinic for routine controls were asked to participate. US evaluation of Achilles tendon and patellar tendon insertion at tibial tuberosity was performed in order to evalu-ate the presence of subclinical enthesopathy. The evaluation of tendons and entheseal thickness was also performed. Finally, athletes were followed up for 1 year and the development of muscular and tendon injuries at lower limb was evaluated. RESULTS: Forty athletes and 20 healthy controls were enrolled for this study. Overall, entheseal US abnormalities were found in 25 (62.5%) athletes. Both Achilles tendon and enthesis thickness were significantly higher in respect to healthy controls. During the follow up, 6 (15%) athletes suffered a muscle injury at lower limb and 1 (2.5%) an Achil-les tendon lesion. None of the enrolled controls reported any injuries. Logistic regression analysis did not find any statistically significant associations between the presence of entheseal abnormalities and the development of injury. However, a tendency to develop muscular injuries at lower limb was found in those athletes with Achilles tendon abnormalities (odds ratio [95% CI]: 6 [0.83-43], P=0.07). CONCLUSIONS: A tendency for an association of US Achilles tendon enthesopathy with muscular lower limb injuries was found. This may suggest that screening of asymptomatic individuals could be of use in identifying those who are at higher risk of developing injury, which may allow targeted modifications of training or other preventative regimens. (Cite this article as: Perrotta FM, Ronga M, Guerra G, Lubrano E. Ultrasonographic evaluation of Achilles tendon and patellar enthesis in football and basketball players: could it be useful to predict muscular and tendon injuries? Med Sport 2022;75:436-45. DOI: 10.23736/S0025-7826.22.04170-9
Prospettive future nell’impianto di condrociti.
No full textLe lesioni cartilaginee a tutto spessore sono una patologia di comune riscontro nella pratica ortopedica e la loro incidenza nella popolazione ha mostrato un andamento in crescita negli ultimi anni dovuto all’aumentata richiesta funzionale in particolare dei pazienti over quaranta anni. Diversi autori hanno dimostrato l’efficacia dell’impianto di condrociti autologhi a medio e lungo termine nel trattamento delle lesioni focali traumatiche e degenerative iniziali. L’evoluzione da un concetto di terapia cellulare ad uno di ingegneria tissutale, grazie all’impiego dei supporti tridimensionali o scaffold, ha fornito vantaggi non solo dal punto di vista chirurgico (minore invasività, utilizzo di tecniche artroscopiche, ridotto numero di complicazioni) ma anche dal punto di vista biologico (migliore differenziazione dei condrociti in coltura, omogenea distribuzione delle cellule nel difetto condrale, ridotta incidenza di ipertrofia dell’impianto). L’attenzione dei ricercatori si è focalizzata negli ultimi anni sul miglioramento della tecnica di base ed in particolare su tre temi fondamentali: tipo di cellule da impiantare, scaffold e fattori d crescita. A tal fine i futuri sviluppi prevederanno una migliore selezione delle cellule da impiantare ed eventualmente l’utilizzo della terapia genica per attivare la produzione di specifiche molecole della matrice extracellulare. Inoltre, l’utilizzo delle cellule staminali potrà incrementare la capacità di riparazione. Diversi studi sperimentali stanno valutando l’efficacia di scaffold biomimetici che facilitino la differenziazione di uno stesso impianto in cartilagine ed osso per la riparazione di difetti osteocondrali. L’utilizzo dei bioreattori, associato al prelievo di cellule totipotenti da sedi extraarticolari, di scaffold e di specifici fattori di crescita, consentirà in futuro di avere un tessuto cartilagineo senza dover sottoporre il paziente ad un duplice intervento chirurgico
Impianto di menisco collagenico: risultati preliminari ed analisi ultrastrutturale e biochimica dell’impianto
No full textArthroscopic autologous chondrocyte implantation for the treatment of a chondral defect in the tibial plateau of the knee
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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