543 research outputs found
Inmunoterapia en pacientes con tumores de cabeza y cuello: Experiencia en nuestro centro
No full textRodriguez Alba, Laura; director de proyecto: Garrido García, Ana2023-2024Grado en MedicinaFacultad de Medicin
Author Correction: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion
No full textThis Article omits a declaration from the Competing Interests statement, which should have included the following: ‘One of the authors, Y.L., is an editor on the staff of Nature Communications, but was not in any way involved in the journal review process. The other authors declare no competing interests.’ Also, the Article contains an error in the name of the author Alba Rodriguez-Meira, which is incorrectly given as Alba Meira. These errors have not been corrected in either the PDF or HTML versions of the Article. © 2019, The Author(s)
Natural variation of response to glyphosate in Sinapis alba (Brassicaceae): Physiological effects, shikimate accumulation and genetic mechanisms
No full text15 Pags.- 7 Figs.- 2 Tabls. Data Availability Statement: The datasets generated and/or analyzed during the current study are available in the Zenodo Repository https://doi.org/10.5281/zenodo.15697367 © 2025 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License.Glyphosate is the most widely used herbicide worldwide, and glyphosate-resistant weeds have increased globally. Resistance mechanisms, including target-site resistance (TSR) and non-target-site resistance (NTSR), are well documented, but their extent and importance are poorly understood among biotypes. This study examines the natural variation in glyphosate sensitivity and its genetic basis in white mustard (Sinapis alba L.) across 192 accessions in Southern Spain. We conducted a multi-population screening to evaluate plant performance, shikimate accumulation, survival and yield under glyphosate exposure and analysed the spatial response pattern. We also assessed the expression of two genes linked to glyphosate resistance, EPSPS and ABCC8, sequenced EPSPS to detect potential mutations and quantified its copy number. Results show glyphosate significantly reduces physiological parameters, with a 90% decrease in photosynthetic rate, a 22% reduction in chlorophyll concentration and a 38% decrease in specific leaf area. However, 32% of accessions survived and produced seeds under glyphosate exposure (1598 g.a.e. ha−1) in the vegetative stage. Survivors accumulated 13% less shikimate, indicating a reduced glyphosate effect on the shikimate pathway. Overexpression of the NTS ABCC8 gene was the most common mechanism in 39% of non-susceptible accessions. Yet, about 20% of survivors were not linked to EPSPS duplication or overexpression of EPSPS or ABCC8, suggesting other genetic mechanisms may contribute to glyphosate resistance in S. alba. Resistant phenotypes were widely dispersed, not confined to specific areas, highlighting the potential role of gene flow in the evolution of herbicide response in S. alba. Our study suggests that the plant resistance to glyphosate may arise from multiple and non-exclusive genetic mechanisms.This study was supported by P18-RT-2834 PAIDI 2020, Junta de Andalucia and Ref. PREDOC_01971 (PAIDI 2020).Peer reviewe
Modelo Predictivo de Caries en Preescolares Mazahuas del Municipio de San José del Rincón, Estado de México
No full textModelo predictivo de caries en preescolares Mazahuas del Municipio de San José del Rincón, Estado de México.Construir un modelo predictivo de caries en preescolares Mazahuas del Municipio de San José del Rincón, Estado de México. Métodos: La muestra fue seleccionada por el método de muestreo no-probabilístico por conveniencia, que incluyó 131 niños de 3 a 5 años de edad de ascendencia Mazahua. La examinación clínica fue realizada mediante el Sistema Internacional para la Detección y Evaluación de Caries (ICDAS). La información de las variables sociodemográficas, de hábitos dietéticos y de higiene oral se obtuvieron a través de una entrevista con los padres o cuidadores principales de los niños. Se construyó un modelo lineal automatizado para identificar los predictores. Resultados: La prevalencia de caries fue de 86.3% donde el 63.4% de los niños presentó Caries Temprana de la Infancia (CTI), mientras que sólo el 22.9% tuvo Caries Temprana de la Infancia Severa (CTI-S). El modelo mostró que el cpos depende de: número de veces que el niño está expuesto a alimentos con azúcares durante las comidas, nivel educativo del cuidador principal, presencia de materia alba, uso de azúcar o miel en el biberón para alimentar al niño. Conclusiones: El modelo predictivo mostró que el cpos fue mayor en los niños que se exponen más veces a azúcares durante las comidas, con presencia de materia alba y aquellos a quienes les dieron biberón y le agregaron azúcar o miel, mientras que fue menor en los niños cuyos cuidadores principales tienen un mayor nivel educativo. Alta prevalencia de caries no tratada
Investigating the impact of different dietary fibres on the gastrointestinal digestion of food proteins
No full textData will be made available on request.In Press.Polysaccharides such as agar, alginate, carrageenan, and cellulose, are highly relevant to the food industry, since they can be naturally found in alternative food sources such as seaweeds, as well as used as functional ingredients in multiple food products. However, their impact on the gastrointestinal digestion of proteins is not yet fully understood. This study investigated the impact of these dietary fibres on the digestion of two model food proteins: casein and whey protein isolate (WPI). In vitro gastrointestinal digestions were carried out, and the resulting digesta were evaluated in terms of digestibility, rheological behaviour, microstructure, and nanostructural organization. Our results showed that adding dietary fibres, especially at higher concentrations (75%), markedly decreased protein digestibility; however, the action mechanism is different depending on the polysaccharide type. Among the tested polysaccharides, alginate and cellulose produced the lowest digestibilities, which in the case of cellulose was mostly driven by limited accessibility of the enzymes towards the protein substrate, while in the case of alginate was due to a combination of strong protein-polysaccharide interactions and increased medium viscosity. SAXS analyses also revealed that the nanoassembly process of the digestion products was strongly affected by the presence of polysaccharides, with protein-polysaccharide interactions hindering the formation of bile salts lamellar structures. These findings provide fundamental insights into how dietary fibres modulate protein digestion, highlighting their relevance in the rational design of functional food systems with improved nutritional and structural properties.This work was funded by European Union (ERC, PRODIGEST, ERC-2022-COG 101086483). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them. Laura Díaz-Piñero is recipient of a pre-doctoral FPU grant from the Spanish Ministry of Universities (FPU21/04504). Synchrotron experiments were performed at NCD beamline at ALBA Synchrotron with the collaboration of ALBA staff (proposals 2023077631 and 2024078506).Peer reviewe
Intertextual References as “Encyclopaedic Implicatures”: The Millenary Tradition of Vampires in Contemporary (Graphic) Novels
No full textThe aim of this article is to analyse how the image of the vampire – as represented in novels and other artistic creations produced throughout the centuries – lives on in many fictional works stemming from contemporaneity. In particular, this paper focuses on the intertextual references and direct quotations often inserted in recent (narrative and graphic) novels in order to create a close connection with the long-standing tradition of the vampire and activate specific scenarios in which, through implicatures and indirect speech acts, the narrative can acquire meaning.
In particular, by bringing together Semiotics, Linguistics and Pragmatics, this article puts forward the notion of “particularized and/or general encyclopaedic implicature” as a new category which might become useful in the analysis of texts of various kinds and the interpretation process they entail.
The analysis developed here focuses in particular on the novels published by American author Ellen Schreiber between 2000 and 2010, and the graphic novels which translate them intersemiotically
Yacana ventania Rodriguez, Armendáriz & Capítulo, 2017, n. sp.
