218 research outputs found
Is this the death of social democracy in Europe?
No full textRoger Liddle argues that structural changes, which have weakened the centre left across Europe, may also explain New Labour's apparent decline. Copyright (c) 2008 The Author. Journal compilation (c) 2008 ippr.
Brexit - was für die EU und Großbritannien auf dem Spiel steht
No full textRoger Liddle und Florian Ranf
The Brussels deal to save the Euro confounded its Anglo-Saxon doubters. The British press once again underestimated how integrated Europe really is
No full textTreaty change looms as the Eurozone edges closer towards greater fiscal union. Roger Liddle looks at what this might mean for the future of the European Union and Britain’s place within it
The Brussels deal to save the Euro confounded its Anglo-Saxon doubters. The British press once again underestimated how integrated Europe really is.
No full textTreaty change looms as the Eurozone edges closer towards greater fiscal union. Roger Liddle looks at what this might mean for the future of the European Union and Britain’s place within it.
Understanding Cameron’s renegotiations: the ‘ever-closer union’ problem
No full textRoger Liddle explains why removing the UK’s commitment to “ever-closer union” is so important to the PM as he renegotiates the UK-EU relationship. But if he does succeed in getting rid of it, how much would really change
Plasma cholecystokinin and pancreatic growth during adaptation to dietary protein
No full text Page G70: Gary M. Green, Van H. Levan, and Roger A. Liddle. “Plasma cholecystokinin and pancreatic growth during adaptation to dietary protein.” Page G70: sentence beginning on line 7, second column, should read “Therefore we hypothesized that increased dietary protein would raise plasma CCK levels only transiently, the levels returning to normal when pancreatic synthesis and secretion of proteases increased sufficiently to inhibit CCK release”. </jats:p
New Labour: A Witness History
No full textThis article is the edited transcript of a witness history seminar which brought together high profile ‘insiders’ and ‘outside’ academic commentators to reflect critically on New Labour’s governance of Britain, 1997-2010. The contributions cover major areas of government activity, notably the economy, industrial policy, social justice, energy policy, ‘Europe’, military intervention, the use of intelligence and government decision-making. In their respective area of expertise, the contributors investigate the Conservative legacy seen through the eyes of New Labour people, the policies New Labour under Tony Blair and Gordon Brown tried to put in place, what changes these policies were intended to bring about and, finally, what the overall balance sheet of achievements was. The concluding section draws out the key domestic and foreign policy lessons learned during the New Labour years. The article presents a fascinating collection of findings that will be hugely relevant to Ed Miliband’s Labour Party as it gears up for the 2015 general election and after
A regional regime? : regeneration in the North East of England
No full textThis dissertation is set in the North East (NE) of England and demonstrates how an experimental form of elite governance, characterised by multi-level, intra and inter-agency negotiation and co-ordination developed within complex and ambiguous socio-political structures and traditional hierarchies to deal with unmet social and economic needs. This emergent form of entrepreneurial governance has resulted from a poorly institutionalised field of regeneration, and allowed elites to seek autonomy by adapting national policies to specifically regional projects. A top-down, managerialist form of governance, it is not entirely democratic or open to public participation, but strategically contingent on global and other constraints. Central to an understanding of regeneration is the way strategies are formulated and implemented.
This regime, with a broader mix of enterprising public servants and politically minded business and other interests, has coalesced over a long period to respond entrepreneurially to the consequences of globalisation and uneven development, and the failure of national and regional policies. A legacy of decline has created a strategic, cohesive and identifiably exclusive regime of actors, who act in the region’s interests.
