102,573 research outputs found
Therapie chronisch entzündlicher Darmerkrankungen bei Kindern und Jugendlichen
No full textDie Zahl an Neuerkrankungen an chronisch entzündlichen Darmerkrankungen (CED) ist nach wie vor steigend, jedoch stellt die Therapie dieses Krankheitsbildes noch immer eine Herausforderung für den behandelnden Arzt dar. Wichtige Erkenntnisse vor allem im Bereich der Pathophysiologie sind in den letzten Jahren hinzugekommen, die Zahl der Risikogene für diese Erkrankungen ist sprunghaft gestiegen. Dieses Lehrbuch bietet in der vorliegenden 2. Auflage kompakte und praktische Informationen und fasst die therapeutischen und diagnostischen Fortschritte der vergangenen Jahre zusammen. Aktuelle klinische Studien sowie die Ergebnisse der Schweizer Kohorten Studie (SIBDC) werden berücksichtigt. Es informiert über aktuelle Entwicklungen in der Therapie von chronisch entzündlichen Darmerkrankungen und dient als praktische Hilfe bei der Behandlung betroffener Patienten
Die Versprachlichung des Konzepts "werden": eine Untersuchung zum Spanischen und Deutschen unter Einbeziehung eines sprachtypologischen Hintergrunds
No full textRogler G. Die Versprachlichung des Konzepts "werden": eine Untersuchung zum Spanischen und Deutschen unter Einbeziehung eines sprachtypologischen Hintergrunds. Linguistik. Aachen: Shaker; 2010
Anomalous monism and mental causality : on the debate of Donald Davidson’s philosophy of the mental
No full textThe English version of the first chapter of Erwin Rogler and Gerhard Preyer: Materialismus, anomaler Monismus und mentale Kausalität. Zur gegenwärtigen Philosophie des Mentalen bei Donald Davidson und David Lewis (2001) "Anomaler Monismus und Mentale Kausalität. Ein Beitrag zur Debatte über Donald Davidsons Philosophie des Mentalen" is a contribution to the current debates on the philosophy of the mental and mental causality initiated from Donald Davidson's philosophy with his article "Mental Events" (1970). It is the intent of the English version to give a response to the controversy among American, British and Australian philosophers in the context of a global exchange of ideas on problems understanding the mental. Contents 1. Preliminary Remarks 2. The Critique of Property-Epiphenomenalism and Counterarguments (a) The Enlargement of Nomological Reasoning (b) The Counterfactual Analysis (c) Supervenient Causality 3. Are Mental Properties real or unreal (fictive)? Abstract Things and events are fundamental entities in Davidson's ontology. Less distinct is the ontological status of properties, especially of mental types. Despite of some eliminative allusions there are weighty reasons to understand Davidson's philosophy of mind as including intentional realism. With it, the question of mental causality arises. There are two striking solutions to this problem: the epiphenomenalism of mental properties and the downward causation of mental events. Davidson cannot accept either. He claims to justify the mental as supervenient causality in order to thus integrate it into physicalism (his version of monism). But his argument at best proves the explanatory, not the causal relevance of mental properties. For this and for other reasons, Davidson fails the aspired synthesis of a sufficiently strong physicalism and the autonomy of the mental; a project whose realization is anyhow hard to achieve
Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion
No full textBrand K, Page S, Rogler G, et al. Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. J. Clin. Invest. 1996;97(7):1715-1722
Serum antibodies in first-degree relatives of patients with IBD: A marker of disease susceptibility? A follow-up pilot-study after 7 years
No full textIntroduction: Various disease-specific serum antibodies were described in patients with inflammatory bowel disease and their yet healthy first-degree relatives. In the latter, serum antibodies are commonly regarded as potential markers of disease susceptibility. The present long-term follow-up study evaluated the fate of antibody-positive first-degree relatives. Patients and Methods: 25 patients with Crohn's disease, 19 patients with ulcerative colitis and 102 first-degree relatives in whom presence of ASCA, pANCA, pancreatic- and goblet-cell antibodies had been assessed were enrolled. The number of incident cases with inflammatory bowel disease was compared between antibody-positive and antibody-negative first-degree relatives 7 years after storage of serum samples. Results: 34 of 102 (33%) first-degree relatives were positive for at least one of the studied serum antibodies. In the group of first-degree relatives, one case of Crohn's disease and one case of ulcerative colitis were diagnosed during the follow-up period. However, both relatives did not display any of the investigated serum antibodies (p = 1). Discussion: The findings of our pilot study argue against a role of serum antibodies as a marker of disease susceptibility in first-degree relatives of patients with inflammatory bowel disease. However, these data have to await confirmation in larger ideally prospective multicenter studies before definite conclusions can be drawn
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Results of the 4th scientific workshop of the ECCO (I): Pathophysiology of intestinal fibrosis in IBD.
No full textThe fourth scientific workshop of the European Crohn's and Colitis Organization (ECCO) focused on the
relevance of intestinal fibrosis in the disease course of inflammatory bowel disease (IBD). The
objective was to better understand the pathophysiological mechanisms of intestinal fibrosis, to
identify useful markers and imaging modalities of fibrosis in order to assess its presence and
progression, and, finally, to point out possible approaches for the prevention and the treatment of
fibrosis.
The results of this workshop are presented in three separate manuscripts. This first section
describes the most important mechanisms that contribute to the initiation and progression of
intestinal fibrosis in IBD including the cellular and molecular mediators, the extracellular matrix molecules and matrix metalloproteinases/tissue inhibitors of metalloproteinases-system, the
microbiota products, the role of fat, genetic and epigenetic factors, as well as the currently
available experimental models. Furthermore, it identifies unanswered questions in the field of
intestinal fibrosis and provides a framework for future research
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
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