No full text<i>Yacana ventania</i> n. sp. <p>(FIgs 2–8)</p> <p> <b>Material examined.</b> HOlOtype (MLP-Cr 27050): 1 ♀, 8.8 mm, whOle specImen stOred In ethanOl, cOllected at Ventana Stream, SIerra de la Ventana, ArgentIna, 38°3'17.74"S 62°4'49.76"W, 28 May 2015. AllOtype (MLP-Cr 27051): 1 ♂, 6.4 mm, dIssected and mOunted On glass slIdes. Paratype (MLP-Cr 27052): 6 specImens, 3 ♀ and 3 ♂, range length 3–3.78 mm; three Of them were cOmpletely dIssected and mOunted On glass slIdes, frOm One specImen Only Its head was dIssected, and the Other fOur are stOred In ethanOl. Other female specImen Is stOred at the InstItutO de LImnOlOgía “Dr. Raúl A. RInguelet” CONICET-UNLP.</p> <p>LOcalIty and cOllectIOn date Of allOtype and paratype are the same as fOr hOlOtype.</p> <p> <b>Diagnosis.</b> Flagellum Of fIrst antenna wIth 4 artIcles and; accessOry flagellum wIth 3 artIcles; antenna 2 wIth gland cOne. Labrum present. The Inner setae Of Outer lObe Of maxIlla1 are bI-dentate. PereIOpOds are prOgressIvely lOnger tOwards pereIOpOd 7; dactylI dIssImIlar: 3 and 4 wIth a bIfId claw, 5–7 wIth sImple claw. PereIOpOd 7 wIth abundant setae On merus and carpus.</p> <p> <b>Description.</b> Female. BOdy elOngated and laterally cOmpressed wIth small setae On each bOdy sOmIte, wIthOut cOlOratIOn (FIg. 2A). Head wIthOut rOstrum, neIther eyes nOr Ocular lObes. Large urOpOds, the secOnd paIr extendIng beyOnd the telsOn. TOtal bOdy length (wIthOut antennae) 8.8 mm.</p> <p>Antenna 1 (FIg. 2 B, C): peduncular artIcle 1 Is as lOng as artIcle 2 and 3 cOmbIned and prOgressIvely shOrter tOwards dIstal, length ratIO as 1:0.57:0.42, all Of them wIth setae. Flagellum cOnsIstIng Of 4 artIcles, artIcles 1–3 wIth 1–3 setae On each, and the last artIcle has 6 setae and a spatulate structure Of unknOwn functIOn; the last 3 artIcles bear One aesthetasc On each Of them. The accessOry flagellum Is 3-artIculated and exceeds the secOnd artIcle Of the flagellum, at mOst wIth 4 setae per artIcle. The dIstal pOrtIOn ends In 2 fIlIfOrm structures and In the mIddle, a structure Of unknOwn functIOn as In the last artIcle Of the flagellum.</p> <p>Antenna 2 (FIg. 2 D): slIghtly shOrter than antenna 1. The peduncle Is 4-artIculated and three tImes as lOng as the flagellum; the fIrst artIcle wIth a gland cOne, the Others wIth 2, 6 and 10 setae, respectIvely. The flagellum cOnsIsts Of 5 artIcles, artIcles 1 and 3 wIth 3 setae whIle artIcles 2, 4 and 5 wIth 4 apIcal setae, the last artIcle alsO has a termInal structure Of unknOwn functIOn as In the antenna 1.</p> <p>Labrum (FIg. 2 E): subquadrangular and as bIg as the fOllOwIng mOuth pIeces, gently depressed On the center Of the Outer sIde.</p> <p>LabIum (FIg. 2 F): wIthOut Inner lObe, the Outer lObes small and separated, On the dIstal part wIth a pOInted end. As It Is mentIOned On remarks Of the genera, a gland draIns tO the pOInted ends.</p> <p>Female mandIbles (FIg. 3 A, B): wIth mOlar prOcess nOn-trIturatIve, reduced, spInIfOrm and serrated On One Of Its sIdes. RIght mandIble: wIth 5-dentIculate IncIsOr, lacInIa mObIlIs wIth 2 lOnger teeth On bOth ends and a flattened blade In between; spIne rOw cOnsIstIng Of twO shOrt strOng bladelIke dentIculate spInes and One plumOse On One Of Its sIde. Left mandIble: IncIsOr subrectangular, 4-dentIculate; lacInIa mObIlIs subrectangular, brOader than IncIsOr and cuttIng edge Irregularly multI-dentIculate; apparently wIthOut spIne rOw.</p> <p>Male mandIbles (FIg. 3 C, D): rIght mandIble: wIth 3-dentIculate IncIsOr, lacInIa mObIlIs wIth 2 lOnger teeth On bOth ends and a flattened blade In between; spIne rOw wIth twO shOrt strOng bladelIke smOOth spInes and One plumOse On One Of Its sIde. Left mandIble: IncIsOr subrectangular, cuttIng edge Irregularly multI-dentIculate; lacInIa mObIlIs wIth One lOng tOOth; the spIne rOw Is as In the rIght mandIble but dentIculate.