1,731 research outputs found
Should I Be Tested for Alzheimer\u27s Disease?
No full textNOTE FROM TED: While some viewers might find this talk helpful as a complementary approach, please do not look to this talk for medical advice. The role of lifestyle in disease remains an ongoing field of study. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/manuals/t... Alzheimer’s disease currently affects over 44 million worldwide and has no cure nor effective treatment. For most people over the age of 60, this disease represents their number one fear. But we don’t have to be afraid of Alzheimer’s. By better understanding our genetic risks, and defending ourselves against it with a variety of common sense, everyday activities, we can increase the odds of overcoming this devastating disease. Troy Rohn has been a professor in the Department of Biological Sciences for the past 20 years where he both teaches and has an active research program involving Alzheimer\u27s disease. For the past 10 years, his research program has focused on understanding how inheritance of the APOE4 gene enhances dementia risk at the molecular level. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/ted
Writers Talk featuring authors Troy Hicks and Elaine Wolf
No full textElaine Wolf, author of Camp, talks to OSU students Erin Reilly-Sanders and Allison Fetzer. Author and teacher Troy Hicks talks to OSU employee Kevin Cordi about the impact of technology on the teaching of writing.The media can be accessed here: http://streaming.osu.edu/knowledgebank/WritersTalk-Audio/WT_2013-3-18-Hicks_Wolf.mp3Ohio State University. Center for the Study and Teaching of Writin
Remarks and observations on the plain of Troy, made during an excursion in June, 1799 /
No full textSignatures: pi⁴ A-G⁴.Errata: p. [2] at end; p. [1] and [3] at end blank.ESTC(RLIN)Mode of access: Internet.Library copy bound with: Description of the plain of Troy : with a map of that region, delineated from an actual survey : read in French before the Royal Society of Edinburgh, Feb. 21 and 28 and March 21 1791 / by the author, M. Chevalier. Edinburgh : Printed for T. Cadell, 1791. (90-B15413
Observations upon a treatise, entitled A description of the Plain of Troy, by Monsieur Le Chevalier /
No full textErrata: p. [1] at end.Signatures: [A]1 B-H⁴.Includes bibliographical references.ESTC(RLIN)Mode of access: Internet.Library copy bound with: Description of the plain of Troy : with a map of that region, delineated from an actual survey : read in French before the Royal Society of Edinburgh, Feb. 21 and 28 and March 21 1791 / by the author, M. Chevalier. Edinburgh : Printed for T. Cadell, 1791. (90-B15413
Characterization of Transgenic Zebrafish (\u3cem\u3eDanio rerio\u3c/em\u3e) Expressing the ApoE4\u3csub\u3e(1-151)\u3c/sub\u3e Fragment: A Study Involving the Strongest Genetic Risk Factor for Developing Late On-Set Alzheimer\u27s Disease
No full textAlzheimer’s disease is a fatal disorder that leads to neuronal cell loss in brain regions crucial for thinking & memory. While the inheritance risk of the APOE4 allele is well documented, the molecular basis for how it leads to enhanced dementia risk is not yet understood. Previous work in the Rohn lab has shown that proteolysis & formation of an amino-terminal protein fragment (ApoE41-151) may contribute to toxicity in vitro. Using zebrafish as an in vivo model organism, mutants expressing this fragment were generated to examine any deleterious effects. As an initial approach, this study seeks to characterize this mutant, transgenic strain of zebrafish to determine any differences in their observed phenotypes
Survivability of Transgenic Zebrafish (\u3cem\u3eDanio rerio\u3c/em\u3e) with the ApoE4 \u3csub\u3e1-151\u3c/sub\u3e Fragment
No full textAlzheimer’s is a fatal disorder that causes neuronal cell loss in brain regions crucial for thinking and memory. While the inheritance risk of the APOE4 allele has been well documented, the molecular basis for how ApoE4 leads to enhanced dementia risk is not yet understood. Previous work in the Rohn lab has shown that proteolysis and formation of an amino-terminal fragment (ApoE41-151) may contribute to toxicity in vitro. Using Zebrafish as an in vivo model organism, mutants expressing this fragment were generated to examine any deleterious effects. As an initial approach, this study seeks to determine the lethality of these transgenic F1 mosaic zebrafish
Linoleic acid causes greater weight gain than saturated fat without hypothalamic inflammation in the male mouse
