1,847 research outputs found
Increased expression of CD40 ligand in activated CD4+ T lymphocytes of systemic sclerosis patients.
No full text*G. Valentini ed M.F. Romano hanno egualmente contribuito al lavor
Increased expression of CD40 ligand in activated CD4+ T lymphocytes of systemic sclerosis patients.
No full text*G. Valentini ed M.F. Romano hanno egualmente contribuito al lavor
The emerging role of FKBP51 in melanoma: characterization of a promising molecular target for innovative therapies
No full textMelanoma is a malignant skin cancer with high metastatic potential. The
number of melanoma cases worldwide is increasing faster than any other cancer. The prognosis is bad in the advanced stages of the disease due to resistance to conventional anti-cancer treatments. Patients diagnosed with advanced stage melanoma continue to pose a significant challenge for clinicians. Although many therapeutic regimens for metastatic melanoma have been tested, very few achieve response rates greater than 25%. There is much hope for targeted therapies and promising agents include those that act on apoptosis-regulating molecules. Very recently, we have identified that an immunophilin, namely FK506 binding protein (FKBP) 51 controls response of melanoma to DNA damaging agents, such as anthracyclines compounds. The aim of this study was to investigate the possible role of FKBP51 in the control of response to ionizing radiation (IR) in malignant melanoma. FKBP51-silenced cells showed reduced clonogenic potential after irradiation compared with non-silenced cells. After IR, we observed apoptosis in FKBP51-silenced cells and autophagy in non-silenced cells. FKBP51 was required for the activation of Rx-induced NF-kappaB, which in turn inhibited apoptosis by
stimulating X-linked inhibitor of apoptosis protein and promoting authophagymediated Bax degradation. Using a tumor-xenograft mouse model, the in vivo pretreatment of tumors with FKBP51-siRNA provoked massive apoptosis after irradiation. Immunohistochemical analysis of 10 normal skin samples and 80 malignant cutaneous melanomas showed that FKBP51 is a marker of melanocyte malignancy, correlating with vertical growth phase and lesion thickness. Moreover, we provided evidence that FKBP51 targeting radiosensitizes cancer stem/initiating cells. Finally, we expanded the study to other types of cancer, including ovarian, pancreatic, prostate, colon, breast and lung cancer and found a strong correlation between the protein expression and malignity of the tumoral lesions. In conclusion, our study identifies a possible molecular target for radiosensitizing therapeutic strategies against malignant melanoma and a potential novel tumoral biomarker
TIPE KEPRIBADIAN TOKOH UTAMA PADA NOVEL “INTROVER” KARYA M.F. HAZIM
No full textThe author tries to analyze the personality of the main characters using the study of literary psychology, whether the main character is more melancholic or pblegmatic. M.F. Hazim in his novel "Introver" tells the story of the world intover. Reading it, we are invited to explore in the mind and soul of an introver who is always nervous, restless, and upset; also the inner conflict that torments him, and how he finds "friends" to fill his loneliness and make his life more meaningful. The author wants to know more clearly what exactly the lives of introverts are in their daily lives. This research is directed to one main problem, namely "What is the personality type of the main character introver in the" Introver "novel by M.F. Hazim ". This research uses descriptive qualitative method with heuristic and hermeneutic reading techniques in order to understand and reveal "something" contained in literary works. The results of the research that have been carried out are in accordance with the research hypothesis, namely the main character Nawawi has an introvert personality type in the novel "Introver" by M.F. Hajim. Researchers found 42 quotes stating that Nawawi has an introverted personality type. Of the 42 quotes that have been found, 28 quotes state that Nawawi has a melancholic personality type and 14 quotes state that Nawawi has a phlegmatic personality type
- …