</p> <p>MaxIlla 1 (FIg. 3 E–G): the cOxal endIte (= Inner lObe) has 4 setae; the basal endIte (= Outer lObe) has 6 setae Of dIfferent type: bIfId Or trIfId, pectInated, sImple, dentate and bI-dentate; the endOpOd (=palp) Is bI-artIculated and has 3 large apIcal setae. PartIcularly, the Outer setae Of the Outer lObe Is bIfId Or trIfId, fOllOwed by a pectInated, sImple and pectInated setae; the fIfth seta has fIve Or sIx teeth In the left maxIlla 1 and three teeth In the rIght One; and fInally the Inner seta Is bI-dentate. ThIs last type Of seta In maxIlla 1 Is a new character, nOt mentIOned befOre In IngOlfIellIds. MaxIlla 2 (FIg. 3 H): the Inner lObe wIth 3 tO 5 setae; Outer lObe wIth 3 tO 5 setae dIstally.</p> <p>MaxIllIped (FIg. 3 I, J): basal endIte small and narrOw, fInger-lIke, wIth an apIcal sIngle curved spIne and a lateral seta; palp cOnsIstIng Of 6 artIcles; IschIum wIth twO sImple setae On Inner margIn; merus, carpus, and prOpOdus each wIth sIngle sImple seta; and fInally, dactylus wIth twO setae, and lOng unguIs.</p> <p>GnathOpOd 1 (FIg. 4 A, B): has a wIde basIs wIth dIstO-ventral seta; shOrt merus wIth a seta and IschIum wIth 2 dIstal setae, One twIce lOnger than the Other. CarpO-subchelate cOnsIstIng Of an elOngated artIcle wIth 3 spInes, the prOxImal One Is On the tOp Of a fInger-shaped prOcess In the Inner sIde; palm margIn smOOth, nOt serrated, armed by a rOw Of 6 Or 7 submargInal setae and Others dIspersed On the palm, On the Inner sIde there Is a nOtch lIke a “pOcket” apparently tO accOmmOdate dIstal pOrtIOn Of unguIs. PrOpOdus and dactylus fOrm the claw; prOpOdus Is dIstally prOduced IntO a fInger-shaped prOcess carryIng a seta and a mInute and brOad spIne. The dactylus has 3 blade-lIke teeth.</p> <p>GnathOpOd 2 (FIg. 4 C, D): The basIs slIghtly elOngate wIth a dIstO-ventral seta; shOrt merus wIth a seta and IschIum wIth 2 dIstal setae and One medIal tIny seta. CarpO-subchelate, stOut and subtrapezOIdal, palm angle defIned by One large seta and wIth a quIte rObust, elOngated tOOth-lIke spIne, palm wIth a medIan smaller spIne, 6 Or 7 setae and a nOtch On the Inner sIde apparently tO accOmmOdate dIstal pOrtIOn Of unguIs. Palm margIn smOOth. PrOpOdus wIth a dIstal Outer seta, and a fInger-lIke fOrm at Its dIstal end wIth a seta and a tIny spIne. FInally, the dactylus has 3 blade-lIke teeth and a seta at the base Of the unguIs. Dactylus strOnger than In gnathOpOd 1.</p> <p>PereIOpOds 3–7 are dIssImIlar (FIgs. 5, 6): 3 and 4 theIr dactylI pOInt backward whIle 5–7 are fOrward pOInted, pereIOpOds 3–5 wIth gIlls and pereIOpOds 6 and 7 wIthOut them, nOne Of them have OOstegItes.</p> <p>PereIOpOds 3 and 4 (FIg. 5 A–D): cOxa wIth 1–2 setae, basIs elOngated armed wIth 4–6 setae; shOrt merus wIth a dIstal seta; IschIum wIth 3 setae; carpus wIth a seta and a spIne; prOpOdus wIth 3 setae alIgned and the dIstal end has 2 spInes One Of them bIfId and, a seta; fInally, the dactylus as a bIfId claw. The suture between dactylus and unguIs Is IncOnspIcuOus In pereIOpOd 3 but nOt vIsIble In pereIOpOd 4.</p> <p>PereIOpOd 5 (FIg. 5 E, F): cOxa wIth a seta; basIs wIth 4 setae; merus wIth a seta; IschIum wIth 1–3 setae and a spIne; carpus has dIstally 6 setae and 3 spInes; prOpOdus bears 2 setae alIgned, 3 termInal spInes and a seta; dactylus lIke a claw, the suture between dactylus and unguIs dOes nOt dIstInguIsh.</p> <p>PereIOpOd 6 (FIg. 6 A–C): cOxa wIth 2 setae; basIs wIth 4 setae; merus wIth a seta; IschIum wIth a seta and a spIne; carpus has at Its end 4 setae and 3 spInes; prOpOdus bears 2 termInal setae and 2 spInes, One Of them bIfId; dactylus lIke a claw and the suture Of the unguIs vIsIble.