2,205 research outputs found
Interview with Philip Gerard
No full textInterview with Philip Gerard, author and professor of creative writing at UNCW. Here, he discusses his background and education, the founding and structure of UNCW's MFA in Creative Writing program, and the concerns of memoir and creative nonfiction
CCDC 960057: Experimental Crystal Structure Determination
No full textRelated Article: Apparao Draksharapu, Arnold J. Boersma, Miriam Leising, Auke Meetsma, Wesley R. Browne, Gerard Roelfes|2015|Dalton Trans.|44|3647|doi:10.1039/C4DT02733G,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Philip Gerard, 25th Annual ODU Literary Festival
No full textPhilip Gerard has published fiction and nonfiction in numerous magazines, including New England Review, Bread Loaf Quarterly, Creative Nonfiction, Hawaii Review, Hayden\u27s Ferry Review, and The World & I. He is the author of three novels: Hatteras Light, Cape Fear Rising, Desert Kill; two books of nonfiction, Brilliant Passage...a schooning memoir and Creative Nonfiction - Researching and Crafting Stories of Real Life, and Writing a Book that Makes a Difference. His most recent book is Secret Soldiers, about the first and last battlefield deception outfit ever authorized by the U.S. Army. Gerard has written shows for public television and radio. He teaches creative writing at the University of North Carolina at Wilmington
CCDC 1820683: Experimental Crystal Structure Determination
No full textRelated Article: Arjan Geersing, Nathalie Ségaud, Monique G. P. van der Wijst, Marianne G. Rots, Gerard Roelfes|2018|Inorg.Chem.|57|7748|doi:10.1021/acs.inorgchem.8b00714,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Kant and Gerard on imagination
Get PDFAlexander Gerard, a schottish philosopher, is nowadays almost
forgotten, but at the time of Kant’s philosophical development he was a very
popular author and his works were translated to german. Kant mentioned Gerard
sometimes in his lectures on anthropology, particularly about genius and
imagination. A near analysis and comparing of their conception of genius and
imagination shows a significant influence of Gerard on Kant. Purpose of this
paper is to analyse this influence in the particular case of imagination and active
imagination.O filósofo escocês Alexander Gerard foi quase que inteiramente
esquecido pela história da filosofia. Mas na época em que Kant estava
desenvolvendo sua filosofia crítica, particularmente nos anos 1770, Gerard era
um autor bastante popular, tendo seus principais escritos traduzidos inclusive
para o alemão. Kant o menciona algumas vezes nas lições sobre antropologia,
permitindo assim documentar sua leitura. Este artigo procura mostrar a
influência de Gerard sobre Kant na concepção de uma imaginação ativa, peça
central da filosofia transcendental kantiana
Philip Gerard : an individual /
No full textMode of access: Internet."This first and limited edition of 'Philip Gerard, an individual,' printed for the Faculty and students of Drake University, and for the personal friends of the author, consists of five hundred copies. The number of this book is 98." Signed by author
DNA and RNA induced enantioselectivity in chemical synthesis
No full textOne of the hallmarks of DNA and RNA structures is their elegant chirality. Using these chiral structures to induce enantioselectivity in chemical synthesis is as enticing as it is challenging. In recent years, three general approaches have been developed to achieve this, including chirality transfer by nucleotide templated synthesis, enantioselective catalysis by RNA/DNAzymes and DNA-based asymmetric catalysis. In this article the concepts behind these strategies as well as the important achievements in this field will be discussed.
Reconstructing embedded liberalism: John Gerard Ruggie and constructivist approaches to the study of the international trade regime
No full textIn 1982, John Gerard Ruggie published a study of the postwar international trade and monetary regimes in which he introduced the concept of ‘embedded liberalism’. A large and growing number of international trade scholars are finding Ruggie’s concept of embedded liberalism an appealing one, and it now occupies a significant place on our conceptual horizon. In this article, the author returns to Ruggie’s original article to excavate lessons which are peculiarly relevant for current trade law scholarship. He argues that Ruggie’s account of embedded liberalism usefully serves to destabilize common assumptions about the objectives and normative underpinnings of the trade regime and thereby to expand our conceptions of what a liberal trade regime might plausibly look like. On the other hand, he explains why he does not share the enthusiasm of those who see in embedded liberalism an attractive normative vision to guide WTO reform. In addition, and most importantly, the author draws attention to the constructivist theoretical framework of Ruggie’s piece. He suggests that Ruggie’s article provides a useful introduction to the central elements of constructivist thinking about international institutions and shows how attention to constructivist insights has the potential to significantly enrich and expand our understanding of the trade regime and of trade law
Synthesis of a siderophore-thiostrepton conjugate for targeting of Gram-negative bacteria
No full textIn this study, the synthesis of siderophore-thiostrepton conjugates was investigated.
In order to bypass antibiotic resistance, science started to focus attention on peptide antibiotics, like the ribosomally synthesised and post-translational modified peptides (RiPPs). Thiostrepton is a peptide antibiotic, active against Gram-positive bacteria, that belongs to a class of RiPPs called thiopeptides, containing dehydroaminoacids. Among these, the dehydroalanine residue (Dha) is interesting because of its electrophilic properties that allow different reactions in a site-selective way. For instance, Dha that occurs in thiostrepton can undergo a Diels-Alder reaction without causing the antibiotic to lose its antimicrobial activity and a IEDDA ‘click’ reaction in order to introduce a tetrazine.
Tetrazine is a suitable tool for the attachment of targeting groups to enhance the antimicrobial activity of thiostrepton and to improve its pharmacological properties. An example of such a targeting group are siderophores, a class of low molecular weight iron chelators that bacteria synthesise and excrete under low iron conditions. The iron-siderophore complex, formed outside the cell, is actively transferred inside bacteria where the iron is released. This mechanism has inspired the strategy to synthesise siderophore-thiostrepton conjugates that work as ‘Trojan horse’ for bacteria. During iron uptake the antibiotic is accumulated inside the cell where its antimicrobial action takes place. This strategy could enable thiostrepton to broaden its antimicrobial activity allowing the antibiotic to cross the outer cell membrane of Gram-negative bacteria, to reach its intracellular target and to effectively inhibit cell growth.
In this project the synthesis of two different siderophores with a 1,2,4,5-tetrazine moiety is studied. Siderophore 5, characterized by two benzyl protected catecholate groups, is successfully obtained. However, the deprotection to provide free catechols, very important for the interaction between siderophore and iron, failed. Siderophore 12 with two catecholate groups and an extra hydroxamic acid group, which is essential for a higher binding affinity with iron, was also investigated. Unfortunately, the synthesis could not be completed because of the failure of amide coupling reaction, although significant synthetic intermediates were actually obtained
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