This regime is unlike the static or re-constructive regimes prevalent in other regions, rather it blends the positive aspects of traditional regional decision making with a more innovative approach. Democratic forms of managing regional space have gradually been replaced by a more adaptable and flexible form more suited to modern day and future needs. Power and influence shift dynamically over time, space and initiative, activities are legitimised by absorbing state officials into activities, and being in close proximity to civic society. As part of the history of change, and embedded in the social system, elites interact formally and informally
Data from: Gut mucosal cells transfer α-synuclein to the vagus nerve
No full text<p>Tabular raw data corresponding to figure sets used in the study. </p>
<p><strong>Figure 1. α-Synuclein expression and seeding activity in SNCAA53T mice.</strong> ELISA quantification of human α-synuclein in (C) duodenum (α-synuclein quantification in ng/mg of nodose tissue), (D) nodose ganglia (α-synuclein quantification in pg/mg of nodose tissue), and (E) hindbrain (α-synuclein quantification in ng/mg of nodose tissue), from Snca–/– and SNCAA53T mice. RT-QuIC analysis of (F) duodenum, (G) nodose ganglia, and (H) hindbrain of Snca–/– and SNCAA53T mice. </p>
<p><strong>Figure 3. Conditional human α-synuclein expression induces α-synuclein seeding activity in gut organoids.</strong> (C) A representative ThT fluorescence profile for these genotypes is provided. (D) Endpoint values were collected after 100 hours of RT-QuIC relative to negative controls.</p>
<p><strong>Figure 4. Conditional human α-synuclein expression in gut mucosal cells produces in α-synuclein seeding activity in nodose ganglia.</strong> (C) ELISA quantification of human α-synuclein protein in nodose ganglia of nontransgenic, Snca–/–, and SNCAbow mice. (D) A representative ThT fluorescence profile (RT-QuIC) and endpoint analysis of nodose ganglia from nontransgenic (nTg), Snca–/–, and SNCAbow mice at 1 month of age. (E) RT-QuIC analysis of nodose ganglia from 6-month-old nTg, Snca–/–, and SNCAbow mice.</p>
<p><strong>Figure 5. Vagotomy spares the nodose ganglia from α-synuclein seeding activity and prevents spread to the hindbrain. </strong>(C) ELISA measurements of α-synuclein protein in the gut 3 months after tamoxifen treatment. RT-QuIC analysis of (D and E) vagal nodose ganglia and (F and G) hindbrain analyzed 3 months after tamoxifen treatment. Representative ThT fluorescence profiles are shown in D and F.</p>
<p>Epidemiological and histopathological findings have raised the possibility that misfolded α-synuclein protein might spread from the gut to the brain and increase the risk of Parkinson's disease. Although past experimental studies in mouse models have relied on gut injections of exogenous recombinant α-synuclein fibrils to study gut-to-brain α-synuclein transfer, the possible origins of misfolded α-synuclein within the gut have remained elusive. We recently demonstrated that sensory cells of intestinal mucosa express α-synuclein. Here, we employed mouse intestinal organoids expressing human α-synuclein to observe the transfer of α-synuclein protein from epithelial cells in organoids to cocultured nodose neurons devoid of α-synuclein. In mice expressing human α-synuclein, but no mouse α-synuclein, α-synuclein fibril-templating activity emerged in α-synuclein–seeded fibril aggregation assays in intestine, vagus nerve, and dorsal motor nucleus. In newly engineered transgenic mice that restrict pathological human α-synuclein expression to intestinal epithelial cells, α-synuclein fibril-templating activity transfered to the vagus nerve and dorsal motor nucleus. Subdiaphragmatic vagotomy prior to induction of α-synuclein expression in intestinal epithelial cells effectively protected the hindbrain from emergence of α-synuclein fibril-templating activity. Overall, these findings highlight a potential non-neuronal source of fibrillar α-synuclein protein that might arise in gut mucosal cells.</p>
Book review: the Europe dilemma: Britain and the drama of EU integration by Roger Liddle
No full textWhat is Britain’s future in Europe? What future should Britain want for the EU? Roger Liddle‘s book provides valuable commentary on a topic that is highly salient in Britain and could radically change the trajectory of the country on multiple levels, writes Amani El Sehrawey
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