</p> <p>Female pereIOpOd 7 (FIg. 6 D–F): Is the lOngest appendIx frOm the pereIOn; cOxa wIth 2 setae, basIs wIth a seta, merus shOrt and wIth a seta; IschIum wIth 5 setae and a spIne, 3 Of whIch are as lOng as the carpus and One bIfId; carpus has On the dIstal part 6 setae and a spIne, One Of the seta Is pectInated (FIg. 6 D, E, arrOwed); prOpOdus wIth 4 setae and a spIne, 3 Of them dIstally; dactylus wIth claw and unguIs.</p> <p>Male pereIOpOd 7 (FIg. 6 G–J): as In the female Is the lOngest appendIx frOm the pereIOn; cOxa wIth a seta, basIs wIth 4 setae, merus shOrt and wIthOut any seta; IschIum wIth 5 medIal setae and at Its end, a spIne surrOunded by many setae: 3 Of them are as lOng as the carpus, the Other 3 smaller; carpus has a prOxImal small seta, On the dIstal part has 2 setae, a spIne, and alsO 9 setae In a transversal rOw, the Outer One Is pectInated (FIg. 6 G, H, arrOwed); prOpOdus wIth 4 setae, 3 Of them dIstally; dactylus wIth claw and unguIs. It Is remarkable that thIs pereIOpOd Is mOre setOse In males than females.</p> <p>PleOpOds (FIg. 7 A–F): unIramOus and armed wIth 1–2 dIstal setae; On females (FIg. 7 A–C) the pleOpOds are almOst trIangular, the secOnd pleOpOd Is the wIdest and wIth feeble serratIOns On the Inner sIde. PleOpOds 1 and 3 has a small seta On the lateral surface near the apex. On males (FIg. 7 D–F), the fIrst pleOpOd Is lIke a lOng fIn havIng 2–3 setae, frOm them 1 Or 2 are lOng and On the apex.</p> <p>UrOpOd 1 (FIg. 7 G, I): wIth a large peduncle; the external ramus Is unarmed, fIve tImes shOrter than the peduncle and pOInted end; the Internal ramus Is half lOng than the peduncle, the dIstal end Of the ramus Is prOvIded wIth 2 sharp, tOOth-lIke prOjectIOns and a medIal lanceOlate structure. In females the peduncle has a rOw Of 3 setae On anterOlateral margIn and a seta On the OppOsIte sIde, whIle In males It has a rOw Of 7 setae On anterOlateral margIn and 2 lOnely setae On the Other sIde.</p> <p>UrOpOd 2 (FIg. 7 H, J): Is barely lOnger than urOpOd 1; the peduncle Is mOre rObust than urOpOd 1, On Its Inner surface bears OblIque rOws Of setae wIth a lOnger seta at the upper end Of each Of these rOws, On the Outer surface has 3 small setae and a dIstal large One; ramI Of U2 subequal In length and wIdth, each ramus wIth 3–4 setae. On hOlOtype female the peduncle has 7 rOws Of setae but In Other females It has fewer rOws, On males It has 5 rOws Of setae.</p> <p>UrOpOd 3 Is rudImentary (FIg. 7 K, L); the peduncle wIth a seta dIstO-dOrsally; the ramus Is shOrt wIth a very lOng sImple seta termInally.</p> <p>The telsOn (FIg. 7 K, L): Is a fleshy lObe prOvIded wIth a paIr Of quIte lOng setae.</p> <p> <b>Remarks.</b> The maIn features fOund In <i>Yacana ventania</i> <b>n. gen. n. sp.</b>, are: the presence Of a termInal structure Of unknOwn functIOn at the end Of the flagellum Of bOth antennae and at the accessOry flagellum Of antenna 1. In sOme specIes, lIke <i>I. alba</i> and <i>I. arganoi</i>, the authOrs (IannIllI <i>et al</i>. 2008; IannIllI & VOnk 2013) descrIbe thIs structure On the last artIcle Of the flagellum Of antenna 2 as an aesthetasc. The new taxOn here descrIbed has mandIbles wIth mOlar prOcesses vestIgIal and serrated On One sIde, spIne rOws wIth twO bladelIke and plumOse spInes. The Outer lObe Of the maxIlla 1 has twO dIstInctIve setae: One bI-dentate On the Inner sIde and Other bIfId Or trIfId On the Outer sIde. The suture between dactylus and unguIs Of the pereIOpOds Is vIsIble Only In sOme Of them, regardless If the specImens are females Or males. The paratype females agree In almOst all characters wIth the hOlOtype, nevertheless the peduncle Of urOpOd 2 has mOre rOws Of setae In the hOlOtype than the paratypes; thIs cOuld be due tO the bIgger sIze Of the hOlOtype In respect tO the paratypes.</p> <p> <b>Etymology.</b> The specIfIc epIthet refers tO the geOgraphIcal regIOn and the type lOcalIty.