No full textA significant change in the Western diet, concurrent with the obesity epidemic, was a substitution of saturated fatty acids with polyunsaturated, specifically linoleic acid (LA). Despite increasing investigation on type as well as amount of fat, it is unclear which fatty acids are most obesogenic. The objective of this study was to determine the obesogenic potency of LA vs. saturated fatty acids and the involvement of hypothalamic inflammation. Forty-eight mice were divided into four groups: low-fat or three high-fat diets (HFDs, 45% kcals from fat) with LA comprising 1%, 15% and 22.5% of kilocalories, the balance being saturated fatty acids. Over 12 weeks, bodyweight, body composition, food intake, calorimetry, and glycemia assays were performed. Arcuate nucleus and blood were collected for mRNA and protein analysis. All HFD-fed mice were heavier and less glucose tolerant than control. The diet with 22.5% LA caused greater bodyweight gain, decreased activity, and insulin resistance compared to control and 1% LA. All HFDs elevated leptin and decreased ghrelin in plasma. Neuropeptides gene expression was higher in 22.5% HFD. The inflammatory gene Ikk was suppressed in 1% and 22.5% LA. No consistent pattern of inflammatory gene expression was observed, with suppression and augmentation of genes by one or all of the HFDs relative to control. These data indicate that, in male mice, LA induces obesity and insulin resistance and reduces activity more than saturated fat, supporting the hypothesis that increased LA intake may be a contributor to the obesity epidemic.Peer reviewe
Some observations upon the Vindication of Homer, and of the ancient poets and historians, who have recorded the siege and fall of Troy, written by I.B.S. Morritt, esq. /
No full textFinal leaf blank, with errata slip attached.Signatures: A² B-N⁴ [M]1.ESTC(RLIN)Mode of access: Internet.Library copy bound with: Description of the plain of Troy : with a map of that region, delineated from an actual survey : read in French before the Royal Society of Edinburgh, Feb. 21 and 28 and March 21 1791 / by the author, M. Chevalier. Edinburgh : Printed for T. Cadell, 1791. (90-B15413
Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation
No full textThe study of protein function in neurons has been hindered by the lack of highly efficient, nontoxic methods of inducing RNA interference in such cells. Here we show that application of synthetic small interfering RNA( siRNA) linked to the vector peptide Penetratin1 results in rapid, highly efficient uptake of siRNA by entire populations of cultured primary mammalian hippocampal and sympathetic neurons. This treatment leads to specific knock-down of targeted proteins within hours without the toxicity associated with transfection. In contrast to current methods, our technique permits study of protein function across entire populations with minimal disturbance of complex cellular networks. Using this technique, we found that protein knock-down ( evident after 6 hr) precedes any decrease in targeted message ( evident after 24 hr), suggesting an early, translational repression by perfectly targeted siRNAs.PT: J; CR: BARTEL DP, 2004, CELL, V116, P281 BERTRAND E, 2001, MOL CELL NEUROSCI, V18, P503 DEROSSI D, 1994, J BIOL CHEM, V269, P10444 DOENCH JG, 2003, GENE DEV, V17, P438 DOSTIE JE, 2003, RNA, V9, P180 ELBASHIR SM, 2001, EMBO J, V20, P6877 FINK CC, 2003, NEURON, V39, P283 FIRE A, 1998, NATURE, V391, P806 GAUDILLIERE B, 2002, J BIOL CHEM, V277, P46442 HANNON GJ, 2002, NATURE, V418, P244 HUTVAGNER G, 2002, SCIENCE, V297, P2056 JOHNSTON RJ, 2003, NATURE, V426, P845 JOLIOT A, 2004, NAT CELL BIOL, V6, P189 KHVOROVA A, 2003, CELL, V115, P209 KIM J, 2004, P NATL ACAD SCI USA, V101, P360 KRICHEVSKY AM, 2002, P NATL ACAD SCI USA, V99, P11926 KRICHEVSKY AM, 2003, RNA, V9, P1274 LAI EC, 2003, CURR BIOL, V13, R925 LLAVE C, 2002, SCIENCE, V297, P2053 MURATOVSKA A, 2004, FEBS LETT, V558, P63 OMI K, 2004, FEBS LETT, V558, P89 RABACCHI SA, 2004, NEUROBIOL AGING, V25, P1057 REYNOLDS A, 2004, NAT BIOTECHNOL, V22, P326 SAXENA S, 2003, J BIOL CHEM, V278, P44312 SCHERER LJ, 2003, NAT BIOTECHNOL, V21, P1457 SCHWARZ DS, 2003, CELL, V115, P199 THEODORE L, 1995, J NEUROSCI, V15, P7158 TOROCSIK B, 2002, J NEUROSCI, V22, P8971 TROY CM, 1994, P NATL ACAD SCI USA, V91, P6384 TROY CM, 1996, J NEUROSCI, V16, P253 TROY CM, 1996, P NATL ACAD SCI USA, V93, P5635 TROY CM, 2001, J NEUROSCI, V21, P5007 TROY CM, 2002, J BIOL CHEM, V277, P34295 VICKERS TA, 2003, J BIOL CHEM, V278, P7108 ZENG Y, 2003, P NATL ACAD SCI USA, V100, P9779; NR: 35; TC: 22; J9: J NEUROSCI; PG: 7; GA: 869ZASource type: Electronic(1
West, by God
No full textMy thesis is a collection of short stories to satisfy the requirements of the MFA program.M.F.A.by Troy J. Graha
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