</p> <p> <b>Distribution and biology.</b> <i>Yacana ventania</i> <b>n. gen. n. sp</b>. was cOllected at Ventana Stream, VentanIa HIlls, BuenOs AIres prOvInce, ArgentIna On 28th May 2015 In the rIthrOn substrate. Female sIzes varIed between 3.55 and 8.8 mm; the smaller shOwed three rOws Of setae In the secOnd paIr Of urOpOds, whIle the larger exhIbIted 7 rOws Of setae. WIth regard tO males, theIr sIzes varIed between 3.0 and 6.4 mm; the smaller shOwed twO rOws Of setae In the secOnd paIr Of urOpOds, fIve rOws In the larger specImen.</p> <p>When the cOllectIOn tOOk place the physIcOchemIcal parameters regIstered were: temperature 14.40 °C, pH 8.97, flOw speed 0.2 m s -1, average depth 0.25 m, cOnductIvIty 0.164 mS cm -1, dIssOlved Oxygen 7.42 mg L -1, nutrIents: P-PO4 0.023 mg L -1, N-NO3 0.833 mg L -1, N-NO2 0.003 mg L -1 y N-NH4<0.001mg L -1.</p> <p> The maIn accOmpanyIng fauna were the flatwOrms DugesIIdae, the OlIgOchaetes EnchytraeIdae and NaIdIdae, the pOlychaetes AeOlOsOmatIdae, the black flIes SImulIdae, the caddIsflIes HydrOpsychIdae and COpepOda. VegetatIOn at the samplIng sIte: <i>Ludwigia peploides</i>, <i>Rorippa nasturtium-aquaticum</i> and <i>Gymnocoronis spilanthoides</i>.</p> <p> ExamInatIOn Of the gut cOntent revealed that <i>Yacana ventania</i> n. gen, n. sp. mIght be detrItIvOrOus because partIcles frOm 5 µ tO 12.5 µ were fOund In It. AlthOugh Only nIne specImens were cOllected, we suppOse a sex ratIO (♀♀/♂♂) Of 1.25 In the pOpulatIOn Of the type lOcalIty.</p>Published as part of <i>Rodriguez, Marianela, Armendáriz, Laura C. & Capítulo, Alberto Rodrígues, 2017, A new genus and species of Ingolfiellidae (Crustacea, Ingolfiellida) from the hyporheic zone in the Sierra de la Ventana, and its biogeographic relevance, pp. 99-112 in Zootaxa 4290 (1)</i> on pages 102-109, DOI: 10.11646/zootaxa.4290.1.5, <a href="http://zenodo.org/record/828923">http://zenodo.org/record/828923</a>
The effect of female participation on fertility in Spain: how does it change as the birth comes closer.
No full textIn this paper we anaIyze the effect of female labor force participation on fertility decisions. We focus on two issues that emerge when estimating such effect: (i) the endogeneity between fertility and participation; and (ii) the period in which participation is measured with respect to fertility. We account for the first problem by using an empirical model based on the assumption that women decide on labor force participation and childbearing in response to incentives provided by prices and incomes. The second issue is addressed exploiting the panel structure of our data (matched EPA files). which allow us to measure women labor force participation at several points in the time preceding a birth. Our results show that it is important to account for the endogeneity between participation and fertility and that women's attitude toward the labour market changes along the pregnancy.Fertility; Femal labor force participation; Endogeneity;
El Trabajo Del Tratamiento Penitenciario Incide En El Proceso De Rehabilitación De Los Sentenciados – Varones Del Establecimiento Penitenciario De Chimbote, 2017
No full textLa presente tesis de investigación titulada “EL TRABAJO DEL TRATAMIENTO
PENITENCIARIO INCIDE EN EL PROCESO DE REHABILITACIÓN DE LOS
SENTENCIADOS – VARONES DEL E. P. DE CHIMBOTE, 2017”, se ha desarrollado con
el propósito de verificar la norma, tal y como se determina en el Código de Ejecución Penal,
porque existe un gran porcentaje de delincuencia a nivel nacional y de ahí surgió la duda de
cómo se llevaba a cabo el tratamiento penitenciario, siendo el trabajo el cual nosotras
consideramos uno de los más importantes, y teniendo en cuenta que el fin inmediato del
trabajo es la rehabilitación del sentenciado.
El objetivo general de la presente investigación es: Evaluar si el Trabajo del Tratamiento
Penitenciario incide en el proceso de rehabilitación de los sentenciados – varones del
Establecimiento Penitenciario de Chimbote; y como objetivos específicos: Analizar el
cumplimiento del trabajo en cuanto a derecho y deber de todos los sentenciados varones,
determinar que el trabajo penitenciario realizado, logra cumplir con el objeto de cambio de
la conducta de los sentenciados varones, analizar el tipo de trabajo que se viene realizando,
sea idóneo para la rehabilitación de los sentenciados varones y por ultimo determinar cuáles
son los factores que posibilitan o dificultan la realización del trabajo penitenciario.
El trabajo se ha desarrollado aplicando la metodología de la investigación científica de
conformidad con los lineamientos establecidos por la Universidad. Para tal efecto se
aplicaron las técnicas de la encuesta. Con la información recogida mediante las técnicas e
instrumentos se ha consolidado la presente información. La información obtenida se ha
clasificado para compararse los datos reales con la hipótesis planteada y los objetivos
propuestos en la presente tesis de investigación.
Como resultado de la presente tesis se ha concluido que si se realiza el Trabajo del
Tratamiento Penitenciario y este si llega a incidir en el proceso de rehabilitación de los
sentenciados varones, aunque se tenga pocos alcances y recursos, se lleva de la mejor
manera tratando de que se cumpla con el objetivo del trabajo penitenciario
Silk fibroin nanoparticles constitute a vector for controlled release of resveratrol in an experimental model of inflammatory bowel disease in rats
No full textAntonio Abel Lozano-Pérez,1 Alba Rodriguez-Nogales,2 Víctor Ortiz-Cullera,1 Francesca Algieri,2 José Garrido-Mesa,2 Pedro Zorrilla,2 M Elena Rodriguez-Cabezas,2 Natividad Garrido-Mesa,2 M Pilar Utrilla,2 Laura De Matteis,3 Jesús Martínez de la Fuente,3 José Luis Cenis,1 Julio Gálvez2 1Instituto Murciano de Investigación y Desarrollo Agrario y Alimentario, Murcia, Spain; 2Centro de Investigaciones Biomédicas en Red – Enfermedades Hepáticas y Digestivas, Department of Pharmacology, ibs Granada, Center for Biomedical Research, University of Granada, Granada, Spain; 3Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Zaragoza, Spain Purpose: We aimed to evaluate the intestinal anti-inflammatory properties of silk fibroin nanoparticles, around 100 nm in size, when loaded with the stilbene compound resveratrol, in an experimental model of rat colitis. Methods: Nanoparticles were loaded with resveratrol by adsorption. The biological effects of the resveratrol-loaded nanoparticles were tested both in vitro, in a cell culture of RAW 264.7 cells (mouse macrophages), and in vivo, in the trinitrobenzenesulfonic acid model of rat colitis, when administered intracolonically.Results: The resveratrol liberation in 1× phosphate-buffered saline (PBS; pH 7.4) was characterized by fast liberation, reaching the solubility limit in 3 hours, which was maintained over a period of 80 hours. The in vitro assays revealed immunomodulatory properties exerted by these resveratrol-loaded nanoparticles since they promoted macrophage activity in basal conditions and inhibited this activity when stimulated with lipopolysaccharide. The in vivo experiments showed that after evaluation of the macroscopic symptoms, inflammatory markers, and intestinal barrier function, the fibroin nanoparticles loaded with resveratrol had a better effect than the single treatments, being similar to that produced by the glucocorticoid dexamethasone. Conclusion: Silk fibroin nanoparticles constitute an attractive strategy for the controlled release of resveratrol, showing immunomodulatory properties and intestinal anti-inflammatory effects. Keywords: immunomodulatory, cytokines, TNBS rat colitis, RAW 264.7 macrophage cells, antioxidan
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